(Q38837028)

6 September 2017

1 reference

title

Understanding the Bases of Function and Modulation of α7 Nicotinic Receptors: Implications for Drug Discovery (English)

1 reference

6 September 2017

1 reference

Jeremías Corradi

1

1 reference

PubMed ID

27190210

6 September 2017

Cecilia Bouzat

series ordinal

2

1 reference

6 September 2017

9 May 2016

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6 September 2017

Molecular Pharmacology

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6 September 2017

90

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6 September 2017

3

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6 September 2017

288-299

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Mammalian nicotinic acetylcholine receptors: from structure to function

6 September 2017

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Functional relationships between agonist binding sites and coupling regions of homomeric Cys-loop receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Stoichiometry for activation of neuronal α7 nicotinic receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Exploring the positive allosteric modulation of human α7 nicotinic receptors from a single-channel perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Activation of the Macrophage α7 Nicotinic Acetylcholine Receptor and Control of Inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

The Antinociceptive and Antiinflammatory Properties of 3-furan-2-yl-N-p-tolyl-acrylamide, a Positive Allosteric Modulator of α7 Nicotinic Acetylcholine Receptors in Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Structural basis of activation of cys-loop receptors: the extracellular-transmembrane interface as a coupling region

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Positive allosteric modulation of the alpha7 nicotinic acetylcholine receptor: ligand interactions with distinct binding sites and evidence for a prominent role of the M2-M3 segment

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Allosteric modulation of nicotinic acetylcholine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

In vivo pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107: preclinical considerations in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

New insights into the structural bases of activation of Cys-loop receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

The interface between extracellular and transmembrane domains of homomeric Cys-loop receptors governs open-channel lifetime and rate of desensitization

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Coupling of agonist binding to channel gating in an ACh-binding protein linked to an ion channel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Positive allosteric modulator of α7 nicotinic-acetylcholine receptors, PNU-120596 augments the effects of donepezil on learning and memory in aged rodents and non-human primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Improved gating of a chimeric alpha7-5HT3A receptor upon mutations at the M2-M3 extracellular loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Dual role of the RIC-3 protein in trafficking of serotonin and nicotinic acetylcholine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

The nicotinic acetylcholine receptor and its prokaryotic homologues: Structure, conformational transitions & allosteric modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Use of a snake venom toxin to characterize the cholinergic receptor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Competitive binding at a nicotinic receptor transmembrane site of two α7-selective positive allosteric modulators with differing effects on agonist-evoked desensitization

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

A novel mechanism of modulation of 5-HT₃A receptors by hydrocortisone

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Single-channel kinetic analysis for activation and desensitization of homomeric 5-HT(3)A receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Structure and pharmacology of pentameric receptor channels: from bacteria to brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Single-channel and structural foundations of neuronal α7 acetylcholine receptor potentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Stoichiometry for α-bungarotoxin block of α7 acetylcholine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Stoichiometry for drug potentiation of a pentameric ion channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Intracellular Ca2+ signals evoked by stimulation of nicotinic acetylcholine receptors in SH-SY5Y cells: contribution of voltage-operated Ca2+ channels and Ca2+ stores

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

The alpha7 nicotinic acetylcholine receptor as a pharmacological target for inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Crystal structure of the extracellular domain of nAChR alpha1 bound to alpha-bungarotoxin at 1.94 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Relationship between alpha 7 nAChR and apoptosis in human lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

The 15q13.3 deletion syndrome: Deficient α(7)-containing nicotinic acetylcholine receptor-mediated neurotransmission in the pathogenesis of neurodevelopmental disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

In search of allosteric modulators of a7-nAChR by solvent density guided virtual screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Presynaptic alpha 7- and beta 2-containing nicotinic acetylcholine receptors modulate excitatory amino acid release from rat prefrontal cortex nerve terminals via distinct cellular mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Nicotinic ACh receptors as therapeutic targets in CNS disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Characterization of 2-[[4-fluoro-3-(trifluoromethyl)phenyl]amino]-4-(4-pyridinyl)-5-thiazolemethanol (JNJ-1930942), a novel positive allosteric modulator of the {alpha}7 nicotinic acetylcholine receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Old and new pharmacology: positive allosteric modulation of the alpha7 nicotinic acetylcholine receptor by the 5-hydroxytryptamine(2B/C) receptor antagonist SB-206553 (3,5-dihydro-5-methyl-N-3-pyridinylbenzo[1,2-b:4,5-b']di pyrrole-1(2H)-carboxamide)

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Anti-inflammatory role of microglial alpha7 nAChRs and its role in neuroprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

The selective nicotinic acetylcholine receptor alpha7 agonist JN403 is active in animal models of cognition, sensory gating, epilepsy and pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

JN403, in vitro characterization of a novel nicotinic acetylcholine receptor alpha7 selective agonist.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

A series of α7 nicotinic acetylcholine receptor allosteric modulators with close chemical similarity but diverse pharmacological properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Contrasting properties of α7-selective orthosteric and allosteric agonists examined on native nicotinic acetylcholine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Agonist activation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Neuronal nicotinic receptors: from structure to pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Importance of M2-M3 loop in governing properties of genistein at the α7 nicotinic acetylcholine receptor inferred from α7/5-HT3A chimera

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Brain α7 Nicotinic Acetylcholine Receptor Assembly Requires NACHO.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Decreased protein levels of nicotinic receptor subunits in the hippocampus and temporal cortex of patients with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Positive allosteric modulation of alpha-7 nicotinic receptors promotes cell death by inducing Ca(2+) release from the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

The selective alpha7 nicotinic acetylcholine receptor agonist PNU-282987 [N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide hydrochloride] enhances GABAergic synaptic activity in brain slices and restores auditory gating deficits in anesthetize

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Galanthamine and Non-competitive Inhibitor Binding to ACh-binding Protein: Evidence for a Binding Site on Non-α-subunit Interfaces of Heteromeric Neuronal Nicotinic Receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Stimulation of α7 nicotinic acetylcholine receptor by AR-R17779 suppresses atherosclerosis and aortic aneurysm formation in apolipoprotein E-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

X-ray structure of the mouse serotonin 5-HT3 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

TC-5619: an alpha7 neuronal nicotinic receptor-selective agonist that demonstrates efficacy in animal models of the positive and negative symptoms and cognitive dysfunction of schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Principles of activation and permeation in an anion-selective Cys-loop receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

X-ray structure of a prokaryotic pentameric ligand-gated ion channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

The L293 residue in transmembrane domain 2 of the 5-HT3A receptor is a molecular determinant of allosteric modulation by 5-hydroxyindole

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Nicotinic acetylcholine receptors: from basic science to therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Multiple binding sites in the nicotinic acetylcholine receptors: An opportunity for polypharmacolgy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Identification of propofol binding sites in a nicotinic acetylcholine receptor with a photoreactive propofol analog

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Proteins interacting with nicotinic acetylcholine receptors: expanding functional and therapeutic horizons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Precise localization of alpha7 nicotinic acetylcholine receptors on glutamatergic axon terminals in the rat ventral tegmental area.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Are nicotinic acetylcholine receptors coupled to G proteins?

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

PET imaging of cortical 11C-nicotine binding correlates with the cognitive function of attention in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

A positive allosteric modulator of α7 nAChRs augments neuroprotective effects of endogenous nicotinic agonists in cerebral ischaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Donepezil and the alpha-7 agonist PHA 568487, but not risperidone, ameliorate spatial memory deficits in a subchronic MK-801 mouse model of cognitive impairment in schizophrenia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Expression of non-neuronal acetylcholine in lymphocytes and its contribution to the regulation of immune function

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Identification and Characterization of a G Protein-binding Cluster in α7 Nicotinic Acetylcholine Receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

On the reaction of cells and of nerve-endings to certain poisons, chiefly as regards the reaction of striated muscle to nicotine and to curari

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

On the nature of partial agonism in the nicotinic receptor superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

LGICdb: the ligand-gated ion channel database

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Molecular evolution of the nicotinic acetylcholine receptor: an example of multigene family in excitable cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Principal pathway coupling agonist binding to channel gating in nicotinic receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

α7 nicotinic acetylcholine receptors and their role in cognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Cys-loop receptors: new twists and turns

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Ligand-binding domain of an α7-nicotinic receptor chimera and its complex with agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Functional α7β2 nicotinic acetylcholine receptors expressed in hippocampal interneurons exhibit high sensitivity to pathological level of amyloid β peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

A novel nicotinic acetylcholine receptor subtype in basal forebrain cholinergic neurons with high sensitivity to amyloid peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Localization by site-directed mutagenesis of a galantamine binding site on α7 nicotinic acetylcholine receptor extracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

In vitro pharmacological characterization of a novel allosteric modulator of alpha 7 neuronal acetylcholine receptor, 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), exhibiting unique pharmacological profile

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

The cholinergic anti-inflammatory pathway: a critical review

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Genistein improves 3-NPA-induced memory impairment in ovariectomized rats: impact of its antioxidant, anti-inflammatory and acetylcholinesterase modulatory properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Genistein improves sensorimotor gating: Mechanisms related to its neuroprotective effects on the striatum

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

CB2 cannabinoid receptors: new vistas

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Crystal structure of a human GABAA receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

The novel α7β2-nicotinic acetylcholine receptor subtype is expressed in mouse and human basal forebrain: biochemical and pharmacological characterization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Insights into Distinct Modulation of 7 and 7 2 Nicotinic Acetylcholine Receptors by the Volatile Anesthetic Isoflurane

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Detection and trapping of intermediate states priming nicotinic receptor channel opening

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Creating an 7 Nicotinic Acetylcholine Recognition Domain from the Acetylcholine-binding Protein: CRYSTALLOGRAPHIC AND LIGAND SELECTIVITY ANALYSES

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Genetic variations in CHRNA7 or CHRFAM7 and susceptibility to dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

A potential role of alpha-7 nicotinic acetylcholine receptor in cardiac angiogenesis in a pressure-overload rat model

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Positive allosteric modulation of alpha 7 nicotinic acetylcholine receptors enhances recognition memory and cognitive flexibility in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

An interaction between α7 nicotinic receptors and a G-protein pathway complex regulates neurite growth in neural cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vi

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Proof-of-concept trial of an alpha7 nicotinic agonist in schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Activation of α7 nicotinic receptors by orthosteric and allosteric agonists: influence on single-channel kinetics and conductance

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Neuronal nicotinic alpha 7 receptor expressed in Xenopus oocytes presents five putative binding sites for methyllycaconitine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Comparative pharmacology of rat and human alpha7 nAChR conducted with net charge analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

The microglial α7-acetylcholine nicotinic receptor is a key element in promoting neuroprotection by inducing heme oxygenase-1 via nuclear factor erythroid-2-related factor 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Neuroprotective effect of nicotine on dopaminergic neurons by anti-inflammatory action.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Proteomic analysis of an alpha7 nicotinic acetylcholine receptor interactome

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

SSR180711, a novel selective alpha7 nicotinic receptor partial agonist: (II) efficacy in experimental models predictive of activity against cognitive symptoms of schizophrenia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

A single point mutation confers properties of the muscle-type nicotinic acetylcholine receptor to homomeric alpha7 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

EVP-6124, a novel and selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Alpha7 nicotinic receptors as therapeutic targets for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Number and locations of agonist binding sites required to activate homomeric Cys-loop receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

T cells express alpha7-nicotinic acetylcholine receptor subunits that require a functional TCR and leukocyte-specific protein tyrosine kinase for nicotine-induced Ca2+ response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Characterization of RO5126946, a Novel α7 nicotinic acetylcholine receptor-positive allosteric modulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Nicotinic acetylcholine receptors in human genetic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Nicotinic cholinergic signaling in hippocampal astrocytes involves calcium-induced calcium release from intracellular stores

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Functional α7 nicotinic ACh receptors on astrocytes in rat hippocampal CA1 slices

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

A randomised, double-blind, placebo-controlled trial of tropisetron in patients with schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Cholinergic modulation of microglial activation by alpha 7 nicotinic receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

End-plate acetylcholine receptor: structure, mechanism, pharmacology, and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Recent advances in Cys-loop receptor structure and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

The human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

A 2-base pair deletion polymorphism in the partial duplication of the alpha7 nicotinic acetylcholine gene (CHRFAM7A) on chromosome 15q14 is associated with schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the α7 nicotinic acetylcholine receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

A type-II positive allosteric modulator of α7 nAChRs reduces brain injury and improves neurological function after focal cerebral ischemia in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Selective alpha7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Mode of action of the positive modulator PNU-120596 on α7 nicotinic acetylcholine receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Functional organization and conformational dynamics of the nicotinic receptor: a plausible structural interpretation of myasthenic mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

The positive allosteric modulator of α7 nicotinic acetylcholine receptors, 3-furan-2-yl-N-p-tolyl-acrylamide, enhances memory processes and stimulates ERK1/2 phosphorylation in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Nicotinic ligands as multifunctional agents for the treatment of neuropsychiatric disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Type I and II positive allosteric modulators differentially modulate agonist-induced up-regulation of α7 nicotinic acetylcholine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

α7 and β2 Nicotinic Acetylcholine Receptor Subunits Form Heteromeric Receptor Complexes that Are Expressed in the Human Cortex and Display Distinct Pharmacological Properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

An allosteric modulator of the alpha7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Calcium mobilization elicited by two types of nicotinic acetylcholine receptors in mouse substantia nigra pars compacta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

The therapeutic promise of positive allosteric modulation of nicotinic receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

AR-R 17779 improves social recognition in rats by activation of nicotinic alpha7 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Cholinergic receptors modulate immune complex-induced inflammation in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Alpha7 neuronal nicotinic receptors as a drug target in schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

RG3487, a novel nicotinic α7 receptor partial agonist, improves cognition and sensorimotor gating in rodents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Targeting the nicotinic alpha7 acetylcholine receptor to enhance cognition in disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

The duplicated α7 subunits assemble and form functional nicotinic receptors with the full-length α7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Intrinsically low open probability of α7 nicotinic acetylcholine receptors can be overcome by positive allosteric modulation and serum factors leading to the generation of excitotoxic currents at physiological temperatures

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

The effective opening of nicotinic acetylcholine receptors with single agonist binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Investigation of the molecular mechanism of the α7 nicotinic acetylcholine receptor positive allosteric modulator PNU-120596 provides evidence for two distinct desensitized states

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Positive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: advantages and limitations

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Ric-3 promotes functional expression of the nicotinic acetylcholine receptor alpha7 subunit in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

The coupling interface and pore domain codetermine the single-channel activity of the α7 nicotinic receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Rational engineering of enzyme allosteric regulation through sequence evolution analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Potentiation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

The structural mechanism of the Cys-loop receptor desensitization

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Alcohols potentiate the function of 5-HT3 receptor-channels on NCB-20 neuroblastoma cells by favouring and stabilizing the open channel state

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Inhibition of the Prokaryotic Pentameric Ligand-Gated Ion Channel ELIC by Divalent Cations

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

Diversity of native nicotinic receptor subtypes in mammalian brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

The cholinergic system in rat testis is of non-neuronal origin

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FMOL.116.104240

21 January 2018

Identifiers

DOI

10.1124/MOL.116.104240

1 reference

6 September 2017

1 reference

PubMed ID

27190210