(Q38130850)

29 August 2017

Disrupting proton dynamics and energy metabolism for cancer therapy (English)

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29 August 2017

3

Jacques Pouysségur

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29 August 2017

Scott K Parks

1

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29 August 2017

Johanna Chiche

series ordinal

2

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29 August 2017

language of work or name

English

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publication date

1 September 2013

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29 August 2017

Nature Reviews Cancer

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29 August 2017

13

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29 August 2017

9

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29 August 2017

611-623

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https://scigraph.springernature.com/pub.10.1038/nrc3579

29 August 2017

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cites work

THE METABOLISM OF TUMORS IN THE BODY

1 reference

Understanding the Warburg effect: the metabolic requirements of cell proliferation

31 March 2020

1 reference

How cancer metabolism is tuned for proliferation and vulnerable to disruption

31 March 2020

1 reference

Hypoxia signalling in cancer and approaches to enforce tumour regression

31 March 2020

1 reference

Why do cancers have high aerobic glycolysis?

31 March 2020

1 reference

Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation

31 March 2020

1 reference

Proton-sensing G-protein-coupled receptors

31 March 2020

1 reference

Physiological carbon dioxide, bicarbonate, and pH sensing

31 March 2020

1 reference

Sensors and regulators of intracellular pH.

31 March 2020

1 reference

Hypoxia-inducible factors in physiology and medicine

31 March 2020

1 reference

Evolutionary dynamics of carcinogenesis and why targeted therapy does not work.

31 March 2020

1 reference

Membrane-bound carbonic anhydrases are key pH regulators controlling tumor growth and cell migration

31 March 2020

1 reference

Acid-mediated tumor invasion: a multidisciplinary study

31 March 2020

1 reference

Interfering with pH regulation in tumours as a therapeutic strategy

31 March 2020

1 reference

pH control mechanisms of tumor survival and growth

31 March 2020

1 reference

New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation

31 March 2020

1 reference

Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH.

31 March 2020

1 reference

Hypoxia promotes tumor cell survival in acidic conditions by preserving ATP levels

31 March 2020

1 reference

The role of carbonic anhydrase 9 in regulating extracellular and intracellular ph in three-dimensional tumor cell growths

31 March 2020

1 reference

Tumor-associated carbonic anhydrase 9 spatially coordinates intracellular pH in three-dimensional multicellular growths

31 March 2020

1 reference

The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis.

31 March 2020

1 reference

Na+/H+ exchanger-dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation-associated phenotypes.

31 March 2020

1 reference

In vivo pH in metabolic-defective Ras-transformed fibroblast tumors: key role of the monocarboxylate transporter, MCT4, for inducing an alkaline intracellular pH.

31 March 2020

1 reference

CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors

31 March 2020

1 reference

The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism.

31 March 2020

1 reference

Proton dynamics in cancer

31 March 2020

1 reference

Intracellular pH and activation of sea urchin eggs after fertilisation

31 March 2020

1 reference

Modifier role of internal H+ in activating the Na+–H+ exchanger in renal microvillus membrane vesicles

31 March 2020

1 reference

Primary structure and transmembrane orientation of the murine anion exchange protein

31 March 2020

1 reference

Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporter

31 March 2020

1 reference

A specific mutation abolishing Na+/H+ antiport activity in hamster fibroblasts precludes growth at neutral and acidic pH

31 March 2020

1 reference

Intracellular pH controls growth factor-induced ribosomal protein S6 phosphorylation and protein synthesis in the G0----G1 transition of fibroblasts

31 March 2020

1 reference

Cytoplasmic pH, a key determinant of growth factor-induced DNA synthesis in quiescent fibroblasts

31 March 2020

1 reference

Growth factor activation of an amiloride-sensitive Na+/H+ exchange system in quiescent fibroblasts: coupling to ribosomal protein S6 phosphorylation

31 March 2020

1 reference

Regulation of mTORC1 signaling by pH

31 March 2020

1 reference

Inhibition of the regulation of intracellular pH: potential of 5-(N,N-hexamethylene) amiloride in tumour-selective therapy

31 March 2020

1 reference

Repression of NHE1 expression by PPARgamma activation is a potential new approach for specific inhibition of the growth of tumor cells in vitro and in vivo

31 March 2020

1 reference

NHE1, NHE2, and NHE4 contribute to regulation of cell pH in T84 colon cancer cells

31 March 2020

1 reference

Molecular physiology of vertebrate Na+/H+ exchangers

31 March 2020

1 reference

Sodium-hydrogen exchange inhibition by cariporide to reduce the risk of ischemic cardiac events in patients undergoing coronary artery bypass grafting: results of the EXPEDITION study

31 March 2020

1 reference

Targeting Na+/H+ exchanger regulation for cardiac protection: a RSKy approach?

31 March 2020

1 reference

Dual inhibition of sodium-mediated proton and calcium efflux triggers non-apoptotic cell death in malignant gliomas

31 March 2020

1 reference

Chronic hypoxia elevates intracellular pH and activates Na+/H+ exchange in pulmonary arterial smooth muscle cells

31 March 2020

1 reference

HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes.

31 March 2020

1 reference

Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer

31 March 2020

1 reference

Hypoxia-induced invadopodia formation involves activation of NHE-1 by the p90 ribosomal S6 kinase (p90RSK).

31 March 2020

1 reference

Regulation of intracellular pH in cancer cell lines under normoxia and hypoxia

31 March 2020

1 reference

Low cytoplasmic pH inhibits endocytosis and transport from the trans-Golgi network to the cell surface

31 March 2020

1 reference

Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling

31 March 2020

1 reference

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

31 March 2020

1 reference

Role of ion channels and transporters in cell migration

31 March 2020

1 reference

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

31 March 2020

1 reference

Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH.

31 March 2020

1 reference

Targeting hypoxic tumor cell viability with carbohydrate-based carbonic anhydrase IX and XII inhibitors

31 March 2020

1 reference

Role of carbonic anhydrase IX in human tumor cell growth, survival, and invasion

31 March 2020

1 reference

Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors.

31 March 2020

1 reference

Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche.

31 March 2020

1 reference

Knock-down of hypoxia-induced carbonic anhydrases IX and XII radiosensitizes tumor cells by increasing intracellular acidosis

31 March 2020

1 reference

Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation.

31 March 2020

1 reference

Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapy

31 March 2020

1 reference

Function of carbonic anhydrase IX in glioblastoma multiforme

31 March 2020

1 reference

The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian alpha-carbonic anhydrase isoforms.

31 March 2020

1 reference

A clinical phase I/II trial with the monoclonal antibody cG250 (RENCAREX®) and interferon-alpha-2a in metastatic renal cell carcinoma patients

31 March 2020

1 reference

A transport metabolon. Functional interaction of carbonic anhydrase II and chloride/bicarbonate exchangers

31 March 2020

1 reference

Evaluating the role of carbonic anhydrases in the transport of HCO3--related species

31 March 2020

1 reference

Effect of human carbonic anhydrase II on the activity of the human electrogenic Na/HCO3 cotransporter NBCe1-A in Xenopus oocytes.

31 March 2020

1 reference

Evidence against a Direct Interaction between Intracellular Carbonic Anhydrase II and Pure C-terminal Domains of SLC4 Bicarbonate Transporters

31 March 2020

1 reference

Membrane transport metabolons

31 March 2020

1 reference

Nonenzymatic proton handling by carbonic anhydrase II during H+-lactate cotransport via monocarboxylate transporter 1.

31 March 2020

1 reference

Intramolecular proton shuttle supports not only catalytic but also noncatalytic function of carbonic anhydrase II.

31 March 2020

1 reference

The SLC26 gene family of multifunctional anion exchangers

31 March 2020

1 reference

The SLC4 family of HCO 3 - transporters

31 March 2020

1 reference

Chloride--bicarbonate exchange in red blood cells: physiology of transport and chemical modification of binding sites

31 March 2020

1 reference

Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2.

31 March 2020

1 reference

NBCn1 and NHE1 expression and activity in DeltaNErbB2 receptor-expressing MCF-7 breast cancer cells: contributions to pHi regulation and chemotherapy resistance.

31 March 2020

1 reference

The Na+/H+ exchanger NHE1, but not the Na+, HCO3(-) cotransporter NBCn1, regulates motility of MCF7 breast cancer cells expressing constitutively active ErbB2.

31 March 2020

1 reference

Contribution of Na+,HCO3(-)-cotransport to cellular pH control in human breast cancer: a role for the breast cancer susceptibility locus NBCn1 (SLC4A7).

31 March 2020

1 reference

Aerobic glycolysis: meeting the metabolic requirements of cell proliferation

31 March 2020

1 reference

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

31 March 2020

1 reference

Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

31 March 2020

1 reference

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

31 March 2020

1 reference

Hypoxia and energetic tumour metabolism

31 March 2020

1 reference

Transport of lactate and other monocarboxylates across mammalian plasma membranes

31 March 2020

1 reference

The monocarboxylate transporter family--Structure and functional characterization

31 March 2020

1 reference

Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle

31 March 2020

1 reference

N-terminal protein sequence analysis of the rabbit erythrocyte lactate transporter suggests identity with the cloned monocarboxylate transport protein MCT1.

31 March 2020

1 reference

Role of monocarboxylate transporters in human cancers: state of the art.

31 March 2020

1 reference

Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets

31 March 2020

1 reference

CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression

31 March 2020

1 reference

Monocarboxylate transporter MCT1 is a target for immunosuppression

31 March 2020

1 reference

CD147 silencing inhibits lactate transport and reduces malignant potential of pancreatic cancer cells in in vivo and in vitro models.

31 March 2020

1 reference

The H+-linked monocarboxylate transporter (MCT1/SLC16A1): a potential therapeutic target for high-risk neuroblastoma

31 March 2020

1 reference

Transport activity of MCT1 expressed in Xenopus oocytes is increased by interaction with carbonic anhydrase

31 March 2020

1 reference

Transport activity of the high-affinity monocarboxylate transporter MCT2 is enhanced by extracellular carbonic anhydrase IV but not by intracellular carbonic anhydrase II

31 March 2020

1 reference

Interaction of monocarboxylate transporter 4 with beta1-integrin and its role in cell migration

31 March 2020

1 reference

Monocarboxylate transporter 4 regulates maturation and trafficking of CD147 to the plasma membrane in the metastatic breast cancer cell line MDA-MB-231.

31 March 2020

1 reference

Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology

31 March 2020

1 reference

Proton pump inhibitor-induced tumour cell death by inhibition of a detoxification mechanism

31 March 2020

1 reference

Vacuolar-type H(+)-ATPases are functionally expressed in plasma membranes of human tumor cells

31 March 2020

1 reference

pH and drug resistance. I. functional expression of plasmalemmal V-type H+-ATPase in drug-resistant human breast carcinoma cell lines

31 March 2020

1 reference

Expression and functional role of vacuolar H(+)-ATPase in human hepatocellular carcinoma.

31 March 2020

1 reference

ATP6V0C competes with von Hippel-Lindau protein in hypoxia-inducible factor 1alpha (HIF-1alpha) binding and mediates HIF-1alpha expression by bafilomycin A1.

31 March 2020

1 reference

Does bafilomycin A1 block the fusion of autophagosomes with lysosomes?

31 March 2020

1 reference

Omeprazole and bafilomycin, two proton pump inhibitors: differentiation of their effects on gastric, kidney and bone H(+)-translocating ATPases

31 March 2020

1 reference

Evidence for a common binding site for omeprazole and N-ethylmaleimide in subunit A of chromaffin granule vacuolar-type H(+)-ATPase

31 March 2020

1 reference

Omeprazole inhibits proliferation and modulates autophagy in pancreatic cancer cells

31 March 2020

1 reference

pH-dependent antitumor activity of proton pump inhibitors against human melanoma is mediated by inhibition of tumor acidity

31 March 2020

1 reference

Proton pump inhibitors induce apoptosis of human B-cell tumors through a caspase-independent mechanism involving reactive oxygen species.

31 March 2020

1 reference

Proton pump inhibition induces autophagy as a survival mechanism following oxidative stress in human melanoma cells

31 March 2020

1 reference

Autophagy is a protective mechanism for human melanoma cells under acidic stress

31 March 2020

1 reference

Importance of intracellular pH in determining the uptake and efficacy of the weakly basic chemotherapeutic drug, doxorubicin

31 March 2020

1 reference

Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments

31 March 2020

1 reference

Amino acids and mTORC1: from lysosomes to disease

31 March 2020

1 reference

mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase

31 March 2020

1 reference

A family of yeast proteins mediating bidirectional vacuolar amino acid transport

31 March 2020

1 reference

Termination of autophagy and reformation of lysosomes regulated by mTOR

31 March 2020

1 reference

Hypoxia-induced autophagy: cell death or cell survival?

31 March 2020

1 reference

Chloroquine in cancer therapy: a double-edged sword of autophagy.

31 March 2020

1 reference

31 March 2020

1 reference

THE ESTIMATION OF THE HYDROGEN-ION CONCENTRATION OF THE TISSUES IN LIVING ANIMALS

31 March 2020

1 reference

The relevance of tumour pH to the treatment of malignant disease

31 March 2020

1 reference

MRI of the tumor microenvironment.

31 March 2020

1 reference

Regulation of intracellular pH.

31 March 2020

1 reference

A microenvironmental model of carcinogenesis.

31 March 2020

1 reference

Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice

31 March 2020

1 reference

Carbonic anhydrase IX interacts with bicarbonate transporters in lamellipodia and increases cell migration via its catalytic domain.

31 March 2020

1 reference

Acidity generated by the tumor microenvironment drives local invasion

31 March 2020

1 reference

Bicarbonate increases tumor pH and inhibits spontaneous metastases

31 March 2020

1 reference

The potential role of systemic buffers in reducing intratumoral extracellular pH and acid-mediated invasion

31 March 2020

1 reference

Systemic buffers inhibit carcinogenesis in TRAMP mice

31 March 2020

1 reference

HIF2α acts as an mTORC1 activator through the amino acid carrier SLC7A5.

31 March 2020

1 reference

Targeting metabolic transformation for cancer therapy.

31 March 2020

1 reference

Targeting oxidative phosphorylation: why, when, and how.

31 March 2020

1 reference

Imatinib (STI571)-mediated changes in glucose metabolism in human leukemia BCR-ABL-positive cells

31 March 2020

1 reference

Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF.

31 March 2020

1 reference

LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin

31 March 2020

1 reference

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

31 March 2020

1 reference

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

31 March 2020

1 reference

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

31 March 2020

1 reference

Cytotoxicity of compounds that interfere with the regulation of intracellular pH: a potential new class of anticancer drugs

31 March 2020

1 reference

12 December 2020

On respiratory impairment in cancer cells

1 reference

12 December 2020

Hypoxia-inducible expression of tumor-associated carbonic anhydrases

1 reference

12 December 2020

Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality

1 reference

12 December 2020

Requirement of the Na+/H+ exchanger for tumor growth

1 reference

12 December 2020

Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

1 reference

12 December 2020

Apoptosis of leukemic cells accompanies reduction in intracellular pH after targeted inhibition of the Na(+)/H(+) exchanger

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12 December 2020

Cellular potentials of normal and cancerous fibroblasts and hepatocytes

1 reference

12 December 2020

A reaction-diffusion model of cancer invasion.

1 reference

12 December 2020

Biochemical characterization of the amiloride-sensitive Na+/H+ antiport in Chinese hamster lung fibroblasts

1 reference

12 December 2020

The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily

1 reference

12 December 2020

Regulation of intracellular pH in human melanoma: potential therapeutic implications.

1 reference

12 December 2020

Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer.

1 reference

12 December 2020

Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells

1 reference

12 December 2020

Growth factor action and intracellular pH regulation in fibroblasts. Evidence for a major role of the Na+/H+ antiport

1 reference

12 December 2020

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

1 reference

12 December 2020

pHi, aerobic glycolysis and vascular endothelial growth factor in tumour growth.

1 reference

12 December 2020

The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells

1 reference

12 December 2020

Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle

1 reference

12 December 2020

Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix-loop-helix DNA binding segment

1 reference

12 December 2020

Quantitative in vivo characterization of intracellular and extracellular pH profiles in heterogeneous tumors: a novel method enabling multiparametric pH analysis

1 reference

12 December 2020

Reduction of intracellular pH as a possible mechanism for killing cells in acidic regions of solid tumors: effects of carbonylcyanide-3-chlorophenylhydrazone.

1 reference

12 December 2020

Paclitaxel induces apoptosis via protein kinase A- and p38 mitogen-activated protein-dependent inhibition of the Na+/H+ exchanger (NHE) NHE isoform 1 in human breast cancer cells

1 reference

12 December 2020

Influence of hypoxia and an acidic environment on the metabolism and viability of cultured cells: potential implications for cell death in tumors

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRC3579

1 reference

Dimensions Publication ID

29 August 2017

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