(Q52572385)

3 May 2018

title

Acute myelogenous leukemia-derived SMAD4 mutations target the protein to ubiquitin-proteasome degradation. (English)

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3 May 2018

1 reference

Lei Yang

1

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3 May 2018

Ning Wang

2

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3 May 2018

Yi Tang

3

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3 May 2018

Xu Cao

4

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3 May 2018

Mei Wan

5

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3 May 2018

publication date

1 September 2006

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3 May 2018

published in

Human Mutation

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3 May 2018

volume

27

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3 May 2018

issue

9

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3 May 2018

page(s)

897-905

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3 May 2018

SCF(beta-TrCP1) controls Smad4 protein stability in pancreatic cancer cells

cites work

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Role of transforming growth factor beta in human disease

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7 January 2021

Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage

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7 January 2021

Loss of functional cell surface transforming growth factor beta (TGF-beta) type 1 receptor correlates with insensitivity to TGF-beta in chronic lymphocytic leukemia

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7 January 2021

Smad-dependent and Smad-independent pathways in TGF-beta family signalling

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7 January 2021

Regulation of the G1 to S transition by the ubiquitin pathway

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https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

SCF and Cullin/Ring H2-based ubiquitin ligases

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https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

Genetic evidence for the essential role of beta-transducin repeat-containing protein in the inducible processing of NF-kappa B2/p100

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https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

Estrogens down-regulate p27Kip1 in breast cancer cells through Skp2 and through nuclear export mediated by the ERK pathway

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https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin.

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https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

The many faces of beta-TrCP E3 ubiquitin ligases: reflections in the magic mirror of cancer

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https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

Recombinant transforming growth factor beta 1 and beta 2 protect mice from acutely lethal doses of 5-fluorouracil and doxorubicin

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https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo

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https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

Missense mutations of MADH4: characterization of the mutational hot spot and functional consequences in human tumors

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

Mutations of the Smad4 gene in acute myelogeneous leukemia and their functional implications in leukemogenesis

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

The SCF ubiquitin ligase: an extended look

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

Transforming growth factor-beta signaling in normal and malignant hematopoiesis

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

The oncoprotein Evi-1 represses TGF-beta signalling by inhibiting Smad3

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

Heterogenous response of B lymphocytes to transforming growth factor-beta in B-cell chronic lymphocytic leukaemia: correlation with the expression of TGF-beta receptors

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

Proteasome inhibitors: valuable new tools for cell biologists

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

Negative regulation of prolactin receptor stability and signaling mediated by SCF(beta-TrCP) E3 ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

Ubiquitination and proteolysis of cancer-derived Smad4 mutants by SCFSkp2

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

A ubiquitin ligase complex essential for the NF-kappaB, Wnt/Wingless, and Hedgehog signaling pathways

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

Regulation of the discs large tumor suppressor by a phosphorylation-dependent interaction with the beta-TrCP ubiquitin ligase receptor

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

TGF-beta signal transduction

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

Loss of Smad4 function in pancreatic tumors: C-terminal truncation leads to decreased stability

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

Differential ubiquitination defines the functional status of the tumor suppressor Smad4.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

Increased expression of the E3-ubiquitin ligase receptor subunit betaTRCP1 relates to constitutive nuclear factor-kappaB activation and chemoresistance in pancreatic carcinoma cells

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

Regulation of the cell cycle by SCF-type ubiquitin ligases

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

Mechanisms underlying ubiquitination

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

Novel non-viral method for transfection of primary leukemia cells and cell lines

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

A structural basis for mutational inactivation of the tumour suppressor Smad4

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

A quantitative analysis of signal transduction from activin receptor to nucleus and its relevance to morphogen gradient interpretation

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

A DNA vector-based RNAi technology to suppress gene expression in mammalian cells

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

Gene therapy for pancreatic cancer based on genetic characterization of the disease

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

Targeting beta-transducin repeat-containing protein E3 ubiquitin ligase augments the effects of antitumor drugs on breast cancer cells

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

Smad4 protein stability is regulated by ubiquitin ligase SCF beta-TrCP1.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor beta signaling by targeting Smads to the ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

Identification of the receptor component of the IkappaBalpha-ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

Transforming growth factor-beta signal transduction in epithelial cells.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20387

7 January 2021

Identifiers

DOI

10.1002/HUMU.20387

1 reference

3 May 2018

PubMed ID

16865698

1 reference

3 May 2018