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Nutrient sensing and TOR signaling in yeast and mammals
scientific article published on 17 January 2017
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scholarly article
1 reference
stated in
Europe PubMed Central
PMCID
5694944
retrieved
19 February 2018
reference URL
http://europepmc.org/abstract/PMC/5694944
title
Nutrient sensing and TOR signaling in yeast and mammals
(English)
1 reference
stated in
Europe PubMed Central
PMCID
5694944
retrieved
19 February 2018
reference URL
http://europepmc.org/abstract/PMC/5694944
author
Michael N. Hall
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMCID
5694944
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28096180%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 June 2020
author name string
Asier González
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMCID
5694944
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28096180%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 June 2020
language of work or name
English
0 references
publication date
17 January 2017
1 reference
stated in
Europe PubMed Central
PMCID
5694944
retrieved
19 February 2018
reference URL
http://europepmc.org/abstract/PMC/5694944
published in
The EMBO Journal
1 reference
stated in
Europe PubMed Central
PMCID
5694944
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28096180%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 June 2020
volume
36
1 reference
stated in
Europe PubMed Central
PMCID
5694944
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28096180%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 June 2020
issue
4
1 reference
stated in
Europe PubMed Central
PMCID
5694944
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28096180%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 June 2020
page(s)
397-408
1 reference
stated in
Europe PubMed Central
PMCID
5694944
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28096180%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 June 2020
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15 June 2018
Amino acids and mTORC1: from lysosomes to disease
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15 June 2018
Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes
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mTOR signaling in growth control and disease
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15 June 2018
AMPK: a nutrient and energy sensor that maintains energy homeostasis
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15 June 2018
Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway
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Leucyl-tRNA synthetase controls TORC1 via the EGO complex
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15 June 2018
Regulation of amino acid, nucleotide, and phosphate metabolism in Saccharomyces cerevisiae
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15 June 2018
Target of rapamycin (TOR) in nutrient signaling and growth control
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15 June 2018
mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase
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15 June 2018
A phosphodegron controls nutrient-induced proteasomal activation of the signaling protease Ssy5.
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15 June 2018
Structural conservation of components in the amino acid sensing branch of the TOR pathway in yeast and mammals
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15 June 2018
Structural and functional insights into Saccharomyces cerevisiae Tpa1, a putative prolylhydroxylase influencing translation termination and transcription
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15 June 2018
Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation
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PubMed Central
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15 June 2018
The prodomain of Ssy5 protease controls receptor-activated proteolysis of transcription factor Stp1.
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PubMed Central
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15 June 2018
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
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PubMed Central
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15 June 2018
Integration of general amino acid control and target of rapamycin (TOR) regulatory pathways in nitrogen assimilation in yeast
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15 June 2018
The nuts and bolts of AGC protein kinases
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15 June 2018
The Vam6 GEF controls TORC1 by activating the EGO complex
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15 June 2018
Bidirectional transport of amino acids regulates mTOR and autophagy
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PubMed Central
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15 June 2018
p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling
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PubMed Central
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15 June 2018
Regulation of TORC1 by Rag GTPases in nutrient response
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PubMed Central
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15 June 2018
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
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PubMed Central
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15 June 2018
AMPK phosphorylation of raptor mediates a metabolic checkpoint
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PubMed Central
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15 June 2018
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy
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PubMed Central
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15 June 2018
Dal81 enhances Stp1- and Stp2-dependent transcription necessitating negative modulation by inner nuclear membrane protein Asi1 in Saccharomyces cerevisiae.
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PubMed Central
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15 June 2018
Effect of 21 different nitrogen sources on global gene expression in the yeast Saccharomyces cerevisiae
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15 June 2018
Regulation of transcription factor latency by receptor-activated proteolysis
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
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15 June 2018
Mapping of an internal protease cleavage site in the Ssy5p component of the amino acid sensor of Saccharomyces cerevisiae and functional characterization of the resulting pro- and protease domains by gain-of-function genetics
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
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15 June 2018
TOR signaling in growth and metabolism
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15 June 2018
Divergence of Stp1 and Stp2 transcription factors in Candida albicans places virulence factors required for proper nutrient acquisition under amino acid control
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PubMed Central
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15 June 2018
Translational regulation of GCN4 and the general amino acid control of yeast
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15 June 2018
Rheb binds and regulates the mTOR kinase
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PubMed Central
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15 June 2018
The external amino acid signaling pathway promotes activation of Stp1 and Uga35/Dal81 transcription factors for induction of the AGP1 gene in Saccharomyces cerevisiae
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15 June 2018
TSC2 mediates cellular energy response to control cell growth and survival
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PubMed Central
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15 June 2018
Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation
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15 June 2018
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
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PubMed Central
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15 June 2018
Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
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PubMed Central
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15 June 2018
Translational control by TOR and TAP42 through dephosphorylation of eIF2alpha kinase GCN2.
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15 June 2018
Receptor-mediated endoproteolytic activation of two transcription factors in yeast.
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15 June 2018
Gcn4p, a master regulator of gene expression, is controlled at multiple levels by diverse signals of starvation and stress
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PubMed Central
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15 June 2018
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
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15 June 2018
Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors
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15 June 2018
Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
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15 June 2018
Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling
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PubMed Central
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15 June 2018
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
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PubMed Central
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15 June 2018
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
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15 June 2018
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
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15 June 2018
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
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15 June 2018
ATF4 is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
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15 June 2018
An amino-acid taste receptor
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
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15 June 2018
A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells
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15 June 2018
A family of yeast proteins mediating bidirectional vacuolar amino acid transport
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15 June 2018
Genetic and biochemical analysis of the yeast plasma membrane Ssy1p-Ptr3p-Ssy5p sensor of extracellular amino acids
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
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15 June 2018
Regulated translation initiation controls stress-induced gene expression in mammalian cells
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
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15 June 2018
Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
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15 June 2018
Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
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15 June 2018
A family of candidate taste receptors in human and mouse
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
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15 June 2018
The Saccharomyces cerevisiae Rheb G-protein is involved in regulating canavanine resistance and arginine uptake
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
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15 June 2018
Ssy1p and Ptr3p are plasma membrane components of a yeast system that senses extracellular amino acids
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
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15 June 2018
Saccharomyces cerevisiae putative G protein, Gtr1p, which forms complexes with itself and a novel protein designated as Gtr2p, negatively regulates the Ran/Gsp1p G protein cycle through Gtr2p
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
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15 June 2018
Amino acid signaling in Saccharomyces cerevisiae: a permease-like sensor of external amino acids and F-Box protein Grr1p are required for transcriptional induction of the AGP1 gene, which encodes a broad-specificity amino acid permease
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
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15 June 2018
Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
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15 June 2018
RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
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15 June 2018
The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
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15 June 2018
TOR controls translation initiation and early G1 progression in yeast
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
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15 June 2018
Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
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15 June 2018
A mammalian protein targeted by G1-arresting rapamycin-receptor complex
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
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15 June 2018
Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
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15 June 2018
RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
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15 June 2018
The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
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15 June 2018
RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
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PubMed Central
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15 June 2018
Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases
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PubMed Central
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15 June 2018
Evidence for translational regulation of the activator of general amino acid control in yeast
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
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15 June 2018
Juxtaposition of domains homologous to protein kinases and histidyl-tRNA synthetases in GCN2 protein suggests a mechanism for coupling GCN4 expression to amino acid availability
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PubMed Central
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15 June 2018
Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast
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PubMed Central
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15 June 2018
Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast
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15 June 2018
Leucyl-tRNA Synthetase Activates Vps34 in Amino Acid-Sensing mTORC1 Signaling
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17 June 2018
Multiple amino acid sensing inputs to mTORC1.
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17 June 2018
mTOR in health and in sickness
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17 June 2018
TSC2 mediates hyperosmotic stress-induced inactivation of mTORC1.
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17 June 2018
AMPK--sensing energy while talking to other signaling pathways
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17 June 2018
The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
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17 June 2018
Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
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17 June 2018
Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways
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17 June 2018
ATF4-dependent transcription mediates signaling of amino acid limitation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
retrieved
17 June 2018
Amino-acid-induced signalling via the SPS-sensing pathway in yeast
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
retrieved
17 June 2018
Amino acid signaling in yeast: casein kinase I and the Ssy5 endoprotease are key determinants of endoproteolytic activation of the membrane-bound Stp1 transcription factor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
retrieved
17 June 2018
Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
retrieved
17 June 2018
MCRS1 binds and couples Rheb to amino acid-dependent mTORC1 activation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
retrieved
21 August 2018
Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
retrieved
21 August 2018
Glutaminolysis activates Rag-mTORC1 signaling.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
retrieved
21 August 2018
TORC1 controls degradation of the transcription factor Stp1, a key effector of the SPS amino-acid-sensing pathway in Saccharomyces cerevisiae.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
retrieved
21 August 2018
Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
retrieved
21 August 2018
Dimerization is required for activation of eIF2 kinase Gcn2 in response to diverse environmental stress conditions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
retrieved
21 August 2018
Rapamycin-induced translational derepression of GCN4 mRNA involves a novel mechanism for activation of the eIF2 alpha kinase GCN2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
retrieved
21 August 2018
Tsc2 null murine neuroepithelial cells are a model for human tuber giant cells, and show activation of an mTOR pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
retrieved
21 August 2018
The permease homologue Ssy1p controls the expression of amino acid and peptide transporter genes in Saccharomyces cerevisiae.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5694944
retrieved
21 August 2018
Genetic and biochemical evidence for yeast GCN2 protein kinase polymerization
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/28096180
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.15252/EMBJ.201696010
1 reference
stated in
Europe PubMed Central
PMCID
5694944
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28096180%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 June 2020
PMCID
5694944
1 reference
stated in
Europe PubMed Central
PMCID
5694944
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28096180%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 June 2020
PubMed ID
28096180
1 reference
stated in
Europe PubMed Central
PMCID
5694944
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28096180%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 June 2020
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