(Q35044801)

6 August 2017

title

Development of inhibitors in the ubiquitination cascade (English)

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6 August 2017

main subject

protein ubiquitination

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Wei Zhang

1

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6 August 2017

Sachdev S Sidhu

series ordinal

2

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6 August 2017

language of work or name

English

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publication date

12 November 2013

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6 August 2017

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6 August 2017

volume

588

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6 August 2017

issue

2

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6 August 2017

page(s)

356-367

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Ubiquitin-binding proteins: decoders of ubiquitin-mediated cellular functions

6 August 2017

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Small molecules that bind the Mdm2 RING stabilize and activate p53.

21 January 2018

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21 January 2018

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Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Systematic and quantitative assessment of the ubiquitin-modified proteome

21 January 2018

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21 January 2018

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Ubistatins inhibit proteasome-dependent degradation by binding the ubiquitin chain.

21 January 2018

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Breaking the chains: structure and function of the deubiquitinases

21 January 2018

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Deubiquitinases in cancer: new functions and therapeutic options.

21 January 2018

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Discovery of Inhibitors that Elucidate the Role of UCH-L1 Activity in the H1299 Lung Cancer Cell Line

21 January 2018

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Structure-activity relationship, kinetic mechanism, and selectivity for a new class of ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitors

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.003

Pharmacological targets in the ubiquitin system offer new ways of treating cancer, neurodegenerative disorders and infectious diseases

21 January 2018

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A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication

21 January 2018

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USP1 deubiquitinates ID proteins to preserve a mesenchymal stem cell program in osteosarcoma

21 January 2018

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Expanded roles of the Fanconi anemia pathway in preserving genomic stability

21 January 2018

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Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype.

21 January 2018

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A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway

21 January 2018

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Selective and cell-active inhibitors of the USP1/ UAF1 deubiquitinase complex reverse cisplatin resistance in non-small cell lung cancer cells

21 January 2018

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Deubiquitylating enzymes and DNA damage response pathways

21 January 2018

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The multifaceted roles of USP7: new therapeutic opportunities

21 January 2018

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Inhibiting the p53-MDM2 interaction: an important target for cancer therapy

21 January 2018

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Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

21 January 2018

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A dynamic role of HAUSP in the p53-Mdm2 pathway

21 January 2018

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Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells

21 January 2018

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A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.003

Discovery of specific inhibitors of human USP7/HAUSP deubiquitinating enzyme

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.003

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.003

Multiple associated proteins regulate proteasome structure and function

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.003

Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.003

Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.003

Ubiquitin-binding domains

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.003

The ubiquitin binding region of the Smurf HECT domain facilitates polyubiquitylation and binding of ubiquitylated substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.003

Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.003

Conformational Dynamics and Structural Plasticity Play Critical Roles in the Ubiquitin Recognition of a UIM Domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.003

A Strategy for Modulation of Enzymes in the Ubiquitin System

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.003

Regulation of Epidermal Growth Factor Receptor Ubiquitination and Trafficking by the USP8·STAM Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.003

Role of ubiquitylation and USP8-dependent deubiquitylation in the endocytosis and lysosomal targeting of plasma membrane KCa3.1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.003

ERBB2 is a target for USP8-mediated deubiquitination

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.003

Essential role of ubiquitin-specific protease 8 for receptor tyrosine kinase stability and endocytic trafficking in vivo

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.003

Conformational stabilization of ubiquitin yields potent and selective inhibitors of USP7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.003

Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.003

Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.003

OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.003

Physiological functions of the HECT family of ubiquitin ligases

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.003

Determinants of Functionality in the Ubiquitin Conjugating Enzyme Family

21 January 2018

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Inhibitors for E3 ubiquitin ligases

21 January 2018

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Stuck in the Middle: Drugging the Ubiquitin System at the E2 Step

21 January 2018

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Structural basis of ubiquitin recognition by the deubiquitinating protease USP2

21 January 2018

1 reference

12 December 2020

Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays

1 reference

12 December 2020

Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations.

1 reference

12 December 2020

Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown

1 reference

12 December 2020

A UbcH5/ubiquitin noncovalent complex is required for processive BRCA1-directed ubiquitination

1 reference

12 December 2020

RING-type E3 ligases: master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination

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12 December 2020

Regulation of proteolysis by human deubiquitinating enzymes

1 reference

12 December 2020

A novel small-molecule inhibitor of NF-kappaB signaling

1 reference

12 December 2020

Mammalian HECT ubiquitin-protein ligases: biological and pathophysiological aspects

1 reference

12 December 2020

The ubiquitin proteasome system - implications for cell cycle control and the targeted treatment of cancer

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6 August 2017

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