(Q37851012)

24 August 2017

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title

Cancer epigenetics reaches mainstream oncology (English)

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24 August 2017

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2

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24 August 2017

Manuel Rodríguez-Paredes

object named as

Manuel Rodríguez-Paredes

series ordinal

1

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language of work or name

English

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publication date

1 March 2011

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24 August 2017

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24 August 2017

volume

17

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24 August 2017

issue

3

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24 August 2017

page(s)

330-339

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Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer.

24 August 2017

cites work

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12 December 2020

Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

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12 December 2020

The significance of aberrant CHFR methylation for clinical response to microtubule inhibitors in gastric cancer

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12 December 2020

DNMT3A Mutations in Acute Myeloid Leukemia

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12 December 2020

Chromosomal Instability and Tumors Promoted by DNA Hypomethylation

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12 December 2020

Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation

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12 December 2020

NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis.

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12 December 2020

Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma

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12 December 2020

Expression profiling of sodium butyrate (NaB)-treated cells: identification of regulation of genes related to cytokine signaling and cancer metastasis by NaB.

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12 December 2020

MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo

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12 December 2020

Isoform-selective histone deacetylase inhibitors.

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12 December 2020

A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma

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12 December 2020

Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate

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12 December 2020

MS-qFRET: a quantum dot-based method for analysis of DNA methylation

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12 December 2020

DNA methylation markers and early recurrence in stage I lung cancer

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12 December 2020

Epigenetic inactivation of CHFR in human tumors

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12 December 2020

Quantitation of GSTP1 methylation in non-neoplastic prostatic tissue and organ-confined prostate adenocarcinoma.

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12 December 2020

Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation

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12 December 2020

Sirtuins: critical regulators at the crossroads between cancer and aging

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12 December 2020

Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines.

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12 December 2020

Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma

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12 December 2020

Global histone modification patterns predict risk of prostate cancer recurrence

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12 December 2020

The epigenomics of cancer

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12 December 2020

Integrated analysis of DNA methylation and gene expression reveals specific signaling pathways associated with platinum resistance in ovarian cancer

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12 December 2020

Chromosomal instability correlates with genome-wide DNA demethylation in human primary colorectal cancers.

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12 December 2020

Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers

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12 December 2020

The silent estrogen receptor--can we make it speak?

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12 December 2020

Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9.

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12 December 2020

Epigenetic repression of microRNA-129-2 leads to overexpression of SOX4 oncogene in endometrial cancer

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12 December 2020

CpG island hypermethylation of the DNA repair enzyme methyltransferase predicts response to temozolomide in primary gliomas

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12 December 2020

IGFBP-3 hypermethylation-derived deficiency mediates cisplatin resistance in non-small-cell lung cancer.

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12 December 2020

Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells

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12 December 2020

The histone deacetylase inhibitor MS-275 induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia cells

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12 December 2020

New nomenclature for chromatin-modifying enzymes

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12 December 2020

MGMT promoter methylation in malignant gliomas: ready for personalized medicine?

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12 December 2020

Reversal of drug resistance in human tumor xenografts by 2'-deoxy-5-azacytidine-induced demethylation of the hMLH1 gene promoter

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12 December 2020

Frequent hypermethylation of the DNA repair gene MGMT in long-term survivors of glioblastoma multiforme.

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12 December 2020

Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect.

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12 December 2020

Clinical experience with intravenous and oral formulations of the novel histone deacetylase inhibitor suberoylanilide hydroxamic acid in patients with advanced hematologic malignancies

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12 December 2020

A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells

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12 December 2020

Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma

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12 December 2020

Mutation in TET2 in myeloid cancers

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12 December 2020

SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells

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12 December 2020

Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

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12 December 2020

Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis

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12 December 2020

Mutations truncating the EP300 acetylase in human cancers

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12 December 2020

Principles and challenges of genomewide DNA methylation analysis

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12 December 2020

Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents

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12 December 2020

Low concentrations of the histone deacetylase inhibitor, depsipeptide, enhance the effects of gemcitabine and docetaxel in hormone refractory prostate cancer cells

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12 December 2020

Phase I pharmacokinetic and pharmacodynamic study of the aurora kinase inhibitor danusertib in patients with advanced or metastatic solid tumors

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12 December 2020

Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells.

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12 December 2020

DNA methylation based biomarkers in non-invasive cancer screening

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12 December 2020

The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases

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12 December 2020

Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response

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12 December 2020

Targeting DNA methylation for epigenetic therapy

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12 December 2020

High-resolution profiling of histone methylations in the human genome

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12 December 2020

Activation and transposition of endogenous retroviral elements in hypomethylation induced tumors in mice.

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12 December 2020

Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts

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12 December 2020

Delivery of 5-azacytidine to human cancer cells by elaidic acid esterification increases therapeutic drug efficacy

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12 December 2020

Genetic unmasking of an epigenetically silenced microRNA in human cancer cells

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12 December 2020

MOZ and MOZ-CBP cooperate with NF-kappaB to activate transcription from NF-kappaB-dependent promoters.

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12 December 2020

Aurora kinase inhibitors--rising stars in cancer therapeutics?

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12 December 2020

JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin

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12 December 2020

Activity of the histone deacetylase inhibitor belinostat (PXD101) in preclinical models of prostate cancer

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12 December 2020

Epigenetics in cancer

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12 December 2020

DNA hypomethylation and human diseases.

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12 December 2020

Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes

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12 December 2020

Histone deacetylase inhibitors: current status and overview of recent clinical trials

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12 December 2020

An update on the safety and efficacy of decitabine in the treatment of myelodysplastic syndromes

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12 December 2020

Cancer epigenetics comes of age

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12 December 2020

epigenetic multiple ligands: mixed histone/protein methyltransferase, acetyltransferase, and class III deacetylase (sirtuin) inhibitors.

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12 December 2020

Re-activation of a dormant tumor suppressor gene maspin by designed transcription factors

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12 December 2020

Low O6-methylguanine-DNA methyltransferase (MGMT) expression and response to temozolomide in aggressive pituitary tumours.

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12 December 2020

DNA methylation patterns and epigenetic memory

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12 December 2020

Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity

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12 December 2020

Concentrations of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine (FdCyd) and its cytotoxic metabolites in plasma of patients treated with FdCyd and tetrahydrouridine (THU).

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12 December 2020

MS-275, a potent orally available inhibitor of histone deacetylases--the development of an anticancer agent

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12 December 2020

A phase 1 pharmacokinetic and pharmacodynamic study of the histone deacetylase inhibitor belinostat in patients with advanced solid tumors

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12 December 2020

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

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12 December 2020

Hepatocellular carcinoma displays distinct DNA methylation signatures with potential as clinical predictors

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12 December 2020

Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour

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12 December 2020

Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer

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12 December 2020

DNA methylation landscapes: provocative insights from epigenomics

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12 December 2020

A gene hypermethylation profile of human cancer

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12 December 2020

Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening

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12 December 2020

An evaluation of new criteria for CpG islands in the human genome as gene markers

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12 December 2020

Sodium butyrate induces growth arrest and senescence-like phenotypes in gynecologic cancer cells

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12 December 2020

Determination of enriched histone modifications in non-genic portions of the human genome

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12 December 2020

The contribution of gene expression profiling to breast cancer classification, prognostication and prediction: a retrospective of the last decade

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12 December 2020

Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma

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12 December 2020

A phase 1 and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia.

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12 December 2020

Cancer epigenetics is no Mickey Mouse

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12 December 2020

Tumor O(6)-methylguanine-DNA methyltransferase inactivation by oral lomeguatrib

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12 December 2020

Promoter methylation in APC, RUNX3, and GSTP1 and mortality in prostate cancer patients

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12 December 2020

Histone H3 serine 10 phosphorylation by Aurora B causes HP1 dissociation from heterochromatin

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12 December 2020

Cancer epigenomics: DNA methylomes and histone-modification maps

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12 December 2020

Temozolomide-mediated radiation enhancement in glioblastoma: a report on underlying mechanisms

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12 December 2020

Chromatin modifications and their function

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12 December 2020

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

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12 December 2020

Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications

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12 December 2020

CpG island hypermethylation profile in the serum of men with clinically localized and hormone refractory metastatic prostate cancer

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12 December 2020

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

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12 December 2020

The MLL recombinome of adult CD10-negative B-cell precursor acute lymphoblastic leukemia: results from the GMALL study group.

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12 December 2020

Reactivation of tumor suppressor genes by the cardiovascular drugs hydralazine and procainamide and their potential use in cancer therapy

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12 December 2020

Promoter demethylation accompanies reactivation of the HOX11 proto-oncogene in leukemia

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12 December 2020

Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma

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12 December 2020

Discovery of two novel, small-molecule inhibitors of DNA methylation

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12 December 2020

Anticancer activities of histone deacetylase inhibitors

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12 December 2020

The DNA methylome of human peripheral blood mononuclear cells

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12 December 2020

DNA methylation profiling in doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment response

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12 December 2020

Phase I/IIa study of cilengitide and temozolomide with concomitant radiotherapy followed by cilengitide and temozolomide maintenance therapy in patients with newly diagnosed glioblastoma

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12 December 2020

Polycomb group proteins: navigators of lineage pathways led astray in cancer

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12 December 2020

Small molecule regulators of protein arginine methyltransferases

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12 December 2020

Aberrant methylation in the promoter region of the reduced folate carrier gene is a potential mechanism of resistance to methotrexate in primary central nervous system lymphomas

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12 December 2020

Sensitive digital quantification of DNA methylation in clinical samples

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12 December 2020

CG island methylation changes near the GSTP1 gene in prostatic intraepithelial neoplasia

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12 December 2020

Antimitogenic and chemosensitizing effects of the methylation inhibitor zebularine in ovarian cancer

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12 December 2020

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

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12 December 2020

Quantitative methylation-specific polymerase chain reaction gene patterns in urine sediment distinguish prostate cancer patients from control subjects.

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12 December 2020

In vivo synergy between topoisomerase II and histone deacetylase inhibitors: predictive correlates

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12 December 2020

The HDAC inhibitor LBH589 (panobinostat) is an inhibitory modulator of aromatase gene expression

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12 December 2020

Procainamide is a specific inhibitor of DNA methyltransferase 1.

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12 December 2020

Coactivator-associated arginine methyltransferase 1 (CARM1) is a positive regulator of the Cyclin E1 gene

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12 December 2020

Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription

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12 December 2020

Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells

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12 December 2020

Inactivation of glutathione S-transferase P1 gene by promoter hypermethylation in human neoplasia.

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12 December 2020

Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state.

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12 December 2020

Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator.

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12 December 2020

Detection in fecal DNA of colon cancer-specific methylation of the nonexpressed vimentin gene.

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12 December 2020

The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells

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12 December 2020

Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells

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12 December 2020

Human DNA methylomes at base resolution show widespread epigenomic differences

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12 December 2020

Gene silencing in cancer in association with promoter hypermethylation

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12 December 2020

Identification of a small molecule inhibitor of Sir2p

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12 December 2020

The dynamic DNA methylomes of double-stranded DNA viruses associated with human cancer

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12 December 2020

Quantitation of promoter methylation of multiple genes in urine DNA and bladder cancer detection

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12 December 2020

Chaetocin: a promising new antimyeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress

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12 December 2020

Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression

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12 December 2020

An operational definition of epigenetics

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12 December 2020

Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort

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12 December 2020

Histone deacetylase (HDAC) inhibitor LBH589 increases duration of gamma-H2AX foci and confines HDAC4 to the cytoplasm in irradiated non-small cell lung cancer

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12 December 2020

Abrogation of MAPK and Akt signaling by AEE788 synergistically potentiates histone deacetylase inhibitor-induced apoptosis through reactive oxygen species generation

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12 December 2020

New insights to the MLL recombinome of acute leukemias

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12 December 2020

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

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12 December 2020

A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition

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12 December 2020

MGMT gene silencing and benefit from temozolomide in glioblastoma

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12 December 2020

Chromatin-modifying enzymes as therapeutic targets--Part 1

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12 December 2020

Role of curcumin in cancer therapy

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12 December 2020

Phase 2 study of romiplostim in patients with low- or intermediate-risk myelodysplastic syndrome receiving azacitidine therapy

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12 December 2020

Recruitment of CBP/p300, TATA-binding protein, and S8 to distinct regions at the N terminus of adenovirus E1A.

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12 December 2020

Gene-promoter hypermethylation as a biomarker in lung cancer

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12 December 2020

A phase I dose escalation and bioavailability study of oral sodium phenylbutyrate in patients with refractory solid tumor malignancies.

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12 December 2020

Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

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12 December 2020

The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

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12 December 2020

Epigenetic control of mouse Oct-4 gene expression in embryonic stem cells and trophoblast stem cells

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12 December 2020

Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells

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12 December 2020

Aberrant CpG-island methylation has non-random and tumour-type-specific patterns.

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12 December 2020

Regulation of tumor angiogenesis by EZH2.

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12 December 2020

Molecular detection of prostate cancer in urine by GSTP1 hypermethylation

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12 December 2020

MLL translocations, histone modifications and leukaemia stem-cell development

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12 December 2020

Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors

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12 December 2020

Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation

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12 December 2020

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia

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12 December 2020

BRCA1 CpG Island Hypermethylation Predicts Sensitivity to Poly(Adenosine Diphosphate)- Ribose Polymerase Inhibitors

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12 December 2020

Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients

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12 December 2020

A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations

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12 December 2020

A microRNA DNA methylation signature for human cancer metastasis

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12 December 2020

Epigenetic reprogramming by adenovirus e1a.

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12 December 2020

Role for DNA methylation in the control of cell type specific maspin expression

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12 December 2020

The power and the promise of DNA methylation markers

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12 December 2020

Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1

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12 December 2020

The role of chromatin during transcription

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12 December 2020

Genome-scale DNA methylation maps of pluripotent and differentiated cells

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12 December 2020

The molecular underpinning of lobular histological growth pattern: a genome-wide transcriptomic analysis of invasive lobular carcinomas and grade- and molecular subtype-matched invasive ductal carcinomas of no special type.

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Crossref

https://api.crossref.org/works/10.1038%2FNM.2305

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NM.2305

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24 August 2017

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