(Q90633426)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31601026%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

title

A Smo/Gli Multitarget Hedgehog Pathway Inhibitor Impairs Tumor Growth (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31601026%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

5

1 reference

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15 April 2020

Mattia Mori

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31601026%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

author name string

Ludovica Lospinoso Severini

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31601026%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

Deborah Quaglio

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31601026%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

Irene Basili

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31601026%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

Francesca Ghirga

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31601026%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

Miriam Caimano

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31601026%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

Silvia Balducci

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31601026%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

Marta Moretti

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31601026%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

Isabella Romeo

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31601026%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

Elena Loricchio

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31601026%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

Marella Maroder

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31601026%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

Bruno Botta

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31601026%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

Paola Infante

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31601026%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

Lucia Di Marcotullio

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31601026%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

publication date

9 October 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31601026%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31601026%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

volume

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31601026%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

issue

10

1 reference

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Creative Commons Attribution 4.0 International

15 April 2020

copyright license

start time

9 October 2019

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6826940/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Identification of an amplified, highly expressed gene in a human glioma

1 reference

12 December 2020

Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers

1 reference

12 December 2020

Altered neural cell fates and medulloblastoma in mouse patched mutants

1 reference

12 December 2020

The developmental biology of brain tumors.

1 reference

12 December 2020

Mutations in SUFU predispose to medulloblastoma

1 reference

12 December 2020

Improved protein-ligand docking using GOLD

1 reference

12 December 2020

Regulation of Gli1 localization by the cAMP/protein kinase A signaling axis through a site near the nuclear localization signal

1 reference

12 December 2020

Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination.

1 reference

12 December 2020

The Gli code: an information nexus regulating cell fate, stemness and cancer.

1 reference

12 December 2020

Medulloblastoma in childhood: new biological advances

1 reference

12 December 2020

Hedgehog: functions and mechanisms

1 reference

12 December 2020

Pediatric medulloblastoma: toxicity of current treatment and potential role of protontherapy

1 reference

12 December 2020

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449

1 reference

12 December 2020

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

1 reference

12 December 2020

Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation

1 reference

12 December 2020

Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal

1 reference

12 December 2020

Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma.

1 reference

12 December 2020

FRED pose prediction and virtual screening accuracy

1 reference

12 December 2020

Hedgehog fights back: mechanisms of acquired resistance against Smoothened antagonists

1 reference

12 December 2020

Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples

1 reference

12 December 2020

Hedgehog/Gli control by ubiquitination/acetylation interplay.

1 reference

12 December 2020

The crosstalk of mTOR/S6K1 and Hedgehog pathways

1 reference

12 December 2020

1 reference

12 December 2020

FRED and HYBRID docking performance on standardized datasets.

1 reference

12 December 2020

Inhibiting the hedgehog pathway in patients with the basal-cell nevus syndrome

1 reference

12 December 2020

The Hedgehog signal transduction network

1 reference

12 December 2020

The mechanisms of Hedgehog signalling and its roles in development and disease

1 reference

12 December 2020

PCAF ubiquitin ligase activity inhibits Hedgehog/Gli1 signaling in p53-dependent response to genotoxic stress

1 reference

12 December 2020

Personalizing the treatment of pediatric medulloblastoma: Polo-like kinase 1 as a molecular target in high-risk children

1 reference

12 December 2020

Neuropilin-2 contributes to tumorigenicity in a mouse model of Hedgehog pathway medulloblastoma

1 reference

12 December 2020

Unraveling the therapeutic potential of the Hedgehog pathway in cancer

1 reference

12 December 2020

Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography

1 reference

12 December 2020

Targeting of Smoothened for therapeutic gain

1 reference

12 December 2020

1 reference

12 December 2020

Context-dependent signal integration by the GLI code: the oncogenic load, pathways, modifiers and implications for cancer therapy

1 reference

12 December 2020

Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition

1 reference

12 December 2020

Isoflavones: chemistry, analysis, functions and effects on health and cancer

1 reference

12 December 2020

Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors.

1 reference

12 December 2020

β-Catenin-Gli1 interaction regulates proliferation and tumor growth in medulloblastoma.

1 reference

12 December 2020

Cooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapy

1 reference

12 December 2020

Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma

1 reference

12 December 2020

Smoothened variants explain the majority of drug resistance in basal cell carcinoma

1 reference

12 December 2020

Targeting GLI factors to inhibit the Hedgehog pathway.

1 reference

12 December 2020

Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032.

1 reference

12 December 2020

Non-Canonical Hh Signaling in Cancer-Current Understanding and Future Directions

1 reference

12 December 2020

Targeting the Hedgehog Pathway in Pediatric Medulloblastoma

1 reference

12 December 2020

In vitro models of medulloblastoma: Choosing the right tool for the job

1 reference

12 December 2020

Hedgehog Signal Transduction: Key Players, Oncogenic Drivers, and Cancer Therapy

1 reference

12 December 2020

Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype

1 reference

12 December 2020

Development of anticancer agents targeting the Hedgehog signaling

1 reference

12 December 2020

Strategies to target the Hedgehog signaling pathway for cancer therapy.

1 reference

12 December 2020

Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61.

1 reference

12 December 2020

Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis.

1 reference

12 December 2020

Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold

1 reference

12 December 2020

Current trends in Hedgehog signaling pathway inhibition by small molecules

1 reference

12 December 2020

Targeting the Oncoprotein Smoothened by Small Molecules: Focus on Novel Acylguanidine Derivatives as Potent Smoothened Inhibitors

1 reference

12 December 2020

Natural Products Inspired Modulators of Cancer Stem Cells-specific Signaling Pathways Notch and Hedgehog

1 reference

12 December 2020

Targeting Hedgehog Signalling through the Ubiquitylation Process: The Multiple Roles of the HECT-E3 Ligase Itch

1 reference

12 December 2020

1 reference

12 December 2020

Non-canonical Hedgehog Signaling Pathway in Cancer: Activation of GLI Transcription Factors Beyond Smoothened.

1 reference

12 December 2020

ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP

1 reference

12 December 2020

Identifiers

DOI

10.3390/CANCERS11101518

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31601026%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31601026%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

1 reference