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26 April 2020

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The elusive tau molecular structures: can we translate the recent breakthroughs into new targets for intervention? (English)

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translational medical research

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26 April 2020

Caroline Smet

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26 April 2020

Joke Verelst

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Eugeen Vanmechelen

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26 April 2020

Bernard J Hanseeuw

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26 April 2020

Miguel Medina

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26 April 2020

Luc Buée

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26 April 2020

Isabelle Landrieu

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26 April 2020

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Yann Fichou

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26 April 2020

François Devred

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26 April 2020

Philipp O Tsvetkov

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26 April 2020

Joris Winderickx

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26 April 2020

Nick Geukens

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26 April 2020

Audrey Perrotin

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26 April 2020

Louise Serpell

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1 March 2019

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26 April 2020

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30 September 2020

Acta Neuropathologica Communications

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cites work

A protein factor essential for microtubule assembly

1 reference

12 December 2020

Tubulin requires tau for growth onto microtubule initiating sites

1 reference

12 December 2020

Measurement of distinct immunochemical presentations of tau protein in Alzheimer disease.

1 reference

12 December 2020

Identification of 3- and 4-repeat tau isoforms within the PHF in Alzheimer's disease

1 reference

12 December 2020

Structural characterization of the core of the paired helical filament of Alzheimer disease

1 reference

12 December 2020

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

1 reference

12 December 2020

Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domains

1 reference

12 December 2020

Alzheimer's disease and tau proteins.

1 reference

12 December 2020

Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.

1 reference

12 December 2020

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

1 reference

12 December 2020

The primary structure and heterogeneity of tau protein from mouse brain.

1 reference

12 December 2020

Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease

1 reference

12 December 2020

Staging of Alzheimer's disease-related neurofibrillary changes

1 reference

12 December 2020

Hyperphosphorylation of tau in PHF

1 reference

12 December 2020

Molecular characterization of the minimal protease resistant tau unit of the Alzheimer's disease paired helical filament

1 reference

12 December 2020

Monitoring pathological assembly of tau and beta-amyloid proteins in Alzheimer's disease

1 reference

12 December 2020

Mechanism of neurofibrillary degeneration in Alzheimer's disease.

1 reference

12 December 2020

Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease

1 reference

12 December 2020

Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules.

1 reference

12 December 2020

Comparison of the neurofibrillary pathology in Alzheimer's disease and familial presenile dementia with tangles

1 reference

12 December 2020

Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans.

1 reference

12 December 2020

The structural basis of monoclonal antibody Alz50's selectivity for Alzheimer's disease pathology.

1 reference

12 December 2020

Frequency of stages of Alzheimer-related lesions in different age categories

1 reference

12 December 2020

RNA sequestration to pathological lesions of neurodegenerative diseases.

1 reference

12 December 2020

New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry

1 reference

12 December 2020

Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments

1 reference

12 December 2020

Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure

1 reference

12 December 2020

C-terminal inhibition of tau assembly in vitro and in Alzheimer's disease.

1 reference

12 December 2020

Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments

1 reference

12 December 2020

A genomic sequence analysis of the mouse and human microtubule-associated protein tau.

1 reference

12 December 2020

Tau filaments from human brain and from in vitro assembly of recombinant protein show cross-beta structure

1 reference

12 December 2020

Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms.

1 reference

12 December 2020

Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease

1 reference

12 December 2020

Tau paired helical filaments from Alzheimer's disease brain and assembled in vitro are based on beta-structure in the core domain

1 reference

12 December 2020

Folding of Alzheimer's core PHF subunit revealed by monoclonal antibody 423.

1 reference

12 December 2020

Template-assisted filament growth by parallel stacking of tau.

1 reference

12 December 2020

O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease

1 reference

12 December 2020

C-terminal truncation modulates both nucleation and extension phases of tau fibrillization

1 reference

12 December 2020

Spectroscopic approaches to the conformation of tau protein in solution and in paired helical filaments

1 reference

12 December 2020

Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration

1 reference

12 December 2020

Disruption of microtubule network by Alzheimer abnormally hyperphosphorylated tau.

1 reference

12 December 2020

Atomic structures of amyloid cross-beta spines reveal varied steric zippers

1 reference

12 December 2020

Assembly of two distinct dimers and higher-order oligomers from full-length tau.

1 reference

12 December 2020

Amyloid fibrils of the HET-s(218-289) prion form a beta solenoid with a triangular hydrophobic core

1 reference

12 December 2020

Characterization of Alzheimer's-like paired helical filaments from the core domain of tau protein using solid-state NMR spectroscopy

1 reference

12 December 2020

What determines the molecular composition of abnormal protein aggregates in neurodegenerative disease?

1 reference

12 December 2020

Proline-directed pseudo-phosphorylation at AT8 and PHF1 epitopes induces a compaction of the paperclip folding of Tau and generates a pathological (MC-1) conformation

1 reference

12 December 2020

Tau isoform regulation is region- and cell-specific in mouse brain.

1 reference

12 December 2020

Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease

1 reference

12 December 2020

Advances and pitfalls of protein structural alignment

1 reference

12 December 2020

Low micromolar zinc accelerates the fibrillization of human tau via bridging of Cys-291 and Cys-322.

1 reference

12 December 2020

Caspase activation precedes and leads to tangles

1 reference

12 December 2020

Serine-409 phosphorylation and oxidative damage define aggregation of human protein tau in yeast

1 reference

12 December 2020

The role of zinc in Alzheimer's disease

1 reference

12 December 2020

Accelerated human mutant tau aggregation by knocking out murine tau in a transgenic mouse model

1 reference

12 December 2020

Are tangles as toxic as they look?

1 reference

12 December 2020

Towards a Pharmacophore for Amyloid

1 reference

12 December 2020

New insights into tau-microtubules interaction revealed by isothermal titration calorimetry

1 reference

12 December 2020

The dynamic structure of filamentous tau

1 reference

12 December 2020

Propagation of tau pathology in a model of early Alzheimer's disease

1 reference

12 December 2020

Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature

1 reference

12 December 2020

Tau isoform composition influences rate and extent of filament formation

1 reference

12 December 2020

Conformational basis for asymmetric seeding barrier in filaments of three- and four-repeat tau.

1 reference

12 December 2020

The self-perpetuating tau truncation circle.

1 reference

12 December 2020

β-Sheet core of tau paired helical filaments revealed by solid-state NMR.

1 reference

12 December 2020

Development and assessment of sensitive immuno-PCR assays for the quantification of cerebrospinal fluid three- and four-repeat tau isoforms in tauopathies.

1 reference

12 December 2020

Extracellular Tau levels are influenced by variability in Tau that is associated with tauopathies

1 reference

12 December 2020

An Ultra-specific Avian Antibody to Phosphorylated Tau Protein Reveals a Unique Mechanism for Phosphoepitope Recognition

1 reference

12 December 2020

PET imaging of neuropathology in tauopathies: progressive supranuclear palsy

1 reference

12 December 2020

Tau phosphorylation affects its axonal transport and degradation

1 reference

12 December 2020

CAPITO--a web server-based analysis and plotting tool for circular dichroism data

1 reference

12 December 2020

Early clinical PET imaging results with the novel PHF-tau radioligand [F18]-T808.

1 reference

12 December 2020

Characterization of novel CSF Tau and ptau biomarkers for Alzheimer's disease

1 reference

12 December 2020

A functional fragment of Tau forms fibers without the need for an intermolecular cysteine bridge

1 reference

12 December 2020

Zinc binding directly regulates tau toxicity independent of tau hyperphosphorylation

1 reference

12 December 2020

Specific profile of tau isoforms in argyrophylic grain disease

1 reference

12 December 2020

Mechanism of Tau-Promoted Microtubule Assembly As Probed by NMR Spectroscopy

1 reference

12 December 2020

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease.

1 reference

12 December 2020

Oligomer formation of tau protein hyperphosphorylated in cells

1 reference

12 December 2020

Alpha-synuclein and tau: teammates in neurodegeneration?

1 reference

12 December 2020

The need for better AD animal models

1 reference

12 December 2020

Tau monoclonal antibody generation based on humanized yeast models: impact on Tau oligomerization and diagnostics

1 reference

12 December 2020

Nuclear magnetic resonance spectroscopy characterization of interaction of Tau with DNA and its regulation by phosphorylation

1 reference

12 December 2020

Harvard Aging Brain Study: Dataset and accessibility

1 reference

12 December 2020

A Phosphorylation-Induced Turn Defines the Alzheimer's Disease AT8 Antibody Epitope on the Tau Protein.

1 reference

12 December 2020

Tau stabilizes microtubules by binding at the interface between tubulin heterodimers

1 reference

12 December 2020

Repetitive head trauma, chronic traumatic encephalopathy and tau: Challenges in translating from mice to men.

1 reference

12 December 2020

Longitudinal Cerebrospinal Fluid Biomarker Changes in Preclinical Alzheimer Disease During Middle Age.

1 reference

12 December 2020

Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice

1 reference

12 December 2020

Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue

1 reference

12 December 2020

Structure of the toxic core of α-synuclein from invisible crystals

1 reference

12 December 2020

Tau positron emission tomographic imaging in aging and early Alzheimer disease

1 reference

12 December 2020

Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau

1 reference

12 December 2020

Tau Protein Quantification in Human Cerebrospinal Fluid by Targeted Mass Spectrometry at High Sequence Coverage Provides Insights into Its Primary Structure Heterogeneity.

1 reference

12 December 2020

Epitope mapping and structural basis for the recognition of phosphorylated tau by the anti-tau antibody AT8

1 reference

12 December 2020

Characterization of Neuronal Tau Protein as a Target of Extracellular Signal-regulated Kinase

1 reference

12 December 2020

Co-immunoprecipitation with Tau Isoform-specific Antibodies Reveals Distinct Protein Interactions and Highlights a Putative Role for 2N Tau in Disease

1 reference

12 December 2020

FLEXITau: Quantifying Post-translational Modifications of Tau Protein in Vitro and in Human Disease

1 reference

12 December 2020

Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer's disease.

1 reference

12 December 2020

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein.

1 reference

12 December 2020

Fracture and Growth Are Competing Forces Determining the Fate of Conformers in Tau Fibril Populations

1 reference

12 December 2020

New Features about Tau Function and Dysfunction

1 reference

12 December 2020

The neuritic plaque facilitates pathological conversion of tau in an Alzheimer's disease mouse model

1 reference

12 December 2020

The Cerebrospinal Fluid Neurogranin/BACE1 Ratio is a Potential Correlate of Cognitive Decline in Alzheimer's Disease

1 reference

12 December 2020

Temporal T807 binding correlates with CSF tau and phospho-tau in normal elderly

1 reference

12 December 2020

Plasma tau in Alzheimer disease

1 reference

12 December 2020

Pathological concentration of zinc dramatically accelerates abnormal aggregation of full-length human Tau and thereby significantly increases Tau toxicity in neuronal cells.

1 reference

12 December 2020

Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo.

1 reference

12 December 2020

Tau passive immunization inhibits not only tau but also Aβ pathology

1 reference

12 December 2020

Relationships between flortaucipir PET tau binding and amyloid burden, clinical diagnosis, age and cognition

1 reference

12 December 2020

Fluorodeoxyglucose metabolism associated with tau-amyloid interaction predicts memory decline.

1 reference

12 December 2020

Signature of an aggregation-prone conformation of tau.

1 reference

12 December 2020

Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain

1 reference

12 December 2020

Propagation of Tau aggregates

1 reference

12 December 2020

DNA-binding mode transition of tau in the presence of Zinc ions

1 reference

12 December 2020

Cryo-EM structures of tau filaments from Alzheimer's disease.

1 reference

12 December 2020

Amyloid β concentrations and stable isotope labeling kinetics of human plasma specific to central nervous system amyloidosis

1 reference

12 December 2020

Zinc binding to RNA recognition motif of TDP-43 induces the formation of amyloid-like aggregates.

1 reference

12 December 2020

Regulation of the interaction between the neuronal BIN1 isoform 1 and Tau proteins - role of the SH3 domain.

1 reference

12 December 2020

Identification of the Tau phosphorylation pattern that drives its aggregation.

1 reference

12 December 2020

Liquid-liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau.

1 reference

12 December 2020

Neurotoxicity of Zinc.

1 reference

12 December 2020

Alzheimer's Disease-like Paired Helical Filament Assembly from Truncated Tau Protein Is Independent of Disulfide Crosslinking.

1 reference

12 December 2020

Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes

1 reference

12 December 2020

EuroTau: towing scientists to tau without tautology.

1 reference

12 December 2020

Atypical, non-standard functions of the microtubule associated Tau protein

1 reference

12 December 2020

The tau positron-emission tomography tracer AV-1451 binds with similar affinities to tau fibrils and monoamine oxidases.

1 reference

12 December 2020

Associations between [18F]AV1451 tau PET and CSF measures of tau pathology in a clinical sample

1 reference

12 December 2020

Structure-based inhibitors of tau aggregation.

1 reference

12 December 2020

An N-terminal motif unique to primate tau enables differential protein-protein interactions.

1 reference

12 December 2020

High performance plasma amyloid-β biomarkers for Alzheimer's disease.

1 reference

12 December 2020

Tau protein liquid-liquid phase separation can initiate tau aggregation.

1 reference

12 December 2020

Secretion of full-length Tau or Tau fragments in cell culture models. Propagation of Tau in vivo and in vitro

1 reference

12 December 2020

Digital ELISA for the quantification of attomolar concentrations of Alzheimer's disease biomarker protein Tau in biological samples.

1 reference

12 December 2020

Longitudinal tau PET in ageing and Alzheimer's disease.

1 reference

12 December 2020

Tau Kinetics in Neurons and the Human Central Nervous System

1 reference

12 December 2020

18F-Flortaucipir Binding in Choroid Plexus: Related to Race and Hippocampus Signal.

1 reference

12 December 2020

Annexins A2 and A6 interact with the extreme N-terminus of tau and thereby contribute to tau's axonal localization.

1 reference

12 December 2020

Heparin-induced tau filaments are structurally heterogeneous and differ from Alzheimer's disease filaments

1 reference

12 December 2020

Tau Antibody Structure Reveals a Molecular Switch Defining a Pathological Conformation of the Tau Protein.

1 reference

12 December 2020

Is longitudinal tau PET ready for use in Alzheimer's disease clinical trials?

1 reference

12 December 2020

Near-atomic model of microtubule-tau interactions

1 reference

12 December 2020

Tau Conformation as a Target for Disease-Modifying Therapy: The Role of Truncation

1 reference

12 December 2020

Zinc Exacerbates Tau Pathology in a Tau Mouse Model

1 reference

12 December 2020

Commutability of the certified reference materials for the standardization of β-amyloid 1-42 assay in human cerebrospinal fluid: lessons for tau and β-amyloid 1-40 measurements

1 reference

12 December 2020

Inert and seed-competent tau monomers suggest structural origins of aggregation.

1 reference

12 December 2020

Amyloidogenic cross-seeding of Tau protein: Transient emergence of structural variants of fibrils

1 reference

12 December 2020

Anti-Tau Monoclonal Antibodies Derived from Soluble and Filamentous Tau Show Diverse Functional Properties in vitro and in vivo

1 reference

12 December 2020

Cysteine-Independent Inhibition of Alzheimer's Disease-like Paired Helical Filament Assembly by Leuco-Methylthioninium (LMT)

1 reference

12 December 2020

Structures of filaments from Pick's disease reveal a novel tau protein fold

1 reference

12 December 2020

Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease

1 reference

12 December 2020

Two Tau binding sites on tubulin revealed by thiol-disulfide exchanges

1 reference

12 December 2020

Structural disorder in four-repeat Tau fibrils reveals a new mechanism for barriers to cross-seeding of Tau isoforms

1 reference

12 December 2020

Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold

1 reference

12 December 2020

Structural Basis for Recognition of a Unique Epitope by a Human Anti-tau Antibody

1 reference

12 December 2020

Genome-wide identification of genic and intergenic neuronal DNA regions bound by Tau protein under physiological and stress conditions

1 reference

12 December 2020

Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex

1 reference

12 December 2020

Direct Crosstalk Between -GlcNAcylation and Phosphorylation of Tau Protein Investigated by NMR Spectroscopy

1 reference

12 December 2020

Different tau species lead to heterogeneous tau pathology propagation and misfolding

1 reference

12 December 2020

Correlation of In Vivo [18F]Flortaucipir With Postmortem Alzheimer Disease Tau Pathology

1 reference

12 December 2020

Biomarkers for tau pathology.

1 reference

12 December 2020

Cofactors are essential constituents of stable and seeding-active tau fibrils

1 reference

12 December 2020

Zinc Induces Temperature-Dependent Reversible Self-Assembly of Tau

1 reference

12 December 2020

Longitudinal tau accumulation and atrophy in aging and alzheimer disease

1 reference

12 December 2020

Functional Status of Neuronal Calcium Sensor-1 Is Modulated by Zinc Binding

1 reference

12 December 2020

Role of tau N-terminal motif in the secretion of human tau by End Binding proteins

1 reference

12 December 2020

Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases

1 reference

12 December 2020

Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors.

1 reference

12 December 2020

A walk through tau therapeutic strategies

1 reference

12 December 2020

10.1186/S40478-019-0682-X

Identifiers

DOI

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26 April 2020

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26 April 2020

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