(Q38124247)

English

The role of AKT/mTOR pathway in stress response to UV-irradiation: implication in skin carcinogenesis by regulation of apoptosis, autophagy and senescence

scientific article published on 24 July 2013

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

29 August 2017

11 references

3 April 2019

30 June 2019

2 August 2019

28 September 2019

21 October 2019

18 December 2019

1 September 2020

18 September 2020

20 October 2020

1 December 2020

28 January 2021

The role of AKT/mTOR pathway in stress response to UV-irradiation: implication in skin carcinogenesis by regulation of apoptosis, autophagy and senescence (English)

1 reference

Europe PubMed Central

PMC publication ID

29 August 2017

0 references

proto-oncogene protein

1 reference

2 August 2019

1 reference

28 September 2019

integumentary system

1 reference

21 October 2019

neoplasm protein

1 reference

18 December 2019

AKT serine/threonine kinase 1

1 reference

1 September 2020

1 reference

1 December 2020

1 reference

20 October 2020

Serine/threonine-protein kinase TOR

1 reference

28 January 2021

apoptotic process

1 reference

based on heuristic

inferred from title

author name string

Elwira Strozyk

1

1 reference

Europe PubMed Central

PMC publication ID

29 August 2017

Dagmar Kulms

2

1 reference

Europe PubMed Central

PMC publication ID

29 August 2017

language of work or name

0 references

publication date

24 July 2013

11 references

Europe PubMed Central

PMC publication ID

29 August 2017

3 April 2019

30 June 2019

2 August 2019

28 September 2019

21 October 2019

18 December 2019

1 September 2020

20 October 2020

1 December 2020

28 January 2021

International Journal of Molecular Sciences

11 references

Europe PubMed Central

PMC publication ID

29 August 2017

3 April 2019

30 June 2019

2 August 2019

28 September 2019

21 October 2019

18 December 2019

1 September 2020

20 October 2020

1 December 2020

28 January 2021

14

1 reference

Europe PubMed Central

PMC publication ID

29 August 2017

8

1 reference

Europe PubMed Central

PMC publication ID

29 August 2017

15260-15285

1 reference

Europe PubMed Central

PMC publication ID

29 August 2017

copyright license

Creative Commons Attribution 3.0 Unported

10 references

Europe PubMed Central

3 April 2019

Europe PubMed Central

30 June 2019

Europe PubMed Central

2 August 2019

Europe PubMed Central

28 September 2019

Europe PubMed Central

21 October 2019

Europe PubMed Central

18 December 2019

Europe PubMed Central

1 September 2020

Europe PubMed Central

20 October 2020

Europe PubMed Central

1 December 2020

Europe PubMed Central

28 January 2021

copyright status

0 references

Autophagy has a significant role in determining skin color by regulating melanosome degradation in keratinocytes

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Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy

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Inhibition of mTOR suppresses UVB-induced keratinocyte proliferation and survival.

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Alkannin, HSP70 inducer, protects against UVB-induced apoptosis in human keratinocytes.

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GSK3β signaling is involved in ultraviolet B-induced activation of autophagy in epidermal cells

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Melanoma induction by ultraviolet A but not ultraviolet B radiation requires melanin pigment

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Shining light on skin pigmentation: the darker and the brighter side of effects of UV radiation

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Functional protein pathway activation mapping of the progression of normal skin to squamous cell carcinoma

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Targeting protective autophagy exacerbates UV-triggered apoptotic cell death

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6 September 2017

Protein kinases and transcription factors activation in response to UV-radiation of skin: implications for carcinogenesis

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6 September 2017

Chromatin structure following UV-induced DNA damage-repair or death?

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6 September 2017

RAS/RAF/MEK/ERK and PI3K/PTEN/AKT Signaling in Malignant Melanoma Progression and Therapy

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Cell death pathology: cross-talk with autophagy and its clinical implications

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The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

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6 September 2017

Protection from UV-induced skin carcinogenesis by genetic inhibition of the ataxia telangiectasia and Rad3-related (ATR) kinase

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6 September 2017

UV irradiation resistance-associated gene suppresses apoptosis by interfering with BAX activation

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Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition.

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6 September 2017

NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-α feedforward signaling

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6 September 2017

DNA damage and autophagy

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6 September 2017

Inhibition of the JNK/Bim pathway by Hsp70 prevents Bax activation in UV-induced apoptosis

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6 September 2017

Autophagy and the integrated stress response

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6 September 2017

Negative regulation of autophagy

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6 September 2017

Autophagy in mammalian development and differentiation

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6 September 2017

PI(3)king apart PTEN's role in cancer.

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6 September 2017

Melanocytes are deficient in repair of oxidative DNA damage and UV-induced photoproducts

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6 September 2017

Paradoxical suppression of cellular senescence by p53

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6 September 2017

Cellular stress responses: cell survival and cell death

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6 September 2017

Suppression of melanin production by expression of HSP70

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Autophagy regulation by p53.

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6 September 2017

Autophagy and tumorigenesis

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6 September 2017

UVB-induced ERK/AKT-dependent PTEN suppression promotes survival of epidermal keratinocytes

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6 September 2017

p53 prevents immature escaping from cell cycle G2 checkpoint arrest through inhibiting cdk2-dependent NF-Y phosphorylation

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The UV response of the skin: a review of the MAPK, NFkappaB and TNFalpha signal transduction pathways.

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Erbb2 suppresses DNA damage-induced checkpoint activation and UV-induced mouse skin tumorigenesis

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6 September 2017

The role of BRAF mutation and p53 inactivation during transformation of a subpopulation of primary human melanocytes

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Parameters of protection against ultraviolet radiation-induced skin cell damage

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Molecular mechanisms of mTOR-mediated translational control

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ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery

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Requirement for metalloproteinase-dependent ERK and AKT activation in UVB-induced G1-S cell cycle progression of human keratinocytes

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6 September 2017

The p53 family and programmed cell death

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PI3K/Akt: getting it right matters

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UVA-induced cell cycle progression is mediated by a disintegrin and metalloprotease/epidermal growth factor receptor/AKT/Cyclin D1 pathways in keratinocytes

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UV damage and DNA repair in malignant melanoma and nonmelanoma skin cancer

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6 September 2017

To die or not to die: that is the autophagic question

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UVB-induced senescence in human keratinocytes requires a functional insulin-like growth factor-1 receptor and p53.

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6 September 2017

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6 September 2017

AKT/PKB signaling: navigating downstream

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6 September 2017

Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1

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6 September 2017

DNA double-strand break repair: from mechanistic understanding to cancer treatment

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6 September 2017

Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

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Knockdown of ribosomal protein S3 protects human cells from genotoxic stress

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6 September 2017

Cyclobutane pyrimidine dimers are predominant DNA lesions in whole human skin exposed to UVA radiation.

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6 September 2017

Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG

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6 September 2017

mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

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6 September 2017

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6 September 2017

DNA lesions induced by UV A1 and B radiation in human cells: comparative analyses in the overall genome and in the p53 tumor suppressor gene.

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6 September 2017

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6 September 2017

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6 September 2017

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

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6 September 2017

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6 September 2017

A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells

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6 September 2017

How to activate p53

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6 September 2017

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

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6 September 2017

Two CD95 (APO-1/Fas) signaling pathways

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6 September 2017

Ultraviolet light induces apoptosis via direct activation of CD95 (Fas/APO-1) independently of its ligand CD95L

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6 September 2017

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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6 September 2017

Molecular cloning of a novel human gene encoding a 63-kDa protein and its sublocalization within the 11q13 locus

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6 September 2017

Mechanism of activation of protein kinase B by insulin and IGF-1

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6 September 2017

Frequent clones of p53-mutated keratinocytes in normal human skin

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6 September 2017

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

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6 September 2017

MRE11 promotes AKT phosphorylation in direct response to DNA double-strand breaks.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

6 September 2017

The UV (Ribotoxic) stress response of human keratinocytes involves the unexpected uncoupling of the Ras-extracellular signal-regulated kinase signaling cascade from the activated epidermal growth factor receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

14 September 2017

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

14 September 2017

Heat stress upregulates chaperone heat shock protein 70 and antioxidant manganese superoxide dismutase through reactive oxygen species (ROS), p38MAPK, and Akt.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

14 September 2017

AMP-activated protein kinase contributes to UV- and H2O2-induced apoptosis in human skin keratinocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

14 September 2017

Identification of PP2A as a crucial regulator of the NF-kappaB feedback loop: its inhibition by UVB turns NF-kappaB into a pro-apoptotic factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

14 September 2017

Mitochondrial dysfunction and cellular stress progression after ultraviolet B irradiation in human keratinocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

14 September 2017

Development of thermotolerance requires interaction between polymerase-beta and heat shock proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

14 September 2017

Epidermal growth factor receptor pathway mitigates UVA-induced G2/M arrest in keratinocyte cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

14 September 2017

UV light-induced DNA damage and tolerance for the survival of nucleotide excision repair-deficient human cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

14 September 2017

Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

14 September 2017

Reversal of senescence in mouse fibroblasts through lentiviral suppression of p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

14 September 2017

Role of p53 in G2/M cell cycle arrest and apoptosis in response to gamma-irradiation in ovarian carcinoma cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

14 September 2017

Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

28 September 2017

Interleukin-1 protects transformed keratinocytes from tumor necrosis factor-related apoptosis-inducing ligand- and CD95-induced apoptosis but not from ultraviolet radiation-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

28 September 2017

Overexpression of the small heat shock protein, hsp27, confers resistance to hyperthermia, but not to oxidative stress and UV-induced cell death, in a stably transfected squamous cell carcinoma cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

28 September 2017

Autophagy and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

23 June 2018

Suppression of PTEN transcription by UVA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

23 June 2018

Changes in mitochondrial DNA alter expression of nuclear encoded genes associated with tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

23 June 2018

Novel Insights into the Interplay between Apoptosis and Autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

23 June 2018

Differential activation of signaling pathways by UVA and UVB radiation in normal human epidermal keratinocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

23 June 2018

p53 mutations in human cutaneous melanoma correlate with sun exposure but are not always involved in melanomagenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

23 June 2018

p53 mutations in human immortalized epithelial cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

23 June 2018

Induction of heat shock protein 70 ameliorates ultraviolet-induced photokeratitis in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

31 August 2018

Protein kinase B/Akt1 inhibits autophagy by down-regulating UVRAG expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

31 August 2018

Infrared radiation does not enhance the frequency of ultraviolet radiation-induced skin tumors, but their growth behaviour in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

31 August 2018

Aldose reductase in keratinocytes attenuates cellular apoptosis and senescence induced by UV radiation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

31 August 2018

Differential localization of ATM is correlated with activation of distinct downstream signaling pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

31 August 2018

Infrared radiation confers resistance to UV-induced apoptosis via reduction of DNA damage and upregulation of antiapoptotic proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

31 August 2018

Activation of the mammalian target of rapamycin signalling pathway in epidermal tumours and its correlation with cyclin-dependent kinase 2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

31 August 2018

HSP70i accelerates depigmentation in a mouse model of autoimmune vitiligo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

31 August 2018

Downregulation of melanin synthesis by haginin A and its application to in vivo lightening model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

31 August 2018

Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

31 August 2018

Differential effects of NF-kappaB on apoptosis induced by DNA-damaging agents: the type of DNA damage determines the final outcome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

31 August 2018

Distinct activation mechanisms of protein kinase B by growth-factor stimulation and heat-shock treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

31 August 2018

Epidermal growth factor receptor-dependent, NF-kappaB-independent activation of the phosphatidylinositol 3-kinase/Akt pathway inhibits ultraviolet irradiation-induced caspases-3, -8, and -9 in human keratinocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

31 August 2018

Comet assay combined with p53 detection as a sensitive approach for DNA photoprotection assessment in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

31 August 2018

DNA damage, death receptor activation and reactive oxygen species contribute to ultraviolet radiation-induced apoptosis in an essential and independent way.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

31 August 2018

Cytokine-induced p38 activation feedback regulates the prolonged activation of AKT cell survival pathway initiated by reactive oxygen species in response to UV irradiation in human keratinocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

31 August 2018

Individual determination of the yield of the main UV-induced dimeric pyrimidine photoproducts in DNA suggests a high mutagenicity of CC photolesions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

31 August 2018

Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

31 August 2018

p53-regulated apoptosis is differentiation dependent in ultraviolet B-irradiated mouse keratinocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759859

31 August 2018

Cell cycle arrest is not senescence

1 reference

https://api.crossref.org/works/10.3390%2FIJMS140815260

21 January 2018

Checkpoints: How to activate p53

1 reference

https://api.crossref.org/works/10.3390%2FIJMS140815260

21 January 2018

Sunburn and p53 in the onset of skin cancer

1 reference

https://api.crossref.org/works/10.3390%2FIJMS140815260

21 January 2018

Activation of protein kinase B induced by H(2)O(2) and heat shock through distinct mechanisms dependent and independent of phosphatidylinositol 3-kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/23887651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ligand-activated PPARδ inhibits UVB-induced senescence of human keratinocytes via PTEN-mediated inhibition of superoxide production

1 reference

https://pubmed.ncbi.nlm.nih.gov/23887651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NF{kappa}B-dependent down-regulation of tumor necrosis factor receptor-associated proteins contributes to interleukin-1-mediated enhancement of ultraviolet B-induced apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23887651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ATG genes involved in non-selective autophagy are conserved from yeast to man, but the selective Cvt and pexophagy pathways also require organism-specific genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23887651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Perifosine sensitizes UVB-induced apoptosis in skin cells: new implication of skin cancer prevention?

1 reference

https://pubmed.ncbi.nlm.nih.gov/23887651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspases: the proteases of the apoptotic pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/23887651

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3390/IJMS140815260

1 reference

Europe PubMed Central

PMC publication ID

29 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

29 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

29 August 2017

ResearchGate publication ID

0 references

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