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Principles of allosteric interactions in cell signaling
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26 August 2020
title
Principles of allosteric interactions in cell signaling
(English)
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main subject
signal transduction
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PubMed
retrieved
26 August 2020
author
Ruth Nussinov
series ordinal
1
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Jin Liu
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Jin Liu
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3
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Chung-Jung Tsai
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2
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Chung-Jung Tsai
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language of work or name
English
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publication date
24 December 2014
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PubMed
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PubMed Central
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26 August 2020
published in
Journal of the American Chemical Society
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PubMed
stated in
PubMed Central
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26 August 2020
volume
136
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PubMed
issue
51
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PubMed
page(s)
17692-701
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PubMed
cites work
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
28 September 2017
The mechanism of ubiquitination in the cullin-RING E3 ligase machinery: conformational control of substrate orientation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
28 September 2017
'7TM receptor allostery: putting numbers to shapeshifting proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
28 September 2017
Measurement of methyl group motional parameters of invisible, excited protein states by NMR spectroscopy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
28 September 2017
The origin of allosteric functional modulation: multiple pre-existing pathways
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
28 September 2017
Specific phosphorylation and activation of ERK1c by MEK1b: a unique route in the ERK cascade
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
28 September 2017
DNA-binding specificity and in vivo targets of Caenorhabditis elegans nuclear factor I.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
28 September 2017
Inhibitor hijacking of Akt activation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
28 September 2017
Controlling proteins through molecular springs
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
28 September 2017
Frameworks for understanding long-range intra-protein communication
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
28 September 2017
Protein allostery, signal transmission and dynamics: a classification scheme of allosteric mechanisms
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
28 September 2017
Visualizing lowly-populated regions of the free energy landscape of macromolecular complexes by paramagnetic relaxation enhancement
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
28 September 2017
Allosteric regulation and catalysis emerge via a common route.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
28 September 2017
Allostery and cooperativity revisited
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
28 September 2017
Energy flow in proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
28 September 2017
Allostery: absence of a change in shape does not imply that allostery is not at play
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
28 September 2017
Probing invisible, low-populated States of protein molecules by relaxation dispersion NMR spectroscopy: an application to protein folding
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
28 September 2017
Allosteric effects in the marginally stable von Hippel-Lindau tumor suppressor protein and allostery-based rescue mutant design
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
28 September 2017
Intrinsic disorder as a mechanism to optimize allosteric coupling in proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
28 September 2017
Signal amplification by allosteric catalysis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
28 September 2017
The role of DNA response elements as allosteric modulators of steroid receptor function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
28 September 2017
Functional dynamics of PDZ binding domains: a normal-mode analysis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
28 September 2017
Is allostery an intrinsic property of all dynamic proteins?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
28 September 2017
Mechanism of the nuclear receptor molecular switch
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
28 September 2017
Multiple diverse ligands binding at a single protein site: a matter of pre-existing populations
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
28 September 2017
Structured disorder and conformational selection
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
28 September 2017
Molecular recognition by induced fit: how fit is the concept?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
28 September 2017
Two classes of androgen receptor elements mediate cooperativity through allosteric interactions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
28 September 2017
Folding and binding cascades: dynamic landscapes and population shifts
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
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28 September 2017
Folding funnels and binding mechanisms
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
28 September 2017
Folding and binding cascades: shifts in energy landscapes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
28 September 2017
Folding funnels, binding funnels, and protein function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
28 September 2017
Estrogen response elements function as allosteric modulators of estrogen receptor conformation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
28 September 2017
Navigating the folding routes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
28 September 2017
Allosterically tunable, DNA-based switches triggered by heavy metals.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
31 May 2018
An interdomain energetic tug-of-war creates the allosterically active state in Hsp70 molecular chaperones
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
31 May 2018
Using distal-site mutations and allosteric inhibition to tune, extend, and narrow the useful dynamic range of aptamer-based sensors.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
31 May 2018
Evolving a robust signal transduction pathway from weak cross-talk
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
31 May 2018
p53 activates transcription by directing structural shifts in Mediator
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
31 May 2018
Transient non-native hydrogen bonds promote activation of a signaling protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
31 May 2018
Surface sites for engineering allosteric control in proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
31 May 2018
Using the population-shift mechanism to rationally introduce "Hill-type" cooperativity into a normally non-cooperative receptor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
28 November 2018
Evolutionarily distinct versions of the multidomain enzyme α-isopropylmalate synthase share discrete mechanisms of V-type allosteric regulation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
28 November 2018
Atomistic kinetic model for population shift and allostery in biomolecules.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
28 November 2018
Allo-network drugs: harnessing allostery in cellular networks
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
28 November 2018
During transitions proteins make fleeting bonds.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
28 November 2018
Intramolecular signaling pathways revealed by modeling anisotropic thermal diffusion
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
retrieved
28 November 2018
Modeling the functional effects of allosteric modulators at pharmacological receptors: an extension of the two-state model of receptor activation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291754
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28 November 2018
Molecular basis for the pH dependent structural transition of Nitrophorin 4
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PubMed
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https://pubmed.ncbi.nlm.nih.gov/25474128
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Allosteric Effects Govern Nuclear Receptor Action: DNA Appears as a Player
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25474128
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identification of specificity and promiscuity of PDZ domain interactions through their dynamic behavior
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25474128
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Pump-probe molecular dynamics as a tool for studying protein motion and long range coupling
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25474128
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1021/JA510028C
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1083234
OpenCitations bibliographic resource ID
1083234
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1083234
PMC publication ID
4291754
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1083234
PubMed publication ID
25474128
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1083234
ResearchGate publication ID
269181451
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