(Q34241242)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22522601%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

title

Many pathways in laboratory evolution can lead to improved enzymes: how to escape from local minima (English)

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29 January 2020

1 reference

1

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29 January 2020

Joaquin Sanchis

series ordinal

2

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29 January 2020

3

Manfred T Reetz

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29 January 2020

publication date

20 April 2012

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29 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22522601%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

volume

13

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29 January 2020

issue

7

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29 January 2020

page(s)

1060-1066

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Directed evolution of enzymes and biosynthetic pathways

29 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Directed evolution drives the next generation of biocatalysts

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Protein Design by Directed Evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Advances in laboratory evolution of enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Exploring protein fitness landscapes by directed evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Enzyme engineering for enantioselectivity: from trial-and-error to rational design?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Advances in generating functional diversity for directed protein evolution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Status of protein engineering for biocatalysts: how to design an industrially useful biocatalyst

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Directed evolution of enzyme stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Construction of stabilized proteins by combinatorial consensus mutagenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Temperature adaptation of enzymes: lessons from laboratory evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Laboratory evolution of stereoselective enzymes: a prolific source of catalysts for asymmetric reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Novel methods for directed evolution of enzymes: quality, not quantity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Site-saturation mutagenesis is more efficient than DNA shuffling for the directed evolution of beta-fucosidase from beta-galactosidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Finding better protein engineering strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Enzyme optimization: moving from blind evolution to statistical exploration of sequence-function space

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Iterative saturation mutagenesis (ISM) for rapid directed evolution of functional enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Structure of Aspergillus niger epoxide hydrolase at 1.8 A resolution: implications for the structure and function of the mammalian microsomal class of epoxide hydrolases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Addressing the numbers problem in directed evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Shedding light on the efficacy of laboratory evolution based on iterative saturation mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Directed evolution of an enantioselective epoxide hydrolase: uncovering the source of enantioselectivity at each evolutionary stage

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Structure-guided directed evolution of alkenyl and arylmalonate decarboxylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Structure-based and random mutagenesis approaches increase the organophosphate-degrading activity of a phosphotriesterase homologue from Deinococcus radiodurans

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Altering coenzyme specificity of Pichia stipitis xylose reductase by the semi-rational approach CASTing

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Creating lactose phosphorylase enzymes by directed evolution of cellobiose phosphorylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Engineering monolignol 4-O-methyltransferases to modulate lignin biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Conversion of a cyclodextrin glucanotransferase into an alpha-amylase: assessment of directed evolution strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Inverting enantioselectivity of Burkholderia gladioli esterase EstB by directed and designed evolution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Iterative saturation mutagenesis accelerates laboratory evolution of enzyme stereoselectivity: rigorous comparison with traditional methods.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Manipulating the stereoselectivity of limonene epoxide hydrolase by directed evolution based on iterative saturation mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Revisiting the lipase from Pseudomonas aeruginosa: directed evolution of substrate acceptance and enantioselectivity using iterative saturation mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Constructing and analyzing the fitness landscape of an experimental evolutionary process

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Learning from directed evolution: Further lessons from theoretical investigations into cooperative mutations in lipase enantioselectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Focusing mutations into the P. fluorescens esterase binding site increases enantioselectivity more effectively than distant mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Combinatorial reshaping of the Candida antarctica lipase A substrate pocket for enantioselectivity using an extremely condensed library

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

An active enzyme constructed from a 9-amino acid alphabet

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Enhancing the thermal robustness of an enzyme by directed evolution: least favorable starting points and inferior mutants can map superior evolutionary pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

When second best is good enough: another probabilistic look at saturation mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Protein engineers turned evolutionists

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

The subtle benefits of being promiscuous: adaptive evolution potentiated by enzyme promiscuity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

21 January 2018

Molecular quasi-species

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Functionally diverging molecular quasi-species evolve by crossing two enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Identification of emerging quasi-species in directed enzyme evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

The evolutionary origin of complex features

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

A genetic selection system for evolving enantioselectivity of enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

A novel genetic selection system for improved enantioselectivity of Bacillus subtilis lipase A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Darwinian evolution can follow only very few mutational paths to fitter proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Empirical fitness landscapes reveal accessible evolutionary paths

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Rapid evolution of a protein in vitro by DNA shuffling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Negative epistasis between beneficial mutations in an evolving bacterial population

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Directed evolution of enantioselective enzymes: iterative cycles of CASTing for probing protein-sequence space

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Directed Evolution of an Enantioselective Enzyme through Combinatorial Multiple-Cassette Mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Greatly reduced amino acid alphabets in directed evolution: making the right choice for saturation mutagenesis at homologous enzyme positions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Asymmetric Organic Synthesis with Enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Stabilization of Escherichia coli uridine phosphorylase by evolution and immobilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Directed evolution of an enantioselective lipase with broad substrate scope for hydrolysis of alpha-substituted esters

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

Dramatically improved catalytic activity of an artificial (S)-selective arylmalonate decarboxylase by structure-guided directed evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201100784

21 January 2018

Identifiers

DOI

10.1002/CBIC.201100784

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22522601%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

1 reference