(Q38580336)

4 September 2017

title

A tale of two domains - a structural perspective of the pseudokinase, MLKL. (English)

1 reference

4 September 2017

James M Murphy

2

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author name string

Peter E Czabotar

series ordinal

1

1 reference

4 September 2017

language of work or name

English

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publication date

3 September 2015

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4 September 2017

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4 September 2017

volume

282

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4 September 2017

issue

22

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4 September 2017

page(s)

4268-4278

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Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4.

4 September 2017

cites work

1 reference

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The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism

21 January 2018

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Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis

21 January 2018

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RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis

21 January 2018

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RIPK1 can function as an inhibitor rather than an initiator of RIPK3-dependent necroptosis

21 January 2018

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Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product

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Virus inhibition of RIP3-dependent necrosis

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Herpes simplex virus suppresses necroptosis in human cells

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Suppression of RIP3-dependent necroptosis by human cytomegalovirus

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Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule

21 January 2018

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Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

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Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation

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Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha

21 January 2018

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Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase

21 January 2018

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Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

21 January 2018

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The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis

21 January 2018

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Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop

21 January 2018

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Programmed necrosis and necroptosis signalling

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Cloaked in ubiquitin, a killer hides in plain sight: the molecular regulation of RIPK1.

21 January 2018

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IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

21 January 2018

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IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

21 January 2018

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cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms

21 January 2018

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The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs

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Identification of RIP1 kinase as a specific cellular target of necrostatins

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RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition

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RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis

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RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis.

21 January 2018

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Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis

21 January 2018

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Cutting edge: RIPK1 Kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo

21 January 2018

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Structural basis of RIP1 inhibition by necrostatins

21 January 2018

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RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3

21 January 2018

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TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1.

21 January 2018

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RIPK1- and RIPK3-induced cell death mode is determined by target availability

21 January 2018

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RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis.

21 January 2018

1 reference

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Distinct roles of RIP1-RIP3 hetero- and RIP3-RIP3 homo-interaction in mediating necroptosis

21 January 2018

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Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL.

21 January 2018

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DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB

21 January 2018

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The protein kinase complement of the human genome

21 January 2018

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Dawn of the dead: protein pseudokinases signal new adventures in cell biology

21 January 2018

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Day of the dead: pseudokinases and pseudophosphatases in physiology and disease

21 January 2018

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A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties

21 January 2018

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Kinases and pseudokinases: lessons from RAF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13504

Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL

21 January 2018

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Structural insights into RIP3-mediated necroptotic signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13504

A plug release mechanism for membrane permeation by MLKL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13504

Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13504

MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13504

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13504

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13504

Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13504

Necroptosis induced by RIPK3 requires MLKL but not Drp1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13504

Widespread mitochondrial depletion via mitophagy does not compromise necroptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13504

Tumor necrosis factor-induced nonapoptotic cell death requires receptor-interacting protein-mediated cellular reactive oxygen species accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13504

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13504

Necroptosis: is there a role for mitochondria?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13504

Cutting Edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13504

TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13504

Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13504

RIP3, a kinase promoting necroptotic cell death, mediates adverse remodelling after myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13504

RIP3 induces apoptosis independent of pronecrotic kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13504

Caspase-8 blocks kinase RIPK3-mediated activation of the NLRP3 inflammasome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13504

Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13504

Going for broke: targeting the human cancer pseudokinome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13504

An ATP-Competitive Inhibitor Modulates the Allosteric Function of the HER3 Pseudokinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13504

Pharmacological targeting of the pseudokinase Her3

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13504

Electrostatics of nanosystems: application to microtubules and the ribosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13504

PDB2PQR: expanding and upgrading automated preparation of biomolecular structures for molecular simulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13504

https://api.fatcat.wiki/v0/release/x7wclzijujhwxlx445663rmzc4

21 January 2018

Identifiers

1 reference

mapped directly with Wikidata item

30 July 2022

based on heuristic

Fatcat ID

release_x7wclzijujhwxlx445663rmzc4

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/x7wclzijujhwxlx445663rmzc4

mapped directly with Wikidata item

30 July 2022

based on heuristic

https://api.fatcat.wiki/v0/release/x7wclzijujhwxlx445663rmzc4

1 reference