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MDM2 and MDMX: Alone and together in regulation of p53
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scholarly article
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stated in
PubMed
PubMed ID
23002429
retrieved
3 February 2017
title
MDM2 and MDMX: Alone and together in regulation of p53
(English)
1 reference
stated in
PubMed
PubMed ID
23002429
retrieved
3 February 2017
author name string
Miriam Shadfan
series ordinal
1
1 reference
stated in
PubMed
PubMed ID
23002429
retrieved
3 February 2017
Vanessa Lopez-Pajares
series ordinal
2
1 reference
stated in
PubMed
PubMed ID
23002429
retrieved
3 February 2017
Zhi-Min Yuan
series ordinal
3
1 reference
stated in
PubMed
PubMed ID
23002429
retrieved
3 February 2017
publication date
1 August 2012
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stated in
PubMed
PubMed ID
23002429
retrieved
3 February 2017
published in
Translational cancer research
1 reference
stated in
PubMed
PubMed ID
23002429
retrieved
3 February 2017
volume
1
1 reference
stated in
PubMed
PubMed ID
23002429
retrieved
3 February 2017
issue
2
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stated in
PubMed
PubMed ID
23002429
retrieved
3 February 2017
page(s)
88–89
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stated in
PubMed
PubMed ID
23002429
retrieved
3 February 2017
cites work
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17 March 2017
Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase
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PubMed Central
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17 March 2017
MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway
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PubMed Central
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17 March 2017
Regulation of autophagy by cytoplasmic p53
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17 March 2017
Phosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 binding
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PubMed Central
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17 March 2017
Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans
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17 March 2017
The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop
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17 March 2017
Monoubiquitylation promotes mitochondrial p53 translocation
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PubMed Central
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17 March 2017
An essential function of the extreme C-terminus of MDM2 can be provided by MDMX
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PubMed Central
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17 March 2017
MDMX regulation of p53 response to ribosomal stress
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PubMed Central
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17 March 2017
14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation
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PubMed Central
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17 March 2017
Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3.
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17 March 2017
PUMA couples the nuclear and cytoplasmic proapoptotic function of p53
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17 March 2017
Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2
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PubMed Central
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17 March 2017
Inhibition of HDM2 and activation of p53 by ribosomal protein L23
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PubMed Central
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17 March 2017
Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5
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PubMed Central
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17 March 2017
Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity
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PubMed Central
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A dynamic role of HAUSP in the p53-Mdm2 pathway
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17 March 2017
Posttranslational modification of MDM2
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PubMed Central
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17 March 2017
Ribosomal Protein L11 Negatively Regulates Oncoprotein MDM2 and Mediates a p53-Dependent Ribosomal-Stress Checkpoint Pathway
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PubMed Central
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17 March 2017
Regulation of HDM2 activity by the ribosomal protein L11
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PubMed Central
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17 March 2017
Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein
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17 March 2017
MDMX inhibits the p300/CBP-mediated acetylation of p53
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
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17 March 2017
Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
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17 March 2017
Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development
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PubMed Central
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17 March 2017
Mutual dependence of MDM2 and MDMX in their functional inactivation of p53
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PubMed Central
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17 March 2017
Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53
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PubMed Central
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17 March 2017
ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage
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17 March 2017
The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation
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PubMed Central
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17 March 2017
Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase
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PubMed Central
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17 March 2017
Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein
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PubMed Central
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17 March 2017
P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2
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stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
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17 March 2017
MDM2 interacts with MDMX through their RING finger domains
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PubMed Central
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17 March 2017
Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
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17 March 2017
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
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PubMed Central
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17 March 2017
Isolation and identification of the human homolog of a new p53-binding protein, Mdmx
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PubMed Central
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17 March 2017
Regulation of p53 stability by Mdm2
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PubMed Central
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17 March 2017
Mdm2 promotes the rapid degradation of p53
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PubMed Central
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17 March 2017
MDMX: a novel p53-binding protein with some functional properties of MDM2
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PubMed Central
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17 March 2017
Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein
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PubMed Central
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17 March 2017
Mapping of the p53 and mdm-2 interaction domains
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17 March 2017
Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line
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17 March 2017
p53 mutations in human cancers
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17 March 2017
Amplification of a gene encoding a p53-associated protein in human sarcomas
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17 March 2017
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
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PubMed Central
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17 March 2017
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
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7 April 2017
Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
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PubMed Central
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7 April 2017
Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
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7 April 2017
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
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PubMed Central
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7 April 2017
Nucleolar Arf sequesters Mdm2 and activates p53
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
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7 April 2017
Tumor spectrum analysis in p53-mutant mice
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PubMed Central
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7 April 2017
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
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7 April 2017
Recruitment of RPL11 at promoter sites of p53-regulated genes upon nucleolar stress through NEDD8 and in an Mdm2-dependent manner
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
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3 June 2018
A critical role for noncoding 5S rRNA in regulating Mdmx stability
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
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3 June 2018
The evolution of MDM2 family genes
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
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3 June 2018
The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
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3 June 2018
Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
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3 June 2018
The structure-based design of Mdm2/Mdmx-p53 inhibitors gets serious
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
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3 June 2018
The nucleolar SUMO-specific protease SMT3IP1/SENP3 attenuates Mdm2-mediated p53 ubiquitination and degradation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
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3 June 2018
c-Abl phosphorylation of Mdm2 facilitates Mdm2-Mdmx complex formation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
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3 June 2018
Deconstructing nucleotide binding activity of the Mdm2 RING domain
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
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3 June 2018
Differential binding of p53 and nutlin to MDM2 and MDMX: computational studies
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
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3 June 2018
The p53 orchestra: Mdm2 and Mdmx set the tone
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
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3 June 2018
Ribosomal protein S7 is both a regulator and a substrate of MDM2
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
3 June 2018
c-Abl phosphorylates Hdmx and regulates its interaction with p53.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
3 June 2018
Regulation of MDMX expression by mitogenic signaling
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
3 June 2018
High levels of the p53 inhibitor MDM4 in head and neck squamous carcinomas
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
3 June 2018
RING domain-mediated interaction is a requirement for MDM2's E3 ligase activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
3 June 2018
C-terminal modifications regulate MDM2 dissociation and nuclear export of p53.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
3 June 2018
Hetero-oligomerization with MdmX rescues the ubiquitin/Nedd8 ligase activity of RING finger mutants of Mdm2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
3 June 2018
The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
3 June 2018
HDM4 (HDMX) is widely expressed in adult pre-B acute lymphoblastic leukemia and is a potential therapeutic target
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
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3 June 2018
Inactivation of the p53 pathway in retinoblastoma.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
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3 June 2018
Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
3 June 2018
Binding of p53 to the central domain of Mdm2 is regulated by phosphorylation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
3 June 2018
Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
3 June 2018
Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
3 June 2018
Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
3 June 2018
The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
3 June 2018
Post-translational modification of p53 in tumorigenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
3 June 2018
Ataxia-telangiectasia, an evolving phenotype
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
3 June 2018
Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
3 June 2018
HAUSP is required for p53 destabilization
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
3 June 2018
Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
3 June 2018
Mono- versus polyubiquitination: differential control of p53 fate by Mdm2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
3 June 2018
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
3 June 2018
DNA damage-induced MDMX degradation is mediated by MDM2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
3 June 2018
MDM2 promotes ubiquitination and degradation of MDMX
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
3 June 2018
Critical contribution of the MDM2 acidic domain to p53 ubiquitination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
3 June 2018
Critical role for a central part of Mdm2 in the ubiquitylation of p53.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
3 June 2018
Polyubiquitination of p53 by a ubiquitin ligase activity of p300.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
3 June 2018
P14ARF promotes accumulation of SUMO-1 conjugated (H)Mdm2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
3 June 2018
Hdmx recruitment into the nucleus by Hdm2 is essential for its ability to regulate p53 stability and transactivation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
3 June 2018
A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
3 June 2018
c-Abl regulates p53 levels under normal and stress conditions by preventing its nuclear export and ubiquitination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
3 June 2018
Organization, expression, and localization of the murine mdmx gene and pseudogene
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
3 June 2018
Aberrant expression of HDMX proteins in tumor cells correlates with wild-type p53.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
3 June 2018
An intact HDM2 RING-finger domain is required for nuclear exclusion of p53.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
3 June 2018
MdmX protects p53 from Mdm2-mediated degradation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
3 June 2018
Constitutive mdmx expression during cell growth, differentiation, and DNA damage
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
3 June 2018
Regulation of p53 downstream genes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
3 June 2018
The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
3 June 2018
MDM2 function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
3 June 2018
Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
3 June 2018
Mdm2: keeping p53 under control
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
3 June 2018
Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
3 June 2018
p14ARF links the tumour suppressors RB and p53.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
20 June 2018
Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
27 November 2018
Akt enhances Mdm2-mediated ubiquitination and degradation of p53.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
27 November 2018
The MDM2 RING-finger domain is required to promote p53 nuclear export
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
27 November 2018
Amplification and overexpression of the MDM4 (MDMX) gene from 1q32 in a subset of malignant gliomas without TP53 mutation or MDM2 amplification.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448287
retrieved
27 November 2018
p53 Mutation and MDM2 amplification in human soft tissue sarcomas
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23002429
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Mdm-2 phosphorylation by DNA-dependent protein kinase prevents interaction with p53
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23002429
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Switching mechanisms of cell death in mdm2- and mdm4-null mice by deletion of p53 downstream targets
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23002429
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Hdmx stabilizes Mdm2 and p53
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23002429
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Mdm2, but not Mdm4, protects terminally differentiated smooth muscle cells from p53-mediated caspase-3-independent cell death
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23002429
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23002429
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
mdmx is a negative regulator of p53 activity in vivo
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23002429
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
OpenCitations bibliographic resource ID
3535624
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3535624
PMCID
3448287
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3535624
PubMed ID
23002429
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3535624
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