(Q33687591)

28 July 2017

title

Cdk5 activity in the brain - multiple paths of regulation (English)

1 reference

28 July 2017

0 references

0 references

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Kavita Shah

1

1 reference

28 July 2017

Debomoy K Lahiri

series ordinal

2

1 reference

28 July 2017

language of work or name

English

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publication date

1 June 2014

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28 July 2017

published in

Journal of Cell Science

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28 July 2017

volume

127

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28 July 2017

issue

Pt 11

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28 July 2017

page(s)

2391-2400

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Lessons from a BACE1 inhibitor trial: off-site but not off base.

28 July 2017

cites work

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Cdk5 is required for memory function and hippocampal plasticity via the cAMP signaling pathway.

21 June 2018

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S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by beta-amyloid peptide

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21 June 2018

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Glutathione-S-transferase P1 is a critical regulator of Cdk5 kinase activity

21 June 2018

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The role of miR-103 and miR-107 in regulation of CDK5R1 expression and in cellular migration

21 June 2018

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Cdk5-mediated phosphorylation of endophilin B1 is required for induced autophagy in models of Parkinson's disease

21 June 2018

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Muskelin regulates actin filament- and microtubule-based GABA(A) receptor transport in neurons.

21 June 2018

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Nuclear envelope dispersion triggered by deregulated Cdk5 precedes neuronal death

21 June 2018

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MicroRNA-101 downregulates Alzheimer's amyloid-β precursor protein levels in human cell cultures and is differentially expressed.

21 June 2018

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Regulation and role of cyclin-dependent kinase activity in neuronal survival and death

21 June 2018

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S-nitrosylation of cyclin-dependent kinase 5 (cdk5) regulates its kinase activity and dendrite growth during neuronal development.

21 June 2018

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Delayed treatment with systemic (S)-roscovitine provides neuroprotection and inhibits in vivo CDK5 activity increase in animal stroke models

21 June 2018

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Membrane association facilitates degradation and cleavage of the cyclin-dependent kinase 5 activators p35 and p39.

21 June 2018

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No difference in kinetics of tau or histone phosphorylation by CDK5/p25 versus CDK5/p35 in vitro

21 June 2018

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21 June 2018

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Direct and indirect roles of cyclin-dependent kinase 5 as an upstream regulator in the c-Jun NH2-terminal kinase cascade: relevance to neurotoxic insults in Alzheimer's disease

21 June 2018

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Cyclin I activates Cdk5 and regulates expression of Bcl-2 and Bcl-XL in postmitotic mouse cells

21 June 2018

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c-Abl tyrosine kinase modulates tau pathology and Cdk5 phosphorylation in AD transgenic mice

21 June 2018

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Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1.

21 June 2018

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Tumor necrosis factor-alpha regulates cyclin-dependent kinase 5 activity during pain signaling through transcriptional activation of p35.

21 June 2018

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Dopaminergic and glutamatergic signaling crosstalk in Huntington's disease neurodegeneration: the role of p25/cyclin-dependent kinase 5.

21 June 2018

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Novel genetic tools reveal Cdk5's major role in Golgi fragmentation in Alzheimer's disease

21 June 2018

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Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing

21 June 2018

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Calmodulin binding and Cdk5 phosphorylation of p35 regulate its effect on microtubules

21 June 2018

1 reference

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New approaches to the discovery of cdk5 inhibitors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Cdk5--p39 is a labile complex with the similar substrate specificity to Cdk5--p35.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

AKT and CDK5/p35 mediate brain-derived neurotrophic factor induction of DARPP-32 in medium size spiny neurons in vitro

21 June 2018

1 reference

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Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Suppression of calpain-dependent cleavage of the CDK5 activator p35 to p25 by site-specific phosphorylation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

A nestin scaffold links Cdk5/p35 signaling to oxidant-induced cell death

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Abl deregulates Cdk5 kinase activity and subcellular localization in Drosophila neurodegeneration

21 June 2018

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Role of heat-shock factor 2 in cerebral cortex formation and as a regulator of p35 expression

21 June 2018

1 reference

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Cyclin-dependent kinase 5 activity regulates pain signaling.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Recent evidence regarding a role for Cdk5 dysregulation in Alzheimer's disease

21 June 2018

1 reference

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A specific interaction between muskelin and the cyclin-dependent kinase 5 activator p39 promotes peripheral localization of muskelin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Interferon gamma induces neurite outgrowth by up-regulation of p35 neuron-specific cyclin-dependent kinase 5 activator via activation of ERK1/2 pathway.

21 June 2018

1 reference

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Induction of cyclin-dependent kinase 5 and its activator p35 through the extracellular-signal-regulated kinase and protein kinase A pathways during retinoic-acid mediated neuronal differentiation in human neuroblastoma SK-N-BE(2)C cells

21 June 2018

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Up-regulation of Egr1 by 1,25-dihydroxyvitamin D3 contributes to increased expression of p35 activator of cyclin-dependent kinase 5 and consequent onset of the terminal phase of HL60 cell differentiation

21 June 2018

1 reference

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Cdk5/p35 and Rho-kinase mediate ephrin-A5-induced signaling in retinal ganglion cells

21 June 2018

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Localization of phosphorylated ERK/MAP kinases to mitochondria and autophagosomes in Lewy body diseases

21 June 2018

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Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles

21 June 2018

1 reference

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Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease

21 June 2018

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The calpains in aging and aging-related diseases

21 June 2018

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A critical analysis of new molecular targets and strategies for drug developments in Alzheimer's disease

21 June 2018

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Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex

21 June 2018

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A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains

21 June 2018

1 reference

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Cyclin-dependent kinase 5 is required for associative learning

21 June 2018

1 reference

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Transcriptional regulation of cortical neuron migration by POU domain factors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

21 June 2018

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Structure and regulation of the CDK5-p25(nck5a) complex

21 June 2018

1 reference

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p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment

21 June 2018

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deltaFosB: a molecular switch underlying long-term neural plasticity.

21 June 2018

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Induction of cyclin-dependent kinase 5 in the hippocampus by chronic electroconvulsive seizures: role of [Delta]FosB.

21 June 2018

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Amplification of dopaminergic signaling by a positive feedback loop

21 June 2018

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Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth

21 June 2018

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Neurotoxicity induces cleavage of p35 to p25 by calpain

21 June 2018

1 reference

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Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

21 June 2018

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Decreased glutathione transferase activity in brain and ventricular fluid in Alzheimer's disease.

21 June 2018

1 reference

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Evidence for the participation of the neuron-specific CDK5 activator P35 during laminin-enhanced axonal growth.

21 June 2018

1 reference

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Cyclin D2 interacts with cdk-5 and modulates cellular cdk-5/p35 activity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.

21 June 2018

1 reference

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Identification of functional domains in the neuronal Cdk5 activator protein

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

The cdk2 kinase is required for the G1-to-S transition in mammalian cells.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Detoxication of base propenals and other alpha, beta-unsaturated aldehyde products of radical reactions and lipid peroxidation by human glutathione transferases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

An Isoform of the Neuronal Cyclin-dependent Kinase 5 (Cdk5) Activator

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Cyclin I: a new cyclin encoded by a gene isolated from human brain

21 June 2018

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Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2

21 June 2018

1 reference

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Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family.

21 June 2018

1 reference

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Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1

21 June 2018

1 reference

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Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase

21 June 2018

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A family of human cdc2-related protein kinases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Purification and characterization of a novel proline-directed protein kinase from bovine brain.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Tau protein kinase I converts normal tau protein into A68-like component of paired helical filaments

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Neuronal cdc2-like kinase: a cdc2-related protein kinase with predominantly neuronal expression

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Specific inhibition of p25/Cdk5 activity by the Cdk5 inhibitory peptide reduces neurodegeneration in vivo.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Deregulated Cdk5 triggers aberrant activation of cell cycle kinases and phosphatases inducing neuronal death

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Phosphorylation of p35 and p39 by Cdk5 determines the subcellular location of the holokinase in a phosphorylation-site-specific manner.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Calpastatin, an endogenous calpain-inhibitor protein, regulates the cleavage of the Cdk5 activator p35 to p25.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Cdk5 is a major regulator of p38 cascade: relevance to neurotoxicity in Alzheimer's disease

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Deregulated Cdk5 promotes oxidative stress and mitochondrial dysfunction.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cyclin-dependent kinase 5 complexes

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Expression of cyclin-dependent kinase 5 mRNA and protein in the human brain following acute ischemic stroke.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Impairment of hippocampal long-term depression and defective spatial learning and memory in p35 mice.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Control of cyclin-dependent kinase 5 (Cdk5) activity by glutamatergic regulation of p35 stability

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Cdk5 regulates axonal transport and phosphorylation of neurofilaments in cultured neurons

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Brain levels of CDK5 activator p25 are not increased in Alzheimer's or other neurodegenerative diseases with neurofibrillary tangles

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

The cyclin-dependent kinase 5 activator, p39, is expressed in stripes in the mouse cerebellum.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

A peptide derived from cyclin-dependent kinase activator (p35) specifically inhibits Cdk5 activity and phosphorylation of tau protein in transfected cells

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Phosphorylation of MEK1 by cdk5/p35 down-regulates the mitogen-activated protein kinase pathway

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Calpain-mediated degradation of p35 to p25 in postmortem human and rat brains.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Elevated neuronal Cdc2-like kinase activity in the Alzheimer disease brain.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Region-specific expression of cyclin-dependent kinase 5 (cdk5) and its activators, p35 and p39, in the developing and adult rat central nervous system

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Myt1: a Wee1-type kinase that phosphorylates Cdc2 on residue Thr14.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

A brain-specific activator of cyclin-dependent kinase 5.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Neurobiology: p25 protein in neurodegeneration

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Fas engagement induces neurite growth through ERK activation and p35 upregulation

30 October 2018

1 reference

12 December 2020

Identification of nuclear import mechanisms for the neuronal Cdk5 activator

1 reference

12 December 2020

Activation of cyclin-dependent kinase 5 (Cdk5) in primary sensory and dorsal horn neurons by peripheral inflammation contributes to heat hyperalgesia

1 reference

12 December 2020

Cyclin-dependent Kinase 5 (Cdk5) Activation Domain of Neuronal Cdk5 Activator

1 reference

12 December 2020

Evaluation of cyclin D1 expression and its subcellular distribution in mouse tissues

1 reference

12 December 2020

Brain-derived neurotrophic factor stimulates the neural differentiation of human umbilical cord blood-derived mesenchymal stem cells and survival of differentiated cells through MAPK/ERK and PI3K/Akt-dependent signaling pathways

1 reference

12 December 2020

Neurodegeneration in an Aβ-induced model of Alzheimer’s disease: the role of Cdk5

1 reference

12 December 2020

Cyclin I-Cdk5 governs survival in post-mitotic cells

1 reference

12 December 2020

An integrated approach to genome studies

1 reference

12 December 2020

Identifiers

DOI

10.1242/JCS.147553

1 reference

28 July 2017

1 reference

28 July 2017

1 reference