(Q38863830)

1 July 2019

review article

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title

Endoplasmic Reticulum-Associated Degradation and Lipid Homeostasis (English)

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1 July 2019

main subject

endoplasmic reticulum

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author

James Olzmann

series ordinal

3

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1 July 2019

author name string

Julian Stevenson

series ordinal

1

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1 July 2019

Edmond Y Huang

series ordinal

2

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1 July 2019

language of work or name

English

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publication date

26 May 2016

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1 July 2019

Annual Review of Nutrition

published in

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1 July 2019

volume

36

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1 July 2019

page(s)

511-542

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1 July 2019

Regulation of diacylglycerol acyltransferase 2 protein stability by gp78-associated endoplasmic-reticulum-associated degradation

cites work

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12 December 2020

A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation

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12 December 2020

Triglyceride accumulation protects against fatty acid-induced lipotoxicity

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12 December 2020

Squalene mono-oxygenase, a key enzyme in cholesterol synthesis, is stabilized by unsaturated fatty acids.

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12 December 2020

Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake

1 reference

12 December 2020

Enzymatic blockade of the ubiquitin-proteasome pathway

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12 December 2020

Inactivation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in vitro. An adenine nucleotide-dependent reaction catalyzed by a factor in human fibroblasts

1 reference

12 December 2020

Ubiquitin-proteasome-dependent degradation of mammalian ER stearoyl-CoA desaturase.

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12 December 2020

The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER

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12 December 2020

The ubiquitin-like (UBX)-domain-containing protein Ubx2/Ubxd8 regulates lipid droplet homeostasis

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12 December 2020

Dissecting the ER-associated degradation of a misfolded polytopic membrane protein

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12 December 2020

Design principles of a universal protein degradation machine

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12 December 2020

Bridging the gap: membrane contact sites in signaling, metabolism, and organelle dynamics

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12 December 2020

Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum

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12 December 2020

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

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12 December 2020

Active and inactive forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase in the liver of the rat. Comparison with the rate of cholesterol synthesis in different physiological states

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12 December 2020

Role of stearoyl-coenzyme A desaturase in regulating lipid metabolism

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12 December 2020

Translocation efficiency, susceptibility to proteasomal degradation, and lipid responsiveness of apolipoprotein B are determined by the presence of beta sheet domains

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12 December 2020

Cholesterol through the looking glass: ability of its enantiomer also to elicit homeostatic responses

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12 December 2020

Multivalent control of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Mevalonate-derived product inhibits translation of mRNA and accelerates degradation of enzyme.

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12 December 2020

Role of cholesterol and lipid organization in disease

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12 December 2020

A regulator of secretory vesicle size, Kelch-like protein 12, facilitates the secretion of apolipoprotein B100 and very-low-density lipoproteins--brief report

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12 December 2020

Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins

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12 December 2020

Apoprotein B100 has a prolonged interaction with the translocon during which its lipidation and translocation change from dependence on the microsomal triglyceride transfer protein to independence.

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12 December 2020

A membrane protein required for dislocation of misfolded proteins from the ER

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12 December 2020

Cleaning up in the endoplasmic reticulum: ubiquitin in charge

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12 December 2020

SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation

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12 December 2020

A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation

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12 December 2020

Isolation of sterol-resistant Chinese hamster ovary cells with genetic deficiencies in both Insig-1 and Insig-2.

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12 December 2020

CD4 and BST-2/tetherin proteins retro-translocate from endoplasmic reticulum to cytosol as partially folded and multimeric molecules

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12 December 2020

Central pore residues mediate the p97/VCP activity required for ERAD

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12 December 2020

Ubiquitination regulates the assembly of VLDL in HepG2 cells and is the committing step of the apoB-100 ERAD pathway

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12 December 2020

Protein sensors for membrane sterols

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12 December 2020

Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins

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12 December 2020

The Regulatory Domain of Squalene Monooxygenase Contains a Re-entrant Loop and Senses Cholesterol via a Conformational Change.

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12 December 2020

Aggresomes: a cellular response to misfolded proteins

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12 December 2020

Evolution and mechanism of apolipoprotein B-containing lipoprotein assembly

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12 December 2020

CFTR: folding, misfolding and correcting the ΔF508 conformational defect.

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12 December 2020

BAP31 and BiP are essential for dislocation of SV40 from the endoplasmic reticulum to the cytosol

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12 December 2020

A deubiquitinase negatively regulates retro-translocation of nonubiquitinated substrates

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12 December 2020

Insig-mediated, sterol-accelerated degradation of the membrane domain of hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase in insect cells

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12 December 2020

Quality control: ER-associated degradation: protein quality control and beyond

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12 December 2020

Overexpression of the tumor autocrine motility factor receptor Gp78, a ubiquitin protein ligase, results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in HepG2 cells

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12 December 2020

Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes

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12 December 2020

Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1

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12 December 2020

Hypoxia stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase through accumulation of lanosterol and hypoxia-inducible factor-mediated induction of insigs.

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12 December 2020

Structural basis of an ERAD pathway mediated by the ER-resident protein disulfide reductase ERdj5

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12 December 2020

The membrane domain of 3-hydroxy-3-methylglutaryl-coenzyme A reductase confers endoplasmic reticulum localization and sterol-regulated degradation onto beta-galactosidase.

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12 December 2020

A ubiquitin-like domain recruits an oligomeric chaperone to a retrotranslocation complex in endoplasmic reticulum-associated degradation

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12 December 2020

Targeting sequences of UBXD8 and AAM-B reveal that the ER has a direct role in the emergence and regression of lipid droplets

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12 December 2020

Complete structure of p97/valosin-containing protein reveals communication between nucleotide domains

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12 December 2020

Cholesterol-dependent degradation of squalene monooxygenase, a control point in cholesterol synthesis beyond HMG-CoA reductase

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12 December 2020

Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism

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12 December 2020

SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins

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12 December 2020

TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I.

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12 December 2020

Co-translational degradation of apolipoprotein B100 by the proteasome is prevented by microsomal triglyceride transfer protein. Synchronized translation studies on HepG2 cells treated with an inhibitor of microsomal triglyceride transfer protein

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12 December 2020

Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol

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12 December 2020

Dose-dependent effects of lovastatin on cell cycle progression. Distinct requirement of cholesterol and non-sterol mevalonate derivatives.

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12 December 2020

Mutations within the membrane domain of HMG-CoA reductase confer resistance to sterol-accelerated degradation

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12 December 2020

Identifying the ERAD ubiquitin E3 ligases for viral and cellular targeting of MHC class I

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12 December 2020

Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system

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12 December 2020

Erlins restrict SREBP activation in the ER and regulate cellular cholesterol homeostasis

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12 December 2020

Model systems, lipid rafts, and cell membranes

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12 December 2020

Apoprotein B100, an inefficiently translocated secretory protein, is bound to the cytosolic chaperone, heat shock protein 70

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12 December 2020

Protein export at the ER: loading big collagens into COPII carriers

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12 December 2020

Lipid-mediated, reversible misfolding of a sterol-sensing domain protein

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12 December 2020

Replacement of serine-871 of hamster 3-hydroxy-3-methylglutaryl-CoA reductase prevents phosphorylation by AMP-activated kinase and blocks inhibition of sterol synthesis induced by ATP depletion

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12 December 2020

Apoprotein B degradation is promoted by the molecular chaperones hsp90 and hsp70.

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12 December 2020

Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p

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12 December 2020

A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum

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12 December 2020

Signal recognition particle: an essential protein-targeting machine

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12 December 2020

Cotranslational and posttranslocational N-glycosylation of proteins in the endoplasmic reticulum

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12 December 2020

ERdj5 is required as a disulfide reductase for degradation of misfolded proteins in the ER

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12 December 2020

Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling

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12 December 2020

Characterization of an ERAD pathway for nonglycosylated BiP substrates, which require Herp

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12 December 2020

Structure of the Mammalian Ribosome-Sec61 Complex to 3.4 Å Resolution

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12 December 2020

The role of multiubiquitination in dislocation and degradation of the alpha subunit of the T cell antigen receptor

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12 December 2020

STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein

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12 December 2020

An endoplasmic reticulum (ER) membrane complex composed of SPFH1 and SPFH2 mediates the ER-associated degradation of inositol 1,4,5-trisphosphate receptors

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12 December 2020

The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the cholesterol synthesis pathway.

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12 December 2020

Lipid Droplets Are Essential for Efficient Clearance of Cytosolic Inclusion Bodies

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12 December 2020

USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation

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12 December 2020

Ubiquitination of 3-hydroxy-3-methylglutaryl-CoA reductase in permeabilized cells mediated by cytosolic E1 and a putative membrane-bound ubiquitin ligase.

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12 December 2020

Review: biogenesis of the multifunctional lipid droplet: lipids, proteins, and sites

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12 December 2020

UAS domain of Ubxd8 and FAF1 polymerizes upon interaction with long-chain unsaturated fatty acids

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12 December 2020

Deubiquitinases sharpen substrate discrimination during membrane protein degradation from the ER

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12 December 2020

Structural basis for oligosaccharide recognition of misfolded glycoproteins by OS-9 in ER-associated degradation

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12 December 2020

The endoplasmic reticulum-associated Hsp40 DNAJB12 and Hsc70 cooperate to facilitate RMA1 E3-dependent degradation of nascent CFTRDeltaF508

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12 December 2020

Regulated endoplasmic reticulum-associated degradation of a polytopic protein: p97 recruits proteasomes to Insig-1 before extraction from membranes

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12 December 2020

The mammalian endoplasmic reticulum-associated degradation system

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12 December 2020

Cholesterol-induced conformational change in SCAP enhanced by Insig proteins and mimicked by cationic amphiphiles

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12 December 2020

Misfolded membrane proteins are specifically recognized by the transmembrane domain of the Hrd1p ubiquitin ligase

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12 December 2020

Identification of Ubxd8 protein as a sensor for unsaturated fatty acids and regulator of triglyceride synthesis

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12 December 2020

Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins

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12 December 2020

How cells handle cholesterol.

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12 December 2020

Dual role of ancient ubiquitous protein 1 (AUP1) in lipid droplet accumulation and endoplasmic reticulum (ER) protein quality control

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12 December 2020

Inhibition of p97-dependent protein degradation by Eeyarestatin I

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12 December 2020

Reglucosylation by UDP-glucose:glycoprotein glucosyltransferase 1 delays glycoprotein secretion but not degradation

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12 December 2020

Making the cut: intramembrane cleavage by a rhomboid protease promotes ERAD.

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12 December 2020

The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cleavage

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12 December 2020

Dislocation of HMG-CoA reductase and Insig-1, two polytopic endoplasmic reticulum proteins, en route to proteasomal degradation

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12 December 2020

Nonvesicular lipid transfer from the endoplasmic reticulum

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12 December 2020

Endoplasmic reticulum protein quality control is determined by cooperative interactions between Hsp/c70 protein and the CHIP E3 ligase

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12 December 2020

Rescuing protein conformation: prospects for pharmacological therapy in cystic fibrosis

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12 December 2020

Lipid droplets are arrested in the ER membrane by tight binding of lipidated apolipoprotein B-100.

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12 December 2020

The N terminus of microsomal delta 9 stearoyl-CoA desaturase contains the sequence determinant for its rapid degradation

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12 December 2020

Endogenous 24(S),25-epoxycholesterol fine-tunes acute control of cellular cholesterol homeostasis

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12 December 2020

Tetra-glutamic acid residues adjacent to Lys248 in HMG-CoA reductase are critical for the ubiquitination mediated by gp78 and UBE2G2.

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12 December 2020

Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis

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12 December 2020

Proteome-wide mapping of cholesterol-interacting proteins in mammalian cells

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12 December 2020

The TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathways

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12 December 2020

Oleate stimulates secretion of apolipoprotein B-containing lipoproteins from Hep G2 cells by inhibiting early intracellular degradation of apolipoprotein B

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12 December 2020

Derlin-1 and UBXD8 are engaged in dislocation and degradation of lipidated ApoB-100 at lipid droplets

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12 December 2020

Endoplasmic reticulum quality control regulates the fate of transthyretin variants in the cell

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12 December 2020

When worlds collide: IP(3) receptors and the ERAD pathway

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12 December 2020

Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP

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12 December 2020

Sterol homeostasis requires regulated degradation of squalene monooxygenase by the ubiquitin ligase Doa10/Teb4

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12 December 2020

Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTRDeltaF508.

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12 December 2020

X-ray structure of a protein-conducting channel

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12 December 2020

Complexity in the secretory pathway: the assembly and secretion of apolipoprotein B-containing lipoproteins

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12 December 2020

EDEM1 recognition and delivery of misfolded proteins to the SEL1L-containing ERAD complex

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12 December 2020

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

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12 December 2020

Physiological and nutritional regulation of enzymes of triacylglycerol synthesis

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12 December 2020

Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step

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12 December 2020

Ablation of gp78 in liver improves hyperlipidemia and insulin resistance by inhibiting SREBP to decrease lipid biosynthesis

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12 December 2020

N-linked sugar-regulated protein folding and quality control in the ER

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12 December 2020

Identification of luminal Loop 1 of Scap protein as the sterol sensor that maintains cholesterol homeostasis

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12 December 2020

Effectors of rapid homeostatic responses of endoplasmic reticulum cholesterol and 3-hydroxy-3-methylglutaryl-CoA reductase

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12 December 2020

Protein unfolding is not a prerequisite for endoplasmic reticulum-to-cytosol dislocation

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12 December 2020

A plasminogen-like protein selectively degrades stearoyl-CoA desaturase in liver microsomes

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12 December 2020

RNF170 protein, an endoplasmic reticulum membrane ubiquitin ligase, mediates inositol 1,4,5-trisphosphate receptor ubiquitination and degradation

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12 December 2020

Staying in touch: the molecular era of organelle contact sites

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12 December 2020

Cytosolic degradation of T-cell receptor alpha chains by the proteasome

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12 December 2020

Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation

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12 December 2020

The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages

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12 December 2020

Cholesterol facilitates the native mechanism of Ca2+-triggered membrane fusion

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12 December 2020

Glucose trimming and reglucosylation determine glycoprotein association with calnexin in the endoplasmic reticulum

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12 December 2020

The yeast ERAD-C ubiquitin ligase Doa10 recognizes an intramembrane degron

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12 December 2020

Mechanisms targeting apolipoprotein B100 to proteasomal degradation: evidence that degradation is initiated by BiP binding at the N terminus and the formation of a p97 complex at the C terminus

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12 December 2020

Proteasomal degradation of ubiquitinated Insig proteins is determined by serine residues flanking ubiquitinated lysines

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12 December 2020

The peroxisomal importomer constitutes a large and highly dynamic pore

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12 December 2020

Lipid rafts and signal transduction

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12 December 2020

Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u

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12 December 2020

Membrane-associated ubiquitin ligase complex containing gp78 mediates sterol-accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase

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12 December 2020

Role of the ubiquitin-selective CDC48(UFD1/NPL4 )chaperone (segregase) in ERAD of OLE1 and other substrates

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12 December 2020

Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig

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12 December 2020

Lipid droplet formation is dispensable for endoplasmic reticulum-associated degradation

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12 December 2020

Stearoyl-CoA desaturase activity is elevated by the suppression of its degradation by clofibric acid in the liver of rats

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12 December 2020

Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8.

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12 December 2020

Protein quality control at the inner nuclear membrane

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12 December 2020

Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: a delicate balance

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12 December 2020

Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR.

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12 December 2020

Endoplasmic reticulum targeting and insertion of tail-anchored membrane proteins by the GET pathway

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12 December 2020

Sequential actions of the AAA-ATPase valosin-containing protein (VCP)/p97 and the proteasome 19 S regulatory particle in sterol-accelerated, endoplasmic reticulum (ER)-associated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

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12 December 2020

IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation

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12 December 2020

Colocalization of SCD1 and DGAT2: implying preference for endogenous monounsaturated fatty acids in triglyceride synthesis.

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12 December 2020

Peroxisomal protein import and ERAD: variations on a common theme

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12 December 2020

The endoplasmic reticulum-associated degradation pathways of budding yeast

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12 December 2020

Degradation of CFTR by the ubiquitin-proteasome pathway

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12 December 2020

Inhibition of degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in vivo by cysteine protease inhibitors.

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12 December 2020

Stringent requirement for HRD1, SEL1L, and OS-9/XTP3-B for disposal of ERAD-LS substrates

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12 December 2020

Human OS-9, a lectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-glycans

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12 December 2020

A large and intact viral particle penetrates the endoplasmic reticulum membrane to reach the cytosol

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12 December 2020

Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets.

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12 December 2020

Glycosylation-independent ERAD pathway serves as a backup system under ER stress

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12 December 2020

A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol

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12 December 2020

Unassembled CD147 is an endogenous endoplasmic reticulum-associated degradation substrate

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12 December 2020

Forcible destruction of severely misfolded mammalian glycoproteins by the non-glycoprotein ERAD pathway

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12 December 2020

Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme

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12 December 2020

Membrane topology and identification of key functional amino acid residues of murine acyl-CoA:diacylglycerol acyltransferase-2.

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12 December 2020

Sterol-induced dislocation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from endoplasmic reticulum membranes into the cytosol through a subcellular compartment resembling lipid droplets

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12 December 2020

gp78 functions downstream of Hrd1 to promote degradation of misfolded proteins of the endoplasmic reticulum

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12 December 2020

Key steps in ERAD of luminal ER proteins reconstituted with purified components

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12 December 2020

Cell cholesterol homeostasis: mediation by active cholesterol

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12 December 2020

Membrane protein insertion at the endoplasmic reticulum

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12 December 2020

Quality control of inner nuclear membrane proteins by the Asi complex

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12 December 2020

Unsaturated fatty acids down-regulate srebp isoforms 1a and 1c by two mechanisms in HEK-293 cells

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12 December 2020

Protein folding and modification in the mammalian endoplasmic reticulum.

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12 December 2020

Der1 promotes movement of misfolded proteins through the endoplasmic reticulum membrane

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12 December 2020

A glycosylated type I membrane protein becomes cytosolic when peptide: N-glycanase is compromised

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12 December 2020

The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER

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12 December 2020

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12 December 2020

The delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiology

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12 December 2020

Glycosylation-directed quality control of protein folding

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12 December 2020

A proteasomal ATPase contributes to dislocation of endoplasmic reticulum-associated degradation (ERAD) substrates.

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12 December 2020

Characterization of the interaction of diacylglycerol acyltransferase-2 with the endoplasmic reticulum and lipid droplets

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12 December 2020

The biological and chemical basis for tissue-selective amyloid disease

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12 December 2020

Cytoplasmic lipid droplets are sites of convergence of proteasomal and autophagic degradation of apolipoprotein B.

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12 December 2020

The AAA-ATPase p97 facilitates degradation of apolipoprotein B by the ubiquitin-proteasome pathway

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12 December 2020

EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step

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12 December 2020

Lipolysis - a highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores

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12 December 2020

A novel processing system of sterol regulatory element-binding protein-1c regulated by polyunsaturated fatty acid

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12 December 2020

Uncoupling retro-translocation and degradation in the ER-associated degradation of a soluble protein

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12 December 2020

Ancient ubiquitous protein-1 mediates sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in lipid droplet-associated endoplasmic reticulum membranes

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12 December 2020

Endoplasmic reticulum lectin XTP3-B inhibits endoplasmic reticulum-associated degradation of a misfolded α1-antitrypsin variant.

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12 December 2020

Ubiquitin-dependent regulation of COPII coat size and function

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12 December 2020

Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

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12 December 2020

Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnover

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12 December 2020

Lipid droplets and cellular lipid metabolism

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12 December 2020

Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain

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12 December 2020

Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase

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12 December 2020

Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78

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12 December 2020

Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase

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12 December 2020

Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols.

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12 December 2020

OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD

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12 December 2020

Structural control of endoplasmic reticulum-associated degradation: effect of chemical chaperones on 3-hydroxy-3-methylglutaryl-CoA reductase

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12 December 2020

Ufd1 is a cofactor of gp78 and plays a key role in cholesterol metabolism by regulating the stability of HMG-CoA reductase

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12 December 2020

Regulation of glutamine carrier proteins by RNF5 determines breast cancer response to ER stress-inducing chemotherapies

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12 December 2020

Differential regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome system.

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12 December 2020

The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductase

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12 December 2020

COPII and the regulation of protein sorting in mammals

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12 December 2020

Defining human ERAD networks through an integrative mapping strategy

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12 December 2020

10.1146/ANNUREV-NUTR-071715-051030

Identifiers

DOI

1 reference

1 July 2019

PMC publication ID

6268005

1 reference

1 July 2019

PubMed publication ID

27296502

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1 July 2019