(Q38561919)

4 September 2017

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title

Affinity purification in target identification: the specificity challenge (English)

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4 September 2017

Wenlu Zheng

1

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4 September 2017

Gang Li

series ordinal

2

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4 September 2017

Xiaoyu Li

series ordinal

3

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4 September 2017

publication date

8 August 2015

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Archives of Pharmacal Research

4 September 2017

published in

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4 September 2017

volume

38

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4 September 2017

issue

9

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4 September 2017

page(s)

1661-1685

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https://scigraph.springernature.com/pub.10.1007/s12272-015-0635-2

4 September 2017

exact match

0 references

cites work

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Trifunctional chemical probes for the consolidated detection and identification of enzyme activities from complex proteomes

21 January 2018

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Global analysis of protein folding thermodynamics for disease state characterization

21 January 2018

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Direct binding of ethanol to bovine serum albumin: a fluorescent and 13C NMR multiplet relaxation study.

21 January 2018

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Roscovitine targets, protein kinases and pyridoxal kinase

21 January 2018

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Integration of virtual and high-throughput screening

21 January 2018

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Isothermal microcalorimetry to investigate non specific interactions in biophysical chemistry

21 January 2018

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Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors

21 January 2018

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Quantitative mass spectrometry in proteomics: a critical review

21 January 2018

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Revealing promiscuous drug-target interactions by chemical proteomics.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Identification of the A2 adenosine receptor binding subunit by photoaffinity crosslinking

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

A three-hybrid approach to scanning the proteome for targets of small molecule kinase inhibitors

21 January 2018

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Methods for the detection and analysis of protein-protein interactions

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Poisson-Boltzmann calculations of nonspecific salt effects on protein-protein binding free energies

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Chemical biology approaches to target validation in cancer

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Hit and lead generation: beyond high-throughput screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Development and application of diazirines in biological and synthetic macromolecular systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

The mechanism of action of colchicine. Binding of colchincine-3H to cellular protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

The mechanism of action of colchicine. Colchicine binding to sea urchin eggs and the mitotic apparatus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Natural products and their biological targets: proteomic and metabolomic labeling strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Target identification in chemical genetics: the (often) missing link

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Natural products reveal cancer cell dependence on oxysterol-binding proteins

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Developing photoactive affinity probes for proteomic profiling: hydroxamate-based probes for metalloproteases.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Recent advances and method development for drug target identification

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Simplified proteomics approach to discover protein-ligand interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Reactivity of functional groups on the protein surface: development of epoxide probes for protein labeling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Terazosin activates Pgk1 and Hsp90 to promote stress resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Searching for the protein targets of bioactive molecules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

A yeast-based screen reveals that sulfasalazine inhibits tetrahydrobiopterin biosynthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Identification and validation of bioactive small molecule target through phenotypic screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Fully functionalized small-molecule probes for integrated phenotypic screening and target identification

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Chemical genetics-based target identification in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Activity-based protein profiling: from enzyme chemistry to proteomic chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

21 January 2018

Affinity chromatography

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Selective enzyme purification by affinity chromatography

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Aliphatic diazirines as photoaffinity probes for proteins: recent developments

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Thermodynamic analysis of protein-ligand interactions in complex biological mixtures using a shotgun proteomics approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Synthetic small molecules that control stem cell fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Using photolabile ligands in drug discovery and development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Drug discovery: a historical perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Diazirine based photoaffinity labeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

The why and how of phenotypic small-molecule screens

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

The application of phenotypic high-throughput screening techniques to cardiovascular research

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Mechanism-based profiling of enzyme families

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Mapping the subcellular protein distribution in three human cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Actin microfilament aggregation induced by withaferin A is mediated by annexin II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Determination of protein-ligand binding affinity by NMR: observations from serum albumin model systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Target identification of small molecules based on chemical biology approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Isolation of the lac repressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Discovery of novel targets of quinoline drugs in the human purine binding proteome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Quantitative analysis of complex protein mixtures using isotope-coded affinity tags

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Thermodynamic stoichiometries of participation of water, cations and anions in specific and non-specific binding of lac repressor to DNA. Possible thermodynamic origins of the "glutamate effect" on protein-DNA interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Identification of a novel Vpr-binding compound that inhibits HIV-1 multiplication in macrophages by chemical array

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Photoaffinity labeling the agonist binding domain of alpha4beta4 and alpha4beta2 neuronal nicotinic acetylcholine receptors with [(125)I]epibatidine and 5[(125)I]A-85380.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Mass spectrometry for proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Finding the target after screening the phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Photoaffinity labeling in drug discovery and developments: chemical gateway for entering proteomic frontier

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

FR225659-binding proteins: identification as serine/threonine protein phosphatase PP1 and PP2A using high-performance affinity beads

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Design of dantrolene-derived probes for radioisotope-free photoaffinity labeling of proteins involved in the physiological Ca2+ release from sarcoplasmic reticulum of skeletal muscle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Novel bifunctional probe for radioisotope-free photoaffinity labeling: compact structure comprised of photospecific ligand ligation and detectable tag anchoring units

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Marinopyrrole A target elucidation by acyl dye transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

High-throughput screening assays for the identification of chemical probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Identification of a primary target of thalidomide teratogenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Identification of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) as a novel target of bisphenol A

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

The discovery and mechanism of action of novel tumor-selective and apoptosis-inducing 3,5-diaryl-1,2,4-oxadiazole series using a chemical genetics approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Quantitative analysis of the yeast proteome by incorporation of isotopically labeled leucine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Identification of the F1F0 mitochondrial ATPase as a target for modulating skin pigmentation by screening a tagged triazine library in zebrafish

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Terpestacin inhibits tumor angiogenesis by targeting UQCRB of mitochondrial complex III and suppressing hypoxia-induced reactive oxygen species production and cellular oxygen sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Identification and validation of calmodulin as a binding protein of an anti-proliferative small molecule 3,4-dihydroisoquinolinium salt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Porphyrin accumulation in mitochondria is mediated by 2-oxoglutarate carrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Structure and flexibility adaptation in nonspecific and specific protein-DNA complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Mapping the protein interaction landscape for fully functionalized small-molecule probes in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Photo-cross-linked small-molecule microarrays as chemical genomic tools for dissecting protein-ligand interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Photo-cross-linked small-molecule affinity matrix for facilitating forward and reverse chemical genetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Immobilization of natural products on glass slides by using a photoaffinity reaction and the detection of protein-small-molecule interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Chemical proteomics for drug discovery based on compound-immobilized affinity chromatography

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Binding is not enough: flexibility is needed for photocrosslinking of Lck kinase by benzophenone photoligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

The identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Facilitated forward chemical genetics using a tagged triazine library and zebrafish embryo screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

HIF-1α suppressing small molecule, LW6, inhibits cancer cell growth by binding to calcineurin b homologous protein 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Immunoprecipitation techniques for the analysis of transcription factor complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

p42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Target-specific chemical acylation of lectins by ligand-tethered DMAP catalysts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Splicing factor SF3b as a target of the antitumor natural product pladienolide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

A vancomycin photoprobe identifies the histidine kinase VanSsc as a vancomycin receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Activity-based proteomics: enzyme chemistry redux

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Active site profiling reveals coupling between domains in SRC-family kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Activity-based probes for studying the activity of flavin-dependent oxidases and for the protein target profiling of monoamine oxidase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Adenosine Kinase of T. b. Rhodesiense identified as the putative target of 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine using chemical proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Design and synthesis of an all-in-one 3-(1,1-difluoroprop-2-ynyl)-3H-diazirin-3-yl functional group for photo-affinity labeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Target deconvolution techniques in modern phenotypic profiling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Probing small molecule-protein interactions: A new perspective for functional proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

A Biochemically Specific Method for Enzyme Isolation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Identification of the cellular targets of bioactive small organic molecules using affinity reagents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Probing the anticancer mechanism of (-)-ainsliatrimer A through diverted total synthesis and bioorthogonal ligation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Identification of a GABAA receptor anesthetic binding site at subunit interfaces by photolabeling with an etomidate analog.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Photoaffinity labeling of small-molecule-binding proteins by DNA-templated chemistry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Multivalent photoaffinity probe for labeling small molecule binding proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

"Minimalist" cyclopropene-containing photo-cross-linkers suitable for live-cell imaging and affinity-based protein labeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Photoaffinity labeling of transcription factors by DNA-templated crosslinking

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Target identification using drug affinity responsive target stability (DARTS)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Identification of direct protein targets of small molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

A genome-wide overexpression screen in yeast for small-molecule target identification

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Impact of high-throughput screening in biomedical research

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Photo-leucine incorporation reveals the target of a cyclodepsipeptide inhibitor of cotranslational translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Chemical proteomics reveals bolinaquinone as a clathrin-mediated endocytosis inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Specific detection and imaging of enzyme activity by signal-amplifiable self-assembling (19)F MRI probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Drug receptor identification from multiple tissues using cellular-derived mRNA display libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Photocross-linking of nucleic acids to associated proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Purification and Properties of the Cholinergic Receptor Protein from Electrophorus electricus Electric Tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

LDAI-based chemical labeling of intact membrane proteins and its pulse-chase analysis under live cell conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Forward chemical genetic approach identifies new role for GAPDH in insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Salt effects on protein-DNA interactions. The lambda cI repressor and EcoRI endonuclease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Salt effects on ligand-DNA binding. Minor groove binding antibiotics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Phenotypic screening in cancer drug discovery - past, present and future

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Enantiodifferential approach for the detection of the target membrane protein of the jasmonate glycoside that controls the leaf movement of Albizzia saman

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Enzyme inhibitor discovery by activity-based protein profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Affinity purification methods. Nonspecific adsorption of proteins due to ionic groups in cyanogen bromide treated agarose

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Activity-based protein profiling for biochemical pathway discovery in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

The effects of salt on the TATA binding protein-DNA interaction from a hyperthermophilic archaeon

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Accurate quantitation of protein expression and site-specific phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Quantitative chemical proteomics for identifying candidate drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Identification of NIPSNAP1 as a nocistatin-interacting protein involving pain transmission

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Vipirinin, a coumarin-based HIV-1 Vpr inhibitor, interacts with a hydrophobic region of VPR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Identifying cellular targets of small-molecule probes and drugs with biochemical enrichment and SILAC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Mass spectrometry-based proteomics turns quantitative

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

A practical recipe for stable isotope labeling by amino acids in cell culture (SILAC)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Identifying the proteins to which small-molecule probes and drugs bind in cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Drug affinity responsive target stability (DARTS) for small-molecule target identification

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Pulse proteolysis: A simple method for quantitative determination of protein stability and ligand binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

From noncovalent to covalent bonds: a paradigm shift in target protein identification

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Discovery and target identification of an antiproliferative agent in live cells using fluorescence difference in two-dimensional gel electrophoresis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Opiate Receptor: Demonstration in Nervous Tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Drug target deconvolution by chemical proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

RETRACTED: Selective killing of cancer cells by a small molecule targeting the stress response to ROS

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Affinity-Based Probes Based on Type II Kinase Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Target profiling of small molecules by chemical proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

RNA-peptide fusions for the in vitro selection of peptides and proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Tagging and detection strategies for activity-based proteomics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Activity-based probes for the proteomic profiling of metalloproteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Active/inactive dual-probe system for selective photoaffinity labeling of small molecule-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Selective fluorescence detection of small-molecule-binding proteins by using a dual photoaffinity labeling system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Activity-based probes for proteomic profiling of histone deacetylase complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Optimization of activity-based probes for proteomic profiling of histone deacetylase complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Xanthohumol impairs autophagosome maturation through direct inhibition of valosin-containing protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Marine natural product aurilide activates the OPA1-mediated apoptosis by binding to prohibitin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Biochemical target isolation for novices: affinity-based strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Target identification and mechanism of action in chemical biology and drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Subchronic atrazine exposure changes defensive behaviour profile and disrupts brain acetylcholinesterase activity of zebrafish.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Isolation of a protein subunit from microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Properties of the protein subunit of central-pair and outer-doublet microtubules of sea urchin flagella

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Mechanism of H-8 inhibition of cyclin-dependent kinase 9: study using inhibitor-immobilized matrices

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

High-performance affinity beads for identifying drug receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Design and synthesis of novel hydrophilic spacers for the reduction of nonspecific binding proteins on affinity resins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Proteomic profiling of metalloprotease activities with cocktails of active-site probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Eponemycin analogues: syntheses and use as probes of angiogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Proteomic methods for drug target discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Profiling enzyme activities in vivo using click chemistry methods

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Thermodynamic analysis of protein-ligand binding interactions in complex biological mixtures using the stability of proteins from rates of oxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Target identification of biologically active small molecules via in situ methods

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Multiplex imaging and cellular target identification of kinase inhibitors via an affinity-based proteome profiling approach.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Recent advances in target characterization and identification by photoaffinity probes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Preparation of conophylline affinity nano-beads and identification of a target protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

How were new medicines discovered?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Use of phage display technology for the determination of the targets for small-molecule therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

One-pot and sequential organic chemistry on an enzyme surface to tether a fluorescent probe at the proximity of the active site with restoring enzyme activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Native FKBP12 engineering by ligand-directed tosyl chemistry: labeling properties and application to photo-cross-linking of protein complexes in vitro and in living cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Photocrosslinkers illuminate interactions in living cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Survey of four different photoreactive moieties for DNA photoaffinity labeling of yeast RNA polymerase III transcription complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Target deconvolution strategies in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Ligand-directed tosyl chemistry for protein labeling in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Quenched ligand-directed tosylate reagents for one-step construction of turn-on fluorescent biosensors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Activity-based protein profiling: new developments and directions in functional proteomics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

The identification of cellular targets of 17β estradiol using a lytic (T7) cDNA phage display approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

cDNA phage display as a novel tool to screen for cellular targets of chemical compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Aptamer-based affinity labeling of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

A natural product inspired tetrahydropyran collection yields mitosis modulators that synergistically target CSE1L and tubulin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Examining the mechanism of action of a kinesin inhibitor using stable isotope labeled inhibitors for cross-linking (SILIC).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Ribosome display and photo-cross-linking techniques for in vitro identification of target proteins of bioactive small molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Diazonamide toxins reveal an unexpected function for ornithine delta-amino transferase in mitotic cell division

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Colchicine-binding protein of mammalian brain and its relation to microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Thermodynamic analysis of protein stability and ligand binding using a chemical modification- and mass spectrometry-based strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Quantitative proteomics approach for identifying protein-drug interactions in complex mixtures using protein stability measurements.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Proteomics accelerating the identification of the target molecule of bioactive small molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Identification of a novel protein regulating microtubule stability through a chemical approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Stable, high capacity and non charged agarose derivatives for immobilization of biologically active compounds and for affinity chromatography.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Triple bioorthogonal ligation strategy for simultaneous labeling of multiple enzymatic activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Bioorthogonal chemistry: applications in activity-based protein profiling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Identification of compounds that bind mitochondrial F1F0 ATPase by screening a triazine library for correction of albinism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

A peptide aldehyde microarray for high-throughput profiling of cellular events

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

A small molecule accelerates neuronal differentiation in the adult rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Thermodynamic analysis of protein folding and stability using a tryptophan modification protocol

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

A versatile method of identifying specific binding proteins on affinity resins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Aminopeptidase N/CD13 induces angiogenesis through interaction with a pro-angiogenic protein, galectin-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Macromolecular crowding and confinement: biochemical, biophysical, and potential physiological consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Target identification for small bioactive molecules: finding the needle in the haystack

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Natural product–inspired cascade synthesis yields modulators of centrosome integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Radicicol Binds and Inhibits Mammalian ATP Citrate Lyase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Exploring the Mode-of-Action of Bioactive Compounds by Chemical-Genetic Profiling in Yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Genetic basis of individual differences in the response to small-molecule drugs in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

Identification of HSP60 as a Primary Target ofo-Carboranylphenoxyacetanilide, an HIF-1α Inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-015-0635-2

10.1007/S12272-015-0635-2

21 January 2018

Identifiers

DOI

1 reference

Dimensions Publication ID

4 September 2017

1047169393

0 references

1 reference