(Q38794219)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27030592%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

title

Oligomeropathies and pathogenesis of Alzheimer and Parkinson's diseases (English)

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31 March 2020

0 references

1

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31 March 2020

author name string

Vladimiro Artuso

series ordinal

2

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31 March 2020

Pietro La Vitola

series ordinal

3

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31 March 2020

Claudia Balducci

series ordinal

4

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31 March 2020

language of work or name

English

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publication date

31 March 2016

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31 March 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27030592%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

volume

31

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31 March 2020

issue

6

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31 March 2020

page(s)

771-781

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Protein misfolding in Alzheimer's and Parkinson's disease: genetics and molecular mechanisms

31 March 2020

cites work

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Unfolding the role of protein misfolding in neurodegenerative diseases

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The coexistence of an equal amount of Alzheimer's amyloid-β 40 and 42 forms structurally stable and toxic oligomers through a distinct pathway

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Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques.

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Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models

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Pyroglutamylated amyloid-β is associated with hyperphosphorylated tau and severity of Alzheimer's disease.

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Activity and architecture of pyroglutamate-modified amyloid-β (AβpE3-42) pores

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Self-assembly of Abeta(1-42) into globular neurotoxins.

21 January 2018

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A specific amyloid-beta protein assembly in the brain impairs memory

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Brain amyloid-β oligomers in ageing and Alzheimer's disease

21 January 2018

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Quaternary Structure Defines a Large Class of Amyloid-β Oligomers Neutralized by Sequestration

21 January 2018

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Seeking a mechanism for the toxicity of oligomeric α-synuclein

21 January 2018

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Amyloid-β forms fibrils by nucleated conformational conversion of oligomers

21 January 2018

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Mechanism of Nucleated Conformational Conversion of Aβ42.

21 January 2018

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Conformational differences between two amyloid β oligomers of similar size and dissimilar toxicity

21 January 2018

1 reference

A comparison of the biochemical modifications caused by toxic and non-toxic protein oligomers in cells

21 January 2018

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Amyloid-β oligomer synaptotoxicity is mimicked by oligomers of the model protein HypF-N.

21 January 2018

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The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

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Amyloid-beta peptides stimulate the expression of the p75(NTR) neurotrophin receptor in SHSY5Y human neuroblastoma cells and AD transgenic mice

21 January 2018

1 reference

beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology

21 January 2018

1 reference

A novel nicotinic mechanism underlies β-amyloid-induced neurotoxicity

21 January 2018

1 reference

Regulation of NMDA receptor trafficking by amyloid-beta

21 January 2018

1 reference

Soluble Aβ oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors

21 January 2018

1 reference

Oligomeric Aβ-induced synaptic dysfunction in Alzheimer's disease

21 January 2018

1 reference

Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease.

21 January 2018

1 reference

Inhibition of LTP by beta-amyloid is prevented by activation of beta2 adrenoceptors and stimulation of the cAMP/PKA signalling pathway

21 January 2018

1 reference

Environmental novelty activates β2-adrenergic signaling to prevent the impairment of hippocampal LTP by Aβ oligomers.

21 January 2018

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Reversing EphB2 depletion rescues cognitive functions in Alzheimer model

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Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer's disease

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FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer's disease

21 January 2018

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Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

21 January 2018

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An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers

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Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin.

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Amyloid β oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis

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Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers

21 January 2018

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Interaction between prion protein and Aβ amyloid fibrils revisited

21 January 2018

1 reference

Single-molecule imaging reveals that small amyloid-β1-42 oligomers interact with the cellular prion protein (PrP(C))

21 January 2018

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Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein

21 January 2018

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The neurodegeneration in Alzheimer disease and the prion protein

21 January 2018

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Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model

21 January 2018

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The Binding Receptors of Aβ: an Alternative Therapeutic Target for Alzheimer's Disease

21 January 2018

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Lewy body diseases and multiple system atrophy as alpha-synucleinopathies

21 January 2018

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Applicability of current staging/categorization of alpha-synuclein pathology and their clinical relevance

21 January 2018

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Cortical Lewy bodies and Aβ burden are associated with prevalence and timing of dementia in Lewy body diseases

21 January 2018

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Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein.

21 January 2018

1 reference

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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21 January 2018

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Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease

21 January 2018

1 reference

Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils

21 January 2018

1 reference

Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation.

21 January 2018

1 reference

Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo

21 January 2018

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Direct observation of the interconversion of normal and toxic forms of α-synuclein

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Post-translational modification of α-synuclein in Parkinson's disease

21 January 2018

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The plasma alpha-synuclein levels in patients with Parkinson's disease and multiple system atrophy.

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Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

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Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease

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Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host

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Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years

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1 reference

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

21 January 2018

1 reference

Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice

21 January 2018

1 reference

Pathological alpha-synuclein propagates through neural networks

21 January 2018

1 reference

α-Synuclein strains cause distinct synucleinopathies after local and systemic administration

21 January 2018

1 reference

Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice.

21 January 2018

1 reference

Alpha-synuclein propagation: New insights from animal models

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Accumulation of toxic α-synuclein oligomer within endoplasmic reticulum occurs in α-synucleinopathy in vivo.

21 January 2018

1 reference

The Parkinson's disease-related protein DJ-1 protects dopaminergic neurons in vivo and cultured cells from alpha-synuclein and 6-hydroxydopamine toxicity.

21 January 2018

1 reference

DJ-1 interactions with α-synuclein attenuate aggregation and cellular toxicity in models of Parkinson's disease

21 January 2018

1 reference

Alpha-Synuclein Produces Early Behavioral Alterations via Striatal Cholinergic Synaptic Dysfunction by Interacting With GluN2D N-Methyl-D-Aspartate Receptor Subunit.

21 January 2018

1 reference

Adenosine A2A Receptors Modulate α-Synuclein Aggregation and Toxicity.

21 January 2018

1 reference

Reduced expression of peroxisome-proliferator activated receptor gamma coactivator-1alpha enhances alpha-synuclein oligomerization and down regulates AKT/GSK3beta signaling pathway in human neuronal cells that inducibly express alpha-synuclein

21 January 2018

1 reference

Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization

21 January 2018

1 reference

Glial dysfunction in the pathogenesis of α-synucleinopathies: emerging concepts

21 January 2018

1 reference

Glia and alpha-synuclein in neurodegeneration: A complex interaction

21 January 2018

1 reference

Alpha-synuclein release by neurons activates the inflammatory response in a microglial cell line.

21 January 2018

1 reference

Alpha-synuclein activates stress signaling protein kinases in THP-1 cells and microglia

21 January 2018

1 reference

The acute inflammatory response to intranigral α-synuclein differs significantly from intranigral lipopolysaccharide and is exacerbated by peripheral inflammation.

21 January 2018

1 reference

Polymorphisms in immune/inflammatory cytokine genes are related to Parkinson's disease with cognitive impairment in the Han Chinese population.

21 January 2018

1 reference

Inflammation is genetically implicated in Parkinson's disease.

21 January 2018

1 reference

In vivo application of beta amyloid oligomers: a simple tool to evaluate mechanisms of action and new therapeutic approaches

21 January 2018

1 reference

Recall and recognition of verbal paired associates in early Alzheimer's disease

21 January 2018

1 reference

Memantine rescues transient cognitive impairment caused by high-molecular-weight aβ oligomers but not the persistent impairment induced by low-molecular-weight oligomers.

21 January 2018

1 reference

An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivo

21 January 2018

1 reference

The Continuing Failure of Bexarotene in Alzheimer's Disease Mice.

21 January 2018

1 reference

Microglia: a new frontier for synaptic plasticity, learning and memory, and neurodegenerative disease research.

21 January 2018

1 reference

Neuroinflammation in Alzheimer's disease

21 January 2018

1 reference

α-Synuclein oligomers oppose long-term potentiation and impair memory through a calcineurin-dependent mechanism: relevance to human synucleopathic diseases

21 January 2018

1 reference

Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation.

21 January 2018

1 reference

Neuroinflammation in Lewy body dementia

21 January 2018

1 reference

A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid

21 January 2018

1 reference

The molecular assembly of amyloid aβ controls its neurotoxicity and binding to cellular proteins

21 January 2018

1 reference

Immunotherapeutic Approaches Targeting Amyloid-β, α-Synuclein, and Tau for the Treatment of Neurodegenerative Disorders

21 January 2018

1 reference

Systemic vaccination with anti-oligomeric monoclonal antibodies improves cognitive function by reducing Aβ deposition and tau pathology in 3xTg-AD mice

21 January 2018

1 reference

Antibody against Small Aggregated Peptide Specifically Recognizes Toxic Aβ-42 Oligomers in Alzheimer's Disease

21 January 2018

1 reference

Conformational targeting of intracellular Aβ oligomers demonstrates their pathological oligomerization inside the endoplasmic reticulum.

21 January 2018

1 reference

Immunotherapy targeting α-synuclein protofibrils reduced pathology in (Thy-1)-h[A30P] α-synuclein mice

21 January 2018

1 reference

Preventive study in subjects at risk of fatal familial insomnia: Innovative approach to rare diseases

21 January 2018

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Neuropathology of α-synuclein propagation and braak hypothesis

21 January 2018

1 reference

One single method to produce native and Tat-fused recombinant human α-synuclein in Escherichia coli.

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/MDS.26624

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27030592%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

1 reference