(Q36777373)

16 August 2017

1 reference

title

Reactivation of mutant p53: molecular mechanisms and therapeutic potential (English)

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16 August 2017

Selivanova G

1

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16 August 2017

Wiman KG

series ordinal

2

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16 August 2017

language of work or name

English

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publication date

1 April 2007

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16 August 2017

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16 August 2017

volume

26

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16 August 2017

issue

15

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16 August 2017

page(s)

2243-2254

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Effects of common cancer mutations on stability and DNA binding of full-length p53 compared with isolated core domains.

16 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

p53 contains large unstructured regions in its native state

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Genetic selection of intragenic suppressor mutations that reverse the effect of common p53 cancer mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Thermodynamic stability of wild-type and mutant p53 core domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Structure, function, and aggregation of the zinc-free form of the p53 DNA binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Redox state of tumor suppressor p53 regulates its sequence-specific DNA binding in DNA-damaged cells by cysteine 277

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Small molecules that reactivate mutant p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

PRIMA-1(MET) synergizes with cisplatin to induce tumor cell apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Solution structure of p53 core domain: structural basis for its instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Restoration of transcriptional activity of p53 mutants in human tumour cells by intracellular expression of anti-p53 single chain Fv fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Inhibiting the p53-MDM2 interaction: an important target for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Temporal dissection of p53 function in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

The pathological response to DNA damage does not contribute to p53-mediated tumour suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Biochemical characterization of different conformational states of the Sf9 cell-purified p53His175 mutant protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Evidence for allosteric variants of wild-type p53, a tumour suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Presence of a potent transcription activating sequence in the p53 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Regulation of mutant p53 temperature-sensitive DNA binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Allosteric regulation of the thermostability and DNA binding activity of human p53 by specific interacting proteins. CRC Cell Transformation Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Allosteric activation of latent p53 tetramers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Activation of the cryptic DNA binding function of mutant forms of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Structural basis for understanding oncogenic p53 mutations and designing rescue drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Structures of p53 cancer mutants and mechanism of rescue by second-site suppressor mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Therapeutic exploitation of the p53 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Selective induction of apoptosis in mutant p53 premalignant and malignant cancer cells by PRIMA-1 through the c-Jun-NH2-kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Biological significance of a small highly conserved region in the N terminus of the p53 tumour suppressor protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

The p53 stabilizing compound CP-31398 induces apoptosis by activating the intrinsic Bax/mitochondrial/caspase-9 pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

A common polymorphism acts as an intragenic modifier of mutant p53 behaviour

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Cancer gene therapy: fringe or cutting edge?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

p53 linear diffusion along DNA requires its C terminus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Efficient specific DNA binding by p53 requires both its central and C-terminal domains as revealed by studies with high-mobility group 1 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Identification of an additional negative regulatory region for p53 sequence-specific DNA binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Effects of PRIMA-1 on chronic lymphocytic leukaemia cells with and without hemizygous p53 deletion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

The Rb/E2F pathway and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Human p53 phosphorylation mimic, S392E, increases nonspecific DNA affinity and thermal stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Mechanism of rescue of common p53 cancer mutations by second-site suppressor mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Restoration of wild-type conformation and activity of a temperature-sensitive mutant of p53 (p53(V272M)) by the cytoprotective aminothiol WR1065 in the esophageal cancer cell line TE-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

The structure of p53 tumour suppressor protein reveals the basis for its functional plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

The IARC TP53 database: new online mutation analysis and recommendations to users

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Inhibition of MDM2 by hsp90 contributes to mutant p53 stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Activation of p53 by the cytoprotective aminothiol WR1065: DNA-damage-independent pathway and redox-dependent modulation of p53 DNA-binding activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Proteomic identification of heat shock protein 90 as a candidate target for p53 mutation reactivation by PRIMA-1 in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Characterization of the p53-rescue drug CP-31398 in vitro and in living cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

CRINEPT-TROSY NMR reveals p53 core domain bound in an unfolded form to the chaperone Hsp90.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Regulation of ES cell differentiation by functional and conformational modulation of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

ASPP proteins specifically stimulate the apoptotic function of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Reactivation of mutant p53: a new strategy for cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Reactivation of mutant p53 through interaction of a C-terminal peptide with the core domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Selenomethionine regulation of p53 by a ref1-dependent redox mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Isolation of Temperature-sensitive p53 Mutations from a Comprehensive Missense Mutation Library

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

The consensus coding sequences of human breast and colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Treatment of terminal peritoneal carcinomatosis by a transducible p53-activating peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

ASPP2: a gene that controls life and death in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Live or let die: the cell's response to p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Hsp90 chaperones wild-type p53 tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Small-molecule modulators of p53 family signaling and antitumor effects in p53-deficient human colon tumor xenografts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Stabilization of p53 by CP-31398 inhibits ubiquitination without altering phosphorylation at serine 15 or 20 or MDM2 binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Strategies for therapeutic targeting of the p53 pathway in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

CP-31398, a novel p53-stabilizing agent, induces p53-dependent and p53-independent glioma cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Hot-spot mutants of p53 core domain evince characteristic local structural changes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

The p53-Mdm2 pathway: targets for the development of new anticancer therapeutics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Change of Conformation of the DNA-binding Domain of p53 Is the Only Key Element for Binding of and Interference with p73

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Physical and Functional Interaction between p53 Mutants and Different Isoforms of p73

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

Kinetic Instability of p53 Core Domain Mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

7 January 2021

p53 gene mutation: software and database

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

7 January 2021

Human tumor-derived p53 proteins exhibit binding site selectivity and temperature sensitivity for transactivation in a yeast-based assay

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

7 January 2021

Pharmacological rescue of mutant p53 conformation and function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

7 January 2021

Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

7 January 2021

Conformational and molecular basis for induction of apoptosis by a p53 C-terminal peptide in human cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

7 January 2021

Analysis of the most representative tumour-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

7 January 2021

Tumor-derived mutations within the DNA-binding domain of p53 that phenotypically resemble the deletion of the proline-rich domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

7 January 2021

Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

7 January 2021

The mutant p53-conformation modifying drug, CP-31398, can induce apoptosis of human cancer cells and can stabilize wild-type p53 protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

7 January 2021

The 'wildtype' conformation of p53: epitope mapping using hybrid proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

7 January 2021

Structure-based rescue of common tumor-derived p53 mutants

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

7 January 2021

A temperature-sensitive mutant of human p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210295

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1210295

1 reference

Dimensions Publication ID

16 August 2017

1024873323

0 references

1 reference