(Q38240032)

31 August 2017

title

Oncometabolites-driven tumorigenesis: From genetics to targeted therapy (English)

1 reference

31 August 2017

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25124653%20AND%20SRC:MED&resulttype=core&format=json

Anne-Paule Gimenez-Roqueplo

3 June 2020

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25124653%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Judith Favier

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25124653%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

author name string

Aurélie Morin

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25124653%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

language of work or name

English

0 references

publication date

14 August 2014

1 reference

International Journal of Cancer

31 August 2017

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25124653%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

volume

135

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25124653%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

issue

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25124653%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

page(s)

2237-2248

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25124653%20AND%20SRC:MED&resulttype=core&format=json

Metabolic reprogramming: a cancer hallmark even warburg did not anticipate

3 June 2020

cites work

1 reference

Metabolic targets for cancer therapy

21 January 2018

1 reference

Understanding the Warburg effect: the metabolic requirements of cell proliferation

21 January 2018

1 reference

Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma

21 January 2018

1 reference

SDHA is a tumor suppressor gene causing paraganglioma

21 January 2018

1 reference

Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma

21 January 2018

1 reference

Mutations in SDHC cause autosomal dominant paraganglioma, type 3.

21 January 2018

1 reference

SDHAF2 mutations in familial and sporadic paraganglioma and phaeochromocytoma

21 January 2018

1 reference

Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations

21 January 2018

1 reference

SDHA loss of function mutations in a subset of young adult wild-type gastrointestinal stromal tumors

21 January 2018

1 reference

Germline SDHB mutations and familial renal cell carcinoma.

21 January 2018

1 reference

Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

21 January 2018

1 reference

Germline mutations in FH confer predisposition to malignant pheochromocytomas and paragangliomas

21 January 2018

1 reference

An integrated genomic analysis of human glioblastoma multiforme

21 January 2018

1 reference

Recurring mutations found by sequencing an acute myeloid leukemia genome

21 January 2018

1 reference

IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours

21 January 2018

1 reference

Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping

21 January 2018

1 reference

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

21 January 2018

1 reference

Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations

21 January 2018

1 reference

Carotid body tumors in inhabitants of altitudes higher than 2000 meters above sea level

21 January 2018

1 reference

The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathway

21 January 2018

1 reference

Functional consequences of a SDHB gene mutation in an apparently sporadic pheochromocytoma

21 January 2018

1 reference

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

21 January 2018

1 reference

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

21 January 2018

1 reference

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

21 January 2018

1 reference

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

21 January 2018

1 reference

Mitochondrial succinate is instrumental for HIF1alpha nuclear translocation in SDHA-mutant fibroblasts under normoxic conditions

21 January 2018

1 reference

A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas

21 January 2018

1 reference

Research resource: Transcriptional profiling reveals different pseudohypoxic signatures in SDHB and VHL-related pheochromocytomas

21 January 2018

1 reference

Epithelial to mesenchymal transition is activated in metastatic pheochromocytomas and paragangliomas caused by SDHB gene mutations.

21 January 2018

1 reference

The Warburg effect is genetically determined in inherited pheochromocytomas

21 January 2018

1 reference

Loss of the SdhB, but Not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis.

21 January 2018

1 reference

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

21 January 2018

1 reference

Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling

21 January 2018

1 reference

Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha

21 January 2018

1 reference

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.

21 January 2018

1 reference

Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases.

21 January 2018

1 reference

An operational definition of epigenetics

21 January 2018

1 reference

The language of covalent histone modifications

21 January 2018

1 reference

Chromatin modifications and their function

21 January 2018

1 reference

New nomenclature for chromatin-modifying enzymes

21 January 2018

1 reference

The role of chromatin during transcription

21 January 2018

1 reference

High-resolution profiling of histone methylations in the human genome

21 January 2018

1 reference

Regulation of nucleosome dynamics by histone modifications

21 January 2018

1 reference

21 January 2018

Epigenetics in cancer

1 reference

The control of histone methylation and gene expression by oxidative stress, hypoxia, and metals

21 January 2018

1 reference

Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis

21 January 2018

1 reference

Succinate inhibition of alpha-ketoglutarate-dependent enzymes in a yeast model of paraganglioma

21 January 2018

1 reference

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

21 January 2018

1 reference

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

21 January 2018

1 reference

IDH mutation impairs histone demethylation and results in a block to cell differentiation

21 January 2018

1 reference

Inhibition of succinate dehydrogenase dysregulates histone modification in mammalian cells

21 January 2018

1 reference

Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

21 January 2018

1 reference

SDH mutations establish a hypermethylator phenotype in paraganglioma.

21 January 2018

1 reference

Linking DNA methylation and histone modification: patterns and paradigms

21 January 2018

1 reference

The epigenetic progenitor origin of human cancer

21 January 2018

1 reference

A mouse skin multistage carcinogenesis model reflects the aberrant DNA methylation patterns of human tumors

21 January 2018

1 reference

Cancer epigenetics reaches mainstream oncology

21 January 2018

1 reference

Gene silencing in cancer in association with promoter hypermethylation

21 January 2018

1 reference

Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation

21 January 2018

1 reference

Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

21 January 2018

1 reference

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

21 January 2018

1 reference

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

21 January 2018

1 reference

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

21 January 2018

1 reference

Succinate dehydrogenase mutation underlies global epigenomic divergence in gastrointestinal stromal tumor

21 January 2018

1 reference

Induction of sarcomas by mutant IDH2

21 January 2018

1 reference

Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma

21 January 2018

1 reference

Genome-scale analysis of aberrant DNA methylation in colorectal cancer

21 January 2018

1 reference

A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing

21 January 2018

1 reference

Aberrant CpG-island methylation has non-random and tumour-type-specific patterns.

21 January 2018

1 reference

Epigenetic regulation in adult stem cells and cancers

21 January 2018

1 reference

Isocitrate dehydrogenase (IDH) mutations promote a reversible ZEB1/microRNA (miR)-200-dependent epithelial-mesenchymal transition (EMT).

21 January 2018

1 reference

5-Hydroxymethylcytosine is strongly depleted in human cancers but its levels do not correlate with IDH1 mutations

21 January 2018

1 reference

Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers.

21 January 2018

1 reference

Distribution of 5-hydroxymethylcytosine in different human tissues

21 January 2018

1 reference

Tet family proteins and 5-hydroxymethylcytosine in development and disease

21 January 2018

1 reference

Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma

21 January 2018

1 reference

Decreased 5-hydroxymethylcytosine is associated with neural progenitor phenotype in normal brain and shorter survival in malignant glioma

21 January 2018

1 reference

2-Hydroxyglutarate in IDH mutant acute myeloid leukemia: predicting patient responses, minimal residual disease and correlations with methylcytosine and hydroxymethylcytosine levels.

21 January 2018

1 reference

Low values of 5-hydroxymethylcytosine (5hmC), the "sixth base," are associated with anaplasia in human brain tumors

21 January 2018

1 reference

TET2 promoter methylation in low-grade diffuse gliomas lacking IDH1/2 mutations

21 January 2018

1 reference

Nuclear exclusion of TET1 is associated with loss of 5-hydroxymethylcytosine in IDH1 wild-type gliomas

21 January 2018

1 reference

An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.

21 January 2018

1 reference

(R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible

21 January 2018

1 reference

Expanding chemical biology of 2-oxoglutarate oxygenases

21 January 2018

1 reference

Structural studies on human 2-oxoglutarate dependent oxygenases

21 January 2018

1 reference

Inhibition of 2-oxoglutarate dependent oxygenases

21 January 2018

1 reference

Absence of post-translational aspartyl beta-hydroxylation of epidermal growth factor domains in mice leads to developmental defects and an increased incidence of intestinal neoplasia

21 January 2018

1 reference

Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing

21 January 2018

1 reference

Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans

21 January 2018

1 reference

Post-translational processing of procollagens

21 January 2018

1 reference

Collagens, modifying enzymes and their mutations in humans, flies and worms

21 January 2018

1 reference

Increased invasive behaviour in cutaneous squamous cell carcinoma with loss of basement-membrane type VII collagen.

21 January 2018

1 reference

D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function

21 January 2018

1 reference

Repair of alkylated DNA: recent advances

21 January 2018

1 reference

Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA

21 January 2018

1 reference

Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA

21 January 2018

1 reference

TP53 regulates human AlkB homologue 2 expression in glioma resistance to Photofrin-mediated photodynamic therapy.

21 January 2018

1 reference

IDH mutations predict longer survival and response to temozolomide in secondary glioblastoma

21 January 2018

1 reference

Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer

21 January 2018

1 reference

Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice

21 January 2018

1 reference

The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor

21 January 2018

1 reference

Oxidative stress and cancer: an overview

21 January 2018

1 reference

Mutation of succinate dehydrogenase subunit C results in increased O2.-, oxidative stress, and genomic instability

21 January 2018

1 reference

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

21 January 2018

1 reference

Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming.

21 January 2018

1 reference

An antioxidant response phenotype shared between hereditary and sporadic type 2 papillary renal cell carcinoma

21 January 2018

1 reference

Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status

21 January 2018

1 reference

Current and future treatments for malignant pheochromocytoma and sympathetic paraganglioma

21 January 2018

1 reference

Rationale for anti-angiogenic therapy in pheochromocytoma and paraganglioma.

21 January 2018

1 reference

A report of succinate dehydrogenase B deficiency associated with metastatic papillary renal cell carcinoma: successful treatment with the multi-targeted tyrosine kinase inhibitor sunitinib

21 January 2018

1 reference

Rationale and evidence for sunitinib in the treatment of malignant paraganglioma/pheochromocytoma

21 January 2018

1 reference

Patient with malignant paraganglioma responding to the multikinase inhibitor sunitinib malate

21 January 2018

1 reference

Use of the tyrosine kinase inhibitor sunitinib in a patient with von Hippel-Lindau disease: targeting angiogenic factors in pheochromocytoma and other von Hippel-Lindau disease-related tumors

21 January 2018

1 reference

Treatment with sunitinib for patients with progressive metastatic pheochromocytomas and sympathetic paragangliomas.

21 January 2018

1 reference

Cancer epigenetics: from mechanism to therapy

21 January 2018

1 reference

Clinical experience with intravenous and oral formulations of the novel histone deacetylase inhibitor suberoylanilide hydroxamic acid in patients with advanced hematologic malignancies

21 January 2018

1 reference

Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma

21 January 2018

1 reference

Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study

21 January 2018

1 reference

5-azacitidine prolongs overall survival in patients with myelodysplastic syndrome--a systematic review and meta-analysis

21 January 2018

1 reference

Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells

21 January 2018

1 reference

DNA hypermethylation as a chemotherapy target

21 January 2018

1 reference

Concentrations of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine (FdCyd) and its cytotoxic metabolites in plasma of patients treated with FdCyd and tetrahydrouridine (THU).

21 January 2018

1 reference

Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine.

21 January 2018

1 reference

Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer

21 January 2018

1 reference

Antitumor effects of 2-oxoglutarate through inhibition of angiogenesis in a murine tumor model

21 January 2018

1 reference

Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells

21 January 2018

1 reference

Reactivating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death.

21 January 2018

1 reference

Breathing-in epigenetic change with vitamin C.

21 January 2018

1 reference

Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine

21 January 2018

1 reference

Vitamin C modulates TET1 function during somatic cell reprogramming

21 January 2018

1 reference

Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells

21 January 2018

1 reference

Vitamin C: intravenous use by complementary and alternative medicine practitioners and adverse effects

21 January 2018

1 reference

Supplemental ascorbate in the supportive treatment of cancer: Reevaluation of prolongation of survival times in terminal human cancer

21 January 2018

1 reference

Orthomolecular oncology review: ascorbic acid and cancer 25 years later

21 January 2018

1 reference

The effects of high concentrations of vitamin C on cancer cells

21 January 2018

1 reference

Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation

21 January 2018

1 reference

TETonic shift: biological roles of TET proteins in DNA demethylation and transcription

21 January 2018

1 reference

SDHBmutations are associated with response to temozolomide in patients with metastatic pheochromocytoma or paraganglioma

21 January 2018

1 reference