(Q57540447)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29671834%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

title

Using Peptidomimetics and Constrained Peptides as Valuable Tools for Inhibiting Protein⁻Protein Interactions (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29671834%20AND%20SRC:MED&resulttype=core&format=json

protein-protein interaction

23 March 2020

main subject

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29671834%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

David R. Spring

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29671834%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

language of work or name

English

0 references

publication date

19 April 2018

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29671834%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29671834%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

volume

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29671834%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29671834%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

23 March 2020

page(s)

959

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copyright license

start time

19 April 2018

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Cyclic parathyroid hormone-related protein antagonists: lysine 13 to aspartic acid 17 [i to (i + 4)] side chain to side chain lactamization

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12 December 2020

Helix stabilization by Glu-...Lys+ salt bridges in short peptides of de novo design

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12 December 2020

A hot spot of binding energy in a hormone-receptor interface

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12 December 2020

The energetics of ion-pair and hydrogen-bonding interactions in a helical peptide

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12 December 2020

Principles of protein-protein interactions

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12 December 2020

Lactam bridge stabilization of alpha-helical peptides: ring size, orientation and positional effects

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12 December 2020

Anatomy of hot spots in protein interfaces

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12 December 2020

Peptidomimetic design

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12 December 2020

The atomic structure of protein-protein recognition sites

1 reference

12 December 2020

Photo-control of helix content in a short peptide

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12 December 2020

Click Chemistry: Diverse Chemical Function from a Few Good Reactions

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12 December 2020

Toward proteomimetics: terphenyl derivatives as structural and functional mimics of extended regions of an alpha-helix

1 reference

12 December 2020

The outstanding biological stability of beta- and gamma-peptides toward proteolytic enzymes: an in vitro investigation with fifteen peptidases

1 reference

12 December 2020

Exploring the stereochemistry of CXCR4-peptide recognition and inhibiting HIV-1 entry with D-peptides derived from chemokines

1 reference

12 December 2020

Using an azobenzene cross-linker to either increase or decrease peptide helix content upon trans-to-cis photoisomerization.

1 reference

12 December 2020

Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides

1 reference

12 December 2020

The outstanding metabolic stability of a 14C-labeled beta-nonapeptide in rats--in vitro and in vivo pharmacokinetic studies.

1 reference

12 December 2020

Design and application of an alpha-helix-mimetic scaffold based on an oligoamide-foldamer strategy: antagonism of the Bak BH3/Bcl-xL complex

1 reference

12 December 2020

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

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12 December 2020

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix

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12 December 2020

Hot regions in protein--protein interactions: the organization and contribution of structurally conserved hot spot residues

1 reference

12 December 2020

Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells.

1 reference

12 December 2020

Single turn peptide alpha helices with exceptional stability in water

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12 December 2020

Photo-leucine and photo-methionine allow identification of protein-protein interactions in living cells

1 reference

12 December 2020

Terephthalamide derivatives as mimetics of helical peptides: disruption of the Bcl-x(L)/Bak interaction

1 reference

12 December 2020

Strategies for targeting protein-protein interactions with synthetic agents.

1 reference

12 December 2020

Photocontrolling peptide alpha helices.

1 reference

12 December 2020

Protein-protein interactions in human disease

1 reference

12 December 2020

A stapled BID BH3 helix directly binds and activates BAX

1 reference

12 December 2020

Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide

1 reference

12 December 2020

Secondary structure based analysis and classification of biological interfaces: identification of binding motifs in protein-protein interactions.

1 reference

12 December 2020

Heterocyclic alpha-helix mimetics for targeting protein-protein interactions

1 reference

12 December 2020

Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family

1 reference

12 December 2020

Stabilization of folded peptide and protein structures via distance matching with a long, rigid cross-linker

1 reference

12 December 2020

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

1 reference

12 December 2020

Principles of protein-protein interactions: what are the preferred ways for proteins to interact?

1 reference

12 December 2020

ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

1 reference

12 December 2020

Estimating the size of the human interactome

1 reference

12 December 2020

Synthesis and biophysical characterization of stabilized alpha-helices of BCL-2 domains

1 reference

12 December 2020

Consecutive Cyclic Pentapeptide Modules Form Shortα-Helices that are Very Stable to Water and Denaturants

1 reference

12 December 2020

Photocontrollable peptide-based switches target the anti-apoptotic protein Bcl-xL.

1 reference

12 December 2020

Synthesis and biological evaluation of a 5-6-5 imidazole-phenyl-thiazole based alpha-helix mimetic

1 reference

12 December 2020

An empirical framework for binary interactome mapping

1 reference

12 December 2020

Synthetic inhibitors of extended helix-protein interactions based on a biphenyl 4,4'-dicarboxamide scaffold

1 reference

12 December 2020

Ribosomal synthesis of cyclic peptides with a fluorogenic oxidative coupling reaction.

1 reference

12 December 2020

Phage-encoded combinatorial chemical libraries based on bicyclic peptides

1 reference

12 December 2020

Mirror image phage display--a method to generate D-peptide ligands for use in diagnostic or therapeutical applications

1 reference

12 December 2020

Novel amphiphilic alpha-helix mimetics based on a bis-benzamide scaffold

1 reference

12 December 2020

Replacement of Ala by Aib improves structuration and biological stability in thymine-based alpha-nucleopeptides.

1 reference

12 December 2020

Determinants of BH3 Binding Specificity for Mcl-1 versus Bcl-xL

1 reference

12 December 2020

N-alkylated oligoamide alpha-helical proteomimetics

1 reference

12 December 2020

Oligobenzamide proteomimetic inhibitors of the p53-hDM2 protein-protein interaction

1 reference

12 December 2020

Introduction of all-hydrocarbon i,i+3 staples into alpha-helices via ring-closing olefin metathesis

1 reference

12 December 2020

Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic

1 reference

12 December 2020

Systematic analysis of helical protein interfaces reveals targets for synthetic inhibitors

1 reference

12 December 2020

Novel helix-constrained nociceptin derivatives are potent agonists and antagonists of ERK phosphorylation and thermal analgesia in mice

1 reference

12 December 2020

Protein-protein interactions: Interactome under construction

1 reference

12 December 2020

Synthesis of all-hydrocarbon stapled α-helical peptides by ring-closing olefin metathesis

1 reference

12 December 2020

Metabolic stability of peptidomimetics: N-methyl and aza heptapeptide analogs of a PKB/Akt inhibitor.

1 reference

12 December 2020

Design of triazole-stapled BCL9 α-helical peptides to target the β-catenin/B-cell CLL/lymphoma 9 (BCL9) protein-protein interaction

1 reference

12 December 2020

Stapled peptides for intracellular drug targets

1 reference

12 December 2020

Bicyclic peptide inhibitor reveals large contact interface with a protease target

1 reference

12 December 2020

Relaxation of the rigid backbone of an oligoamide-foldamer-based α-helix mimetic: identification of potent Bcl-xL inhibitors.

1 reference

12 December 2020

Amphiphilic α-helix mimetics based on a benzoylurea scaffold

1 reference

12 December 2020

A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers.

1 reference

12 December 2020

2-O-alkylated para-benzamide α-helix mimetics: the role of scaffold curvature.

1 reference

12 December 2020

Enaminone-based mimics of extended and hydrophilic α-helices

1 reference

12 December 2020

Development of α-helical calpain probes by mimicking a natural protein-protein interaction

1 reference

12 December 2020

Microwave assisted solid phase synthesis of highly functionalized N-alkylated oligobenzamide α-helix mimetics

1 reference

12 December 2020

Predicting permanent and transient protein-protein interfaces

1 reference

12 December 2020

Plucking the high hanging fruit: a systematic approach for targeting protein-protein interactions

1 reference

12 December 2020

Chapter 4: Protein interactions and disease

1 reference

12 December 2020

Stapled peptide to enter human testing, but affinity questions remain

1 reference

12 December 2020

Inhibition of α-helix-mediated protein-protein interactions using designed molecules

1 reference

12 December 2020

A perfluoroaryl-cysteine S(N)Ar chemistry approach to unprotected peptide stapling

1 reference

12 December 2020

Effect of sequence and stereochemistry reversal on p53 peptide mimicry

1 reference

12 December 2020

Monosubstituted alkenyl amino acids for peptide "stapling".

1 reference

12 December 2020

Conformational change of Sos-derived proline-rich peptide upon binding Grb2 N-terminal SH3 domain probed by NMR.

1 reference

12 December 2020

Structure-activity relationships of peptidomimetics that inhibit PPI of HER2-HER3.

1 reference

12 December 2020

A new i, i + 3 peptide stapling system for α-helix stabilization.

1 reference

12 December 2020

Peptide ligands stabilized by small molecules

1 reference

12 December 2020

A FIM study to assess safety and exposure of inhaled single doses of AP301-A specific ENaC channel activator for the treatment of acute lung injury.

1 reference

12 December 2020

Hydrocarbon-stapled peptides: principles, practice, and progress

1 reference

12 December 2020

Investigating peptide sequence variations for 'double-click' stapled p53 peptides

1 reference

12 December 2020

Hot spots in protein-protein interfaces: towards drug discovery.

1 reference

12 December 2020

How proteins bind macrocycles.

1 reference

12 December 2020

Orthogonal functionalisation of α-helix mimetics

1 reference

12 December 2020

Stitched α-helical peptides via bis ring-closing metathesis

1 reference

12 December 2020

Robust asymmetric synthesis of unnatural alkenyl amino acids for conformationally constrained α-helix peptides

1 reference

12 December 2020

Design, solid-phase synthesis, and evaluation of a phenyl-piperazine-triazine scaffold as α-helix mimetics

1 reference

12 December 2020

Linear aliphatic dialkynes as alternative linkers for double-click stapling of p53-derived peptides

1 reference

12 December 2020

Dual-purpose linker for alpha helix stabilization and imaging agent conjugation to glucagon-like peptide-1 receptor ligands.

1 reference

12 December 2020

Targeting protein-protein interfaces using macrocyclic peptides

1 reference

12 December 2020

Advances in chemical protein modification.

1 reference

12 December 2020

A two-component 'double-click' approach to peptide stapling.

1 reference

12 December 2020

Peptide/protein stapling and unstapling: introduction of s-tetrazine, photochemical release, and regeneration of the peptide/protein

1 reference

12 December 2020

Acetone-Linked Peptides: A Convergent Approach for Peptide Macrocyclization and Labeling

1 reference

12 December 2020

Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes.

1 reference

12 December 2020

A Thiol-Ene Coupling Approach to Native Peptide Stapling and Macrocyclization

1 reference

12 December 2020

Towards more drug-like proteomimetics: two-faced, synthetic α-helix mimetics based on a purine scaffold

1 reference

12 December 2020

α/β-Peptide Foldamers Targeting Intracellular Protein-Protein Interactions with Activity in Living Cells

1 reference

12 December 2020

Neutrophil elastase inhibitors for the treatment of (cardio)pulmonary diseases: Into clinical testing with pre-adaptive pharmacophores

1 reference

12 December 2020

Multi-Facial, Non-Peptidic α-Helix Mimetics

1 reference

12 December 2020

Cyclic and Macrocyclic Peptides as Chemical Tools To Recognise Protein Surfaces and Probe Protein-Protein Interactions

1 reference

12 December 2020

Converting One-Face α-Helix Mimetics into Amphiphilic α-Helix Mimetics as Potent Inhibitors of Protein-Protein Interactions

1 reference

12 December 2020

Double Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled Peptides

1 reference

12 December 2020

Development of a Multifunctional Benzophenone Linker for Peptide Stapling and Photoaffinity Labelling

1 reference

12 December 2020

Bridged Analogues for p53-Dependent Cancer Therapy Obtained by S-Alkylation

1 reference

12 December 2020

Review stapling peptides using cysteine crosslinking.

1 reference

12 December 2020

A Helix-Stabilizing Linker Improves Subcutaneous Bioavailability of a Helical Peptide Independent of Linker Lipophilicity.

1 reference

12 December 2020

Nitrogen Arylation for Macrocyclization of Unprotected Peptides

1 reference

12 December 2020

Azobenzene photocontrol of peptides and proteins.

1 reference

12 December 2020

Synthesis of Pyridazine-Based α-Helix Mimetics

1 reference

12 December 2020

A TPX2 Proteomimetic Has Enhanced Affinity for Aurora-A Due to Hydrocarbon Stapling of a Helix.

1 reference

12 December 2020

Carbonylation as a novel method for the assembly of pyrazine based oligoamide alpha-helix mimetics.

1 reference

12 December 2020

Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer

1 reference

12 December 2020

Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase.

1 reference

12 December 2020

Diversity-Oriented Peptide Stapling: A Third Generation Copper-Catalysed Azide-Alkyne Cycloaddition Stapling and Functionalisation Strategy.

1 reference

12 December 2020

Macrocycles as protein-protein interaction inhibitors

1 reference

12 December 2020

Diversity-Oriented Stapling Yields Intrinsically Cell-Penetrant Inducers of Autophagy.

1 reference

12 December 2020

Cheminformatics-aided discovery of small-molecule Protein-Protein Interaction (PPI) dual inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-κB Ligand (RANKL).

1 reference

12 December 2020

Targeting the Genome-Stability Hub Ctf4 by Stapled-Peptide Design.

1 reference

12 December 2020

Divinylsulfonamides as Specific Linkers for Stapling Disulfide Bonds in Peptides.

1 reference

12 December 2020

Lactam-Stapled Cell-Penetrating Peptides: Cell Uptake and Membrane Binding Properties

1 reference

12 December 2020

Double quick, double click reversible peptide "stapling".

1 reference

12 December 2020

Structure-Based Design of Non-natural Macrocyclic Peptides That Inhibit Protein-Protein Interactions

1 reference

12 December 2020

Divergent unprotected peptide macrocyclisation by palladium-mediated cysteine arylation.

1 reference

12 December 2020

A study of 2-component i, i + 3 peptide stapling using thioethers.

1 reference

12 December 2020

Mix and Match: Mono-substituted Hydrocarbon Diastereomer Combinations Reveal Stapled Peptides with High Structural Fidelity

1 reference

12 December 2020

An intramolecular tryptophan-condensation approach for peptide stapling.

1 reference

12 December 2020

Utilization of peptide phage display to investigate hotspots on IL-17A and what it means for drug discovery.

1 reference

12 December 2020

Method to generate highly stable D-amino acid analogs of bioactive helical peptides using a mirror image of the entire PDB.

1 reference

12 December 2020

Enzymatically-stable oxetane-based dipeptide hydrogels.

1 reference

12 December 2020

High Throughput Screen for Inhibitors of Protein-Protein Interactions in a Reconstituted Heat Shock Protein 70 (Hsp70) Complex.

1 reference

12 December 2020

Highly Efficient Synthesis of Covalently Cross-Linked Peptide Helices by Ring-Closing Metathesis

1 reference

12 December 2020

10.3390/MOLECULES23040959

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29671834%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29671834%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

1 reference