(Q39352425)

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Post-Translational Oxidative Modifications of Mitochondrial Complex I (NADH: Ubiquinone Oxidoreductase): Implications for Pathogenesis and Therapeutics in Human Diseases

scientific article published on 30 May 2017

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scholarly article

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Europe PubMed Central

11 September 2017

1 reference

Europe PubMed Central

Post-Translational Oxidative Modifications of Mitochondrial Complex I (NADH: Ubiquinone Oxidoreductase): Implications for Pathogenesis and Therapeutics in Human Diseases (English)

1 reference

Europe PubMed Central

11 September 2017

author name string

M M Srinivas Bharath

1

1 reference

Europe PubMed Central

11 September 2017

publication date

30 May 2017

1 reference

Europe PubMed Central

11 September 2017

Journal of Alzheimer's Disease

1 reference

Europe PubMed Central

11 September 2017

Gaining mass: the structure of respiratory complex I-from bacterial towards mitochondrial versions

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Mitochondrial respiratory complex I: structure, function and implication in human diseases

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The mechanism of superoxide production by NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria

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How mitochondria produce reactive oxygen species

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Topology of superoxide production from different sites in the mitochondrial electron transport chain

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Dynamics of Human Mitochondrial Complex I Assembly: Implications for Neurodegenerative Diseases

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Complex-I-ty in aging

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Understanding mitochondrial complex I assembly in health and disease

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Mitochondrial disease associated with complex I (NADH-CoQ oxidoreductase) deficiency

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The oxidative phosphorylation (OXPHOS) system: nuclear genes and human genetic diseases

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Diseases of the mitochondrial DNA.

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Catalytic sector of complex I (NADH:ubiquinone oxidoreductase): subunit stoichiometry and substrate-induced conformation changes

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Architecture of mammalian respiratory complex I.

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Assembly factors as a new class of disease genes for mitochondrial complex I deficiency: cause, pathology and treatment options

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Identification and characterization of a common set of complex I assembly intermediates in mitochondria from patients with complex I deficiency

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Structural biology. Mechanistic insight from the crystal structure of mitochondrial complex I

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Energy conversion, redox catalysis and generation of reactive oxygen species by respiratory complex I

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Assembly factors of human mitochondrial respiratory chain complexes: physiology and pathophysiology

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Crystal structure of the entire respiratory complex I

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The Structural and Functional Basis of Catalysis Mediated by NAD(P)H:acceptor Oxidoreductase (FerB) of Paracoccus denitrificans

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Respiratory chain complex I deficiency: an underdiagnosed energy generation disorder

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Modelling the effects of age-related mtDNA mutation accumulation; complex I deficiency, superoxide and cell death.

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High-throughput, pooled sequencing identifies mutations in NUBPL and FOXRED1 in human complex I deficiency

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LHON and other optic nerve atrophies: the mitochondrial connection

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Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy

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The reduction of NADH ubiquinone oxidoreductase 24- and 75-kDa subunits in brains of patients with Down syndrome and Alzheimer's disease

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Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

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Alzheimer's disease: effects of β-amyloid on mitochondria

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DJ-1 deficiency in astrocytes selectively enhances mitochondrial Complex I inhibitor-induced neurotoxicity

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Comparison of mitochondrial respiratory chain enzyme activities in rodent astrocytes and neurones and a human astrocytoma cell line

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Mitochondrial Complex I Activity is Conditioned by Supercomplex I-III2-IV Assembly in Brain Cells: Relevance for Parkinson's Disease.

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Complex I assembly into supercomplexes determines differential mitochondrial ROS production in neurons and astrocytes.

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Cristae formation-linking ultrastructure and function of mitochondria

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Gluing the respiratory chain together. Cardiolipin is required for supercomplex formation in the inner mitochondrial membrane

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Cardiolipin stabilizes respiratory chain supercomplexes

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Origin and functional consequences of the complex I defect in Parkinson's disease

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Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP+, or paraquat.

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Mitochondria-specific accumulation of amyloid β induces mitochondrial dysfunction leading to apoptotic cell death

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Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology

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Amyloid-beta and mitochondria in aging and Alzheimer's disease: implications for synaptic damage and cognitive decline

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The Alzheimer's disease mitochondrial cascade hypothesis

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Mitochondrial dysfunctions in neurodegenerative diseases: relevance to Alzheimer's disease.

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The expression of several mitochondrial and nuclear genes encoding the subunits of electron transport chain enzyme complexes, cytochrome c oxidase, and NADH dehydrogenase, in different brain regions in Alzheimer's disease.

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Decreased levels of complex III core protein 1 and complex V beta chain in brains from patients with Alzheimer's disease and Down syndrome.

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Early dysregulation of the mitochondrial proteome in a mouse model of Alzheimer's disease.

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Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

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Mitochondrial respiratory chain Complexes I and IV are impaired by β-amyloid via direct interaction and through Complex I-dependent ROS production, respectively.

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Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation

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No consistent bioenergetic defects in presynaptic nerve terminals isolated from mouse models of Alzheimer's disease

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The production of reactive oxygen species by complex I.

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Inhibitors of the quinone-binding site allow rapid superoxide production from mitochondrial NADH:ubiquinone oxidoreductase (complex I).

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Superoxide production by NADH:ubiquinone oxidoreductase (complex I) depends on the pH gradient across the mitochondrial inner membrane

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Evidence for two sites of superoxide production by mitochondrial NADH-ubiquinone oxidoreductase (complex I).

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Superoxide is produced by the reduced flavin in mitochondrial complex I: a single, unified mechanism that applies during both forward and reverse electron transfer

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Superoxide production is inversely related to complex I activity in inherited complex I deficiency.

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Increased oxidative damage and decreased antioxidant function in aging human substantia nigra compared to striatum: implications for Parkinson's disease.

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Elevated oxidative stress and decreased antioxidant function in the human hippocampus and frontal cortex with increasing age: implications for neurodegeneration in Alzheimer's disease.

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Inducible alterations of glutathione levels in adult dopaminergic midbrain neurons result in nigrostriatal degeneration.

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Glutathione depletion in PC12 results in selective inhibition of mitochondrial complex I activity. Implications for Parkinson's disease.

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Metal and redox modulation of cysteine protein function

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Rapid purification and mass spectrometric characterization of mitochondrial NADH dehydrogenase (Complex I) from rodent brain and a dopaminergic neuronal cell line.

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Glutaredoxin 2 catalyzes the reversible oxidation and glutathionylation of mitochondrial membrane thiol proteins: implications for mitochondrial redox regulation and antioxidant DEFENSE.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Acute cadmium exposure inactivates thioltransferase (Glutaredoxin), inhibits intracellular reduction of protein-glutathionyl-mixed disulfides, and initiates apoptosis.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Human brain thioltransferase: constitutive expression and localization by fluorescence in situ hybridization

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Down-regulation of glutaredoxin by estrogen receptor antagonist renders female mice susceptible to excitatory amino acid mediated complex I inhibition in CNS.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Complex I within oxidatively stressed bovine heart mitochondria is glutathionylated on Cys-531 and Cys-704 of the 75-kDa subunit: potential role of CYS residues in decreasing oxidative damage

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Site-specific S-glutathiolation of mitochondrial NADH ubiquinone reductase

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Protein thiyl radical mediates S-glutathionylation of complex I.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Mass spectrometry profiles superoxide-induced intramolecular disulfide in the FMN-binding subunit of mitochondrial Complex I

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Sites of inhibition of mitochondrial electron transport in macrophage-injured neoplastic cells

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Nitric oxide: a cytotoxic activated macrophage effector molecule

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Impact of endogenous nitric oxide on microglial cell energy metabolism and labile iron pool

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Nitric oxide, mitochondria and neurological disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Glutathione depletion, lipid peroxidation and mitochondrial dysfunction are induced by chronic stress in rat brain

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Role of nNOS in cardiac ischemia-reperfusion injury

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Selective Nitric Oxide Synthase Inhibitor 7-Nitroindazole Protects against Cocaine-Induced Oxidative Stress in Rat Brain

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Ischemic postconditioning protects the heart against ischemia-reperfusion injury via neuronal nitric oxide synthase in the sarcoplasmic reticulum and mitochondria

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Small-molecule inhibitors at the PSD-95/nNOS interface attenuate MPP+-induced neuronal injury through Sirt3 mediated inhibition of mitochondrial dysfunction

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Hypoxia induces complex I inhibition and ultrastructural damage by increasing mitochondrial nitric oxide in developing CNS.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Oxidative stress and S-nitrosylation of proteins in cells

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Persistent inhibition of cell respiration by nitric oxide: crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Reversal of nitric oxide-, peroxynitrite- and S-nitrosothiol-induced inhibition of mitochondrial respiration or complex I activity by light and thiols

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Nitric oxide and calcium together inactivate mitochondrial complex I and induce cytochrome c release

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Direct evidence for S-nitrosation of mitochondrial complex I.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Persistent S-nitrosation of complex I and other mitochondrial membrane proteins by S-nitrosothiols but not nitric oxide or peroxynitrite: implications for the interaction of nitric oxide with mitochondria

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Chronic exposure to nitric oxide alters the free iron pool in endothelial cells: role of mitochondrial respiratory complexes and heat shock proteins

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Mitochondrial damage by nitric oxide is potentiated by dopamine in PC12 cells

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Nitrosylation and nitration of mitochondrial complex I in Parkinson's disease.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Reversible inactivation of E. coli endonuclease III via modification of its [4Fe-4S] cluster by nitric oxide

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

S-nitrosation of mitochondrial complex I depends on its structural conformation

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Peroxynitrite reactivity with amino acids and proteins

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Increased nitrotyrosine immunoreactivity in substantia nigra neurons in MPTP treated baboons is blocked by inhibition of neuronal nitric oxide synthase.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Mass spectrometric quantification of 3-nitrotyrosine, ortho-tyrosine, and o,o'-dityrosine in brain tissue of 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-treated mice, a model of oxidative stress in Parkinson's disease.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Oxidative damage to mitochondrial complex I due to peroxynitrite: identification of reactive tyrosines by mass spectrometry

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Striatal neuroinflammation promotes Parkinsonism in rats

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Mitochondrial complex I inhibition in Parkinson's disease: how can curcumin protect mitochondria?

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Curcumin treatment alleviates the effects of glutathione depletion in vitro and in vivo: therapeutic implications for Parkinson's disease explained via in silico studies

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Selective nitration of mitochondrial complex I by peroxynitrite: involvement in mitochondria dysfunction and cell death of dopaminergic SH-SY5Y cells

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Glutathione depletion in a midbrain-derived immortalized dopaminergic cell line results in limited tyrosine nitration of mitochondrial complex I subunits: implications for Parkinson's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Nitration of the mitochondrial complex I subunit NDUFB8 elicits RIP1- and RIP3-mediated necrosis

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Protein oxidation in aging, disease, and oxidative stress

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Post-translational oxidative modification and inactivation of mitochondrial complex I in epileptogenesis

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

A disruption in iron-sulfur center biogenesis via inhibition of mitochondrial dithiol glutaredoxin 2 may contribute to mitochondrial and cellular iron dysregulation in mammalian glutathione-depleted dopaminergic cells: implications for Parkinson's d

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170117

21 January 2018

Identifiers

10.3233/JAD-170117

1 reference

Europe PubMed Central

11 September 2017

1 reference

Europe PubMed Central

11 September 2017

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