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Biogenesis and metabolism of Alzheimer's disease Abeta amyloid peptides
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
12128085
retrieved
4 August 2017
review article
1 reference
stated in
Europe PubMed Central
title
Biogenesis and metabolism of Alzheimer's disease Abeta amyloid peptides
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
12128085
retrieved
4 August 2017
main subject
Alzheimer's disease
0 references
author name string
Geneviève Evin
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
12128085
retrieved
4 August 2017
Andreas Weidemann
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
12128085
retrieved
4 August 2017
publication date
1 July 2002
1 reference
stated in
Europe PubMed Central
PubMed ID
12128085
retrieved
4 August 2017
number of pages
13
1 reference
based on heuristic
inferred from page(s)
published in
Peptides
1 reference
stated in
Europe PubMed Central
PubMed ID
12128085
retrieved
4 August 2017
volume
23
1 reference
stated in
Europe PubMed Central
PubMed ID
12128085
retrieved
4 August 2017
issue
7
1 reference
stated in
Europe PubMed Central
PubMed ID
12128085
retrieved
4 August 2017
page(s)
1285-1297
1 reference
stated in
Europe PubMed Central
PubMed ID
12128085
retrieved
4 August 2017
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Expression of active secreted forms of human amyloid beta-protein precursor by recombinant baculovirus-infected insect cells
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The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein
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Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein
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The multiple paradoxes of presenilins
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Unusual spectral energy distribution of a galaxy previously reported to be at redshift 6.68.
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Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion.
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Chelation and intercalation: complementary properties in a compound for the treatment of Alzheimer's disease.
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Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.
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Purified recombinant insulin-degrading enzyme degrades amyloid beta-protein but does not promote its oligomerization
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Alzheimer's disease: correlation of the suppression of beta-amyloid peptide secretion from cultured cells with inhibition of the chymotrypsin-like activity of the proteasome.
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Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice
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Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells
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Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
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What the evolution of the amyloid protein precursor supergene family tells us about its function
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Expression of the amyloid precursor protein of Alzheimer's disease on the surface of transfected HeLa cells.
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Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits
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Presenilins and Alzheimer's disease: biological functions and pathogenic mechanisms
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Study of the synthesis and secretion of normal and artificial mutants of murine amyloid precursor protein (APP): cleavage of APP occurs in a late compartment of the default secretion pathway
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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
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A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
1 reference
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Crossref
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based on heuristic
inferred from DOI database lookup
Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Candidate .gamma.-Secretases in the Generation of the Carboxyl Terminus of the Alzheimer's Disease .beta.A4 Amyloid: Possible Involvement of Cathepsin D
1 reference
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Crossref
reference URL
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retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Presenilin I expression in yeast lowers secretion of the amyloid precursor protein
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease.
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Intraneuronal compartments of the amyloid precursor protein.
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
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7 January 2021
based on heuristic
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Transgenic Drosophila expressing human amyloid precursor protein show gamma-secretase activity and a blistered-wing phenotype
1 reference
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Crossref
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based on heuristic
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Amyloid-beta interactions with chondroitin sulfate-derived monosaccharides and disaccharides. implications for drug development
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
A 109-amino-acid C-terminal fragment of Alzheimer's-disease amyloid precursor protein contains a sequence, -RHDS-, that promotes cell adhesion
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
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Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein
1 reference
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7 January 2021
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Alzheimer's disease: the amyloid cascade hypothesis
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7 January 2021
based on heuristic
inferred from DOI database lookup
Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
The beta A4 amyloid precursor protein binding to copper.
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of beta-amyloid formation identifies proteolytic precursors and subcellular site of catabolism
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
The presenilins and Alzheimer's disease
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Subcellular compartment and molecular subdomain of beta-amyloid precursor protein relevant to the Abeta 42-promoting effects of Alzheimer mutant presenilin 2.
1 reference
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https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Metabolic regulation of brain Abeta by neprilysin.
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Statins and the risk of dementia
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7 January 2021
based on heuristic
inferred from DOI database lookup
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway.
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
beta-Amyloid precursor protein binds to the neurite-promoting IKVAV site of laminin
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
The carboxyl termini of beta-amyloid peptides 1-40 and 1-42 are generated by distinct gamma-secretase activities
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Elevated abeta42 in skeletal muscle of Alzheimer disease patients suggests peripheral alterations of AbetaPP metabolism.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
The type 4 prepilin peptidases comprise a novel family of aspartic acid proteases
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Processing of the Alzheimer's disease amyloid precursor protein in Pichia pastoris: immunodetection of alpha-, beta-, and gamma-secretase products.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Constitutive alpha-secretase cleavage of the beta-amyloid precursor protein in the furin-deficient LoVo cell line: involvement of the pro-hormone convertase 7 and the disintegrin metalloprotease ADAM10.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Retention of the Alzheimer's amyloid precursor fragment C99 in the endoplasmic reticulum prevents formation of amyloid beta-peptide
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Requirement for presenilin 1 in facilitating lagged 2-mediated endoproteolysis and signaling of notch 1.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Amyloid plaque core protein in Alzheimer disease and Down syndrome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Degradation of Alzheimer's beta-amyloid protein by human and rat brain peptidases: involvement of insulin-degrading enzyme.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cell-free assays for gamma-secretase activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of amyloid precursor protein cleavage.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The beta-amyloid precursor protein functions as a cytosolic anchoring site that prevents Fe65 nuclear translocation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human brain beta A4 amyloid protein precursor of Alzheimer's disease: purification and partial characterization.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Insulysin hydrolyzes amyloid beta peptides to products that are neither neurotoxic nor deposit on amyloid plaques.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of the high affinity heparin binding site of the Alzheimer's disease beta A4 amyloid precursor protein (APP) and its enhancement by zinc(II)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of PS1 deficiency on membrane protein trafficking in neurons.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Amino acid sequence RERMS represents the active domain of amyloid beta/A4 protein precursor that promotes fibroblast growth
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G(o)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cleavage of Alzheimer's amyloid precursor protein by alpha-secretase occurs at the surface of neuronal cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Alternative, non-secretase processing of Alzheimer's beta-amyloid precursor protein during apoptosis by caspase-6 and -8.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ovariectomy and 17beta-estradiol modulate the levels of Alzheimer's amyloid beta peptides in brain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A Novel γ-Secretase Assay Based on Detection of the Putative C-terminal Fragment-γ of Amyloid β Protein Precursor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mapping the APP/presenilin (PS) binding domains: the hydrophilic N-terminus of PS2 is sufficient for interaction with APP and can displace APP/PS1 interaction.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cell-surface beta-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Alpha2-macroglobulin enhances the clearance of endogenous soluble beta-amyloid peptide via low-density lipoprotein receptor-related protein in cortical neurons.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proteolysis of A beta peptide from Alzheimer disease brain by gelatinase A.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of beta-amyloid secretion by FE65, an amyloid protein precursor-binding protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protease nexin-2/amyloid beta protein precursor. A tight-binding inhibitor of coagulation factor IXa.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Purification and cloning of amyloid precursor protein beta-secretase from human brain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A distinct ER/IC gamma-secretase competes with the proteasome for cleavage of APP
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The role of presenilins in gamma-secretase activity: catalyst or cofactor?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Platelet coagulation factor XIa-inhibitor, a form of Alzheimer amyloid precursor protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Plaque busters: strategies to inhibit amyloid formation in Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Alzheimer's disease amyloid precursor protein on the surface of cortical neurons in primary culture co-localizes with adhesion patch components
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The amyloid precursor protein of Alzheimer's disease and the Abeta peptide.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Presenilin is required for activity and nuclear access of Notch in Drosophila
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Beta-amyloid precursor protein. Location of transmembrane domain and specificity of gamma-secretase cleavage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Generation of Alzheimer amyloid beta peptide through nonspecific proteolysis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of amyloid beta protein aggregation and neurotoxicity by rifampicin. Its possible function as a hydroxyl radical scavenger.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibiting amyloid precursor protein C-terminal cleavage promotes an interaction with presenilin 1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and beta-amyloid precursor protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Alzheimer's disease amyloid precursor protein modulates copper-induced toxicity and oxidative stress in primary neuronal cultures
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Secreted glypican binds to the amyloid precursor protein of Alzheimer's disease (APP) and inhibits APP-induced neurite outgrowth.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulated formation of Golgi secretory vesicles containing Alzheimer beta-amyloid precursor protein.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Trafficking of cell surface beta-amyloid precursor protein: retrograde and transcytotic transport in cultured neurons
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Metalloendopeptidase EC 3.4.24.15 is necessary for Alzheimer's amyloid-beta peptide degradation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The pathogenesis of Alzheimer's disease. Is amyloid beta-protein the beginning or the end?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mice deficient for the amyloid precursor protein gene.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0196-9781(02)00063-3
1 reference
stated in
Europe PubMed Central
PubMed ID
12128085
retrieved
4 August 2017
PubMed ID
12128085
1 reference
stated in
Europe PubMed Central
PubMed ID
12128085
retrieved
4 August 2017
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