(Q38925531)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27516341%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

review article

1 reference

title

Endoplasmic reticulum proteostasis in hepatic steatosis (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27516341%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

main subject

endoplasmic reticulum

0 references

author

Andrei Baiceanu

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27516341%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Fabienne Foufelle

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27516341%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

author name string

Pierre Mesdom

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27516341%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Marie Lagouge

3

1 reference

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20 March 2020

publication date

12 August 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27516341%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Endocrinology

20 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27516341%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

volume

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27516341%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

issue

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27516341%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

page(s)

710-722

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27516341%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nrendo.2016.124

20 March 2020

exact match

0 references

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UPR, autophagy, and mitochondria crosstalk underlies the ER stress response

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The mechanism of Z alpha 1-antitrypsin accumulation in the liver

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Defining human ERAD networks through an integrative mapping strategy

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Endoplasmic reticulum stress in liver disease

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Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

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Stable binding of ATF6 to BiP in the endoplasmic reticulum stress response

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Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

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The unfolded protein response triggers selective mRNA release from the endoplasmic reticulum

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Regulated translation initiation controls stress-induced gene expression in mammalian cells

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Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development

21 January 2018

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Characterization of the hemin-sensitive eukaryotic initiation factor 2alpha kinase from mouse nonerythroid cells

21 January 2018

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Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase

21 January 2018

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Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2

21 January 2018

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PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress

21 January 2018

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The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response

21 January 2018

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XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

21 January 2018

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The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis

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21 January 2018

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IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.

21 January 2018

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21 January 2018

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ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

21 January 2018

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Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

21 January 2018

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ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals

21 January 2018

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ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

21 January 2018

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Proteostasis control by the unfolded protein response

21 January 2018

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Regulation of Liver Metabolism by Autophagy

21 January 2018

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Cargo recognition and trafficking in selective autophagy

21 January 2018

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The pseudokinase tribbles homologue-3 plays a crucial role in cannabinoid anticancer action.

21 January 2018

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A close connection between the PERK and IRE arms of the UPR and the transcriptional regulation of autophagy.

21 January 2018

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Selective autophagy: talking with the UPS.

21 January 2018

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Decoding cell death signals in liver inflammation

21 January 2018

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Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

21 January 2018

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Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

21 January 2018

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Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss

21 January 2018

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Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease

21 January 2018

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Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress

21 January 2018

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Initiation and execution of lipotoxic ER stress in pancreatic beta-cells

21 January 2018

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Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis

21 January 2018

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Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells

21 January 2018

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The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages

21 January 2018

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Decrease in membrane phospholipid unsaturation induces unfolded protein response

21 January 2018

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Calcium Homeostasis and Organelle Function in the Pathogenesis of Obesity and Diabetes

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Transcriptional regulation of hepatic lipogenesis

21 January 2018

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Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory element-binding protein-1c

21 January 2018

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Selective versus total insulin resistance: a pathogenic paradox

21 January 2018

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GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice

21 January 2018

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Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1

21 January 2018

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Constitutive role for IRE1α-XBP1 signaling pathway in the insulin-mediated hepatic lipogenic program

21 January 2018

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Fibroblast growth factor 21 is regulated by the IRE1α-XBP1 branch of the unfolded protein response and counteracts endoplasmic reticulum stress-induced hepatic steatosis

21 January 2018

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PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation

21 January 2018

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Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice

21 January 2018

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ATF4 protein deficiency protects against high fructose-induced hypertriglyceridemia in mice.

21 January 2018

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The role of the Nrf2/Keap1 pathway in obesity and metabolic syndrome

21 January 2018

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Endoplasmic reticulum stress induces hepatic steatosis via increased expression of the hepatic very low-density lipoprotein receptor

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Activating transcription factor 6 is necessary and sufficient for alcoholic fatty liver disease in zebrafish

21 January 2018

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Mitochondria and redox signaling in steatohepatitis

21 January 2018

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Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver

21 January 2018

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Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease

21 January 2018

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MAM (mitochondria-associated membranes) in mammalian cells: lipids and beyond

21 January 2018

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Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress

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Loss of mitofusin 2 promotes endoplasmic reticulum stress

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Stress-responsive regulation of mitochondria through the ER unfolded protein response.

21 January 2018

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Mitofusin 2 tethers endoplasmic reticulum to mitochondria

21 January 2018

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Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity

21 January 2018

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Regulation of mitochondrial dehydrogenases by calcium ions

21 January 2018

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The effects of calcium ions and adenine nucleotides on the activity of pig heart 2-oxoglutarate dehydrogenase complex

21 January 2018

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ER calcium release promotes mitochondrial dysfunction and hepatic cell lipotoxicity in response to palmitate overload

21 January 2018

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Calcium and ROS: A mutual interplay

21 January 2018

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Oxidative stress caused by mitochondrial calcium overload

21 January 2018

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Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis

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Mitochondrial lipid transport at a glance

21 January 2018

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Formation and regulation of mitochondrial membranes.

21 January 2018

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The PPARα-FGF21 hormone axis contributes to metabolic regulation by the hepatic JNK signaling pathway

21 January 2018

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The roles of c-Jun NH2-terminal kinases (JNKs) in obesity and insulin resistance

21 January 2018

1 reference

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JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

The sterol-sensing domain (SSD) directly mediates signal-regulated endoplasmic reticulum-associated degradation (ERAD) of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase isozyme Hmg2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Regulation of diacylglycerol acyltransferase 2 protein stability by gp78-associated endoplasmic-reticulum-associated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Knockdown of acyl-CoA:diacylglycerol acyltransferase 2 with antisense oligonucleotide reduces VLDL TG and ApoB secretion in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Aberrant hepatic TRIB3 gene expression in insulin-resistant obese humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Lack of evidence for a role of TRB3/NIPK as an inhibitor of PKB-mediated insulin signalling in primary hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Impaired autophagy: A mechanism of mitochondrial dysfunction in anoxic rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Inhibitory effect of dietary lipids on chaperone-mediated autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Altered lipid content inhibits autophagic vesicular fusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Calcium channel blockers as potential therapeutics for obesity-associated autophagy defects and fatty liver pathologies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Deficient chaperone-mediated autophagy in liver leads to metabolic dysregulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: results of a randomized trial

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Berberine activates Nrf2 nuclear translocation and inhibits apoptosis induced by high glucose in renal tubular epithelial cells through a phosphatidylinositol 3-kinase/Akt-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

GLP-1 analogs reduce hepatocyte steatosis and improve survival by enhancing the unfolded protein response and promoting macroautophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Valproate attenuates accelerated atherosclerosis in hyperglycemic apoE-deficient mice: evidence in support of a role for endoplasmic reticulum stress and glycogen synthase kinase-3 in lesion development and hepatic steatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

A molecular chaperone inducer protects neurons from ER stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (P

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Protein folding and modification in the mammalian endoplasmic reticulum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Protein folding and quality control in the endoplasmic reticulum: Recent lessons from yeast and mammalian cell systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Topological orientation of acyl-CoA:diacylglycerol acyltransferase-1 (DGAT1) and identification of a putative active site histidine and the role of the n terminus in dimer/tetramer formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Exiting the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Biosynthesis of cytochrome P-450 on membrane-bound ribosomes and its subsequent incorporation into rough and smooth microsomes in rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Insulin regulates the unfolded protein response in human adipose tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

IRE1α activation protects mice against acetaminophen-induced hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Measuring lipogenesis and cholesterol synthesis in humans with deuterated water: use of simple gas chromatographic/mass spectrometric techniques

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Stereological analysis of normal rabbit pancreatic islets

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Development of rough endoplasmic reticulum in mouse splenic lymphocytes stimulated by mitogens

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Metabolomic analysis of livers and serum from high-fat diet induced obese mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Deletion of C/EBP homologous protein (Chop) in C57Bl/6 mice dissociates obesity from insulin resistance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Ablation of gp78 in liver improves hyperlipidemia and insulin resistance by inhibiting SREBP to decrease lipid biosynthesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Submicrosomal localization of hepatic 3-hydroxy-3-methylglutaryl coenzyme a (HMG-CoA) reductase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Nonvesicular lipid transfer from the endoplasmic reticulum

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

A biochemical and electron microscopic study of changes in the content of cytochrome P-450 in rat livers after cessation of treatment with phenobarbital, .BETA.-naphtoflavone or 3-methylcholanthrene

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

Infusion of glucose and lipids at physiological rates causes acute endoplasmic reticulum stress in rat liver

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2016.124

IRE1 signaling affects cell fate during the unfolded protein response

31 March 2020

1 reference

12 December 2020

Pharmacological ER stress promotes hepatic lipogenesis and lipid droplet formation

1 reference

12 December 2020

Changes in the composition and fluidity of membranes in obese (ob/ob) mice: a study of hepatic microsomal NADPH-cytochrome P450 oxidoreductase activity

1 reference

12 December 2020

Non-alcoholic fatty liver disease and obesity: biochemical, metabolic and clinical presentations

1 reference

12 December 2020

Subcellular localization and membrane topology of serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liver

1 reference

12 December 2020

Apolipoprotein B in the rough endoplasmic reticulum: translation, translocation and the initiation of lipoprotein assembly

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRENDO.2016.124

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27516341%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

1 reference