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Defects in the apoptotic machinery of cancer cells: role in drug resistance
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
12654256
retrieved
6 August 2017
review article
1 reference
stated in
Europe PubMed Central
title
Defects in the apoptotic machinery of cancer cells: role in drug resistance
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
12654256
retrieved
6 August 2017
main subject
apoptotic process
0 references
author
Boris Zhivotovsky
object named as
Boris Zhivotovsky
series ordinal
1
0 references
Sten Orrenius
series ordinal
2
object named as
Sten Orrenius
1 reference
stated in
Europe PubMed Central
PubMed ID
12654256
retrieved
6 August 2017
publication date
1 April 2003
1 reference
stated in
Europe PubMed Central
PubMed ID
12654256
retrieved
6 August 2017
published in
Seminars in Cancer Biology
1 reference
stated in
Europe PubMed Central
PubMed ID
12654256
retrieved
6 August 2017
volume
13
1 reference
stated in
Europe PubMed Central
PubMed ID
12654256
retrieved
6 August 2017
page(s)
125-134
1 reference
stated in
Europe PubMed Central
PubMed ID
12654256
retrieved
6 August 2017
issue
2
1 reference
stated in
Europe PubMed Central
PubMed ID
12654256
retrieved
6 August 2017
cites work
The Hallmarks of Cancer
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7 January 2021
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Apoptosis: a link between cancer genetics and chemotherapy
1 reference
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Crossref
reference URL
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7 January 2021
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Death and anti-death: tumour resistance to apoptosis
1 reference
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Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
Targeting death and decoy receptors of the tumour-necrosis factor superfamily
1 reference
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Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
NF-kappaB at the crossroads of life and death
1 reference
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Crossref
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7 January 2021
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inferred from DOI database lookup
Programmed cell death: alive and well in the new millennium
1 reference
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Crossref
reference URL
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retrieved
7 January 2021
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inferred from DOI database lookup
Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis
1 reference
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reference URL
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7 January 2021
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inferred from DOI database lookup
Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Live or let die: the cell's response to p53
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Crossref
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7 January 2021
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inferred from DOI database lookup
Caspase structure, proteolytic substrates, and function during apoptotic cell death
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Generation and characterization of Smac/DIABLO-deficient mice.
1 reference
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Crossref
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7 January 2021
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Escaping cell death: survival proteins in cancer
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Heat shock proteins: endogenous modulators of apoptotic cell death
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Triggering caspase-independent cell death to combat cancer.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Apoptosis-inducing factor (AIF): a novel caspase-independent death effector released from mitochondria
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Involvement of the CD95 (APO–1/Fas) receptor/ligand system in drug–induced apoptosis in leukemia cells
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Melanoma cell expression of Fas(Apo-1/CD95) ligand: implications for tumor immune escape
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Differences in Expression of Pro-Caspases in Small Cell and Non-small Cell Lung Carcinoma
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A CASP-8 mutation recognized by cytolytic T lymphocytes on a human head and neck carcinoma.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Allelic imbalance on chromosome 2q and alterations of the caspase 8 gene in neuroblastoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A novel single amino acid deletion caspase-8 mutant in cancer cells that lost proapoptotic activity
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inactivating mutations of CASP10 gene in non-Hodgkin lymphomas.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1- and CD-95-induced apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Resistance to CD95-mediated apoptosis through constitutive c-FLIP expression in a non-Hodgkin's lymphoma B cell line.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Intracellular regulation of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human multiple myeloma cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sensitization to TRAIL-induced apoptosis and modulation of FLICE-inhibitory protein in B chronic lymphocytic leukemia by actinomycin D.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The kiss of death: promises and failures of death receptors and ligands in cancer therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Paradox of Bcl-2 (and p53): why may apoptosis-regulating proteins be irrelevant to cell death?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The role of the Bcl-2 protein family in cancer
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Biochemical pathways of caspase activation during apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oncogene-dependent apoptosis is mediated by caspase-9.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Apaf-1 protein deficiency confers resistance to cytochrome c-dependent apoptosis in human leukemic cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Defective cytochrome c-dependent caspase activation in ovarian cancer cell lines due to diminished or absent apoptotic protease activating factor-1 activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inactivation of the apoptosis effector Apaf-1 in malignant melanoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Apaf-1 is a transcriptional target for E2F and p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CARD games in apoptosis and immunity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A caspase-9 variant missing the catalytic site is an endogenous inhibitor of apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Caspase-9 and Apaf-1 are expressed and functionally active in human neuroblastoma tumor cell lines with 1p36 LOH and amplified MYCN.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Co-transduction of Apaf-1 and caspase-9 augments etoposide-induced apoptosis in U-373MG glioma cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of inhibitor of apoptosis proteins in small- and non-small-cell lung carcinoma cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Anti-apoptotic proteins, apoptotic and proliferative parameters and their prognostic significance in cervical carcinoma.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Assessment of IAP (inhibitor of apoptosis) proteins as predictors of response to chemotherapy in advanced non-small-cell lung cancer patients.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of XIAP-deficient mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Drug resistance in melanoma: mechanisms, apoptosis, and new potential therapeutic targets
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative-(BMS 247550) and Apo-2L/TRAIL-induced apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The inhibitor of apoptosis protein-binding domain of Smac is not essential for its proapoptotic activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Apaf-1/cytochrome c-independent and Smac-dependent induction of apoptosis in multiple myeloma (MM) cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Apoptosis in the absence of caspase 3.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pro-caspase-3 overexpression sensitises ovarian cancer cells to proteasome inhibitors.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Defective caspase-3 relocalization in non-small cell lung carcinoma.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Lack of correlation between caspase activation and caspase activity assays in paclitaxel-treated MCF-7 breast cancer cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Raf-induced effects on the differentiation and apoptosis of skeletal myoblasts are determined by the level of Raf signaling: abrogation of apoptosis by Raf is downstream of caspase 3 activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mitochondrial dysfunction is an essential step for killing of non-small cell lung carcinomas resistant to conventional treatment
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Triggering of apoptosis by cathepsins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cathepsin inhibition induces apoptotic death in human leukemia and lymphoma cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An alternative, nonapoptotic form of programmed cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Synthetic peptide sequence from the C-terminus of the insulin-like growth factor-I receptor that induces apoptosis and inhibition of tumor growth
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Resistance of leukemic cells to 2-chlorodeoxyadenosine is due to a lack of calcium-dependent cytochrome c release
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S1044-579X(02)00130-X
1 reference
stated in
Europe PubMed Central
PubMed ID
12654256
retrieved
6 August 2017
PubMed ID
12654256
1 reference
stated in
Europe PubMed Central
PubMed ID
12654256
retrieved
6 August 2017
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