(Q90128958)

PubMed publication ID

31008845

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31008845%20AND%20SRC:MED&resulttype=core&format=json

11 April 2020

title

Axon degeneration: mechanistic insights lead to therapeutic opportunities for the prevention and treatment of peripheral neuropathy (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6481657&resulttype=core&format=json

14 May 2020

main subject

peripheral neuropathy

1 reference

Aaron DiAntonio

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6481657&resulttype=core&format=json

14 May 2020

publication date

1 May 2019

1 reference

PubMed publication ID

31008845

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31008845%20AND%20SRC:MED&resulttype=core&format=json

11 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6481657&resulttype=core&format=json

14 May 2020

volume

160 Suppl 1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6481657&resulttype=core&format=json

14 May 2020

page(s)

S17-S22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6481657&resulttype=core&format=json

Highwire regulates synaptic growth in Drosophila

14 May 2020

cites work

1 reference

12 December 2020

Regulation of presynaptic terminal organization by C. elegans RPM-1, a putative guanine nucleotide exchanger with a RING-H2 finger domain

1 reference

12 December 2020

rpm-1, a conserved neuronal gene that regulates targeting and synaptogenesis in C. elegans

1 reference

12 December 2020

A Ufd2/D4Cole1e chimeric protein and overexpression of Rbp7 in the slow Wallerian degeneration (WldS) mouse

1 reference

12 December 2020

Absence of Wallerian Degeneration does not Hinder Regeneration in Peripheral Nerve

1 reference

12 December 2020

Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration

1 reference

12 December 2020

A local mechanism mediates NAD-dependent protection of axon degeneration

1 reference

12 December 2020

Highwire function at the Drosophila neuromuscular junction: spatial, structural, and temporal requirements.

1 reference

12 December 2020

Highwire restrains synaptic growth by attenuating a MAP kinase signal.

1 reference

12 December 2020

MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival

1 reference

12 December 2020

Axon regeneration requires a conserved MAP kinase pathway.

1 reference

12 December 2020

A dual leucine kinase-dependent axon self-destruction program promotes Wallerian degeneration

1 reference

12 December 2020

Transgenic mice expressing the Nmnat1 protein manifest robust delay in axonal degeneration in vivo

1 reference

12 December 2020

The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration

1 reference

12 December 2020

Endogenous Nmnat2 is an essential survival factor for maintenance of healthy axons

1 reference

12 December 2020

Axonal degeneration is regulated by the apoptotic machinery or a NAD+-sensitive pathway in insects and mammals

1 reference

12 December 2020

Protein turnover of the Wallenda/DLK kinase regulates a retrograde response to axonal injury

1 reference

12 December 2020

Targeting NMNAT1 to axons and synapses transforms its neuroprotective potency in vivo.

1 reference

12 December 2020

Amyloid precursor protein cleavage-dependent and -independent axonal degeneration programs share a common nicotinamide mononucleotide adenylyltransferase 1-sensitive pathway

1 reference

12 December 2020

Axonal degeneration is mediated by the mitochondrial permeability transition pore.

1 reference

12 December 2020

Control of nonapoptotic developmental cell death in Caenorhabditis elegans by a polyglutamine-repeat protein

1 reference

12 December 2020

dSarm/Sarm1 is required for activation of an injury-induced axon death pathway

1 reference

12 December 2020

Dual leucine zipper kinase is required for retrograde injury signaling and axonal regeneration

1 reference

12 December 2020

SCG10 is a JNK target in the axonal degeneration pathway.

1 reference

12 December 2020

The Highwire ubiquitin ligase promotes axonal degeneration by tuning levels of Nmnat protein

1 reference

12 December 2020

Activation of the innate signaling molecule MAVS by bunyavirus infection upregulates the adaptor protein SARM1, leading to neuronal death

1 reference

12 December 2020

Subcellular localization determines the stability and axon protective capacity of axon survival factor Nmnat2.

1 reference

12 December 2020

The Phr1 ubiquitin ligase promotes injury-induced axon self-destruction

1 reference

12 December 2020

Sarm1-mediated axon degeneration requires both SAM and TIR interactions

1 reference

12 December 2020

Sodium and potassium currents influence Wallerian degeneration of injured Drosophila axons.

1 reference

12 December 2020

Neuropathic pain: mechanisms and their clinical implications

1 reference

12 December 2020

Chemotherapy-induced peripheral neuropathy in adults: a comprehensive update of the literature.

1 reference

12 December 2020

Wallerian degeneration: an emerging axon death pathway linking injury and disease

1 reference

12 December 2020

SkpA restrains synaptic terminal growth during development and promotes axonal degeneration following injury

1 reference

12 December 2020

Mitochondrial dysfunction induces Sarm1-dependent cell death in sensory neurons

1 reference

12 December 2020

Preserve and protect: maintaining axons within functional circuits

1 reference

12 December 2020

Pathological axonal death through a MAPK cascade that triggers a local energy deficit

1 reference

12 December 2020

Cytoskeletal disruption activates the DLK/JNK pathway, which promotes axonal regeneration and mimics a preconditioning injury.

1 reference

12 December 2020

Absence of SARM1 rescues development and survival of NMNAT2-deficient axons

1 reference

12 December 2020

SARM1 activation triggers axon degeneration locally via NAD⁺ destruction

1 reference

12 December 2020

Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12)

1 reference

12 December 2020

Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism

1 reference

12 December 2020

Axon Degeneration Gated by Retrograde Activation of Somatic Pro-apoptotic Signaling.

1 reference

12 December 2020

Attenuated traumatic axonal injury and improved functional outcome after traumatic brain injury in mice lacking Sarm1.

1 reference

12 December 2020

Sirtuin inhibitors: An overview from medicinal chemistry perspective

1 reference

12 December 2020

TMEM184b Promotes Axon Degeneration and Neuromuscular Junction Maintenance

1 reference

12 December 2020

Axon degeneration: context defines distinct pathways

1 reference

12 December 2020

SARM1-specific motifs in the TIR domain enable NAD+ loss and regulate injury-induced SARM1 activation

1 reference

12 December 2020

An Atypical SCF-like Ubiquitin Ligase Complex Promotes Wallerian Degeneration through Regulation of Axonal Nmnat2.

1 reference

12 December 2020

NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion.

1 reference

12 December 2020

Prevention of vincristine-induced peripheral neuropathy by genetic deletion of SARM1 in mice.

1 reference

12 December 2020

GSK3B-mediated phosphorylation of MCL1 regulates axonal autophagy to promote Wallerian degeneration.

1 reference

12 December 2020

MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2.

1 reference

12 December 2020

An integrated perspective on diabetic, alcoholic, and drug-induced neuropathy, etiology, and treatment in the US.

1 reference

12 December 2020

Screening with an NMNAT2-MSD platform identifies small molecules that modulate NMNAT2 levels in cortical neurons

1 reference

12 December 2020

PARP inhibitors: Synthetic lethality in the clinic

1 reference

12 December 2020

The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD+ Cleavage Activity that Promotes Pathological Axonal Degeneration.

1 reference

12 December 2020

Deletion of Sarm1 gene is neuroprotective in two models of peripheral neuropathy

1 reference

12 December 2020

Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons.

1 reference

12 December 2020

Axon Death Pathways Converge on Axundead to Promote Functional and Structural Axon Disassembly.

1 reference

12 December 2020

Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease

1 reference

12 December 2020

A Mechanistic Understanding of Axon Degeneration in Chemotherapy-Induced Peripheral Neuropathy

1 reference

12 December 2020

Sarm1 Deletion, but Not WldS, Confers Lifelong Rescue in a Mouse Model of Severe Axonopathy

1 reference

12 December 2020

Paclitaxel Reduces Axonal Bclw to Initiate IP3R1-Dependent Axon Degeneration

1 reference

12 December 2020

NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR.

1 reference

12 December 2020

Transcription factor Pebbled/RREB1 regulates injury-induced axon degeneration

1 reference

12 December 2020

TIR Domain Proteins Are an Ancient Family of NAD+-Consuming Enzymes.

1 reference

12 December 2020

Intrinsic Neuronal Stress Response Pathways in Injury and Disease.

1 reference

12 December 2020

Incidence and disease burden of chemotherapy-induced peripheral neuropathy in a population-based cohort.

1 reference

12 December 2020

Primary traumatic axonopathy in mice subjected to impact acceleration: a reappraisal of pathology and mechanisms with high-resolution anatomical methods.

1 reference

12 December 2020

PAM forms an atypical SCF ubiquitin ligase complex that ubiquitinates and degrades NMNAT2

1 reference

12 December 2020

An axonal stress response pathway: degenerative and regenerative signaling by DLK

1 reference

12 December 2020

Palmitoylation enables MAPK-dependent proteostasis of axon survival factors

1 reference

12 December 2020

An updated understanding of the mechanisms involved in chemotherapy-induced neuropathy

1 reference

12 December 2020

Pharmacological bypass of NAD salvage pathway protects neurons from chemotherapy-induced degeneration

1 reference

12 December 2020

Therapeutic opportunities and pitfalls in the treatment of axon degeneration

1 reference

12 December 2020

Death, TIR, and RHIM: Self-assembling domains involved in innate immunity and cell-death signaling

1 reference

12 December 2020

Gene therapy targeting SARM1 blocks pathological axon degeneration in mice

1 reference

12 December 2020

10.1097/J.PAIN.0000000000001528

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6481657&resulttype=core&format=json

14 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6481657&resulttype=core&format=json

14 May 2020

PubMed publication ID

31008845

1 reference