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Mechanism and medical implications of mammalian autophagy
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scholarly article
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title
Mechanism and medical implications of mammalian autophagy
(English)
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main subject
autophagy
1 reference
based on heuristic
inferred from title
author
Ivan Đikić
object named as
Ivan Dikic
series ordinal
1
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author name string
Zvulun Elazar
series ordinal
2
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publication date
4 April 2018
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published in
Nature Reviews Molecular Cell Biology
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volume
19
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issue
6
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page(s)
349-364
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exact match
https://scigraph.springernature.com/pub.10.1038/s41580-018-0003-4
0 references
cites work
Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue
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Participation of lysosomes in cellular autophagy induced in rat liver by glucagon
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Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae
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Getting ready for building: signaling and autophagosome biogenesis.
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The autophagosome: origins unknown, biogenesis complex
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Autophagy: renovation of cells and tissues
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A comprehensive glossary of autophagy-related molecules and processes (2nd edition)
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7 January 2021
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Autophagosomes form at ER-mitochondria contact sites
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ER-plasma membrane contact sites contribute to autophagosome biogenesis by regulation of local PI3P synthesis
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Dynamic association of the ULK1 complex with omegasomes during autophagy induction.
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Dynamics of mTORC1 activation in response to amino acids.
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7 January 2021
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Autophagosome formation is initiated at phosphatidylinositol synthase-enriched ER subdomains
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7 January 2021
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Nutrient sensing and TOR signaling in yeast and mammals
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mTOR Signaling in Growth, Metabolism, and Disease.
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Regulation of mTORC1 by amino acids
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Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy
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7 January 2021
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ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery
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7 January 2021
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Signals from the lysosome: a control centre for cellular clearance and energy metabolism
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7 January 2021
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Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth
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7 January 2021
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The Lkb1 metabolic sensor maintains haematopoietic stem cell survival
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7 January 2021
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Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1
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7 January 2021
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WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy
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Crossref
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https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
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inferred from DOI database lookup
Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
FoxO3 controls autophagy in skeletal muscle in vivo
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
1 reference
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7 January 2021
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Ambra1 regulates autophagy and development of the nervous system
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7 January 2021
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The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy
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7 January 2021
based on heuristic
inferred from DOI database lookup
FGF signalling regulates bone growth through autophagy
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7 January 2021
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inferred from DOI database lookup
PAQR3 controls autophagy by integrating AMPK signaling to enhance ATG14L-associated PI3K activity
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7 January 2021
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VPS34 Acetylation Controls Its Lipid Kinase Activity and the Initiation of Canonical and Non-canonical Autophagy
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7 January 2021
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Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC
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7 January 2021
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Activation of ULK Kinase and Autophagy by GABARAP Trafficking from the Centrosome Is Regulated by WAC and GM130.
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7 January 2021
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Autophagosome targeting and membrane curvature sensing by Barkor/Atg14(L).
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG
1 reference
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https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
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The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14.
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
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inferred from DOI database lookup
PtdIns(4,5)P2 signaling regulates ATG14 and autophagy
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7 January 2021
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Early steps in autophagy depend on direct phosphorylation of Atg9 by the Atg1 kinase.
1 reference
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https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
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TBC1D14 regulates autophagy via the TRAPP complex and ATG9 traffic
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7 January 2021
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TRAPPIII is responsible for vesicular transport from early endosomes to Golgi, facilitating Atg9 cycling in autophagy
1 reference
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https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
CapZ regulates autophagosomal membrane shaping by promoting actin assembly inside the isolation membrane
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
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inferred from DOI database lookup
WHAMM Directs the Arp2/3 Complex to the ER for Autophagosome Biogenesis through an Actin Comet Tail Mechanism
1 reference
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https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
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The Atg8 family: multifunctional ubiquitin-like key regulators of autophagy
1 reference
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https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
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Kinetics comparisons of mammalian Atg4 homologues indicate selective preferences toward diverse Atg8 substrates
1 reference
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https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Differential processing of Arabidopsis ubiquitin-like Atg8 autophagy proteins by Atg4 cysteine proteases.
1 reference
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https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Formation of the approximately 350-kDa Apg12-Apg5.Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Dimeric coiled-coil structure of Saccharomyces cerevisiae Atg16 and its functional significance in autophagy
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1.
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular mechanism of autophagic membrane-scaffold assembly and disassembly.
1 reference
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7 January 2021
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LC3 and GATE-16 N termini mediate membrane fusion processes required for autophagosome biogenesis
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Remodeling of ER-exit sites initiates a membrane supply pathway for autophagosome biogenesis
1 reference
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https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphatidylinositol 3-kinase and COPII generate LC3 lipidation vesicles from the ER-Golgi intermediate compartment
1 reference
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https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
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inferred from DOI database lookup
ER exit sites are physical and functional core autophagosome biogenesis components
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
based on heuristic
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The ATG conjugation systems are important for degradation of the inner autophagosomal membrane.
1 reference
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https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Atg8 family LC3/GABARAP proteins are crucial for autophagosome-lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation.
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
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inferred from DOI database lookup
Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
1 reference
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7 January 2021
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A reversible phospho-switch mediated by ULK1 regulates the activity of autophagy protease ATG4B.
1 reference
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https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Atg4 proteolytic activity can be inhibited by Atg1 phosphorylation
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of the autophagy protein LC3 by phosphorylation
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes
1 reference
stated in
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reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Temporal analysis of recruitment of mammalian ATG proteins to the autophagosome formation site.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cargo recognition and trafficking in selective autophagy
1 reference
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https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
FYCO1 Contains a C-terminally Extended, LC3A/B-preferring LC3-interacting Region (LIR) Motif Required for Efficient Maturation of Autophagosomes during Basal Autophagy
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3/GABARAP proteins
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation of LC3 by the Hippo kinases STK3/STK4 is essential for autophagy
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
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Rapalogs and mTOR inhibitors as anti-aging therapeutics
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reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of autophagy and inhibition of tumorigenesis by beclin 1
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Autophagy and Tumor Metabolism
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of autophagy by 3-MA potentiates cisplatin-induced apoptosis in esophageal squamous cell carcinoma cells
1 reference
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https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of autophagy at a late stage enhances imatinib-induced cytotoxicity in human malignant glioma cells
1 reference
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reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
A dual role for autophagy in a murine model of lung cancer
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https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pancreatic cancers require autophagy for tumor growth
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis.
1 reference
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https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Aurora kinase A inhibition-induced autophagy triggers drug resistance in breast cancer cells
1 reference
stated in
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reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy
1 reference
stated in
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reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Tumor cell autophagy as an adaptive response mediating resistance to treatments such as antiangiogenic therapy
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Premortem autophagy determines the immunogenicity of chemotherapy-induced cancer cell death
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
An autophagy-dependent anticancer immune response determines the efficacy of melanoma chemotherapy
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7 January 2021
based on heuristic
inferred from DOI database lookup
Natural Killer (NK)/melanoma cell interaction induces NK-mediated release of chemotactic High Mobility Group Box-1 (HMGB1) capable of amplifying NK cell recruitment.
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Autophagy regulates selective HMGB1 release in tumor cells that are destined to die.
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
p53 status determines the role of autophagy in pancreatic tumour development
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cellular and molecular mechanism for secretory autophagy.
1 reference
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reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Secretory autophagy
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Autophagy-dependent production of secreted factors facilitates oncogenic RAS-driven invasion
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Autophagy and the endo/exosomal pathways in health and disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Biology of Cancer Exosomes: Insights and New Perspectives.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Autophagy is activated by TGF-beta and potentiates TGF-beta-mediated growth inhibition in human hepatocellular carcinoma cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Autophagy induction impairs migration and invasion by reversing EMT in glioblastoma cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DEDD interacts with PI3KC3 to activate autophagy and attenuate epithelial-mesenchymal transition in human breast cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of cell proliferation and migration by p62 through stabilization of Twist1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cadherin-6 promotes EMT and cancer metastasis by restraining autophagy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Autophagy inhibition suppresses pulmonary metastasis of HCC in mice via impairing anoikis resistance and colonization of HCC cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Anoikis resistance is a critical feature of highly aggressive ovarian cancer cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of autophagy during ECM detachment is linked to a selective inhibition of mTORC1 by PERK
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of proliferation by PERK regulates mammary acinar morphogenesis and tumor formation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
IκB kinase complex (IKK) triggers detachment-induced autophagy in mammary epithelial cells independently of the PI3K-AKT-MTORC1 pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Anoikis evasion in inflammatory breast cancer cells is mediated by Bim-EL sequestration
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
BH3-only proteins, Bmf and Bim, in autophagy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bim inhibits autophagy by recruiting Beclin 1 to microtubules
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Autophagy Promotes Focal Adhesion Disassembly and Cell Motility of Metastatic Tumor Cells through the Direct Interaction of Paxillin with LC3
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Autophagy plays a critical role in the degradation of active RHOA, the control of cell cytokinesis, and genomic stability.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Autophagy suppresses cell migration by degrading GEF-H1, a RhoA GEF
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p66Shc mediates anoikis through RhoA
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Recessive mutations in EPG5 cause Vici syndrome, a multisystem disorder with defective autophagy.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Defective autophagy in spastizin mutated patients with hereditary spastic paraparesis type 15
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proteasomal and Autophagic Degradation Systems
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Autophagy is required for glucose homeostasis and lung tumor maintenance
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Loss of autophagy in the central nervous system causes neurodegeneration in mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genetic perspective on the role of the autophagy-lysosome pathway in Parkinson disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Advances in the genetics of Parkinson disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Lysosomal Dysfunction and α-Synuclein Aggregation in Parkinson's Disease: Diagnostic Links.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evidence for Immune Response, Axonal Dysfunction and Reduced Endocytosis in the Substantia Nigra in Early Stage Parkinson's Disease.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression analysis of dopaminergic neurons in Parkinson's disease and aging links transcriptional dysregulation of energy metabolism to cell death.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Involvement of the immune system, endocytosis and EIF2 signaling in both genetically determined and sporadic forms of Parkinson's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p62 Pathology Model in the Rat Substantia Nigra with Filamentous Inclusions and Progressive Neurodegeneration
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proteotoxic stress induces phosphorylation of p62/SQSTM1 by ULK1 to regulate selective autophagic clearance of protein aggregates
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ubiquitin and Parkinson's disease through the looking glass of genetics
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nix restores mitophagy and mitochondrial function to protect against PINK1/Parkin-related Parkinson's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of autophagy in the pathogenesis of amyotrophic lateral sclerosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Dynamic recruitment and activation of ALS-associated TBK1 with its target optineurin are required for efficient mitophagy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TBK1 controls autophagosomal engulfment of polyubiquitinated mitochondria through p62/SQSTM1 phosphorylation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Autophagy in antimicrobial immunity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Endogenous MHC class II processing of a viral nuclear antigen after autophagy.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Macroautophagy Proteins Control MHC Class I Levels on Dendritic Cells and Shape Anti-viral CD8(+) T Cell Responses.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Autophagy: controlling cell fate in rheumatic diseases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Autophagy and cellular immune responses
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The IKK complex contributes to the induction of autophagy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Direct molecular interactions between Beclin 1 and the canonical NFκB activation pathway.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p65/RelA modulates BECN1 transcription and autophagy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
NF-kappaB activation represses tumor necrosis factor-alpha-induced autophagy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Prolonged classical NF-kappaB activation prevents autophagy upon E. coli stimulation in vitro: a potential resolving mechanism of inflammation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Autophagy is required for the activation of NFκB.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Downregulation of active IKK beta by Ro52-mediated autophagy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
LUBAC-synthesized linear ubiquitin chains restrict cytosol-invading bacteria by activating autophagy and NF-κB.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Intracellular Staphylococcus aureus eludes selective autophagy by activating a host cell kinase.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of protein kinase G in growth and glutamine metabolism of Mycobacterium bovis BCG.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Plasmodium UIS3 sequesters host LC3 to avoid elimination by autophagy in hepatocytes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Autophagy and burkholderia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Huntingtin functions as a scaffold for selective macroautophagy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Autophagy inhibitors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of a candidate therapeutic autophagy-inducing peptide
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Co-Targeting IGF-1R and Autophagy Enhances the Effects of Cell Growth Suppression and Apoptosis Induced by the IGF-1R Inhibitor NVP-AEW541 in Triple-Negative Breast Cancer Cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A novel ATG4B antagonist inhibits autophagy and has a negative impact on osteosarcoma tumors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Fighting neurodegeneration with rapamycin: mechanistic insights
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sesamol Induces Human Hepatocellular Carcinoma Cells Apoptosis by Impairing Mitochondrial Function and Suppressing Autophagy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Spermidine protects against α-synuclein neurotoxicity.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Curcumin ameliorates the neurodegenerative pathology in A53T α-synuclein cell model of Parkinson's disease through the downregulation of mTOR/p70S6K signaling and the recovery of macroautophagy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
(Poly)phenols protect from α-synuclein toxicity by reducing oxidative stress and promoting autophagy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41580-018-0003-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Neuroprotection of kaempferol by autophagy in models of rotenone-mediated acute toxicity: possible implications for Parkinson's disease
1 reference
stated in
Crossref
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7 January 2021
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From ancient herb to versatile, modern drug: Artemisia annua and artemisinin for cancer therapy
1 reference
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7 January 2021
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Seeking new anti-cancer agents from autophagy-regulating natural products
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7 January 2021
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Fluvastatin Prevents Lung Adenocarcinoma Bone Metastasis by Triggering Autophagy
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7 January 2021
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Elaborating the role of natural products on the regulation of autophagy and their potentials in breast cancer therapy
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7 January 2021
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The multiple pharmaceutical potential of curcumin in Parkinson's disease
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7 January 2021
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Clinical relevance of autophagic therapy in cancer: Investigating the current trends, challenges, and future prospects
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7 January 2021
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Therapeutic Targeting of Autophagy
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7 January 2021
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Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion.
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Autophagy in neurodegenerative diseases: from mechanism to therapeutic approach
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7 January 2021
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Control of autophagy as a therapy for neurodegenerative disease
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7 January 2021
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Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease
1 reference
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7 January 2021
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Roles of autophagy in elimination of intracellular bacterial pathogens
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7 January 2021
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Ohmyungsamycins promote antimicrobial responses through autophagy activation via AMP-activated protein kinase pathway
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Identifiers
DOI
10.1038/S41580-018-0003-4
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PubMed publication ID
29618831
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