(Q48313444)

10 February 2018

title

Shedding light on drug transport: structure and function of the P-glycoprotein multidrug transporter (ABCB1). (English)

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10 February 2018

author

Frances J. Sharom

series ordinal

1

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10 February 2018

publication date

1 December 2006

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10 February 2018

Biochemistry and Cell Biology

published in

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10 February 2018

volume

84

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10 February 2018

issue

6

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10 February 2018

page(s)

979-992

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10 February 2018

Purification and reconstitution of functional human P-glycoprotein.

cites work

1 reference

Relation between the turnover number for vinblastine transport and for vinblastine-stimulated ATP hydrolysis by human P-glycoprotein

21 January 2018

1 reference

Purification and reconstitution of human P-glycoprotein

21 January 2018

1 reference

The power of the pump: mechanisms of action of P-glycoprotein (ABCB1).

21 January 2018

1 reference

Competition of hydrophobic peptides, cytotoxic drugs, and chemosensitizers on a common P-glycoprotein pharmacophore as revealed by its ATPase activity

21 January 2018

1 reference

Mammalian ABC transporters in health and disease

21 January 2018

1 reference

ABC transporters in lipid transport

21 January 2018

1 reference

The translocation mechanism of P-glycoprotein.

21 January 2018

1 reference

Structure of MsbA from Vibrio cholera: a multidrug resistance ABC transporter homolog in a closed conformation

21 January 2018

1 reference

RETRACTED: Structure of MsbA from E. coli: a homolog of the multidrug resistance ATP binding cassette (ABC) transporters

21 January 2018

1 reference

A pharmacophore hypothesis for P-glycoprotein substrate recognition using GRIND-based 3D-QSAR.

21 January 2018

1 reference

Structural biology. Flipping lipids: is the third time the charm?

21 January 2018

1 reference

Structure of a bacterial multidrug ABC transporter

21 January 2018

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Nucleotide binding to the multidrug resistance P-glycoprotein as studied by ESR spectroscopy

21 January 2018

1 reference

Transport properties of P-glycoprotein in plasma membrane vesicles from multidrug-resistant Chinese hamster ovary cells

21 January 2018

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The effects of lipids and detergents on ATPase-active P-glycoprotein

21 January 2018

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The reconstituted P-glycoprotein multidrug transporter is a flippase for glucosylceramide and other simple glycosphingolipids

21 January 2018

1 reference

Analysis of the tangled relationships between P-glycoprotein-mediated multidrug resistance and the lipid phase of the cell membrane

21 January 2018

1 reference

Insight in eukaryotic ABC transporter function by mutation analysis

21 January 2018

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Importance of P-glycoprotein for drug disposition in humans

21 January 2018

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Importance of P-glycoprotein at blood-tissue barriers

21 January 2018

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The multidrug transporter, P-glycoprotein, actively mediates cholesterol redistribution in the cell membrane

21 January 2018

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Quantification and characterization of P-glycoprotein-substrate interactions

21 January 2018

1 reference

Mechanisms of cancer drug resistance

21 January 2018

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The molecular basis of multidrug resistance in cancer: the early years of P-glycoprotein research

21 January 2018

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P-glycoprotein and multidrug resistance

21 January 2018

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Molecular insights into the mechanism of ATP-hydrolysis by the NBD of the ABC-transporter HlyB.

21 January 2018

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Is the multidrug transporter a flippase?

21 January 2018

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The ATP switch model for ABC transporters

21 January 2018

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ATP-binding cassette transporters are enriched in non-caveolar detergent-insoluble glycosphingolipid-enriched membrane domains (DIGs) in human multidrug-resistant cancer cells

21 January 2018

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Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily

21 January 2018

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Subunit interactions in ABC transporters: towards a functional architecture

21 January 2018

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The ABC transporter structure and mechanism: perspectives on recent research.

21 January 2018

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Natural phosphatidylcholine is actively translocated across the plasma membrane to the surface of mammalian cells

21 January 2018

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Transmembrane organization of mouse P-glycoprotein determined by epitope insertion and immunofluorescence

21 January 2018

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Retroviral transfection of Madin-Darby canine kidney cells with human MDR1 results in a major increase in globotriaosylceramide and 10(5)- to 10(6)-fold increased cell sensitivity to verocytotoxin. Role of p-glycoprotein in glycolipid synthesis

21 January 2018

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Projection structure of P-glycoprotein by electron microscopy. Evidence for a closed conformation of the nucleotide binding domains

21 January 2018

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Large scale purification of detergent-soluble P-glycoprotein from Pichia pastoris cells and characterization of nucleotide binding properties of wild-type, Walker A, and Walker B mutant proteins.

21 January 2018

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Site-directed fluorescence labeling of P-glycoprotein on cysteine residues in the nucleotide binding domains.

21 January 2018

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Intrinsic fluorescence of the P-glycoprotein multidrug transporter: sensitivity of tryptophan residues to binding of drugs and nucleotides.

21 January 2018

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The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism

21 January 2018

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Substrate-induced conformational changes in the transmembrane segments of human P-glycoprotein. Direct evidence for the substrate-induced fit mechanism for drug binding.

21 January 2018

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The drug-binding pocket of the human multidrug resistance P-glycoprotein is accessible to the aqueous medium.

21 January 2018

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Covalent modification of human P-glycoprotein mutants containing a single cysteine in either nucleotide-binding fold abolishes drug-stimulated ATPase activity

21 January 2018

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Membrane topology of a cysteine-less mutant of human P-glycoprotein

21 January 2018

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Mutational analysis of human P-glycoprotein.

21 January 2018

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Recent progress in understanding the mechanism of P-glycoprotein-mediated drug efflux.

21 January 2018

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Interaction of LDS-751 and rhodamine 123 with P-glycoprotein: evidence for simultaneous binding of both drugs

21 January 2018

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Interaction of LDS-751 with P-glycoprotein and mapping of the location of the R drug binding site.

21 January 2018

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P-glycoprotein retains function when reconstituted into a sphingolipid- and cholesterol-rich environment

21 January 2018

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Modulation of multidrug resistance efflux pump activity to overcome chemoresistance in cancer

21 January 2018

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Interaction of transported drugs with the lipid bilayer and P-glycoprotein through a solvation exchange mechanism

21 January 2018

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P-glycoprotein and 'lipid rafts': some ambiguous mutual relationships (floating on them, building them or meeting them by chance?).

21 January 2018

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Pharmacophore model of drugs involved in P-glycoprotein multidrug resistance: explanation of structural variety (hypothesis).

21 January 2018

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Transmembrane aromatic amino acid distribution in P-glycoprotein. A functional role in broad substrate specificity.

21 January 2018

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P-glycoprotein substrate binding domains are located at the transmembrane domain/transmembrane domain interfaces: a combined photoaffinity labeling-protein homology modeling approach

21 January 2018

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ABC transporters in the balance: is there a role in multidrug resistance?

21 January 2018

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FRET analysis indicates that the two ATPase active sites of the P-glycoprotein multidrug transporter are closely associated.

21 January 2018

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Proximity of bound Hoechst 33342 to the ATPase catalytic sites places the drug binding site of P-glycoprotein within the cytoplasmic membrane leaflet

21 January 2018

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Transition state P-glycoprotein binds drugs and modulators with unchanged affinity, suggesting a concerted transport mechanism.

21 January 2018

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Stoichiometry and affinity of nucleotide binding to P-glycoprotein during the catalytic cycle

21 January 2018

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P-Glycoprotein is localized in intermediate-density membrane microdomains distinct from classical lipid rafts and caveolar domains

21 January 2018

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Transport of anthracyclines and mitoxantrone across membranes by a flip-flop mechanism

21 January 2018

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RETRACTED: Structure of the ABC transporter MsbA in complex with ADP.vanadate and lipopolysaccharide

21 January 2018

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The ATPase and ATP-binding functions of P-glycoprotein--modulation by interaction with defined phospholipids

21 January 2018

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The membrane lipid environment modulates drug interactions with the P-glycoprotein multidrug transporter.

21 January 2018

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Phospholipid flippase activity of the reconstituted P-glycoprotein multidrug transporter

21 January 2018

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Structure of the multidrug resistance P-glycoprotein to 2.5 nm resolution determined by electron microscopy and image analysis.

21 January 2018

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Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle

21 January 2018

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Three-dimensional structures of the mammalian multidrug resistance P-glycoprotein demonstrate major conformational changes in the transmembrane domains upon nucleotide binding

21 January 2018

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Three-dimensional structure of P-glycoprotein: the transmembrane regions adopt an asymmetric configuration in the nucleotide-bound state.

21 January 2018

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The importance of cholesterol in maintenance of P-glycoprotein activity and its membrane perturbing influence

21 January 2018

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Phosphatidylcholine translocase: a physiological role for the mdr2 gene

21 January 2018

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Conformational and functional characterization of trapped complexes of the P-glycoprotein multidrug transporter.

21 January 2018

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The mechanism of action of multidrug-resistance-linked P-glycoprotein

21 January 2018

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P-Glycoprotein, a gatekeeper in the blood-brain barrier

21 January 2018

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Structural mechanisms of multidrug recognition and regulation by bacterial multidrug transcription factors

21 January 2018

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A general pattern for substrate recognition by P-glycoprotein.

21 January 2018

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Structure-activity relationship of P-glycoprotein substrates and modifiers.

21 January 2018

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ATP hydrolysis by multidrug-resistance protein from Chinese hamster ovary cells.

21 January 2018

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The catalytic cycle of P-glycoprotein

21 January 2018

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Reconstitution of Drug Transport by Purified P-glycoprotein

21 January 2018

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Extraction of Hoechst 33342 from the cytoplasmic leaflet of the plasma membrane by P-glycoprotein.

21 January 2018

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Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities

21 January 2018

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Stoichiometry of coupling of rhodamine 123 transport to ATP hydrolysis by P-glycoprotein

21 January 2018

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Transport of LDS-751 from the cytoplasmic leaflet of the plasma membrane by the rhodamine-123-selective site of P-glycoprotein.

21 January 2018

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P-glycoprotein-mediated Hoechst 33342 transport out of the lipid bilayer.

21 January 2018

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The P-glycoprotein efflux pump: how does it transport drugs?

21 January 2018

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The P-glycoprotein multidrug transporter: interactions with membrane lipids, and their modulation of activity

21 January 2018

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Characterization of the ATPase activity of P-glycoprotein from multidrug-resistant Chinese hamster ovary cells

21 January 2018

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Synthetic hydrophobic peptides are substrates for P-glycoprotein and stimulate drug transport

21 January 2018

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Linear and cyclic peptides as substrates and modulators of P-glycoprotein: peptide binding and effects on drug transport and accumulation

21 January 2018

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Insights into the structure and substrate interactions of the P-glycoprotein multidrug transporter from spectroscopic studies

21 January 2018

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Exploring the structure and function of the P-glycoprotein multidrug transporter using fluorescence spectroscopic tools.

21 January 2018

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New insights into the drug binding, transport and lipid flippase activities of the p-glycoprotein multidrug transporter.

21 January 2018

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X-ray structure of the magnesium(II).ADP.vanadate complex of the Dictyostelium discoideum myosin motor domain to 1.9 A resolution

21 January 2018

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MDR3 P-glycoprotein, a phosphatidylcholine translocase, transports several cytotoxic drugs and directly interacts with drugs as judged by interference with nucleotide trapping

21 January 2018

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ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer

21 January 2018

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Ligand-mediated tertiary structure changes of reconstituted P-glycoprotein. A tryptophan fluorescence quenching analysis

21 January 2018

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Multidrug resistance transporters and modulation

21 January 2018

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The equilibrium and kinetic drug binding properties of the mouse P-gp1a and P-gp1b P-glycoproteins are similar

21 January 2018

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The occluded nucleotide conformation of p-glycoprotein

21 January 2018

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Involvement of the "occluded nucleotide conformation" of P-glycoprotein in the catalytic pathway

21 January 2018

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Modulation of cellular cholesterol alters P-glycoprotein activity in multidrug-resistant cells

21 January 2018

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Effects of lipids on ATPase activity of purified Chinese hamster P-glycoprotein

21 January 2018

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P-glycoprotein is stably inhibited by vanadate-induced trapping of nucleotide at a single catalytic site

21 January 2018

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MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine

21 January 2018

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ABC lipid transporters: extruders, flippases, or flopless activators?

21 January 2018

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Cholesterol interaction with the daunorubicin binding site of P-glycoprotein

21 January 2018

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Structure-activity relationships of multidrug resistance reversers

21 January 2018

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The gut as a barrier to drug absorption: combined role of cytochrome P450 3A and P-glycoprotein

21 January 2018

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A structure-based mechanism for drug binding by multidrug transporters

21 January 2018

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P-glycoprotein is localized in caveolae in resistant cells and in brain capillaries

21 January 2018

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Transport of (glyco)sphingolipids in and between cellular membranes; multidrug transporters and lateral domains

21 January 2018

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Localization of Multidrug Transporter Substrates within Model Membranes†

21 January 2018

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21 January 2018

Identifiers

DOI

10.1139/O06-199

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10 February 2018

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10 February 2018