(Q88978898)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29865056%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

title

Tau Immunotherapies for Alzheimer's Disease and Related Tauopathies: Progress and Potential Pitfalls (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29865056%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

1 reference

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1

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29 March 2020

publication date

1 January 2018

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29865056%20AND%20SRC:MED&resulttype=core&format=json

Journal of Alzheimer's Disease

29 March 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29865056%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

volume

64

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29865056%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

issue

s1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29865056%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

page(s)

S555-S565

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29865056%20AND%20SRC:MED&resulttype=core&format=json

Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau.

29 March 2020

cites work

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12 December 2020

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

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12 December 2020

Tau is essential to beta -amyloid-induced neurotoxicity

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12 December 2020

Infectivity of amyloid diseases

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12 December 2020

Tauopathy-like abnormalities and neurologic deficits in mice immunized with neuronal tau protein.

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12 December 2020

Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

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12 December 2020

Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements.

1 reference

12 December 2020

Immunotherapy targeting pathological tau protein in Alzheimer's disease and related tauopathies.

1 reference

12 December 2020

Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice.

1 reference

12 December 2020

Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model

1 reference

12 December 2020

Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain

1 reference

12 December 2020

Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression.

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12 December 2020

Mechanistic Studies of Antibody-Mediated Clearance of Tau Aggregates Using an ex vivo Brain Slice Model

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12 December 2020

Tau-targeted immunization impedes progression of neurofibrillary histopathology in aged P301L tau transgenic mice

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12 December 2020

Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach

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12 December 2020

Trans-cellular propagation of Tau aggregation by fibrillar species

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12 December 2020

Lessons from tau-deficient mice

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12 December 2020

"Prion-like" templated misfolding in tauopathies

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12 December 2020

Mechanisms of protein seeding in neurodegenerative diseases

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12 December 2020

From frontotemporal lobar degeneration pathology to frontotemporal lobar degeneration biomarkers.

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12 December 2020

Tau passive immunotherapy in mutant P301L mice: antibody affinity versus specificity

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12 December 2020

Repeated immunization of mice with phosphorylated-tau peptides causes neuroinflammation

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12 December 2020

Efficacy and safety of a liposome-based vaccine against protein Tau, assessed in tau.P301L mice that model tauopathy

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12 December 2020

Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo.

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12 December 2020

Two novel Tau antibodies targeting the 396/404 region are primarily taken up by neurons and reduce Tau protein pathology

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12 December 2020

Antibody uptake into neurons occurs primarily via clathrin-dependent Fcγ receptor endocytosis and is a prerequisite for acute tau protein clearance.

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12 December 2020

Harnessing the immune system for treatment and detection of tau pathology.

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12 December 2020

Specific targeting of tau oligomers in Htau mice prevents cognitive impairment and tau toxicity following injection with brain-derived tau oligomeric seeds

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12 December 2020

Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles.

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12 December 2020

p-Tau immunotherapy reduces soluble and insoluble tau in aged 3xTg-AD mice

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12 December 2020

Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice.

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12 December 2020

Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer's disease.

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12 December 2020

Epitope analysis following active immunization with tau proteins reveals immunogens implicated in tau pathogenesis

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12 December 2020

Passive immunization targeting the N-terminal projection domain of tau decreases tau pathology and improves cognition in a transgenic mouse model of Alzheimer disease and tauopathies.

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12 December 2020

Human secreted tau increases amyloid-beta production

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12 December 2020

First-in-man tau vaccine targeting structural determinants essential for pathological tau-tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an Alzheimer's disease model

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12 December 2020

Antibody-derived in vivo imaging of tau pathology

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12 December 2020

Tau immunization: a cautionary tale?

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12 December 2020

Passive immunotherapy of tauopathy targeting pSer413-tau: a pilot study in mice

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12 December 2020

Anti-tau antibody reduces insoluble tau and decreases brain atrophy

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12 December 2020

Tau immunotherapy for Alzheimer's disease

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12 December 2020

Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models

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12 December 2020

Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody.

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12 December 2020

Distinct Therapeutic Mechanisms of Tau Antibodies: Promoting Microglial Clearance Versus Blocking Neuronal Uptake

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12 December 2020

Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy

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12 December 2020

Passive Immunization in JNPL3 Transgenic Mice Using an Array of Phospho-Tau Specific Antibodies

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12 December 2020

Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau

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12 December 2020

Tau-Directed Immunotherapy: A Promising Strategy for Treating Alzheimer's Disease and Other Tauopathies

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12 December 2020

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12 December 2020

Tau Protein Quantification in Human Cerebrospinal Fluid by Targeted Mass Spectrometry at High Sequence Coverage Provides Insights into Its Primary Structure Heterogeneity.

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12 December 2020

Differential Mass Spectrometry Profiles of Tau Protein in the Cerebrospinal Fluid of Patients with Alzheimer's Disease, Progressive Supranuclear Palsy, and Dementia with Lewy Bodies.

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12 December 2020

Internalization of tau antibody and pathological tau protein detected with a flow cytometry multiplexing approach

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12 December 2020

CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis

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12 December 2020

Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement.

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12 December 2020

Affinity of Tau antibodies for solubilized pathological Tau species but not their immunogen or insoluble Tau aggregates predicts in vivo and ex vivo efficacy.

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12 December 2020

Camelid single-domain antibodies: A versatile tool for in vivo imaging of extracellular and intracellular brain targets.

1 reference

12 December 2020

Vectored Intracerebral Immunization with the Anti-Tau Monoclonal Antibody PHF1 Markedly Reduces Tau Pathology in Mutant Tau Transgenic Mice.

1 reference

12 December 2020

Safety and immunogenicity of the tau vaccine AADvac1 in patients with Alzheimer's disease: a randomised, double-blind, placebo-controlled, phase 1 trial.

1 reference

12 December 2020

Passive immunization targeting the N-terminal region of phosphorylated tau (residues 68-71) improves spatial memory in okadaic acid induced tauopathy model rats

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12 December 2020

Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation.

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12 December 2020

Tau passive immunization inhibits not only tau but also Aβ pathology

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12 December 2020

Tau PET imaging: present and future directions

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12 December 2020

In vivo tau PET imaging in dementia: Pathophysiology, radiotracer quantification, and a systematic review of clinical findings.

1 reference

12 December 2020

MultiTEP platform-based DNA epitope vaccine targeting N-terminus of tau induces strong immune responses and reduces tau pathology in THY-Tau22 mice.

1 reference

12 December 2020

Combined effects of scanning ultrasound and a tau-specific single chain antibody in a tau transgenic mouse model

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12 December 2020

Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro

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12 December 2020

AAV-mediated expression of anti-tau scFvs decreases tau accumulation in a mouse model of tauopathy

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12 December 2020

Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy

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12 December 2020

Humanized monoclonal antibody armanezumab specific to N-terminus of pathological tau: characterization and therapeutic potency

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12 December 2020

Emerging Diagnostic and Therapeutic Strategies for Tauopathies

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12 December 2020

Preclinical and Clinical Development of ABBV-8E12, a Humanized Anti-Tau Antibody, for Treatment of Alzheimer's Disease and Other Tauopathies

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12 December 2020

Tau-targeting therapies for Alzheimer disease

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12 December 2020

Identifiers

DOI

10.3233/JAD-179937

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29865056%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29865056%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

PubMed publication ID

29865056

1 reference