(Q27006839)

title

Hijacked in cancer: the KMT2 (MLL) family of methyltransferases (English)

0 references

language of work or name

1 reference

June 2015

1 reference

published in

Nature Reviews Cancer

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25998713%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

volume

15

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25998713%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

issue

6

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25998713%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

page(s)

334-346

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25998713%20AND%20SRC:MED&resulttype=core&format=json

Proteasome inhibitors evoke latent tumor suppression programs in pro-B MLL leukemias through MLL-AF4

12 June 2020

cites work

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TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS

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CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis

21 March 2017

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Exome sequencing identifies MLL2 mutations as a cause of Kabuki syndrome

21 March 2017

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The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis

21 March 2017

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Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression

21 March 2017

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A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription

21 March 2017

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On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex

21 March 2017

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21 March 2017

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21 March 2017

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21 March 2017

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The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex

21 March 2017

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DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA

21 March 2017

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PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex

21 March 2017

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Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex

21 March 2017

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Solution structure of the nonmethyl-CpG-binding CXXC domain of the leukaemia-associated MLL histone methyltransferase

21 March 2017

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Structural basis for molecular recognition and presentation of histone H3 by WDR5

21 March 2017

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Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis

21 March 2017

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Identification of the MLL2 complex as a coactivator for estrogen receptor alpha

21 March 2017

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A genome-wide analysis of CpG dinucleotides in the human genome distinguishes two distinct classes of promoters

21 March 2017

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The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression

21 March 2017

1 reference

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The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription

21 March 2017

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Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF

21 March 2017

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Global and Hox-specific roles for the MLL1 methyltransferase

21 March 2017

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Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors

21 March 2017

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Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus

21 March 2017

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21 March 2017

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Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins

21 March 2017

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Translating the Histone Code

21 March 2017

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21 March 2017

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21 March 2017

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Structural Basis for WDR5 Interaction (Win) Motif Recognition in Human SET1 Family Histone Methyltransferases

21 March 2017

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The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases

21 March 2017

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Structure of the SPRY domain of human Ash2L and its interactions with RbBP5 and DPY30

21 March 2017

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Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

21 March 2017

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Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding

21 March 2017

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Crystal structure of the trithorax group protein ASH2L reveals a forkhead-like DNA binding domain

21 March 2017

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21 March 2017

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MLL2 is required in oocytes for bulk histone 3 lysine 4 trimethylation and transcriptional silencing

21 March 2017

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Structure of the MLL CXXC domain-DNA complex and its functional role in MLL-AF9 leukemia.

21 March 2017

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Structure of WDR5 bound to mixed lineage leukemia protein-1 peptide

21 March 2017

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21 March 2017

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21 March 2017

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21 March 2017

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7 April 2017

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21 March 2017

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21 March 2017

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Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4

21 March 2017

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Wdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network

21 March 2017

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Misguided transcriptional elongation causes mixed lineage leukemia

21 March 2017

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The H3K4 methyltransferase Setd1a is first required at the epiblast stage, whereas Setd1b becomes essential after gastrulation

21 March 2017

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Mutations in Mll2, an H3K4 methyltransferase, result in insulin resistance and impaired glucose tolerance in mice

21 March 2017

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Histone and DNA methylation defects at Hox genes in mice expressing a SET domain-truncated form of Mll.

21 March 2017

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Multiple epigenetic maintenance factors implicated by the loss of Mll2 in mouse development

21 March 2017

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MLL targets SET domain methyltransferase activity to Hox gene promoters

21 March 2017

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Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

21 March 2017

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Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases

22 April 2017

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hDOT1L links histone methylation to leukemogenesis

22 April 2017

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How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers

22 April 2017

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RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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Altered Hox expression and segmental identity in Mll-mutant mice

7 April 2017

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AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes.

7 April 2017

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The same site on the integrase-binding domain of lens epithelium-derived growth factor is a therapeutic target for MLL leukemia and HIV.

28 September 2017

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Histone deacetylase inhibition rescues structural and functional brain deficits in a mouse model of Kabuki syndrome

28 September 2017

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Immunogenetics. Chromatin state dynamics during blood formation

28 September 2017

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DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier

28 September 2017

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Loss-of-function variants in schizophrenia risk and SETD1A as a candidate susceptibility gene

28 September 2017

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MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

A non-active-site SET domain surface crucial for the interaction of MLL1 and the RbBP5/Ash2L heterodimer within MLL family core complexes

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Feedback control of Set1 protein levels is important for proper H3K4 methylation patterns.

28 September 2017

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Essential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency

28 September 2017

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UTX and MLL4 coordinately regulate transcriptional programs for cell proliferation and invasiveness in breast cancer cells

28 September 2017

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28 September 2017

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H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation

28 September 2017

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KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Automethylation activities within the mixed lineage leukemia-1 (MLL1) core complex reveal evidence supporting a "two-active site" model for multiple histone H3 lysine 4 methylation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

MLL becomes functional through intra-molecular interaction not by proteolytic processing

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Functional specificity of CpG DNA-binding CXXC domains in mixed lineage leukemia.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

HGF-MET signals via the MLL-ETS2 complex in hepatocellular carcinoma

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

USF1 and hSET1A mediated epigenetic modifications regulate lineage differentiation and HoxB4 transcription

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Modification of enhancer chromatin: what, how, and why?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

The Drosophila ortholog of MLL3 and MLL4, trithorax related, functions as a negative regulator of tissue growth

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

ASH2L regulates ubiquitylation signaling to MLL: trans-regulation of H3 K4 methylation in higher eukaryotes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Genetic syndromes caused by mutations in epigenetic genes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Trans-tail regulation of MLL4-catalyzed H3K4 methylation by H4R3 symmetric dimethylation is mediated by a tandem PHD of MLL4

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Global identification of MLL2-targeted loci reveals MLL2's role in diverse signaling pathways

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Histone methylase MLL1 has critical roles in tumor growth and angiogenesis and its knockdown suppresses tumor growth in vivo

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

TrxG and PcG proteins but not methylated histones remain associated with DNA through replication

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Carm1 regulates Pax7 transcriptional activity through MLL1/2 recruitment during asymmetric satellite stem cell divisions

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Cfp1 integrates both CpG content and gene activity for accurate H3K4me3 deposition in embryonic stem cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

De novo mutations in MLL cause Wiedemann-Steiner syndrome

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Disruption of an EHMT1-associated chromatin-modification module causes intellectual disability

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Epigenomic enhancer profiling defines a signature of colon cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Enhancers as information integration hubs in development: lessons from genomics.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Knockdown of menin affects pre-mRNA processing and promoter fidelity at the interferon-gamma inducible IRF1 gene

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

ECSASB2 mediates MLL degradation during hematopoietic differentiation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Structural analysis of the core COMPASS family of histone H3K4 methylases from yeast to human

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

HOXC10 is overexpressed in breast cancer and transcriptionally regulated by estrogen via involvement of histone methylases MLL3 and MLL4.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Grasping trimethylation of histone H3 at lysine 4.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Trithorax group proteins: switching genes on and keeping them active

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Histone H2B ubiquitylation and H3 lysine 4 methylation prevent ectopic silencing of euchromatic loci important for the cellular response to heat.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

NF-Y recruits Ash2L to impart H3K4 trimethylation on CCAAT promoters

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Cancer epigenetics reaches mainstream oncology

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

An Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domain

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Histone deacetylase inhibitors stimulate histone H3 lysine 4 methylation in part via transcriptional repression of histone H3 lysine 4 demethylases

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Regulating a master regulator: establishing tissue-specific gene expression in skeletal muscle

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

CpG islands influence chromatin structure via the CpG-binding protein Cfp1.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

The histone 3 lysine 4 methyltransferase, Mll2, is only required briefly in development and spermatogenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Therapeutic targeting of MLL.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

MLL5, a trithorax homolog, indirectly regulates H3K4 methylation, represses cyclin A2 expression, and promotes myogenic differentiation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

A conserved arginine-containing motif crucial for the assembly and enzymatic activity of the mixed lineage leukemia protein-1 core complex

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Menin critically links MLL proteins with LEDGF on cancer-associated target genes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Transcription factor Ap2delta associates with Ash2l and ALR, a trithorax family histone methyltransferase, to activate Hoxc8 transcription

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

MLL protects CpG clusters from methylation within the Hoxa9 gene, maintaining transcript expression.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Malignant transformation initiated by Mll-AF9: gene dosage and critical target cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Risk of malignancy in patients with schizophrenia or bipolar disorder: nested case-control study

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Increased apoptosis and skewed differentiation in mouse embryonic stem cells lacking the histone methyltransferase Mll2.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Molecular regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Molecular recognition of histone H3 by the WD40 protein WDR5.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Regulation of DNA-dependent activities by the functional motifs of the high-mobility-group chromosomal proteins

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

11q23 translocations split the "AT-hook" cruciform DNA-binding region and the transcriptional repression domain from the activation domain of the mixed-lineage leukemia (MLL) gene

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

The histone methyltransferase activity of MLL1 is dispensable for hematopoiesis and leukemogenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Combinatorial effects of multiple enhancer variants in linkage disequilibrium dictate levels of gene expression to confer susceptibility to common traits

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Regulation of transcription by the MLL2 complex and MLL complex-associated AKAP95.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Analysis of the binding of mixed lineage leukemia 1 (MLL1) and histone 3 peptides to WD repeat domain 5 (WDR5) for the design of inhibitors of the MLL1-WDR5 interaction

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

A reconfigured pattern of MLL occupancy within mitotic chromatin promotes rapid transcriptional reactivation following mitotic exit.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Bimodal degradation of MLL by SCFSkp2 and APCCdc20 assures cell cycle execution: a critical regulatory circuit lost in leukemogenic MLL fusions

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Inter-chromosomal recombination of Mll and Af9 genes mediated by cre-loxP in mouse development.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

The SUMO-specific isopeptidase SENP3 regulates MLL1/MLL2 methyltransferase complexes and controls osteogenic differentiation.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Histone-methyltransferase MLL2 (KMT2B) is required for memory formation in mice.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

The histone methyltransferase Wbp7 controls macrophage function through GPI glycolipid anchor synthesis.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

XUTs are a class of Xrn1-sensitive antisense regulatory non-coding RNA in yeast.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

The leukemogenic AF4-MLL fusion protein causes P-TEFb kinase activation and altered epigenetic signatures.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

The AF4.MLL fusion protein is capable of inducing ALL in mice without requirement of MLL.AF4.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Alterations of the CxxC domain preclude oncogenic activation of mixed-lineage leukemia 2.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Mll has a critical role in fetal and adult hematopoietic stem cell self-renewal.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

E2F activation of S phase promoters via association with HCF-1 and the MLL family of histone H3K4 methyltransferases.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Defects in yolk sac hematopoiesis in Mll-null embryos.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493861

Cloning of cDNAs of the MLL gene that detect DNA rearrangements and altered RNA transcripts in human leukemic cells with 11q23 translocations

28 November 2018

1 reference

A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias

31 March 2020

1 reference

Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex

31 March 2020

1 reference

The LxxLL motif: a multifunctional binding sequence in transcriptional regulation

31 March 2020

1 reference

Hoxa9 influences the phenotype but not the incidence of Mll-AF9 fusion gene leukemia

31 March 2020

1 reference

Secondary acute myeloblastic leukemia with a Ph translocation in a treated Wegener's granulomatosis

31 March 2020

1 reference

H3K79 methylation profiles define murine and human MLL-AF4 leukemias

31 March 2020

1 reference

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRC3929

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25998713%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

12 June 2020

1050404447

0 references

Fatcat ID

release_sfirwl7lr5h27dvyjuqmihrnn4

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25998713%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

2 references