(Q38395314)

2 September 2017

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title

Regulatory toxicology in the twenty-first century: challenges, perspectives and possible solutions (English)

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2 September 2017

23

Alfonso Lampen

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Monika Lahrssen-Wiederholt

2 September 2017

22

Monika Lahrssen-Wiederholt

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2 September 2017

15

Helmut Schafft

1 reference

2 September 2017

Christine Müller-Graf

Christine Müller-Graf

11

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Tewes Tralau

Tewes Tralau

1

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Matthias Greiner

Matthias Greiner

21

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Gilbert Schönfelder

Gilbert Schönfelder

25

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Andreas Luch

24

Andreas Luch

1 reference

2 September 2017

author name string

Michael Oelgeschläger

2

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2 September 2017

Rainer Gürtler

3

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2 September 2017

Gerhard Heinemeyer

4

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2 September 2017

Matthias Herzler

5

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2 September 2017

Thomas Höfer

6

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2 September 2017

Heike Itter

7

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2 September 2017

Thomas Kuhl

8

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2 September 2017

Nikola Lange

9

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2 September 2017

Nicole Lorenz

10

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2 September 2017

Ulrike Pabel

12

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2 September 2017

Ralph Pirow

13

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2 September 2017

Vera Ritz

14

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2 September 2017

Heiko Schneider

16

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2 September 2017

Thomas Schulz

17

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2 September 2017

David Schumacher

18

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2 September 2017

Sebastian Zellmer

19

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2 September 2017

Gaby Fleur-Böl

20

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2 September 2017

Roland Solecki

26

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2 September 2017

Reiner Wittkowski

27

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2 September 2017

Andreas Hensel

28

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2 September 2017

publication date

28 March 2015

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2 September 2017

published in

Archives of Toxicology

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2 September 2017

volume

89

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2 September 2017

issue

6

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2 September 2017

page(s)

823-850

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Elevated internal exposure of children in simulated acute inhalation of volatile organic compounds: effects of concentration and duration

2 September 2017

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Reactivity profiling: covalent modification of single nucleophile peptides for skin sensitization risk assessment.

21 January 2018

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Risk assessment of contaminants in food and feed

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21 January 2018

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Network news: innovations in 21st century systems biology

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Prioritizing chemicals and data requirements for screening-level exposure and risk assessment

21 January 2018

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A critical evaluation of in vitro cell culture models for high-throughput drug screening and toxicity

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Tissue models: a living system on a chip.

21 January 2018

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GRADE guidelines: 3. Rating the quality of evidence

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High-content screening of small compounds on human embryonic stem cells.

21 January 2018

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Review of skin irritation/corrosion Hazards on the basis of human data: A regulatory perspective

21 January 2018

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Intralaboratory validation of four in vitro assays for the prediction of the skin sensitizing potential of chemicals

21 January 2018

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Exposure-triggered reproductive toxicity testing under the REACH legislation: a proposal to define significant/relevant exposure.

21 January 2018

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3.3 Trovafloxacin: a case study of idiosyncratic or iatrogenic liver toxicity - molecular mechanisms and lessons for pharmacotoxicity

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Reducing safety-related drug attrition: the use of in vitro pharmacological profiling.

21 January 2018

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Unraveling the health effects of environmental mixtures: an NIEHS priority.

21 January 2018

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Haptenation: chemical reactivity and protein binding

21 January 2018

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Toxicology. Transforming environmental health protection

21 January 2018

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Estimation of toxic hazard—A decision tree approach

21 January 2018

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Design and performance of a spreadsheet-based model for estimating bioavailability of chemicals from dermal exposure

21 January 2018

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Implementation challenges for designing integrated in vitro testing strategies (ITS) aiming at reducing and replacing animal experimentation

21 January 2018

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The refinement of uncertainty/safety factors in risk assessment by the incorporation of data on toxicokinetic variability in humans

21 January 2018

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Scientific Opinion on Risk Assessment for a Selected Group of Pesticides from the Triazole Group to Test Possible Methodologies to Assess Cumulative Effects from Exposure through Food from these Pesticides on Human Health

21 January 2018

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Application of systematic review methodology to food and feed safety assessments to support decision making

21 January 2018

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Guidance on the data required for the risk assessment of flavourings to be used in or on foods

21 January 2018

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Guidance for risk assessment of food and feed from genetically modified plants

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1510-0

Scientific Opinion on the risks for animal and public health related to the presence ofAlternariatoxins in feed and food

21 January 2018

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Guidance for submission for food additive evaluations

21 January 2018

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Guidance on the Use of Probabilistic Methodology for Modelling Dietary Exposure to Pesticide Residues

21 January 2018

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Scientific Opinion on Evaluation of the Toxicological Relevance of Pesticide Metabolites for Dietary Risk Assessment

21 January 2018

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Scientific Opinion on Exploring options for providing advice about possible human health risks based on the concept of Threshold of Toxicological Concern (TTC)

21 January 2018

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Scientific Opinion on the hazard assessment of endocrine disruptors: Scientific criteria for identification of endocrine disruptors and appropriateness of existing test methods for assessing effects mediated by these substances on human health and...

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00204-015-1510-0

Scientific Opinion on the relevance of dissimilar mode of action and its appropriate application for cumulative risk assessment of pesticides residues in food

21 January 2018

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Prediction of a carcinogenic potential of rat hepatocarcinogens using toxicogenomics analysis of short-term in vivo studies

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00204-015-1510-0

Vitamins and minerals: a model for safe addition to foods

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00204-015-1510-0

Cell-based therapies for lung disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00204-015-1510-0

Reconstructing population exposures to environmental chemicals from biomarkers: challenges and opportunities

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00204-015-1510-0

In vitro evaluation of potential hepatotoxicity induced by drugs.

21 January 2018

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Regulatory agency struggles under the weight of genomic data

21 January 2018

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Commentary: dermal penetration of bisphenol A--consequences for risk assessment

21 January 2018

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Comparative toxicology of chlordecone (Kepone) in humans and experimental animals

21 January 2018

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Toxicology for the twenty-first century

21 January 2018

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Use of nutrigenomics endpoints in dietary interventions

21 January 2018

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Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration

21 January 2018

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Skin irritation: prevalence, variability, and regulatory classification of existing in vivo data from industrial chemicals

21 January 2018

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Analysis of drug metabolism activities in a miniaturized liver cell bioreactor for use in pharmacological studies.

21 January 2018

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The virtual liver: a multidisciplinary, multilevel challenge for systems biology.

21 January 2018

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Bioinformatics, multiscale modeling and the IUPS Physiome Project

21 January 2018

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Rat liver sinusoidal endothelial cells survive without exogenous VEGF in 3D perfused co-cultures with hepatocytes.

21 January 2018

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Stress response pathways, toxicity pathways and adverse outcome pathways

21 January 2018

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A genomic biomarker signature can predict skin sensitizers using a cell-based in vitro alternative to animal tests

21 January 2018

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In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast project

21 January 2018

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Analysis of eight oil spill dispersants using rapid, in vitro tests for endocrine and other biological activity

21 January 2018

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Estimating toxicity-related biological pathway altering doses for high-throughput chemical risk assessment

21 January 2018

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Perspectives on validation of high-throughput assays supporting 21st century toxicity testing

21 January 2018

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Alternative methods in toxicology: pre-validated and validated methods

21 January 2018

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Stem cells in toxicology: fundamental biology and practical considerations.

21 January 2018

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Computational toxicology as implemented by the U.S. EPA: providing high throughput decision support tools for screening and assessing chemical exposure, hazard and risk.

21 January 2018

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Update on EPA's ToxCast program: providing high throughput decision support tools for chemical risk management.

21 January 2018

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Identification and characterization of adverse effects in 21st century toxicology

21 January 2018

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Safe addition of vitamins and minerals to foods: setting maximum levels for fortification in the Netherlands

21 January 2018

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Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets

21 January 2018

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Can the pharmaceutical industry reduce attrition rates?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1510-0

Applicability of in vitro tests for skin irritation and corrosion to regulatory classification schemes: substantiating test strategies with data from routine studies

21 January 2018

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Toxicity testing in the 21st century: a vision and a strategy

21 January 2018

1 reference

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OMICS-driven biomarker discovery in nutrition and health

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1510-0

Alternatives to animal testing: current status and future perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1510-0

Alternative methods to safety studies in experimental animals: role in the risk assessment of chemicals under the new European Chemicals Legislation (REACH).

21 January 2018

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Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model

21 January 2018

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Using expression data for quantification of active processes in physiologically based pharmacokinetic modeling

21 January 2018

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Physiologically based toxicokinetic modelling as a tool to support risk assessment: three case studies.

21 January 2018

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Physiologically based toxicokinetic modelling as a tool to assess target organ toxicity in route-to-route extrapolation--the case of coumarin

21 January 2018

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A physiologically based toxicokinetic modelling approach to predict relevant concentrations for in vitro testing

21 January 2018

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Mathematical models of skin permeability: an overview

21 January 2018

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In-silico model of skin penetration based on experimentally determined input parameters. Part II: mathematical modelling of in-vitro diffusion experiments. Identification of critical input parameters.

21 January 2018

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Detailed modeling of skin penetration--an overview

21 January 2018

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Derivation of a chemical-specific adjustment factor (CSAF) for use in the assessment of risk from chronic exposure to ethylene glycol: application of International Programme for Chemical Safety guidelines

21 January 2018

1 reference

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Workshop: use of "read-across" for chemical safety assessment under REACH.

21 January 2018

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Allergic contact dermatitis: epidemiology, molecular mechanisms, in vitro methods and regulatory aspects. Current knowledge assembled at an international workshop at BfR, Germany

21 January 2018

1 reference

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Evolution of gene regulatory networks controlling body plan development

21 January 2018

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Pluripotent human stem cells: A novel tool in drug discovery.

21 January 2018

1 reference

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Twenty-first century approaches to toxicity testing, biomonitoring, and risk assessment: perspectives from the global chemical industry

21 January 2018

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Innovation in safety pharmacology testing.

21 January 2018

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A safe strategy for addition of vitamins and minerals to foods.

21 January 2018

1 reference

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Distributed biological computation with multicellular engineered networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1510-0

Multiscale modeling framework of transdermal drug delivery

21 January 2018

1 reference

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Science and decisions: advancing toxicology to advance risk assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1510-0

A generalized physiologically-based toxicokinetic modeling system for chemical mixtures containing metals

21 January 2018

1 reference

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Vascularised human tissue models: a new approach for the refinement of biomedical research

21 January 2018

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The ReProTect Feasibility Study, a novel comprehensive in vitro approach to detect reproductive toxicants

21 January 2018

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"ToxRTool", a new tool to assess the reliability of toxicological data

21 January 2018

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Why drugs fail--a study on side effects in new chemical entities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1510-0

Developmental toxicity testing in the 21st century: the sword of Damocles shattered by embryonic stem cell assays?

21 January 2018

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A catalogue of reporting guidelines for health research

21 January 2018

1 reference

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Organ engineering based on decellularized matrix scaffolds

21 January 2018

1 reference

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The future of drug safety testing: expanding the view and narrowing the focus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1510-0

Drug-mediated toxicity: illuminating the 'bad' in the test tube by means of cellular assays?

21 January 2018

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"Drugs on oxygen": an update and perspective on the role of cytochrome P450 testing in pharmacology.

21 January 2018

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Wind of change challenges toxicological regulators.

21 January 2018

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Insights on the human microbiome and its xenobiotic metabolism: what is known about its effects on human physiology?

21 January 2018

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Factors to consider in the use of stem cells for pharmaceutic drug development and for chemical safety assessment

21 January 2018

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Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix

21 January 2018

1 reference

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Integration of dosimetry, exposure, and high-throughput screening data in chemical toxicity assessment

21 January 2018

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Keynote review: in vitro safety pharmacology profiling: an essential tool for successful drug development

21 January 2018

1 reference

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Crystal structure of human cytochrome P450 2C9 with bound warfarin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1510-0

The potential of embryonic stem cells combined with -omics technologies as model systems for toxicology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1510-0

Present state and future perspectives of using pluripotent stem cells in toxicology research

21 January 2018

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[Safety of food contact materials].

21 January 2018

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Human embryonic stem cell derived hepatocyte-like cells as a tool for in vitro hazard assessment of chemical carcinogenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1510-0

An illusion of hormesis in the Ames test: statistical significance is not equivalent to biological significance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1510-0

No animals harmed: toward a paradigm shift in toxicity testing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1510-0

Exploring In Vitro/In Vivo Correlation: Lessons Learned from Analyzing Phase I Results of the US EPA's ToxCast Project

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1510-0

Gene expression profiling to identify potentially relevant disease outcomes and support human health risk assessment for carbon black nanoparticle exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1510-0

Epidemiologische Methoden

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1510-0

EU research activities in alternative testing strategies: current status and future perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1510-0

10.1007/S00204-015-1510-0

21 January 2018

Identifiers

DOI

1 reference

Dimensions Publication ID

2 September 2017

1013120969

0 references

1 reference