(Q39372532)

11 September 2017

A dynamic network model of mTOR signaling reveals TSC-independent mTORC2 regulation (English)

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11 September 2017

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Kathrin Thedieck

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author name string

Annika G Sonntag

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11 September 2017

Antje Thien

3

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11 September 2017

Mirja T Prentzell

4

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11 September 2017

Markus Gödel

5

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11 September 2017

Sven Fischer

6

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11 September 2017

Elke Neumann-Haefelin

7

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11 September 2017

Tobias B Huber

8

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11 September 2017

Ralf Baumeister

9

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11 September 2017

Daryl P Shanley

10

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11 September 2017

27 March 2012

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11 September 2017

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11 September 2017

5

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11 September 2017

217

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11 September 2017

ra25

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mTOR: from growth signal integration to cancer, diabetes and ageing

11 September 2017

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

mTOR couples cellular nutrient sensing to organismal metabolic homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Blocking the mTOR pathway: a drug discovery perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

mTOR and the control of whole body metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

TOR complex 2: a signaling pathway of its own.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

New inhibitors of the PI3K-Akt-mTOR pathway: insights into mTOR signaling from a new generation of Tor Kinase Domain Inhibitors (TORKinibs).

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Rag proteins regulate amino-acid-induced mTORC1 signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Activation of mTORC1 in two steps: Rheb-GTP activation of catalytic function and increased binding of substrates to raptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Amino acids activate mammalian target of rapamycin complex 2 (mTORC2) via PI3K/Akt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

The nuts and bolts of AGC protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

TOR regulation of AGC kinases in yeast and mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Protein kinase B (PKB/Akt), a key mediator of the PI3K signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Dysregulation of the TSC-mTOR pathway in human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

The TSC1-TSC2 complex is required for proper activation of mTOR complex 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

A complex interplay between Akt, TSC2 and the two mTOR complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

The long and winding road to rational treatment of cancer associated with LKB1/AMPK/TSC/mTORC1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

mTORC2 is required for proliferation and survival of TSC2-null cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Involvement of the cytoskeleton in controlling leading-edge function during chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

A Ras signaling complex controls the RasC-TORC2 pathway and directed cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Ras-mediated activation of the TORC2-PKB pathway is critical for chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

FMLP activates Ras and Raf in human neutrophils. Potential role in activation of MAP kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

A comprehensive map of the mTOR signaling network

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Signaling logic of activity-triggered dendritic protein synthesis: an mTOR gate but not a feedback switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Mass and information feedbacks through receptor endocytosis govern insulin signaling as revealed using a parameter-free modeling framework.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

The signaling petri net-based simulator: a non-parametric strategy for characterizing the dynamics of cell-specific signaling networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Systems-level interactions between insulin-EGF networks amplify mitogenic signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Model-based hypothesis testing of key mechanisms in initial phase of insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Harmonic oscillator model of the insulin and IGF1 receptors' allosteric binding and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Systems biology reveals new strategies for personalizing cancer medicine and confirms the role of PTEN in resistance to trastuzumab.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Ensemble modeling for analysis of cell signaling dynamics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Models from experiments: combinatorial drug perturbations of cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

A mathematical model of metabolic insulin signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Quantification of the effect of amino acids on an integrated mTOR and insulin signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Modelling the response of FOXO transcription factors to multiple post-translational modifications made by ageing-related signalling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Reconstruction of cellular signalling networks and analysis of their properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

The Systems Biology Graphical Notation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Second AKT: the rise of SGK in cancer signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

FKBP12-Rapamycin-associated Protein (FRAP) Autophosphorylates at Serine 2481 under Translationally Repressive Conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Site-specific mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Rapamycin inhibits mTORC1, but not completely.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Improved semiquantitative Western blot technique with increased quantification range.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Classic and contemporary approaches to modeling biochemical reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Parameter estimation in biochemical pathways: a comparison of global optimization methods

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Parameter estimation in systems biology models using spline approximation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

mu-Opioid receptor activates signaling pathways implicated in cell survival and translational control

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

The segment polarity network is a robust developmental module

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Inferring signaling pathway topologies from multiple perturbation measurements of specific biochemical species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Regulation of protein kinase B/Akt activity and Ser473 phosphorylation by protein kinase Calpha in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.

21 January 2018

1 reference

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The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3,4,5-trisphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Activation of mTORC2 by association with the ribosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis

21 January 2018

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The emerging mechanisms of isoform-specific PI3K signalling

21 January 2018

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Conditional suppression of cellular genes: lentivirus vector-mediated drug-inducible RNA interference

21 January 2018

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COPASI--a COmplex PAthway SImulator

21 January 2018

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Optimization by Simulated Annealing

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002469

Systems Biology Toolbox for MATLAB: a computational platform for research in systems biology.

21 January 2018

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The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models

21 January 2018

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A new look at the statistical model identification

21 January 2018

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10.1126/SCISIGNAL.2002469

21 January 2018

Identifiers

DOI

1 reference

11 September 2017

1 reference