(Q47210476)

11 January 2018

title

Synthetic biology, genome mining, and combinatorial biosynthesis of NRPS-derived antibiotics: a perspective (English)

1 reference

11 January 2018

0 references

1 reference

Richard H Baltz

1

1 reference

11 January 2018

publication date

29 December 2017

1 reference

11 January 2018

Journal of Industrial Microbiology & Biotechnology

published in

1 reference

11 January 2018

Cracking the Nonribosomal Code.

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Development of a genetic system for combinatorial biosynthesis of lipopeptides in Streptomyces fradiae and heterologous expression of the A54145 biosynthesis gene cluster

21 January 2018

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Production of novel lipopeptide antibiotics related to A54145 by Streptomyces fradiae mutants blocked in biosynthesis of modified amino acids and assignment of lptJ, lptK and lptL gene functions.

21 January 2018

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Microbial genome mining for accelerated natural products discovery: is a renaissance in the making?

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Renaissance in antibacterial discovery from actinomycetes

21 January 2018

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Biosynthesis and genetic engineering of lipopeptide antibiotics related to daptomycin

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Daptomycin: mechanisms of action and resistance, and biosynthetic engineering.

21 January 2018

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Genomics and the ancient origins of the daptomycin biosynthetic gene cluster

21 January 2018

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Combinatorial biosynthesis of cyclic lipopeptide antibiotics: a model for synthetic biology to accelerate the evolution of secondary metabolite biosynthetic pathways

21 January 2018

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Genetic manipulation of secondary metabolite biosynthesis for improved production in Streptomyces and other actinomycetes

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Gifted microbes for genome mining and natural product discovery.

21 January 2018

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Molecular beacons to identify gifted microbes for genome mining

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Natural products to drugs: daptomycin and related lipopeptide antibiotics

21 January 2018

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Draft Genome Sequence of Streptomyces fradiae ATCC 19609, a Strain Highly Sensitive to Antibiotics.

21 January 2018

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antiSMASH 4.0-improvements in chemistry prediction and gene cluster boundary identification

21 January 2018

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Natural product and natural product derived drugs in clinical trials.

21 January 2018

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Interdomain and Intermodule Organization in Epimerization Domain Containing Nonribosomal Peptide Synthetases

21 January 2018

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SANDPUMA: Ensemble Predictions of Nonribosomal Peptide Chemistry Reveals Biosynthetic Diversity across Actinobacteria

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

Mapping of the Communication-Mediating Interface in Nonribosomal Peptide Synthetases Using a Genetically Encoded Photocrosslinker Supports an Upside-Down Helix-Hand Motif.

21 January 2018

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Importance of microbial natural products and the need to revitalize their discovery

21 January 2018

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Non-ribosomal peptide synthetase module fusions to produce derivatives of daptomycin in Streptomyces roseosporus

21 January 2018

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Structures of two distinct conformations of holo-non-ribosomal peptide synthetases

21 January 2018

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Mutations in clusters and showers

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

The biochemistry of mutagenesis

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

Clusters of mutations from transient hypermutability

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

Daptomycin: from the mountain to the clinic, with essential help from Francis Tally, MD.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

Directed evolution can rapidly improve the activity of chimeric assembly-line enzymes

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

Microbial natural products: molecular blueprints for antitumor drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

The Streptomyces leeuwenhoekii genome: de novo sequencing and assembly in single contigs of the chromosome, circular plasmid pSLE1 and linear plasmid pSLE2

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

Next Generation Sequencing of Actinobacteria for the Discovery of Novel Natural Products

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

Structural insight into the necessary conformational changes of modular nonribosomal peptide synthetases

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

Synthesis and biological activity of N-Acylated ornithine analogues of daptomycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

Mutants of Streptomyces roseosporus that express enhanced recombination within partially homologous genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

Structure, biosynthetic origin, and engineered biosynthesis of calcium-dependent antibiotics from Streptomyces coelicolor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

Explorations of catalytic domains in non-ribosomal peptide synthetase enzymology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

Comparative genomic hybridizations reveal absence of large Streptomyces coelicolor genomic islands in Streptomyces lividans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

Natural product discovery: past, present, and future

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

Reinvigorating natural product combinatorial biosynthesis with synthetic biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

Harnessing natural product assembly lines: structure, promiscuity, and engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

A structural model for multimodular NRPS assembly lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

A systematic computational analysis of biosynthetic gene cluster evolution: lessons for engineering biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

Biochemical Dissection of the Natural Diversification of Microcystin Provides Lessons for Synthetic Biology of NRPS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

Daptomycin biosynthesis in Streptomyces roseosporus: cloning and analysis of the gene cluster and revision of peptide stereochemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

The lipopeptide antibiotic A54145 biosynthetic gene cluster from Streptomyces fradiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

Genetic engineering in Streptomyces roseosporus to produce hybrid lipopeptide antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

Structures of a Nonribosomal Peptide Synthetase Module Bound to MbtH-Like Proteins Support a Highly Dynamic Domain Architecture

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

Structural Biology of Nonribosomal Peptide Synthetases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

Biosynthesis of the (2S,3R)-3-methyl glutamate residue of nonribosomal lipopeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

1,003 reference genomes of bacterial and archaeal isolates expand coverage of the tree of life

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

Sequencing and analysis of the biosynthetic gene cluster of the lipopeptide antibiotic Friulimicin in Actinoplanes friuliensis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

Genomic basis for natural product biosynthetic diversity in the actinomycetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

Natural Products as Sources of New Drugs from 1981 to 2014.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

A glutamic acid 3-methyltransferase encoded by an accessory gene locus important for daptomycin biosynthesis in Streptomyces roseosporus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

Combinatorial biosynthesis of novel antibiotics related to daptomycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

Genetically engineered lipopeptide antibiotics related to A54145 and daptomycin with improved properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

Generating Functional Recombinant NRPS Enzymes in the Laboratory Setting via Peptidyl Carrier Protein Engineering.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

Genome sequence of the Spinosyns-producing bacterium Saccharopolyspora spinosa NRRL 18395

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

Complete genome sequence of Saccharomonospora viridis type strain (P101).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

A plug-and-play pathway refactoring workflow for natural product research in Escherichia coli and Saccharomyces cerevisiae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

NRPSpredictor2--a web server for predicting NRPS adenylation domain specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

Array synthesis of novel lipodepsipeptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

Synthetic biology to access and expand nature's chemical diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

Production of hybrid glycopeptide antibiotics in vitro and in Streptomyces toyocaensis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

Nonribosomal peptide synthetases: structures and dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

Nonribosomal Peptide Synthesis-Principles and Prospects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

Molecular cloning and identification of the laspartomycin biosynthetic gene cluster from Streptomyces viridochromogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

antiSMASH 3.0-a comprehensive resource for the genome mining of biosynthetic gene clusters

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

The structural biology of biosynthetic megaenzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

Recent advances in engineering nonribosomal peptide assembly lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-017-1999-8

A54145, a new lipopeptide antibiotic complex: discovery, taxonomy, fermentation and HPLC.

21 January 2018

1 reference

12 December 2020

Enzymatic and chemical modifications of lipopeptide antibiotic A21978C: the synthesis and evaluation of daptomycin (LY146032)

1 reference

12 December 2020

Gene transfer and transposition mutagenesis in Streptomyces roseosporus: mapping of insertions that influence daptomycin or pigment production

1 reference

12 December 2020

Molecular cloning and physical mapping of the daptomycin gene cluster from Streptomyces roseosporus

1 reference

12 December 2020

Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains

1 reference

12 December 2020

Complementation of daptomycin dptA and dptD deletion mutations in trans and production of hybrid lipopeptide antibiotics

1 reference

12 December 2020

Control of tylosin biosynthesis in Streptomyces fradiae.

1 reference

12 December 2020

Structural characterization of a lipopeptide antibiotic A54145E(Asn3Asp9) produced by a genetically engineered strain of Streptomyces fradiae

1 reference

12 December 2020

1 reference

12 December 2020

Synthetic biology of polyketide synthases.

1 reference

12 December 2020

10.1007/S10295-017-1999-8

Identifiers

DOI

1 reference

11 January 2018

PubMed ID

29288438

1 reference

11 January 2018