(Q57950380)

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Mutants of the tumour suppressor p53 L1 loop as second-site suppressors for restoring DNA binding to oncogenic p53 mutations: structural and biochemical insights

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Mutants of the tumour suppressor p53 L1 loop as second-site suppressors for restoring DNA binding to oncogenic p53 mutations: structural and biochemical insights (English)

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object named as

Bruno Pagano

6

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Franca Fraternali

object named as

Franca Fraternali

8

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author name string

Assia Merabet

1

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Hellen Houlleberghs

2

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Kate Maclagan

3

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Ester Akanho

4

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Tam T. T. Bui

5

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Alex F. Drake

7

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Penka V. Nikolova

9

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Bruno Pagano

6

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Franca Fraternali

8

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language of work or name

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publication date

15 April 2010

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Biochemical Journal

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427

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2

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225-236

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Structural and functional basis for therapeutic modulation of p53 signaling.

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https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

Strategies for manipulating the p53 pathway in the treatment of human cancer.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

p53 gene mutations are associated with poor survival in low and low-intermediate risk diffuse large B-cell lymphomas.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

The consensus coding sequences of human breast and colorectal cancers

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

Structure-function-rescue: the diverse nature of common p53 cancer mutants

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

Structural biology of the tumor suppressor p53.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

Reactivation of mutant p53: molecular mechanisms and therapeutic potential

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

Peptide aptamers targeting mutant p53 induce apoptosis in tumor cells

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

Targeted rescue of a destabilized mutant of p53 by an in silico screened drug

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

Genetic selection of intragenic suppressor mutations that reverse the effect of common p53 cancer mutations

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

Thermodynamic stability of wild-type and mutant p53 core domain

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

Semirational design of active tumor suppressor p53 DNA binding domain with enhanced stability

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

Mechanism of rescue of common p53 cancer mutations by second-site suppressor mutations

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

Effects of common cancer mutations on stability and DNA binding of full-length p53 compared with isolated core domains.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

In the quest for stable rescuing mutants of p53: computational mutagenesis of flexible loop L1.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

p53-Induced DNA bending: the interplay between p53-DNA and p53-p53 interactions

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

Dissection of the sequence-specific DNA binding and exonuclease activities reveals a superactive yet apoptotically impaired mutant p53 protein

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

Novel human p53 mutations that are toxic to yeast can enhance transactivation of specific promoters and reactivate tumor p53 mutants

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

Mutational analysis of the p53 core domain L1 loop.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

Crystal structure of the mouse p53 core DNA-binding domain at 2.7 A resolution

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

Structural basis for understanding oncogenic p53 mutations and designing rescue drugs

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

Structures of p53 cancer mutants and mechanism of rescue by second-site suppressor mutations

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

Structure of the p53 core domain dimer bound to DNA.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

Structural basis of DNA recognition by p53 tetramers.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

Comparison of the human and worm p53 structures suggests a way for enhancing stability

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

p53 mutants exhibiting enhanced transcriptional activation and altered promoter selectivity are revealed using a sensitive, yeast-based functional assay

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

Increased apoptosis induction by 121F mutant p53

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

Directed evolution of p53 variants with altered DNA-binding specificities by in vitro compartmentalization.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

A global suppressor motif for p53 cancer mutants

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

The screening of the second-site suppressor mutations of the common p53 mutants

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

Structural distortion of p53 by the mutation R249S and its rescue by a designed peptide: implications for "mutant conformation".

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

The p73 DNA binding domain displays enhanced stability relative to its homologue, the tumor suppressor p53, and exhibits cooperative DNA binding.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

Molecular interactions of ASPP1 and ASPP2 with the p53 protein family and the apoptotic promoters PUMA and Bax.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

Structure of the human p53 core domain in the absence of DNA

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

A biomolecular force field based on the free enthalpy of hydration and solvation: the GROMOS force-field parameter sets 53A5 and 53A6

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

Molecular dynamics with coupling to an external bath

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

Canonical sampling through velocity rescaling

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

Dynamite: a simple way to gain insight into protein motions.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

VMD: visual molecular dynamics

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

Hot-spot mutants of p53 core domain evince characteristic local structural changes.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

Correlation of levels of folded recombinant p53 in escherichia coli with thermodynamic stability in vitro.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

Molecular dynamics simulations of p53 DNA-binding domain

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

Kinetic Instability of p53 Core Domain Mutants

1 reference

https://api.crossref.org/works/10.1042%2FBJ20091888

21 January 2018

Identifiers

10.1042/BJ20091888

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