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Multiple amino acid sensing inputs to mTORC1.
scientific article published on 11 December 2015
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scholarly article
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Europe PubMed Central
PMCID
4816134
retrieved
16 August 2017
title
Multiple amino acid sensing inputs to mTORC1.
(English)
1 reference
stated in
Europe PubMed Central
PMCID
4816134
retrieved
16 August 2017
author
Mitsugu Shimobayashi
object named as
Mitsugu Shimobayashi
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1
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author name string
Michael N Hall
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMCID
4816134
retrieved
16 August 2017
publication date
11 December 2015
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stated in
Europe PubMed Central
PMCID
4816134
retrieved
16 August 2017
number of pages
14
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inferred from page(s)
published in
Cell Research
1 reference
stated in
Europe PubMed Central
PMCID
4816134
retrieved
16 August 2017
volume
26
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stated in
Europe PubMed Central
PMCID
4816134
retrieved
16 August 2017
issue
1
1 reference
stated in
Europe PubMed Central
PMCID
4816134
retrieved
16 August 2017
page(s)
7-20
1 reference
stated in
Europe PubMed Central
PMCID
4816134
retrieved
16 August 2017
exact match
https://scigraph.springernature.com/pub.10.1038/cr.2015.146
0 references
cites work
Sestrin2 is a leucine sensor for the mTORC1 pathway
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retrieved
29 September 2017
Amino Acids Stimulate TORC1 through Lst4-Lst7, a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr2.
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PubMed Central
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retrieved
29 September 2017
Aberrant amino acid signaling promotes growth and metastasis of hepatocellular carcinomas through Rab1A-dependent activation of mTORC1 by Rab1A
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PubMed Central
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29 September 2017
Crystal structure of the Ego1-Ego2-Ego3 complex and its role in promoting Rag GTPase-dependent TORC1 signaling.
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Skp2-Mediated RagA Ubiquitination Elicits a Negative Feedback to Prevent Amino-Acid-Dependent mTORC1 Hyperactivation by Recruiting GATOR1.
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Phosphatidylinositol 3-kinase signaling determines kidney size
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The ubiquitination of rag A GTPase by RNF152 negatively regulates mTORC1 activation
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SEA you later alli-GATOR--a dynamic regulator of the TORC1 stress response pathway
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Nutrient-sensing mechanisms and pathways.
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Metabolism. Differential regulation of mTORC1 by leucine and glutamine
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PubMed Central
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29 September 2017
Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1
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29 September 2017
SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1
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mTOR signaling in cellular and organismal energetics
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29 September 2017
Sestrins inhibit mTORC1 kinase activation through the GATOR complex
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PubMed Central
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29 September 2017
Rab1A is an mTORC1 activator and a colorectal oncogene
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PubMed Central
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29 September 2017
The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1
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PubMed Central
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Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling
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PubMed Central
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Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21.
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Nitrogen source activates TOR (target of rapamycin) complex 1 via glutamine and independently of Gtr/Rag proteins
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PubMed Central
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Rag GTPases are cardioprotective by regulating lysosomal function.
1 reference
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RagA, but not RagB, is essential for embryonic development and adult mice
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Making new contacts: the mTOR network in metabolism and signalling crosstalk
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Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome
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reference URL
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The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.
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stated in
PubMed Central
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Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
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Sestrins orchestrate cellular metabolism to attenuate aging
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PubMed Central
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SEACing the GAP that nEGOCiates TORC1 activation: evolutionary conservation of Rag GTPase regulation
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PubMed Central
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A Central role for mTOR in lipid homeostasis
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PubMed Central
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PubMed Central
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p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling
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retrieved
29 September 2017
TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
29 September 2017
A conserved GTPase-containing complex is required for intracellular sorting of the general amino-acid permease in yeast
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
29 September 2017
TOR signaling in growth and metabolism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
29 September 2017
The TOR and EGO protein complexes orchestrate microautophagy in yeast
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
29 September 2017
Rheb binds and regulates the mTOR kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
29 September 2017
Complex chromosome 22 rearrangements in astrocytic tumors identified using microsatellite and chromosome 22 tile path array analysis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
29 September 2017
Functional characterization of the candidate tumor suppressor gene NPRL2/G21 located in 3p21.3C.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
29 September 2017
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
29 September 2017
Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
29 September 2017
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
29 September 2017
Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
29 September 2017
Tumor suppressor genes on chromosome 3p involved in the pathogenesis of lung and other cancers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
29 September 2017
Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
29 September 2017
Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dubé syndrome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
29 September 2017
Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
29 September 2017
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
29 September 2017
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
29 September 2017
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
29 September 2017
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
29 September 2017
A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
29 September 2017
A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
29 September 2017
The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
29 September 2017
A chemical genomics approach toward understanding the global functions of the target of rapamycin protein (TOR).
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
29 September 2017
Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
29 September 2017
Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
29 September 2017
Tsc2(+/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
29 September 2017
Saccharomyces cerevisiae putative G protein, Gtr1p, which forms complexes with itself and a novel protein designated as Gtr2p, negatively regulates the Ran/Gsp1p G protein cycle through Gtr2p
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
29 September 2017
Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
29 September 2017
Control of amino acid permease sorting in the late secretory pathway of Saccharomyces cerevisiae by SEC13, LST4, LST7 and LST8
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
29 September 2017
RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
29 September 2017
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
29 September 2017
Mechanism of activation of protein kinase B by insulin and IGF-1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
29 September 2017
Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
29 September 2017
LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
29 September 2017
Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
28 June 2018
Sestrin2 inhibits mTORC1 through modulation of GATOR complexes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
28 June 2018
The histidine transporter SLC15A4 coordinates mTOR-dependent inflammatory responses and pathogenic antibody production
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
28 June 2018
Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
28 June 2018
Cytosolic pH regulates cell growth through distinct GTPases, Arf1 and Gtr1, to promote Ras/PKA and TORC1 activity.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
5 September 2018
Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
5 September 2018
Glutaminolysis activates Rag-mTORC1 signaling.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
5 September 2018
The Birt-Hogg-Dube and tuberous sclerosis complex homologs have opposing roles in amino acid homeostasis in Schizosaccharomyces pombe.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
5 September 2018
A novel human primary immunodeficiency syndrome caused by deficiency of the endosomal adaptor protein p14.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
5 September 2018
Tsc2 null murine neuroepithelial cells are a model for human tuber giant cells, and show activation of an mTOR pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4816134
retrieved
5 September 2018
NPRL2 gene expression in the progression of colon tumors
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26658722
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1038/CR.2015.146
1 reference
stated in
Europe PubMed Central
PMCID
4816134
retrieved
16 August 2017
PMCID
4816134
1 reference
stated in
Europe PubMed Central
PMCID
4816134
retrieved
16 August 2017
PubMed ID
26658722
1 reference
stated in
Europe PubMed Central
PMCID
4816134
retrieved
16 August 2017
ResearchGate publication ID
286638950
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