(Q46823202)

25 December 2017

title

Identification of putative binding sites of P-glycoprotein based on its homology model (English)

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25 December 2017

2

Ilza K Pajeva

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25 December 2017

Christoph Globisch

series ordinal

1

object named as

Christoph Globisch

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25 December 2017

author name string

Michael Wiese

series ordinal

3

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25 December 2017

publication date

1 February 2008

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25 December 2017

published in

ChemMedChem

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25 December 2017

volume

3

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25 December 2017

issue

2

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25 December 2017

page(s)

280-295

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25 December 2017

GROMACS 3.0: a package for molecular simulation and trajectory analysis

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Human multidrug resistance ABCB and ABCG transporters: participation in a chemoimmunity defense system

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Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview.

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7 January 2021

The ABC transporters MDR1 and MRP2: multiple functions in disposition of xenobiotics and drug resistance

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7 January 2021

Reversing agents for ATP-binding cassette (ABC) transporters: application in modulating multidrug resistance (MDR).

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7 January 2021

Competition of hydrophobic peptides, cytotoxic drugs, and chemosensitizers on a common P-glycoprotein pharmacophore as revealed by its ATPase activity

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7 January 2021

Co-operative, competitive and non-competitive interactions between modulators of P-glycoprotein

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7 January 2021

Extraction of Hoechst 33342 from the cytoplasmic leaflet of the plasma membrane by P-glycoprotein.

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7 January 2021

Stimulation of P-glycoprotein-mediated drug transport by prazosin and progesterone. Evidence for a third drug-binding site.

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7 January 2021

Communication between multiple drug binding sites on P-glycoprotein

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7 January 2021

Identification and characterization of the binding sites of P-glycoprotein for multidrug resistance-related drugs and modulators

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7 January 2021

Defining the drug-binding site in the human multidrug resistance P-glycoprotein using a methanethiosulfonate analog of verapamil, MTS-verapamil

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7 January 2021

Determining the dimensions of the drug-binding domain of human P-glycoprotein using thiol cross-linking compounds as molecular rulers

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7 January 2021

Location of the rhodamine-binding site in the human multidrug resistance P-glycoprotein.

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7 January 2021

Methanethiosulfonate derivatives of rhodamine and verapamil activate human P-glycoprotein at different sites

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7 January 2021

Disulfide cross-linking analysis shows that transmembrane segments 5 and 8 of human P-glycoprotein are close together on the cytoplasmic side of the membrane

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7 January 2021

Val133 and Cys137 in transmembrane segment 2 are close to Arg935 and Gly939 in transmembrane segment 11 of human P-glycoprotein

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https://api.crossref.org/works/10.1002%2FCMDC.200700249

7 January 2021

Identification of ligand-binding regions of P-glycoprotein by activated-pharmacophore photoaffinity labeling and matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry.

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7 January 2021

P-glycoprotein substrate binding domains are located at the transmembrane domain/transmembrane domain interfaces: a combined photoaffinity labeling-protein homology modeling approach

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7 January 2021

Structure of a bacterial multidrug ABC transporter

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7 January 2021

Structure of the multidrug ABC transporter Sav1866 from Staphylococcus aureus in complex with AMP-PNP

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7 January 2021

Evidence for a Sav1866-like architecture for the human multidrug transporter P-glycoprotein

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7 January 2021

The relation between the divergence of sequence and structure in proteins

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7 January 2021

Membrane protein simulations with a united-atom lipid and all-atom protein model: lipid-protein interactions, side chain transfer free energies and model proteins

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7 January 2021

ExPASy: The proteomics server for in-depth protein knowledge and analysis

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7 January 2021

Three-dimensional structure of P-glycoprotein: the transmembrane regions adopt an asymmetric configuration in the nucleotide-bound state.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700249

7 January 2021

Vanadate trapping of nucleotide at the ATP-binding sites of human multidrug resistance P-glycoprotein exposes different residues to the drug-binding site

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700249

7 January 2021

Structure-function relationships of multidrug resistance P-glycoprotein

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700249

7 January 2021

ATP hydrolysis promotes interactions between the extracellular ends of transmembrane segments 1 and 11 of human multidrug resistance P-glycoprotein.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700249

7 January 2021

An atomic detail model for the human ATP binding cassette transporter P‐glycoprotein derived from disulphide cross‐ linking and homology modeling

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https://api.crossref.org/works/10.1002%2FCMDC.200700249

7 January 2021

Mutational analysis of the P-glycoprotein first intracellular loop and flanking transmembrane domains

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https://api.crossref.org/works/10.1002%2FCMDC.200700249

7 January 2021

Evidence for the locations of distinct steroid and Vinca alkaloid interaction domains within the murine mdr1b P-glycoprotein

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https://api.crossref.org/works/10.1002%2FCMDC.200700249

7 January 2021

The use of a novel taxane-based P-glycoprotein inhibitor to identify mutations that alter the interaction of the protein with paclitaxel.

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https://api.crossref.org/works/10.1002%2FCMDC.200700249

7 January 2021

Mutagenesis of transmembrane domain 11 of P-glycoprotein by alanine scanning

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https://api.crossref.org/works/10.1002%2FCMDC.200700249

7 January 2021

Characterization and analysis of conserved motifs in a peroxisomal ATP-binding cassette transporter

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700249

7 January 2021

Mutations to amino acids located in predicted transmembrane segment 6 (TM6) modulate the activity and substrate specificity of human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700249

7 January 2021

Drug-stimulated ATPase activity of a deletion mutant of the human multidrug-resistance protein (MDR1).

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700249

7 January 2021

Cross-linking of human multidrug resistance P-glycoprotein by the substrate, tris-(2-maleimidoethyl)amine, is altered by ATP hydrolysis. Evidence for rotation of a transmembrane helix.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700249

7 January 2021

Transmembrane domain (TM) 9 represents a novel site in P-glycoprotein that affects drug resistance and cooperates with TM6 to mediate [125I]iodoarylazidoprazosin labeling

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700249

7 January 2021

Contribution to substrate specificity and transport of nonconserved residues in transmembrane domain 12 of human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700249

7 January 2021

Alteration of Substrate Specificity by Mutations at the His61Position in Predicted Transmembrane Domain 1 of Human MDR1/P-Glycoprotein†

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700249

7 January 2021

Amino acid substitutions in the first transmembrane domain (TM1) of P-glycoprotein that alter substrate specificity

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700249

7 January 2021

Identification of P-glycoprotein mutations causing a loss of steroid recognition and transport

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700249

7 January 2021

Transmembrane segment 7 of human P-glycoprotein forms part of the drug-binding pocket

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700249

7 January 2021

The topography of transmembrane segment six is altered during the catalytic cycle of P-glycoprotein.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700249

7 January 2021

P-glycoprotein models of the apo and ATP-bound states based on homology with Sav1866 and MalK

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700249

7 January 2021

Structure and function of ABC transporters: the ATP switch provides flexible control

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700249

7 January 2021

Interaction of LDS-751 and rhodamine 123 with P-glycoprotein: evidence for simultaneous binding of both drugs

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700249

7 January 2021

ScanProsite: detection of PROSITE signature matches and ProRule-associated functional and structural residues in proteins

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700249

7 January 2021

Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700249

7 January 2021

Extending the treatment of backbone energetics in protein force fields: limitations of gas-phase quantum mechanics in reproducing protein conformational distributions in molecular dynamics simulations

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https://api.crossref.org/works/10.1002%2FCMDC.200700249

7 January 2021

Molecular dynamics simulations of a fluid bilayer of dipalmitoylphosphatidylcholine at full hydration, constant pressure, and constant temperature

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https://api.crossref.org/works/10.1002%2FCMDC.200700249

7 January 2021

Alamethicin helices in a bilayer and in solution: molecular dynamics simulations

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700249

7 January 2021

An alamethicin channel in a lipid bilayer: molecular dynamics simulations

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700249

7 January 2021

PROCHECK: a program to check the stereochemical quality of protein structures

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700249

7 January 2021

GROMACS: A message-passing parallel molecular dynamics implementation

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700249

7 January 2021

GROMACS: fast, flexible, and free

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700249

7 January 2021

Particle mesh Ewald: An N⋅log(N) method for Ewald sums in large systems

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700249

7 January 2021

A smooth particle mesh Ewald method

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700249

7 January 2021

Identifiers

DOI

10.1002/CMDC.200700249

1 reference

25 December 2017

1 reference

25 December 2017