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23 April 2020

review article

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title

A walk through tau therapeutic strategies (English)

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23 April 2020

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9 September 2020

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23 April 2020

Jesús Ávila de Grado

2

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23 April 2020

Michael Schöll

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23 April 2020

Gabor G. Kovacs

4

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23 April 2020

Luc Buée

11

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23 April 2020

Lewis D Evans

7

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Rostislav Skrabana

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Rostislav Skrabana

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Enikö Kövari

5

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23 April 2020

Eva Kontsekova

8

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23 April 2020

Barbara Malawska

9

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23 April 2020

Rohan de Silva

10

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23 April 2020

Norbert Zilka

12

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23 April 2020

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15 February 2019

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Acta Neuropathologica Communications

23 April 2020

published in

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23 April 2020

9 September 2020

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23 April 2020

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1

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23 April 2020

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Creative Commons Attribution 4.0 International

23 April 2020

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15 February 2019

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https://scigraph.springernature.com/pub.10.1186/s40478-019-0664-z

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Identification of nuclear tau isoforms in human neuroblastoma cells

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Structural characterization of the core of the paired helical filament of Alzheimer disease

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Developmentally regulated expression of specific tau sequences

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Duchenne muscular dystrophy: the gene and the protein

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Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2.

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12 December 2020

Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau

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Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease

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12 December 2020

The purification of tau protein and the occurrence of two phosphorylation states of tau in brain

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12 December 2020

Staging of Alzheimer's disease-related neurofibrillary changes

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Molecular characterization of the minimal protease resistant tau unit of the Alzheimer's disease paired helical filament

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Truncated tau protein as a new marker for Alzheimer's disease.

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12 December 2020

Glycated tau protein in Alzheimer disease: a mechanism for induction of oxidant stress

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12 December 2020

Altered microtubule organization in small-calibre axons of mice lacking tau protein

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12 December 2020

Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding.

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12 December 2020

Beta A4 deposits are constant in the brain of the oldest old: an immunocytochemical study of 20 French centenarians

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12 December 2020

Glycosylation of microtubule-associated protein tau: an abnormal posttranslational modification in Alzheimer's disease.

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12 December 2020

Tau protein in cerebrospinal fluid: a biochemical marker for axonal degeneration in Alzheimer disease?

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12 December 2020

Polymerization of tau into filaments in the presence of heparin: the minimal sequence required for tau-tau interaction

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12 December 2020

Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines

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12 December 2020

Immunocytochemistry of tau phosphoserine 413 and tau protein kinase I in Alzheimer pathology.

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12 December 2020

The tau protein in human cerebrospinal fluid in Alzheimer's disease consists of proteolytically derived fragments

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12 December 2020

Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau.

1 reference

12 December 2020

Two-dimensional characterization of paired helical filament-tau from Alzheimer's disease: demonstration of an additional 74-kDa component and age-related biochemical modifications.

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12 December 2020

Diagnosis and staging of Alzheimer disease

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12 December 2020

Prevalence, incidence and duration of Braak's stages in the general population: can we know?

1 reference

12 December 2020

Atypical form of Alzheimer's disease with prominent posterior cortical atrophy: a review of lesion distribution and circuit disconnection in cortical visual pathways

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12 December 2020

Pathologic correlates of apraxia in Alzheimer disease.

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12 December 2020

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

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12 December 2020

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

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12 December 2020

Affinity dependence of the B cell response to antigen: a threshold, a ceiling, and the importance of off-rate

1 reference

12 December 2020

Extending the range of rate constants available from BIACORE: interpreting mass transport-influenced binding data

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12 December 2020

Phosphorylation of specific sets of tau isoforms reflects different neurofibrillary degeneration processes.

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12 December 2020

Advanced glycation end products in Alzheimer's disease and other neurodegenerative diseases

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12 December 2020

Neuroanatomic correlates of visual agnosia in Alzheimer's disease: a clinicopathologic study.

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12 December 2020

Association of an extended haplotype in the tau gene with progressive supranuclear palsy.

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12 December 2020

Improving biosensor analysis

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12 December 2020

Memory and mental status correlates of modified Braak staging.

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12 December 2020

Clinical validity of Braak neuropathological staging in the oldest-old

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12 December 2020

Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure

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12 December 2020

Neural substrates of spatial and temporal disorientation in Alzheimer's disease.

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12 December 2020

Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work

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12 December 2020

Defects in axonal elongation and neuronal migration in mice with disrupted tau and map1b genes

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12 December 2020

Conformational change as one of the earliest alterations of tau in Alzheimer's disease.

1 reference

12 December 2020

In vitro assembly of tau protein: mapping the regions involved in filament formation

1 reference

12 December 2020

Tau gene mutations and neurodegeneration.

1 reference

12 December 2020

Neurodegenerative tauopathies

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12 December 2020

Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease.

1 reference

12 December 2020

Role of glycosylation in hyperphosphorylation of tau in Alzheimer's disease

1 reference

12 December 2020

Natively unfolded proteins: a point where biology waits for physics

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12 December 2020

Phases of A beta-deposition in the human brain and its relevance for the development of AD.

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12 December 2020

Office of Rare Diseases neuropathologic criteria for corticobasal degeneration.

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12 December 2020

Tau could protect DNA double helix structure.

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12 December 2020

Association of phosphorylation site of tau protein with neuronal apoptosis in Alzheimer's disease.

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12 December 2020

Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer’s disease

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12 December 2020

Nitration of tau protein is linked to neurodegeneration in tauopathies

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12 December 2020

Staging of argyrophilic grains: an age-associated tauopathy

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12 December 2020

Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury.

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12 December 2020

Simultaneous measurement of beta-amyloid(1-42), total tau, and phosphorylated tau (Thr181) in cerebrospinal fluid by the xMAP technology.

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12 December 2020

Neuronal tau induces DNA conformational changes observed by atomic force microscopy

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12 December 2020

Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins

1 reference

12 December 2020

Tau aggregation is driven by a transition from random coil to beta sheet structure

1 reference

12 December 2020

Tau protein as a differential biomarker of tauopathies

1 reference

12 December 2020

p25/Cdk5-mediated retinoblastoma phosphorylation is an early event in neuronal cell death.

1 reference

12 December 2020

Linkage disequilibrium fine mapping and haplotype association analysis of the tau gene in progressive supranuclear palsy and corticobasal degeneration

1 reference

12 December 2020

Environmental reduplicative paramnesia in a case of atypical Alzheimer's disease.

1 reference

12 December 2020

Tyrosine 394 is phosphorylated in Alzheimer's paired helical filament tau and in fetal tau with c-Abl as the candidate tyrosine kinase.

1 reference

12 December 2020

Tau suppression in a neurodegenerative mouse model improves memory function

1 reference

12 December 2020

Regional conformational change involving phosphorylation of tau protein at the Thr231, precedes the structural change detected by Alz-50 antibody in Alzheimer's disease.

1 reference

12 December 2020

Splicing of a critical exon of human Survival Motor Neuron is regulated by a unique silencer element located in the last intron

1 reference

12 December 2020

Small ubiquitin-like modifier (SUMO) modification of natively unfolded proteins tau and alpha-synuclein

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12 December 2020

Incidence and predictors of seizures in patients with Alzheimer's disease

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12 December 2020

Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo.

1 reference

12 December 2020

Intrinsically disordered proteins in the neurodegenerative processes: formation of tau protein paired helical filaments and their analysis

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12 December 2020

Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry

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12 December 2020

Extracellular tau is toxic to neuronal cells.

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12 December 2020

Tau nitration occurs at tyrosine 29 in the fibrillar lesions of Alzheimer's disease and other tauopathies.

1 reference

12 December 2020

The MAPT H1c risk haplotype is associated with increased expression of tau and especially of 4 repeat containing transcripts

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12 December 2020

The "jaws" of the tau-microtubule interaction.

1 reference

12 December 2020

Missorting of tau in neurons causes degeneration of synapses that can be rescued by the kinase MARK2/Par-1.

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12 December 2020

Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

1 reference

12 December 2020

Haplotype-specific expression of the N-terminal exons 2 and 3 at the human MAPT locus

1 reference

12 December 2020

Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements.

1 reference

12 December 2020

Interaction of tau protein with the dynactin complex

1 reference

12 December 2020

Earliest stages of tau conformational changes are related to the appearance of a sequence of specific phospho-dependent tau epitopes in Alzheimer's disease.

1 reference

12 December 2020

Extracellular tau promotes intracellular calcium increase through M1 and M3 muscarinic receptors in neuronal cells

1 reference

12 December 2020

Binding to the minor groove of the double-strand, tau protein prevents DNA from damage by peroxidation

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12 December 2020

Tau exon 10 alternative splicing and tauopathies

1 reference

12 December 2020

Argyrophilic grain disease.

1 reference

12 December 2020

Development of tau aggregation inhibitors for Alzheimer's disease

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12 December 2020

Misfolded tau protein and disease modifying pathways in transgenic rodent models of human tauopathies

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12 December 2020

Propagation of tau misfolding from the outside to the inside of a cell.

1 reference

12 December 2020

Methylene blue and Alzheimer's disease.

1 reference

12 December 2020

Correction of tau mis-splicing caused by FTDP-17 MAPT mutations by spliceosome-mediated RNA trans-splicing

1 reference

12 December 2020

Identification of aminothienopyridazine inhibitors of tau assembly by quantitative high-throughput screening

1 reference

12 December 2020

Genome-wide association study reveals genetic risk underlying Parkinson's disease

1 reference

12 December 2020

Increased metabolic vulnerability in early-onset Alzheimer's disease is not related to amyloid burden

1 reference

12 December 2020

Tau protein and tau aggregation inhibitors

1 reference

12 December 2020

Prevalence of dementia disorders in the oldest-old: an autopsy study.

1 reference

12 December 2020

Spinal muscular atrophy: mechanisms and therapeutic strategies

1 reference

12 December 2020

Role of glycogen synthase kinase-3 in Alzheimer's disease pathogenesis and glycogen synthase kinase-3 inhibitors.

1 reference

12 December 2020

New evidences on Tau-DNA interactions and relevance to neurodegeneration.

1 reference

12 December 2020

Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice.

1 reference

12 December 2020

A NH2 tau fragment targets neuronal mitochondria at AD synapses: possible implications for neurodegeneration.

1 reference

12 December 2020

Tissue-nonspecific alkaline phosphatase promotes the neurotoxicity effect of extracellular tau

1 reference

12 December 2020

Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models

1 reference

12 December 2020

Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21)

1 reference

12 December 2020

Nuclear tau, a key player in neuronal DNA protection

1 reference

12 December 2020

Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model

1 reference

12 December 2020

Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration

1 reference

12 December 2020

First transgenic rat model developing progressive cortical neurofibrillary tangles

1 reference

12 December 2020

Tyrosine nitration within the proline-rich region of Tau in Alzheimer's disease

1 reference

12 December 2020

Characterization of prefibrillar Tau oligomers in vitro and in Alzheimer disease.

1 reference

12 December 2020

Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain

1 reference

12 December 2020

Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy

1 reference

12 December 2020

Selective neuronal vulnerability in neurodegenerative diseases: from stressor thresholds to degeneration

1 reference

12 December 2020

Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression.

1 reference

12 December 2020

In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice

1 reference

12 December 2020

Multi-target-directed ligands in Alzheimer's disease treatment

1 reference

12 December 2020

Tau-targeted immunization impedes progression of neurofibrillary histopathology in aged P301L tau transgenic mice

1 reference

12 December 2020

Tau Overexpression Results in Its Secretion via Membrane Vesicles

1 reference

12 December 2020

Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach

1 reference

12 December 2020

Roles of glycogen synthase kinase 3 in Alzheimer's disease

1 reference

12 December 2020

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export.

1 reference

12 December 2020

Trans-synaptic spread of tau pathology in vivo

1 reference

12 December 2020

Propagation of tau pathology in a model of early Alzheimer's disease

1 reference

12 December 2020

Who fans the flames of Alzheimer's disease brains? Misfolded tau on the crossroad of neurodegenerative and inflammatory pathways

1 reference

12 December 2020

Trans-cellular propagation of Tau aggregation by fibrillar species

1 reference

12 December 2020

Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature

1 reference

12 December 2020

Differential effects of an O-GlcNAcase inhibitor on tau phosphorylation

1 reference

12 December 2020

Hyperphosphorylation and cleavage at D421 enhance tau secretion

1 reference

12 December 2020

Constitutive secretion of tau protein by an unconventional mechanism.

1 reference

12 December 2020

The self-perpetuating tau truncation circle.

1 reference

12 December 2020

Treatment of Alzheimer's disease with the GSK-3 inhibitor tideglusib: a pilot study.

1 reference

12 December 2020

NMDA receptor dysfunction contributes to impaired brain-derived neurotrophic factor-induced facilitation of hippocampal synaptic transmission in a Tau transgenic model.

1 reference

12 December 2020

Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons

1 reference

12 December 2020

Long-term follow-up after gene therapy for canavan disease.

1 reference

12 December 2020

Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like tauopathy

1 reference

12 December 2020

Age-appropriate cognition and subtle dopamine-independent motor deficits in aged tau knockout mice

1 reference

12 December 2020

Tau loss attenuates neuronal network hyperexcitability in mouse and Drosophila genetic models of epilepsy.

1 reference

12 December 2020

Physiological release of endogenous tau is stimulated by neuronal activity.

1 reference

12 December 2020

Tau degradation: the ubiquitin-proteasome system versus the autophagy-lysosome system

1 reference

12 December 2020

Meta-analysis of amyloid-cognition relations in cognitively normal older adults

1 reference

12 December 2020

Tau passive immunotherapy in mutant P301L mice: antibody affinity versus specificity

1 reference

12 December 2020

Tau pathology and neurodegeneration

1 reference

12 December 2020

Brain homogenates from human tauopathies induce tau inclusions in mouse brain

1 reference

12 December 2020

T-cell epitope-dependent immune response in inbred (C57BL/6J, SJL/J, and C3H/HeN) and transgenic P301S and Tg2576 mice

1 reference

12 December 2020

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

1 reference

12 December 2020

Antisense reduction of tau in adult mice protects against seizures

1 reference

12 December 2020

Efficacy and safety of a liposome-based vaccine against protein Tau, assessed in tau.P301L mice that model tauopathy

1 reference

12 December 2020

Globular glial tauopathies (GGT): consensus recommendations

1 reference

12 December 2020

Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo.

1 reference

12 December 2020

Two novel Tau antibodies targeting the 396/404 region are primarily taken up by neurons and reduce Tau protein pathology

1 reference

12 December 2020

Tau protein provides DNA with thermodynamic and structural features which are similar to those found in histone-DNA complex

1 reference

12 December 2020

Glial and neuronal tau pathology in tauopathies: characterization of disease-specific phenotypes and tau pathology progression.

1 reference

12 December 2020

Tau-aggregation inhibitor therapy for Alzheimer's disease

1 reference

12 December 2020

Increasing brain protein O-GlcNAc-ylation mitigates breathing defects and mortality of Tau.P301L mice

1 reference

12 December 2020

AD-linked, toxic NH2 human tau affects the quality control of mitochondria in neurons

1 reference

12 December 2020

Genetic ablation of tau mitigates cognitive impairment induced by type 1 diabetes

1 reference

12 December 2020

Tau promotes neurodegeneration through global chromatin relaxation

1 reference

12 December 2020

Active immunotherapy options for Alzheimer's disease

1 reference

12 December 2020

Neuronal activity regulates extracellular tau in vivo

1 reference

12 December 2020

Vaccination with Sarkosyl insoluble PHF-tau decrease neurofibrillary tangles formation in aged tau transgenic mouse model: a pilot study.

1 reference

12 December 2020

Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles.

1 reference

12 December 2020

A major role for Tau in neuronal DNA and RNA protection in vivo under physiological and hyperthermic conditions

1 reference

12 December 2020

Activity-dependent tau protein translocation to excitatory synapse is disrupted by exposure to amyloid-beta oligomers.

1 reference

12 December 2020

Multi-Target Directed Drugs: A Modern Approach for Design of New Drugs for the treatment of Alzheimer's Disease

1 reference

12 December 2020

Distinct tau prion strains propagate in cells and mice and define different tauopathies

1 reference

12 December 2020

p-Tau immunotherapy reduces soluble and insoluble tau in aged 3xTg-AD mice

1 reference

12 December 2020

Seizure resistance without parkinsonism in aged mice after tau reduction

1 reference

12 December 2020

Cognition and hippocampal synaptic plasticity in mice with a homozygous tau deletion

1 reference

12 December 2020

Ectosomes: a new mechanism for non-exosomal secretion of tau protein

1 reference

12 December 2020

Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice.

1 reference

12 December 2020

Tau reduction prevents disease in a mouse model of Dravet syndrome

1 reference

12 December 2020

Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer's disease.

1 reference

12 December 2020

Motor and cognitive deficits in aged tau knockout mice in two background strains.

1 reference

12 December 2020

Passive immunization targeting the N-terminal projection domain of tau decreases tau pathology and improves cognition in a transgenic mouse model of Alzheimer disease and tauopathies.

1 reference

12 December 2020

Complex Disposition of Methylthioninium Redox Forms Determines Efficacy in Tau Aggregation Inhibitor Therapy for Alzheimer's Disease

1 reference

12 December 2020

1 reference

12 December 2020

SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination

1 reference

12 December 2020

Human secreted tau increases amyloid-beta production

1 reference

12 December 2020

Rescue of impaired late-phase long-term depression in a tau transgenic mouse model.

1 reference

12 December 2020

First-in-man tau vaccine targeting structural determinants essential for pathological tau-tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an Alzheimer's disease model

1 reference

12 December 2020

Identification of structural determinants on tau protein essential for its pathological function: novel therapeutic target for tau immunotherapy in Alzheimer's disease.

1 reference

12 December 2020

Invited review: Neuropathology of tauopathies: principles and practice.

1 reference

12 December 2020

Multitarget drug discovery for Alzheimer's disease: triazinones as BACE-1 and GSK-3β inhibitors.

1 reference

12 December 2020

Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer's disease or corticobasal degeneration brains

1 reference

12 December 2020

Tau reduction diminishes spatial learning and memory deficits after mild repetitive traumatic brain injury in mice.

1 reference

12 December 2020

Invited review: Frontotemporal dementia caused by microtubule-associated protein tau gene (MAPT) mutations: a chameleon for neuropathology and neuroimaging

1 reference

12 December 2020

Chloroquine and chloroquinoline derivatives as models for the design of modulators of amyloid Peptide precursor metabolism.

1 reference

12 December 2020

Nuclear magnetic resonance spectroscopy characterization of interaction of Tau with DNA and its regulation by phosphorylation

1 reference

12 December 2020

PE859, a novel tau aggregation inhibitor, reduces aggregated tau and prevents onset and progression of neural dysfunction in vivo

1 reference

12 December 2020

Antisense oligonucleotides in therapy for neurodegenerative disorders

1 reference

12 December 2020

Passive immunotherapy of tauopathy targeting pSer413-tau: a pilot study in mice

1 reference

12 December 2020

Anti-tau antibody reduces insoluble tau and decreases brain atrophy

1 reference

12 December 2020

Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain

1 reference

12 December 2020

A mechanistic model of tau amyloid aggregation based on direct observation of oligomers

1 reference

12 December 2020

Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models

1 reference

12 December 2020

Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β.

1 reference

12 December 2020

Role of the Tau N-terminal region in microtubule stabilization revealed by new endogenous truncated forms

1 reference

12 December 2020

Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody.

1 reference

12 December 2020

Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy

1 reference

12 December 2020

Distinct Therapeutic Mechanisms of Tau Antibodies: Promoting Microglial Clearance Versus Blocking Neuronal Uptake

1 reference

12 December 2020

A fresh perspective from immunologists and vaccine researchers: active vaccination strategies to prevent and reverse Alzheimer's disease

1 reference

12 December 2020

C-Terminally Truncated Forms of Tau, But Not Full-Length Tau or Its C-Terminal Fragments, Are Released from Neurons Independently of Cell Death.

1 reference

12 December 2020

Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue

1 reference

12 December 2020

Doubly Phosphorylated Peptide Vaccines to Protect Transgenic P301S Mice against Alzheimer's Disease Like Tau Aggregation

1 reference

12 December 2020

Tau positron emission tomographic imaging in aging and early Alzheimer disease

1 reference

12 December 2020

1 reference

12 December 2020

Pivotal role of glycogen synthase kinase-3: A therapeutic target for Alzheimer's disease

1 reference

12 December 2020

Lamin Dysfunction Mediates Neurodegeneration in Tauopathies.

1 reference

12 December 2020

Tau Protein Hyperphosphorylation and Aggregation in Alzheimer's Disease and Other Tauopathies, and Possible Neuroprotective Strategies

1 reference

12 December 2020

Pathological Tau Promotes Neuronal Damage by Impairing Ribosomal Function and Decreasing Protein Synthesis

1 reference

12 December 2020

Molecular Pathological Classification of Neurodegenerative Diseases: Turning towards Precision Medicine

1 reference

12 December 2020

Co-immunoprecipitation with Tau Isoform-specific Antibodies Reveals Distinct Protein Interactions and Highlights a Putative Role for 2N Tau in Disease

1 reference

12 December 2020

1 reference

12 December 2020

Regional profiles of the candidate tau PET ligand 18F-AV-1451 recapitulate key features of Braak histopathological stages.

1 reference

12 December 2020

PET Imaging of Tau Deposition in the Aging Human Brain.

1 reference

12 December 2020

Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer's disease.

1 reference

12 December 2020

The amyloid hypothesis of Alzheimer's disease at 25 years

1 reference

12 December 2020

Navigating the Chemical Space of Multitarget-Directed Ligands: From Hybrids to Fragments in Alzheimer's Disease

1 reference

12 December 2020

Tau and Aβ imaging, CSF measures, and cognition in Alzheimer's disease

1 reference

12 December 2020

Increased 4R-Tau Induces Pathological Changes in a Human-Tau Mouse Model

1 reference

12 December 2020

Pathological conformations involving the amino terminus of tau occur early in Alzheimer's disease and are differentially detected by monoclonal antibodies.

1 reference

12 December 2020

Adeno-Associated Virus-Based Gene Therapy for CNS Diseases.

1 reference

12 December 2020

The relationship between cerebrospinal fluid markers of Alzheimer pathology and positron emission tomography tau imaging

1 reference

12 December 2020

An autoradiographic evaluation of AV-1451 Tau PET in dementia

1 reference

12 December 2020

Neuronal activity enhances tau propagation and tau pathology in vivo.

1 reference

12 December 2020

In vivo cortical spreading pattern of tau and amyloid in the Alzheimer disease spectrum.

1 reference

12 December 2020

18F-AV-1451 tau PET imaging correlates strongly with tau neuropathology in MAPT mutation carriers

1 reference

12 December 2020

In Vivo Tau, Amyloid, and Gray Matter Profiles in the Aging Brain

1 reference

12 December 2020

Evaluation of Tau Imaging in Staging Alzheimer Disease and Revealing Interactions Between β-Amyloid and Tauopathy

1 reference

12 December 2020

3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Aged Tau Transgenic Mice

1 reference

12 December 2020

Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement.

1 reference

12 December 2020

Human Truncated Tau Induces Mature Neurofibrillary Pathology in a Mouse Model of Human Tauopathy.

1 reference

12 December 2020

Affinity of Tau antibodies for solubilized pathological Tau species but not their immunogen or insoluble Tau aggregates predicts in vivo and ex vivo efficacy.

1 reference

12 December 2020

Design and synthesis of curcumin derivatives as tau and amyloid β dual aggregation inhibitors.

1 reference

12 December 2020

Defining imaging biomarker cut points for brain aging and Alzheimer's disease

1 reference

12 December 2020

Antibody titres and boosting after natural malaria infection in BK-SE36 vaccine responders during a follow-up study in Uganda.

1 reference

12 December 2020

No Overt Deficits in Aged Tau-Deficient C57Bl/6.Mapttm1(EGFP)Kit GFP Knockin Mice

1 reference

12 December 2020

Loss of Bin1 Promotes the Propagation of Tau Pathology.

1 reference

12 December 2020

Astrogliopathy predominates the earliest stage of corticobasal degeneration pathology

1 reference

12 December 2020

Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial.

1 reference

12 December 2020

Safety and immunogenicity of the tau vaccine AADvac1 in patients with Alzheimer's disease: a randomised, double-blind, placebo-controlled, phase 1 trial.

1 reference

12 December 2020

17q21.31 duplication causes prominent tau-related dementia with increased MAPT expression.

1 reference

12 December 2020

Novel Phospho-Tau Monoclonal Antibody Generated Using a Liposomal Vaccine, with Enhanced Recognition of a Conformational Tauopathy Epitope

1 reference

12 December 2020

Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation.

1 reference

12 December 2020

Relationships between flortaucipir PET tau binding and amyloid burden, clinical diagnosis, age and cognition

1 reference

12 December 2020

Molecular Mechanisms of Antisense Oligonucleotides

1 reference

12 December 2020

The release and trans-synaptic transmission of Tau via exosomes

1 reference

12 December 2020

Impact of tau and amyloid burden on glucose metabolism in Alzheimer's disease

1 reference

12 December 2020

Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy.

1 reference

12 December 2020

Tau-PET uptake: Regional variation in average SUVR and impact of amyloid deposition

1 reference

12 December 2020

Amyloid and tau PET demonstrate region-specific associations in normal older people.

1 reference

12 December 2020

Association of In Vivo [18F]AV-1451 Tau PET Imaging Results With Cortical Atrophy and Symptoms in Typical and Atypical Alzheimer Disease.

1 reference

12 December 2020

Fluorodeoxyglucose metabolism associated with tau-amyloid interaction predicts memory decline.

1 reference

12 December 2020

Association between tau deposition and antecedent amyloid-β accumulation rates in normal and early symptomatic individuals

1 reference

12 December 2020

Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain

1 reference

12 December 2020

SLM, a novel carbazole-based fluorophore attenuates okadaic acid-induced tau hyperphosphorylation via down-regulating GSK-3β activity in SH-SY5Y cells.

1 reference

12 December 2020

Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro

1 reference

12 December 2020

Exposure of the Amino Terminus of Tau Is a Pathological Event in Multiple Tauopathies.

1 reference

12 December 2020

Humanized monoclonal antibody armanezumab specific to N-terminus of pathological tau: characterization and therapeutic potency

1 reference

12 December 2020

Protein O-GlcNAcylation: emerging mechanisms and functions

1 reference

12 December 2020

The association between tau PET and retrospective cortical thinning in clinically normal elderly.

1 reference

12 December 2020

Subtly Modulating Glycogen Synthase Kinase 3 β: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases

1 reference

12 December 2020

Hierarchical Organization of Tau and Amyloid Deposits in the Cerebral Cortex

1 reference

12 December 2020

Comparison of multiple tau-PET measures as biomarkers in aging and Alzheimer's disease

1 reference

12 December 2020

Association Between Elevated Brain Amyloid and Subsequent Cognitive Decline Among Cognitively Normal Persons

1 reference

12 December 2020

[F-18]-AV-1451 binding correlates with postmortem neurofibrillary tangle Braak staging.

1 reference

12 December 2020

Design, synthesis and multitarget biological profiling of second-generation anti-Alzheimer rhein-huprine hybrids.

1 reference

12 December 2020

Tau deletion promotes brain insulin resistance

1 reference

12 December 2020

Cryo-EM structures of tau filaments from Alzheimer's disease.

1 reference

12 December 2020

RNA stores tau reversibly in complex coacervates

1 reference

12 December 2020

A clinicopathological approach to the diagnosis of dementia

1 reference

12 December 2020

AV-1451 PET imaging of tau pathology in preclinical Alzheimer disease: Defining a summary measure

1 reference

12 December 2020

Off-Target 18F-AV-1451 Binding in the Basal Ganglia Correlates with Age-Related Iron Accumulation.

1 reference

12 December 2020

Tau-imaging in neurodegeneration

1 reference

12 December 2020

Tau protein aggregation in Alzheimer's disease: An attractive target for the development of novel therapeutic agents.

1 reference

12 December 2020

Protein astrogliopathies in human neurodegenerative diseases and aging.

1 reference

12 December 2020

A 31-residue peptide induces aggregation of tau's microtubule-binding region in cells

1 reference

12 December 2020

An emerging case for membrane pore formation as a common mechanism for the unconventional secretion of FGF2 and IL-1β.

1 reference

12 December 2020

A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival

1 reference

12 December 2020

Preclinical Evaluation of (18)F-RO6958948, (11)C-RO6931643 and (11)C-RO6924963 as Novel Radiotracers for Imaging Aggregated Tau in AD with Positron Emission Tomography.

1 reference

12 December 2020

Region-Specific Association of Subjective Cognitive Decline With Tauopathy Independent of Global β-Amyloid Burden

1 reference

12 December 2020

Tau-based therapies in neurodegeneration: opportunities and challenges.

1 reference

12 December 2020

Extracellular truncated tau causes early presynaptic dysfunction associated with Alzheimer's disease and other tauopathies

1 reference

12 December 2020

Lessons learned about [F-18]-AV-1451 off-target binding from an autopsy-confirmed Parkinson's case

1 reference

12 December 2020

Distinct 18F-AV-1451 tau PET retention patterns in early- and late-onset Alzheimer's disease

1 reference

12 December 2020

Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects

1 reference

12 December 2020

Tau pathology and neurodegeneration contribute to cognitive impairment in Alzheimer's disease.

1 reference

12 December 2020

Pathological Tau Strains from Human Brains Recapitulate the Diversity of Tauopathies in Nontransgenic Mouse Brain

1 reference

12 December 2020

Early Alzheimer-type lesions in cognitively normal subjects

1 reference

12 December 2020

Considerations and code for partial volume correcting [18F]-AV-1451 tau PET data

1 reference

12 December 2020

MAO-B Inhibitors Do Not Block In Vivo Flortaucipir([(18)F]-AV-1451) Binding.

1 reference

12 December 2020

Local and distant relationships between amyloid, tau and neurodegeneration in Alzheimer's Disease

1 reference

12 December 2020

Systemic clearance and brain distribution of carbazole-based cyanine compounds as Alzheimer's disease drug candidates

1 reference

12 December 2020

Atypical, non-standard functions of the microtubule associated Tau protein

1 reference

12 December 2020

Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia

1 reference

12 December 2020

Flortaucipir F 18 Quantitation using a Parametric Estimate of Reference Signal Intensity (PERSI).

1 reference

12 December 2020

Entorhinal tau pathology, episodic memory decline and neurodegeneration in aging.

1 reference

12 December 2020

Prophylactic Active Tau Immunization Leads to Sustained Reduction in Both Tau and Amyloid-β Pathologies in 3xTg Mice.

1 reference

12 December 2020

Associations Between Tau, β-Amyloid, and Cognition in Parkinson Disease.

1 reference

12 December 2020

Widespread brain tau and its association with ageing, Braak stage and Alzheimer's dementia

1 reference

12 December 2020

Retiring the term FTDP-17 as MAPT mutations are genetic forms of sporadic frontotemporal tauopathies.

1 reference

12 December 2020

What is the evidence that tau pathology spreads through prion-like propagation?

1 reference

12 December 2020

The tau positron-emission tomography tracer AV-1451 binds with similar affinities to tau fibrils and monoamine oxidases.

1 reference

12 December 2020

SLOH, a carbazole-based fluorophore, mitigates neuropathology and behavioral impairment in the triple-transgenic mouse model of Alzheimer's disease.

1 reference

12 December 2020

[18 F]AV-1451 clustering of entorhinal and cortical uptake in Alzheimer's disease.

1 reference

12 December 2020

Alzheimer's disease biomarker-guided diagnostic workflow using the added value of six combined cerebrospinal fluid candidates: Aβ1-42, total-tau, phosphorylated-tau, NFL, neurogranin, and YKL-40.

1 reference

12 December 2020

Natural antisense transcripts in diseases: From modes of action to targeted therapies.

1 reference

12 December 2020

Design, Synthesis, and Biological Evaluation of 1-Benzylamino-2-hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer's Agents.

1 reference

12 December 2020

A Protein Aggregation Inhibitor, Leuco-Methylthioninium Bis(Hydromethanesulfonate), Decreases α-Synuclein Inclusions in a Transgenic Mouse Model of Synucleinopathy

1 reference

12 December 2020

Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau.

1 reference

12 December 2020

Association Between Amyloid and Tau Accumulation in Young Adults With Autosomal Dominant Alzheimer Disease.

1 reference

12 December 2020

Relevance of Phosphorylation and Truncation of Tau to the Etiopathogenesis of Alzheimer's Disease.

1 reference

12 December 2020

Tau Spreading Mechanisms; Implications for Dysfunctional Tauopathies.

1 reference

12 December 2020

PET imaging of tau protein targets: a methodology perspective.

1 reference

12 December 2020

Cognitive and neuroimaging features and brain β-amyloidosis in individuals at risk of Alzheimer's disease (INSIGHT-preAD): a longitudinal observational study.

1 reference

12 December 2020

1 reference

12 December 2020

Longitudinal and cross-sectional structural magnetic resonance imaging correlates of AV-1451 uptake.

1 reference

12 December 2020

Longitudinal tau PET in ageing and Alzheimer's disease.

1 reference

12 December 2020

Dual GSK-3β/AChE Inhibitors as a New Strategy for Multitargeting Anti-Alzheimer's Disease Drug Discovery.

1 reference

12 December 2020

Extracellular Monomeric and Aggregated Tau Efficiently Enter Human Neurons through Overlapping but Distinct Pathways.

1 reference

12 December 2020

18F-Flortaucipir Binding in Choroid Plexus: Related to Race and Hippocampus Signal.

1 reference

12 December 2020

Early intervention of tau pathology prevents behavioral changes in the rTg4510 mouse model of tauopathy.

1 reference

12 December 2020

Muscarinic and nicotinic acetylcholine receptor agonists: current scenario in Alzheimer's disease therapy.

1 reference

12 December 2020

Subthreshold Amyloid Predicts Tau Deposition in Aging

1 reference

12 December 2020

Large inter- and intra-case variability of first generation tau PET ligand binding in neurodegenerative dementias.

1 reference

12 December 2020

Characterization of 3 Novel Tau Radiopharmaceuticals, 11C-RO-963, 11C-RO-643, and 18F-RO-948, in Healthy Controls and in Alzheimer Subjects

1 reference

12 December 2020

Tau reduction in the presence of amyloid-β prevents tau pathology and neuronal death in vivo

1 reference

12 December 2020

Cell-Penetrating Peptides to Enhance Delivery of Oligonucleotide-Based Therapeutics.

1 reference

12 December 2020

Acute tau knockdown in the hippocampus of adult mice causes learning and memory deficits.

1 reference

12 December 2020

Extracellular Forms of Aβ and Tau from iPSC Models of Alzheimer's Disease Disrupt Synaptic Plasticity.

1 reference

12 December 2020

Unconventional Secretion Mediates the Trans-cellular Spreading of Tau

1 reference

12 December 2020

Tau Kinetics in Neurons and the Human Central Nervous System

1 reference

12 December 2020

In Vivo Characterization and Quantification of Neurofibrillary Tau PET Radioligand 18F-MK-6240 in Humans from Alzheimer Disease Dementia to Young Controls

1 reference

12 December 2020

Elevated medial temporal lobe and pervasive brain tau-PET signal in normal participants.

1 reference

12 December 2020

Tau positron emission tomography imaging in tauopathies: The added hurdle of off-target binding.

1 reference

12 December 2020

Cross-sectional and longitudinal atrophy is preferentially associated with tau rather than amyloid β positron emission tomography pathology.

1 reference

12 December 2020

Antisense oligonucleotides in neurological disorders.

1 reference

12 December 2020

Tau Immunotherapies for Alzheimer's Disease and Related Tauopathies: Progress and Potential Pitfalls

1 reference

12 December 2020

Tau Conformation as a Target for Disease-Modifying Therapy: The Role of Truncation

1 reference

12 December 2020

Brain Imaging of Alzheimer Dementia Patients and Elderly Controls with 18F-MK-6240, a PET Tracer Targeting Neurofibrillary Tangles

1 reference

12 December 2020

Muscarinic M1 Receptor Overstimulation Disrupts Working Memory Activity for Rules in Primate Prefrontal Cortex

1 reference

12 December 2020

Sequential stages and distribution patterns of aging-related tau astrogliopathy (ARTAG) in the human brain.

1 reference

12 December 2020

Tau-targeting therapies for Alzheimer disease

1 reference

12 December 2020

Relationships Between Tau and Glucose Metabolism Reflect Alzheimer’s Disease Pathology in Cognitively Normal Older Adults

1 reference

12 December 2020

Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau.P301S mouse model of Alzheimer's disease and frontotemporal dementia.

1 reference

12 December 2020

Alzheimer's disease drug development pipeline: 2018.

1 reference

12 December 2020

The sulfation code for propagation of neurodegeneration.

1 reference

12 December 2020

Inert and seed-competent tau monomers suggest structural origins of aggregation.

1 reference

12 December 2020

Anti-Tau Monoclonal Antibodies Derived from Soluble and Filamentous Tau Show Diverse Functional Properties in vitro and in vivo

1 reference

12 December 2020

Biomarkers for Alzheimer's disease: current status and prospects for the future

1 reference

12 December 2020

In vivo quantification of neurofibrillary tangles with [F]MK-6240

1 reference

12 December 2020

Influence of tau PET, amyloid PET, and hippocampal volume on cognition in Alzheimer disease

1 reference

12 December 2020

Tau-Centric Multitarget Approach for Alzheimer's Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3β and Tau-Aggregation Inhibitors

1 reference

12 December 2020

Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease

1 reference

12 December 2020

Epitope determines efficacy of therapeutic anti-Tau antibodies in a functional assay with human Alzheimer Tau

1 reference

12 December 2020

Anti-neuroinflammatory effects of SLOH in Aβ-induced BV-2 microglial cells and 3xTg-AD mice involve the inhibition of GSK-3β

1 reference

12 December 2020

Precision Medicine through Antisense Oligonucleotide-Mediated Exon Skipping

1 reference

12 December 2020

Ten Years of Tau-Targeted Immunotherapy: The Path Walked and the Roads Ahead

1 reference

12 December 2020

Different tau species lead to heterogeneous tau pathology propagation and misfolding

1 reference

12 December 2020

10.1186/S40478-019-0664-Z

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30767766%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

23 April 2020

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/s40478-019-0664-z

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30767766%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

1 reference