(Q42696060)

5 November 2017

title

Immunomodulatory drugs disrupt the cereblon-CD147-MCT1 axis to exert antitumor activity and teratogenicity (English)

1 reference

5 November 2017

0 references

22

1 reference

5 November 2017

18

Christian Haass

0 references

Ulrich Germing

13

object named as

Ulrich Germing

1 reference

5 November 2017

12

Uwe Platzbecker

1 reference

5 November 2017

Ruth Eichner

1

1 reference

5 November 2017

Michael Heider

2

1 reference

5 November 2017

Vanesa Fernández-Sáiz

3

1 reference

5 November 2017

Frauke van Bebber

4

1 reference

5 November 2017

Anne-Kathrin Garz

5

1 reference

5 November 2017

Simone Lemeer

6

1 reference

5 November 2017

Martina Rudelius

7

1 reference

5 November 2017

Bianca-Sabrina Targosz

8

1 reference

5 November 2017

Laura Jacobs

9

1 reference

5 November 2017

Anna-Maria Knorn

10

1 reference

5 November 2017

Jolanta Slawska

11

1 reference

5 November 2017

Christian Langer

14

1 reference

5 November 2017

Stefan Knop

15

1 reference

5 November 2017

Herrmann Einsele

16

1 reference

5 November 2017

Christian Peschel

17

1 reference

5 November 2017

Ulrich Keller

19

1 reference

5 November 2017

Bettina Schmid

20

1 reference

5 November 2017

Katharina S Götze

21

1 reference

5 November 2017

Florian Bassermann

23

1 reference

5 November 2017

language of work or name

English

0 references

publication date

13 June 2016

1 reference

5 November 2017

1 reference

5 November 2017

volume

22

1 reference

5 November 2017

issue

7

1 reference

5 November 2017

page(s)

735-743

1 reference

https://scigraph.springernature.com/pub.10.1038/nm.4128

5 November 2017

exact match

0 references

cites work

Thalidomide-analogue biology: immunological, molecular and epigenetic targets in cancer therapy.

1 reference

The evolution of thalidomide and its IMiD derivatives as anticancer agents

21 January 2018

1 reference

Identification of a primary target of thalidomide teratogenicity

21 January 2018

1 reference

Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide.

21 January 2018

1 reference

Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide

21 January 2018

1 reference

DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase

21 January 2018

1 reference

Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery

21 January 2018

1 reference

Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs

21 January 2018

1 reference

Identification and functional characterization of cereblon as a binding protein for large-conductance calcium-activated potassium channel in rat brain

21 January 2018

1 reference

Functional modulation of AMP-activated protein kinase by cereblon

21 January 2018

1 reference

CD147 immunoglobulin superfamily receptor function and role in pathology

21 January 2018

1 reference

CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression

21 January 2018

1 reference

Disrupting proton dynamics and energy metabolism for cancer therapy

21 January 2018

1 reference

CD147 regulates the expression of MCT1 and lactate export in multiple myeloma cells

21 January 2018

1 reference

Increased expression of extracellular matrix metalloproteinase inducer (CD147) in multiple myeloma: role in regulation of myeloma cell proliferation

21 January 2018

1 reference

The Cyclophilin A-CD147 complex promotes the proliferation and homing of multiple myeloma cells.

21 January 2018

1 reference

Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells

21 January 2018

1 reference

The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins

21 January 2018

1 reference

Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.).

21 January 2018

1 reference

Identification of cereblon-binding proteins and relationship with response and survival after IMiDs in multiple myeloma

21 January 2018

1 reference

Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS.

21 January 2018

1 reference

Structural basis of lenalidomide-induced CK1α degradation by the CRL4(CRBN) ubiquitin ligase

21 January 2018

1 reference

Drug response in a genetically engineered mouse model of multiple myeloma is predictive of clinical efficacy

21 January 2018

1 reference

Lon and Clp family proteases and chaperones share homologous substrate-recognition domains

21 January 2018

1 reference

Measuring cereblon as a biomarker of response or resistance to lenalidomide and pomalidomide requires use of standardized reagents and understanding of gene complexity

21 January 2018

1 reference

Cytogenetic response to thalidomide treatment in three patients with myelodysplastic syndrome

21 January 2018

1 reference

Treatment of myelodysplastic syndromes with 5q deletion before the lenalidomide era; the GFM experience with EPO and thalidomide

21 January 2018

1 reference

A randomized phase 3 study of lenalidomide versus placebo in RBC transfusion-dependent patients with Low-/Intermediate-1-risk myelodysplastic syndromes with del5q.

21 January 2018

1 reference

Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion

21 January 2018

1 reference

Lenalidomide as a disease-modifying agent in patients with del(5q) myelodysplastic syndromes: linking mechanism of action to clinical outcomes

21 January 2018

1 reference

Pomalidomide is nonteratogenic in chicken and zebrafish embryos and nonneurotoxic in vitro

21 January 2018

1 reference

The ubiquitin proteasome system - implications for cell cycle control and the targeted treatment of cancer

21 January 2018

1 reference

Safety and tolerability of ixazomib, an oral proteasome inhibitor, in combination with lenalidomide and dexamethasone in patients with previously untreated multiple myeloma: an open-label phase 1/2 study

21 January 2018

1 reference

Front-line transplantation program with lenalidomide, bortezomib, and dexamethasone combination as induction and consolidation followed by lenalidomide maintenance in patients with multiple myeloma: a phase II study by the Intergroupe Francophone du

21 January 2018

1 reference

Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma

21 January 2018

1 reference

Selective inhibition of T cell activation via CD147 through novel modulation of lipid rafts

21 January 2018

1 reference

Involvement of HAb18G/CD147 in T cell activation and immunological synapse formation

21 January 2018

1 reference

CD147 in regulatory T cells

21 January 2018

1 reference

Granulocyte colony-stimulating factor inhibits spontaneous cytochrome c release and mitochondria-dependent apoptosis of myelodysplastic syndrome hematopoietic progenitors

21 January 2018

1 reference

A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes

21 January 2018

1 reference

CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors

21 January 2018

1 reference

MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors

21 January 2018

1 reference

Epidermal growth factor receptor protects proliferating cell nuclear antigen from cullin 4A protein-mediated proteolysis

21 January 2018

1 reference

The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint

21 January 2018

1 reference

SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma

21 January 2018

1 reference

Disruption of the PRKCD-FBXO25-HAX-1 axis attenuates the apoptotic response and drives lymphomagenesis.

21 January 2018

1 reference

Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth

21 January 2018

1 reference

Zebrafish rx3 and mab21l2 are required during eye morphogenesis

21 January 2018

1 reference

Carfilzomib, Lenalidomide, and Dexamethasone for Relapsed Multiple Myeloma

21 January 2018

1 reference

Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide

21 January 2018

1 reference

12 December 2020

The saga of thalidomide. Neuropathy to embryopathy, with case reports of congenital anomalies

1 reference

12 December 2020

Extracellular matrix metalloproteinase inducer stimulates tumor angiogenesis by elevating vascular endothelial cell growth factor and matrix metalloproteinases

1 reference

12 December 2020

Oxygen saturation in the bone marrow of healthy volunteers

1 reference

12 December 2020

Identifiers

DOI

10.1038/NM.4128

1 reference

5 November 2017

1 reference