(Q35091126)

6 August 2017

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title

Defects in the apoptotic machinery of cancer cells: role in drug resistance (English)

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6 August 2017

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Boris Zhivotovsky

1

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Sten Orrenius

series ordinal

2

object named as

Sten Orrenius

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6 August 2017

publication date

1 April 2003

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Seminars in Cancer Biology

6 August 2017

published in

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6 August 2017

volume

13

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6 August 2017

issue

2

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6 August 2017

page(s)

125-134

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6 August 2017

cites work

The Hallmarks of Cancer

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7 January 2021

Apoptosis: a link between cancer genetics and chemotherapy

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7 January 2021

Death and anti-death: tumour resistance to apoptosis

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7 January 2021

Targeting death and decoy receptors of the tumour-necrosis factor superfamily

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7 January 2021

NF-kappaB at the crossroads of life and death

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7 January 2021

Programmed cell death: alive and well in the new millennium

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7 January 2021

Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis

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7 January 2021

Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization

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7 January 2021

Live or let die: the cell's response to p53

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7 January 2021

Caspase structure, proteolytic substrates, and function during apoptotic cell death

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7 January 2021

TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2

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7 January 2021

Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs

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7 January 2021

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

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https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

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7 January 2021

Generation and characterization of Smac/DIABLO-deficient mice.

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7 January 2021

Escaping cell death: survival proteins in cancer

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7 January 2021

Heat shock proteins: endogenous modulators of apoptotic cell death

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7 January 2021

Triggering caspase-independent cell death to combat cancer.

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7 January 2021

Apoptosis-inducing factor (AIF): a novel caspase-independent death effector released from mitochondria

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https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

Involvement of the CD95 (APO–1/Fas) receptor/ligand system in drug–induced apoptosis in leukemia cells

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7 January 2021

Melanoma cell expression of Fas(Apo-1/CD95) ligand: implications for tumor immune escape

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7 January 2021

Differences in Expression of Pro-Caspases in Small Cell and Non-small Cell Lung Carcinoma

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7 January 2021

Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN

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7 January 2021

Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer

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7 January 2021

A CASP-8 mutation recognized by cytolytic T lymphocytes on a human head and neck carcinoma.

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7 January 2021

Allelic imbalance on chromosome 2q and alterations of the caspase 8 gene in neuroblastoma

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7 January 2021

A novel single amino acid deletion caspase-8 mutant in cancer cells that lost proapoptotic activity

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7 January 2021

Inactivating mutations of CASP10 gene in non-Hodgkin lymphomas.

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https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1- and CD-95-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

Resistance to CD95-mediated apoptosis through constitutive c-FLIP expression in a non-Hodgkin's lymphoma B cell line.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

Intracellular regulation of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human multiple myeloma cells

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

Sensitization to TRAIL-induced apoptosis and modulation of FLICE-inhibitory protein in B chronic lymphocytic leukemia by actinomycin D.

1 reference

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7 January 2021

The kiss of death: promises and failures of death receptors and ligands in cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

Paradox of Bcl-2 (and p53): why may apoptosis-regulating proteins be irrelevant to cell death?

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

The role of the Bcl-2 protein family in cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

Biochemical pathways of caspase activation during apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

Oncogene-dependent apoptosis is mediated by caspase-9.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

Apaf-1 protein deficiency confers resistance to cytochrome c-dependent apoptosis in human leukemic cells

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

Defective cytochrome c-dependent caspase activation in ovarian cancer cell lines due to diminished or absent apoptotic protease activating factor-1 activity

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

Apaf-1 is a transcriptional target for E2F and p53

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

CARD games in apoptosis and immunity

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

A caspase-9 variant missing the catalytic site is an endogenous inhibitor of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

Caspase-9 and Apaf-1 are expressed and functionally active in human neuroblastoma tumor cell lines with 1p36 LOH and amplified MYCN.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

Co-transduction of Apaf-1 and caspase-9 augments etoposide-induced apoptosis in U-373MG glioma cells

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

Expression of inhibitor of apoptosis proteins in small- and non-small-cell lung carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

Anti-apoptotic proteins, apoptotic and proliferative parameters and their prognostic significance in cervical carcinoma.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

Assessment of IAP (inhibitor of apoptosis) proteins as predictors of response to chemotherapy in advanced non-small-cell lung cancer patients.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

Characterization of XIAP-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

Drug resistance in melanoma: mechanisms, apoptosis, and new potential therapeutic targets

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative-(BMS 247550) and Apo-2L/TRAIL-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP)

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

The inhibitor of apoptosis protein-binding domain of Smac is not essential for its proapoptotic activity

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

Apaf-1/cytochrome c-independent and Smac-dependent induction of apoptosis in multiple myeloma (MM) cells

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

Apoptosis in the absence of caspase 3.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

Pro-caspase-3 overexpression sensitises ovarian cancer cells to proteasome inhibitors.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

Defective caspase-3 relocalization in non-small cell lung carcinoma.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

Lack of correlation between caspase activation and caspase activity assays in paclitaxel-treated MCF-7 breast cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

Raf-induced effects on the differentiation and apoptosis of skeletal myoblasts are determined by the level of Raf signaling: abrogation of apoptosis by Raf is downstream of caspase 3 activation

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

Mitochondrial dysfunction is an essential step for killing of non-small cell lung carcinomas resistant to conventional treatment

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

Triggering of apoptosis by cathepsins

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

Cathepsin inhibition induces apoptotic death in human leukemia and lymphoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

An alternative, nonapoptotic form of programmed cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

Synthetic peptide sequence from the C-terminus of the insulin-like growth factor-I receptor that induces apoptosis and inhibition of tumor growth

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

Resistance of leukemic cells to 2-chlorodeoxyadenosine is due to a lack of calcium-dependent cytochrome c release

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900130-X

7 January 2021

10.1016/S1044-579X(02)00130-X

Identifiers

DOI

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6 August 2017

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