(Q40085988)

17 September 2017

title

Involvement of prostaglandin E2 in production of amyloid-beta peptides both in vitro and in vivo (English)

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17 September 2017

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8

Shuh Narumiya

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17 September 2017

Tatsuya Hoshino

1

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17 September 2017

Tadashi Nakaya

2

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17 September 2017

Takashi Homan

3

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17 September 2017

Ken-ichiro Tanaka

4

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17 September 2017

Yukihiko Sugimoto

5

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17 September 2017

Wataru Araki

6

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17 September 2017

Masami Narita

7

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17 September 2017

Toshiharu Suzuki

9

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17 September 2017

Tohru Mizushima

10

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17 September 2017

language of work or name

English

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publication date

2 September 2007

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Journal of Biological Chemistry

17 September 2017

number of pages

13

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based on heuristic

inferred from page(s)

published in

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17 September 2017

volume

282

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17 September 2017

issue

45

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17 September 2017

page(s)

32676-32688

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

17 September 2017

cites work

1 reference

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Pathways towards and away from Alzheimer's disease

21 January 2018

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gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M703087200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M703087200

Genetic neurodegenerative diseases: the human illness and transgenic models

21 January 2018

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Novel therapeutic opportunities for Alzheimer's disease: focus on nonsteroidal anti-inflammatory drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

Pharmacological analysis of cyclooxygenase-1 in inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

Increased expression of cyclooxygenases and peroxisome proliferator-activated receptor-gamma in Alzheimer's disease brains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

Distribution of cyclooxygenase-1 and cyclooxygenase-2 mRNAs and proteins in human brain and peripheral organs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

Neuronal cyclooxygenase 2 expression in the hippocampal formation as a function of the clinical progression of Alzheimer disease

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M703087200

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

Nonsteroidal anti-inflammatory drug gastropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

Cardiovascular toxicity of valdecoxib

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

Cyclooxygenase (COX)-2 and COX-1 Potentiate β-Amyloid Peptide Generation through Mechanisms That Involve γ-Secretase Activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

A basic amino acid in the cytoplasmic domain of Alzheimer's beta-amyloid precursor protein (APP) is essential for cleavage of APP at the alpha-site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

Abortive expansion of the cumulus and impaired fertility in mice lacking the prostaglandin E receptor subtype EP(2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

Endoplasmic reticulum chaperones inhibit the production of amyloid-beta peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

Prostaglandin E2 protects gastric mucosal cells from apoptosis via EP2 and EP4 receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

Partial Purification and Characterization of γ-Secretase from Post-mortem Human Brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

Activation of beta2-adrenergic receptor stimulates gamma-secretase activity and accelerates amyloid plaque formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

The formation of prostaglandins in the postmortem cerebral cortex of Alzheimer-type dementia patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

The role of prostaglandin E receptor subtypes (EP1, EP2, EP3, and EP4) in bone resorption: an analysis using specific agonists for the respective EPs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

Increased bleeding tendency and decreased susceptibility to thromboembolism in mice lacking the prostaglandin E receptor subtype EP(3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

Inhibitory effect of a prostaglandin E receptor subtype EP(1) selective antagonist, ONO-8713, on development of azoxymethane-induced aberrant crypt foci in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

Host prostaglandin E(2)-EP3 signaling regulates tumor-associated angiogenesis and tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

EP2 and EP4 prostanoid receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

Epac: a new cAMP target and new avenues in cAMP research

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

cAMP analog mapping of Epac1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

APP processing is regulated by cytoplasmic phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

Increased TNFalpha production and Cox-2 activity in organotypic brain slice cultures from APPsw transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

Mechanisms involved in prostaglandin E2-mediated neuroprotection against TNF-alpha: possible involvement of multiple signal transduction and beta-catenin/T-cell factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

Deletion of the prostaglandin E2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

Endogenous EP4 prostaglandin receptors coupled positively to adenylyl cyclase in Chinese hamster ovary cells: pharmacological characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

Stimulation of PGE receptors EP2 and EP4 protects cultured neurons against oxidative stress and cell death following beta-amyloid exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

Neuroprotective function of the PGE2 EP2 receptor in cerebral ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

Postsynaptically synthesized prostaglandin E2 (PGE2) modulates hippocampal synaptic transmission via a presynaptic PGE2 EP2 receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

Platelet-derived growth factor induces the beta-gamma-secretase-mediated cleavage of Alzheimer's amyloid precursor protein through a Src-Rac-dependent pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

Randomized pilot study of nimesulide treatment in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

Roles of prostaglandin E-receptor subtypes in gastric and duodenal bicarbonate secretion in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

21 January 2018

Towards a better aspirin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703087200

21 January 2018

Identifiers

DOI

10.1074/JBC.M703087200

1 reference

17 September 2017

1 reference