(Q28258028)

Murine leukemia virus-induced T-cell lymphomagenesis: Integration of proviruses in a distinct chromosomal region

21 January 2018

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KID-1, a protein kinase induced by depolarization in brain

21 January 2018

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High-throughput retroviral tagging to identify components of specific signaling pathways in cancer.

21 January 2018

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Predisposition to lymphomagenesis in pim-1 transgenic mice: cooperation with c-myc and N-myc in murine leukemia virus-induced tumors

21 January 2018

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The PIM-1 serine kinase prolongs survival and inhibits apoptosis-related mitochondrial dysfunction in part through a bcl-2-dependent pathway

21 January 2018

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Pim-1 kinase protects hematopoietic FDC cells from genotoxin-induced death

21 January 2018

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Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

21 January 2018

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Delineation of prognostic biomarkers in prostate cancer

21 January 2018

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The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias

21 January 2018

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Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations

21 January 2018

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Protein synthesis is resistant to rapamycin and constitutes a promising therapeutic target in acute myeloid leukemia.

21 January 2018

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Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival

21 January 2018

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Increased expression of the hPim-2 gene in human chronic lymphocytic leukemia and non-Hodgkin lymphoma

21 January 2018

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Gene expression signatures separate B-cell chronic lymphocytic leukaemia prognostic subgroups defined by ZAP-70 and CD38 expression status.

21 January 2018

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Growth and survival mechanisms associated with perineural invasion in prostate cancer

21 January 2018

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PIM3 proto-oncogene kinase is a common transcriptional target of divergent EWS/ETS oncoproteins

21 January 2018

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Aberrant expression of serine/threonine kinase Pim-3 in hepatocellular carcinoma development and its role in the proliferation of human hepatoma cell lines.

21 January 2018

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Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates bad to block bad-mediated apoptosis in human pancreatic cancer cell lines

21 January 2018

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Aberrant Pim-3 expression is involved in gastric adenoma-adenocarcinoma sequence and cancer progression

21 January 2018

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For better or for worse: the role of Pim oncogenes in tumorigenesis

21 January 2018

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The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor

21 January 2018

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A testis-expressed Zn finger gene (ZNF76) in human 6p21.3 centromeric to the MHC is closely linked to the human homolog of the t-complex gene tcp-11

21 January 2018

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Structural basis of constitutive activity and a unique nucleotide binding mode of human Pim-1 kinase

21 January 2018

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Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors

21 January 2018

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Pim-1 regulates cardiomyocyte survival downstream of Akt.

21 January 2018

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Identification of Flk-1 target genes in vasculogenesis: Pim-1 is required for endothelial and mural cell differentiation in vitro.

21 January 2018

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Pim-1 kinase expression during murine mammary development

21 January 2018

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The survival kinases Akt and Pim as potential pharmacological targets

21 January 2018

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Maximal STAT5-induced proliferation and self-renewal at intermediate STAT5 activity levels

21 January 2018

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Novel NEMO/IkappaB kinase and NF-kappa B target genes at the pre-B to immature B cell transition

21 January 2018

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Hypoxia-mediated up-regulation of Pim-1 contributes to solid tumor formation

21 January 2018

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IL-4 signaling is regulated through the recruitment of phosphatases, kinases, and SOCS proteins to the receptor complex

21 January 2018

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Pim serine/threonine kinases regulate the stability of Socs-1 protein

21 January 2018

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Pim-1 kinase inhibits STAT5-dependent transcription via its interactions with SOCS1 and SOCS3.

21 January 2018

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Structure and substrate specificity of the Pim-1 kinase

21 January 2018

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Identification of the autophosphorylation sites of the Xenopus laevis Pim-1 proto-oncogene-encoded protein kinase.

21 January 2018

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Pim-1 kinase stability is regulated by heat shock proteins and the ubiquitin-proteasome pathway

21 January 2018

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Regulation of Pim-1 by Hsp90

21 January 2018

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Down-regulation of micro-RNA-1 (miR-1) in lung cancer. Suppression of tumorigenic property of lung cancer cells and their sensitization to doxorubicin-induced apoptosis by miR-1

21 January 2018

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Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation.

21 January 2018

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Protein phosphatase 2A regulates the stability of Pim protein kinases

21 January 2018

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Negative regulation of Pim-1 protein kinase levels by the B56beta subunit of PP2A.

21 January 2018

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In vivo analysis of Pim-1 deficiency

21 January 2018

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Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase

21 January 2018

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Pim-1 kinase and p100 cooperate to enhance c-Myb activity

21 January 2018

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Pim-1 associates with protein complexes necessary for mitosis

21 January 2018

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Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels

21 January 2018

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The oncogenic serine/threonine kinase Pim-1 phosphorylates and inhibits the activity of Cdc25C-associated kinase 1 (C-TAK1): a novel role for Pim-1 at the G2/M cell cycle checkpoint

21 January 2018

1 reference

Physical and functional interactions between Pim-1 kinase and Cdc25A phosphatase. Implications for the Pim-1-mediated activation of the c-Myc signaling pathway

21 January 2018

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Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis.

21 January 2018

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21 January 2018

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PIM1-dependent phosphorylation of histone H3 at serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformation.

21 January 2018

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Pim kinase-dependent inhibition of c-Myc degradation

21 January 2018

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Histone crosstalk between H3S10ph and H4K16ac generates a histone code that mediates transcription elongation

21 January 2018

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Pim1 kinase synergizes with c-MYC to induce advanced prostate carcinoma

21 January 2018

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Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1(1)

21 January 2018

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PAP-1, a novel target protein of phosphorylation by pim-1 kinase

21 January 2018

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Pim-1 translocates sorting nexin 6/TRAF4-associated factor 2 from cytoplasm to nucleus

21 January 2018

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IL-3 induces a Pim1-dependent antiapoptotic pathway in primary human basophils

21 January 2018

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BAD: undertaker by night, candyman by day.

21 January 2018

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The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death

21 January 2018

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Pim-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper site

21 January 2018

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Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL

21 January 2018

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

21 January 2018

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Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

21 January 2018

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BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis

21 January 2018

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PIM1 protein kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells

21 January 2018

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PIM1 phosphorylates and negatively regulates ASK1-mediated apoptosis

21 January 2018

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Lymphocyte transformation by Pim-2 is dependent on nuclear factor-kappaB activation

21 January 2018

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Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival

21 January 2018

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Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription

21 January 2018

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Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects

21 January 2018

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Elevated levels of oncogenic protein kinase Pim-1 induce the p53 pathway in cultured cells and correlate with increased Mdm2 in mantle cell lymphoma.

21 January 2018

1 reference

Mammalian target of rapamycin: discovery of rapamycin reveals a signaling pathway important for normal and cancer cell growth

21 January 2018

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mTOR signaling at a glance

21 January 2018

1 reference

The Pim kinases control rapamycin-resistant T cell survival and activation

21 January 2018

1 reference

The Pim protein kinases regulate energy metabolism and cell growth

21 January 2018

1 reference

Targeting multidrug resistance in cancer

21 January 2018

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Hypoxia signalling controls metabolic demand

21 January 2018

1 reference

Signal transducer and activator of transcription 3 is required for hypoxia-inducible factor-1alpha RNA expression in both tumor cells and tumor-associated myeloid cells

21 January 2018

1 reference

STAT3 inhibitor WP1066 as a novel therapeutic agent for renal cell carcinoma

21 January 2018

1 reference

PO(2)-dependent differential regulation of multidrug resistance 1 gene expression by the c-Jun NH2-terminal kinase pathway

21 January 2018

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Hypoxia-mediated drug resistance: novel insights on the functional interaction of HIFs and cell death pathways

21 January 2018

1 reference

Pim-1 plays a pivotal role in hypoxia-induced chemoresistance.

21 January 2018

1 reference

Malignant transformation initiated by Mll-AF9: gene dosage and critical target cells

21 January 2018

1 reference

Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival

21 January 2018

1 reference

Pim2 complements Flt3 wild-type receptor in hematopoietic progenitor cell transformation.

21 January 2018

1 reference

Evidence that the Pim1 kinase gene is a direct target of HOXA9

21 January 2018

1 reference

Ki67 and PIM1 expression predict outcome in mantle cell lymphoma treated with high dose therapy, stem cell transplantation and rituximab: a Cancer and Leukemia Group B 59909 correlative science study

21 January 2018

1 reference

Microarray-based classification of diffuse large B-cell lymphoma

21 January 2018

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A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma

21 January 2018

1 reference

Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration

21 January 2018

1 reference

CXCR4 is a prognostic marker in acute myelogenous leukemia.

21 January 2018

1 reference

How do stem cells find their way home?

21 January 2018

1 reference

Regulation of CXCR4 signaling

21 January 2018

1 reference

Complementary functions of the antiapoptotic protein A1 and serine/threonine kinase pim-1 in the BCR/ABL-mediated leukemogenesis

21 January 2018

1 reference

Targeting PIM kinases impairs survival of hematopoietic cells transformed by kinase inhibitor-sensitive and kinase inhibitor-resistant forms of Fms-like tyrosine kinase 3 and BCR/ABL.

21 January 2018

1 reference

The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenes

21 January 2018

1 reference

Pim-1 and Pim-2 kinases are required for efficient pre-B-cell transformation by v-Abl oncogene

21 January 2018

1 reference

PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers

21 January 2018

1 reference

Aberrant somatic hypermutation in multiple subtypes of AIDS-associated non-Hodgkin lymphoma

21 January 2018

1 reference

Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma

21 January 2018

1 reference

Pim kinases are upregulated during Epstein-Barr virus infection and enhance EBNA2 activity

21 January 2018

1 reference

KSHV encoded LANA upregulates Pim-1 and is a substrate for its kinase activity

21 January 2018

1 reference

KSHV reactivation from latency requires Pim-1 and Pim-3 kinases to inactivate the latency-associated nuclear antigen LANA

21 January 2018

1 reference

Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002.

21 January 2018

1 reference

Structural analysis identifies imidazo[1,2-b]pyridazines as PIM kinase inhibitors with in vitro antileukemic activity

21 January 2018

1 reference

The oncogenic PIM kinase family regulates drug resistance through multiple mechanisms

21 January 2018

1 reference

Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor

21 January 2018

1 reference

Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase

21 January 2018

1 reference

Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase

21 January 2018

1 reference

Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase

21 January 2018

1 reference

Comparative molecular field analysis of flavonoid inhibitors of the PIM-1 kinase

21 January 2018

1 reference

A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases

21 January 2018

1 reference

Ruthenium half-sandwich complexes as protein kinase inhibitors: an N-succinimidyl ester for rapid derivatizations of the cyclopentadienyl moiety

21 January 2018

1 reference

Structure-based design of 3-aryl-6-amino-triazolo[4,3-b]pyridazine inhibitors of Pim-1 kinase

21 January 2018

1 reference

Isoxazolo[3,4-b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: chemistry, biological activities, and molecular modeling.

21 January 2018

1 reference

Hit to lead account of the discovery of a new class of inhibitors of Pim kinases and crystallographic studies revealing an unusual kinase binding mode

21 January 2018

1 reference

Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2

21 January 2018

1 reference

The selectivity of inhibitors of protein kinase CK2: an update

21 January 2018

1 reference

High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors

21 January 2018

1 reference

Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells

21 January 2018

1 reference

Pharmacologic inhibition of Pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes

21 January 2018

1 reference

Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia

21 January 2018

1 reference

Targeting PIM kinase activity significantly augments the efficacy of cytarabine.

21 January 2018

1 reference

A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma

21 January 2018

1 reference

PIM Kinase Inhibitors Downregulate STAT3Tyr705 Phosphorylation

21 January 2018

1 reference

Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as potent, highly selective, and orally bioavailable inhibitors of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM) kinases

21 January 2018

1 reference

Targeting PI3K signalling in cancer: opportunities, challenges and limitations

21 January 2018

1 reference

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

21 January 2018

1 reference

R-Ras can activate the phosphoinositide 3-kinase but not the MAP kinase arm of the Ras effector pathways.

21 January 2018

1 reference

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

21 January 2018

1 reference

A Pim kinase inhibitor, please

21 January 2018

1 reference

Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake

21 January 2018

1 reference

Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma

21 January 2018

1 reference

Role of PI3K/AKT/mTOR signaling in the cell cycle progression of human prostate cancer

21 January 2018

1 reference

Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs

21 January 2018

1 reference

Mammalian target of rapamycin inhibition as therapy for hematologic malignancies

21 January 2018

1 reference

Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma

21 January 2018

1 reference

Single nucleotide polymorphism genomic arrays analysis of t(8;21) acute myeloid leukemia cells

21 January 2018

1 reference

Pim-1 expression and monoclonal antibody targeting in human leukemia cell lines

21 January 2018

1 reference

Environmental restrictions within tumor ecosystems select for a convergent, hypoxia-resistant phenotype of cancer stem cells

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1586/EHM.11.69

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

22272708

1 reference

Consolidated OpenCitations Corpus – April 2017