(Q35107623)

6 August 2017

1 reference

title

The secretases of Alzheimer's disease (English)

1 reference

6 August 2017

0 references

Michael S. Wolfe

1

1 reference

PubMed ID

12696752

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12696752

24 December 2023

language of work or name

English

1 reference

National Center for Biotechnology Information

PubMed ID

12696752

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12696752

24 December 2023

publication date

1 January 2003

1 reference

Current Topics in Developmental Biology

6 August 2017

1 reference

6 August 2017

54

1 reference

6 August 2017

233-261

1 reference

The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Notch signaling: cell fate control and signal integration in development

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Modulation of Ras and a-factor function by carboxyl-terminal proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrum

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Generation of amyloid beta protein from its precursor is sequence specific

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Image analysis of beta-amyloid load in Alzheimer's disease and relation to dementia severity

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Flemish and Dutch mutations in amyloid beta precursor protein have different effects on amyloid beta secretion

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Mice lacking both presenilin genes exhibit early embryonic patterning defects

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Second-site cleavage in sterol regulatory element-binding protein occurs at transmembrane junction as determined by cysteine panning

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Cleavage of amyloid beta peptide during constitutive processing of its precursor

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Reversal of the Swedish familial Alzheimer's disease mutant phenotype in cultured cells treated with phorbol 12,13-dibutyrate

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Design of Potent Inhibitors for Human Brain Memapsin 2 (β-Secretase)

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Substrate and inhibitor profile of BACE (beta-secretase) and comparison with other mammalian aspartic proteases

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Amyloid, the presenilins and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Amyloid precursor protein secretion via muscarinic receptors: reduced desensitization using the M1-selective agonist AF102B

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

HIV protease: a novel chemotherapeutic target for AIDS.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Prodomain processing of Asp1 (BACE2) is autocatalytic.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Crystallographic analysis of transition state mimics bound to penicillopepsin: difluorostatine- and difluorostatone-containing peptides

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

The type 4 prepilin peptidases comprise a novel family of aspartic acid proteases

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Zebrafish (Danio rerio) presenilin promotes aberrant amyloid beta-peptide production and requires a critical aspartate residue for its function in amyloidogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

The AMY antigen co-occurs with abeta and follows its deposition in the amyloid plaques of Alzheimer's disease and down syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Mutation of a putative sperm membrane protein in Caenorhabditis elegans prevents sperm differentiation but not its associated meiotic divisions

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Drosophila nicastrin is essential for the intramembranous cleavage of notch

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Activation of microglial cells by beta-amyloid protein and interferon-gamma.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Difluoro ketone peptidomimetics suggest a large S1 pocket for Alzheimer's gamma-secretase: implications for inhibitor design

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Alzheimer's amyloid precursor protein alpha-secretase is inhibited by hydroxamic acid-based zinc metalloprotease inhibitors: similarities to the angiotensin converting enzyme secretase

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

The secretases that cleave angiotensin converting enzyme and the amyloid precursor protein are distinct from tumour necrosis factor-alpha convertase.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

An essential role for ectodomain shedding in mammalian development

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Endoproteolytic processing and stabilization of wild-type and mutant presenilin

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Microglial activation in early stages of amyloid beta protein deposition.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Translating cell biology into therapeutic advances in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Skeletal and CNS defects in Presenilin-1-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

The pro domain of beta-secretase does not confer strict zymogen-like properties but does assist proper folding of the protease domain

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Inhibition and catalytic mechanism of HIV-1 aspartic protease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Purification and cloning of amyloid precursor protein beta-secretase from human brain

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Association of microglia with amyloid plaques in brains of APP23 transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

The biological and pathological function of the presenilin-1 Deltaexon 9 mutation is independent of its defect to undergo proteolytic processing

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

The multispanning membrane protein Ste24p catalyzes CAAX proteolysis and NH2-terminal processing of the yeast a-factor precursor

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Presence of soluble amyloid beta-peptide precedes amyloid plaque formation in Down's syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Design and synthesis of potent and specific renin inhibitors containing difluorostatine, difluorostatone, and related analogues

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch)

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Effects of the amyloid precursor protein Glu693-->Gln 'Dutch' mutation on the production and stability of amyloid beta-protein

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Muscarinic regulation of Alzheimer's disease amyloid precursor protein secretion and amyloid beta-protein production in human neuronal NT2N cells

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Secretase targets for Alzheimer's disease: identification and therapeutic potential

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Subcellular distribution and turnover of presenilins in transfected cells

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Beta-secretase processing of the beta-amyloid precursor protein in transgenic mice is efficient in neurons but inefficient in astrocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2803%2954011-X

7 January 2021

Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide

11

1 reference

https://api.crossref.org/works/10.1016/S0070-2153(03)54011-X

Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation

24 December 2023

22

1 reference

https://api.crossref.org/works/10.1016/S0070-2153(03)54011-X

Astrocytes containing amyloid beta-protein (Abeta)-positive granules are associated with Abeta40-positive diffuse plaques in the aged human brain

24 December 2023

37

1 reference

https://api.crossref.org/works/10.1016/S0070-2153(03)54011-X

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

24 December 2023

46

1 reference

https://api.crossref.org/works/10.1016/S0070-2153(03)54011-X

Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

24 December 2023

60

1 reference

https://api.crossref.org/works/10.1016/S0070-2153(03)54011-X

Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase

24 December 2023

62

1 reference

https://api.crossref.org/works/10.1016/S0070-2153(03)54011-X

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

24 December 2023

63

1 reference

https://api.crossref.org/works/10.1016/S0070-2153(03)54011-X

Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors

24 December 2023

65

1 reference

https://api.crossref.org/works/10.1016/S0070-2153(03)54011-X

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

24 December 2023

68

1 reference

https://api.crossref.org/works/10.1016/S0070-2153(03)54011-X

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

24 December 2023

72

1 reference

https://api.crossref.org/works/10.1016/S0070-2153(03)54011-X

The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain

24 December 2023

74

1 reference

https://api.crossref.org/works/10.1016/S0070-2153(03)54011-X

Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

24 December 2023

75

1 reference

https://api.crossref.org/works/10.1016/S0070-2153(03)54011-X

Cognitive changes and modified processing of amyloid precursor protein in the cortical and hippocampal system after cholinergic synapse loss and muscarinic receptor activation

24 December 2023

76

1 reference

https://api.crossref.org/works/10.1016/S0070-2153(03)54011-X

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

24 December 2023

78

1 reference

https://api.crossref.org/works/10.1016/S0070-2153(03)54011-X

The Notch1 receptor is cleaved constitutively by a furin-like convertase

24 December 2023

79

1 reference

https://api.crossref.org/works/10.1016/S0070-2153(03)54011-X

A family of membrane-embedded metalloproteases involved in regulated proteolysis of membrane-associated transcription factors

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100

1 reference

https://api.crossref.org/works/10.1016/S0070-2153(03)54011-X

Beta-amyloid precursor protein cleavage by a membrane-bound protease

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115

1 reference

https://api.crossref.org/works/10.1016/S0070-2153(03)54011-X

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

24 December 2023

127

1 reference

https://api.crossref.org/works/10.1016/S0070-2153(03)54011-X

Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease

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140

1 reference

https://api.crossref.org/works/10.1016/S0070-2153(03)54011-X

24 December 2023

Identifiers

1 reference

6 August 2017

1 reference

PubMed ID

12696752