(Q35146774)

6 August 2017

title

Viewing serine/threonine protein phosphatases through the eyes of drug designers (English)

1 reference

6 August 2017

Mengmeng Zhang

1

1 reference

6 August 2017

S D Yogesha

2

1 reference

6 August 2017

Joshua E Mayfield

3

1 reference

6 August 2017

Gordon N Gill

4

1 reference

6 August 2017

Yan Zhang

5

1 reference

6 August 2017

language of work or name

English

0 references

publication date

5 September 2013

1 reference

6 August 2017

1 reference

6 August 2017

volume

280

1 reference

6 August 2017

issue

19

1 reference

6 August 2017

page(s)

4739-4760

1 reference

The Molecular Mechanism of Substrate Engagement and Immunosuppressant Inhibition of Calcineurin

6 August 2017

cites work

1 reference

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Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits

28 July 2018

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Challenges and opportunities in the development of protein phosphatase-directed therapeutics.

28 July 2018

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Regulation of protein phosphatase 1 by intrinsically disordered proteins

28 July 2018

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The Molecular Basis for Substrate Specificity of the Nuclear NIPP1:PP1 Holoenzyme

28 July 2018

1 reference

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Tau protein phosphatases in Alzheimer's disease: the leading role of PP2A.

28 July 2018

1 reference

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Small molecules targeted to a non-catalytic "RVxF" binding site of protein phosphatase-1 inhibit HIV-1

28 July 2018

1 reference

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Protein phosphatases and their regulation in the control of mitosis

28 July 2018

1 reference

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The PP1 binding code: a molecular-lego strategy that governs specificity

28 July 2018

1 reference

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Phosphatases driving mitosis: pushing the gas and lifting the brakes

28 July 2018

1 reference

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The role and therapeutic potential of Ser/Thr phosphatase PP2A in apoptotic signalling networks in human cancer cells

28 July 2018

1 reference

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Structural basis for protein phosphatase 1 regulation and specificity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Exploiting the cancer genome: strategies for the discovery and clinical development of targeted molecular therapeutics

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Pleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP): a new player in cell signaling.

28 July 2018

1 reference

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Bio-molecular architects: a scaffold provided by the C-terminal domain of eukaryotic RNA polymerase II

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Deep proteome and transcriptome mapping of a human cancer cell line

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Selective Inactivation of a Human Neuronal Silencing Phosphatase by a Small Molecule Inhibitor

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Targeting SET/I(2)PP2A oncoprotein functions as a multi-pathway strategy for cancer therapy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Molecular investigations of the structure and function of the protein phosphatase 1-spinophilin-inhibitor 2 heterotrimeric complex

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Greatwall phosphorylates an inhibitor of protein phosphatase 2A that is essential for mitosis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Identification of PP2A complexes and pathways involved in cell transformation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Structural signature of the MYPT1-PP1 interaction.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Flexibility in the PP1:spinophilin holoenzyme

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Discovery of small molecule inhibitors of the PH domain leucine-rich repeat protein phosphatase (PHLPP) by chemical and virtual screening

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Regulated protein kinases and phosphatases in cell cycle decisions

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

The extended PP1 toolkit: designed to create specificity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Structural and functional analysis of the phosphoryl transfer reaction mediated by the human small C-terminal domain phosphatase, Scp1

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Sanguinarine as a potent and specific inhibitor of protein phosphatase 2C in vitro and induces apoptosis via phosphorylation of p38 in HL60 cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Serine/threonine phosphatases: mechanism through structure

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

WIP1 phosphatase at the crossroads of cancer and aging

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Structure and function of the PP2A-shugoshin interaction

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

C-terminal sequences of hsp70 and hsp90 as non-specific anchors for tetratricopeptide repeat (TPR) proteins

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Structure-activity relationship studies of fostriecin, cytostatin, and key analogs, with PP1, PP2A, PP5, and( beta12-beta13)-chimeras (PP1/PP2A and PP5/PP2A), provide further insight into the inhibitory actions of fostriecin family inhibitors

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Targeting protein serine/threonine phosphatases for drug development

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

PPM1D is a potential therapeutic target in ovarian clear cell carcinomas

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Protein phosphatase 5 regulates the function of 53BP1 after neocarzinostatin-induced DNA damage

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

The Structure of Fcp1, an Essential RNA Polymerase II CTD Phosphatase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Therapeutic protein kinase inhibitors

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Crystal Structures of Protein Phosphatase-1 Bound to Nodularin-R and Tautomycin: A Novel Scaffold for Structure-based Drug Design of Serine/Threonine Phosphatase Inhibitors

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Cracking the RNA polymerase II CTD code

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

The type 2C phosphatase Wip1: an oncogenic regulator of tumor suppressor and DNA damage response pathways.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

The role of serine/threonine protein phosphatase type 5 (PP5) in the regulation of stress-induced signaling networks and cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Role of PP2Calpha in cell growth, in radio- and chemosensitivity, and in tumorigenicity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Medulloblastomas overexpress the p53-inactivating oncogene WIP1/PPM1D

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

CIP2A inhibits PP2A in human malignancies

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS development

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Determinants for Dephosphorylation of the RNA Polymerase II C-Terminal Domain by Scp1

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming growth factor-beta pathways.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

The alpha4 regulatory subunit exerts opposing allosteric effects on protein phosphatases PP6 and PP2A.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Characterization of a novel human protein phosphatase 2C family member, PP2Ckappa.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Discovery of protein phosphatase 2C inhibitors by virtual screening

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Crystal structures of protein phosphatase-1 bound to motuporin and dihydromicrocystin-LA: elucidation of the mechanism of enzyme inhibition by cyanobacterial toxins

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Multisite protein phosphorylation makes a good threshold but can be a poor switch

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

The promise of molecular targeted therapies: protein kinase inhibitors in the treatment of cutaneous malignancies.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Protein serine/threonine phosphatases: life, death, and sleeping.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor of mitogen-activated protein kinase phosphatase-1.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Phosphoryl group transfer: evolution of a catalytic scaffold

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

The p53-induced oncogenic phosphatase PPM1D interacts with uracil DNA glycosylase and suppresses base excision repair

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Structural basis of protein phosphatase 1 regulation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Microcystin-LR and okadaic acid-induced cellular effects: a dualistic response.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Functional diversity of protein phosphatase-1, a cellular economizer and reset button

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

A comparison of phosphonothioic acids with phosphonic acids as phosphatase inhibitors.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Regulation of IL4 gene expression by T cells and therapeutic perspectives

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

A Novel RNA Polymerase II C-terminal Domain Phosphatase That Preferentially Dephosphorylates Serine 5

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Fostriecin: chemistry and biology

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Protein kinases--the major drug targets of the twenty-first century?

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Crystal structure of the complex between calyculin A and the catalytic subunit of protein phosphatase 1

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Protein phosphatase 1--targeted in many directions

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Opposing effects of Ctk1 kinase and Fcp1 phosphatase at Ser 2 of the RNA polymerase II C-terminal domain

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Crystal structure of the tumor-promoter okadaic acid bound to protein phosphatase-1

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Calcineurin: form and function

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

FK506, an immunosuppressant targeting calcineurin function

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Molecular cloning, expression, and characterization of a novel human serine/threonine protein phosphatase, PP7, that is homologous to Drosophila retinal degeneration C gene product (rdgC)

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Fostriecin, an antitumor antibiotic with inhibitory activity against serine/threonine protein phosphatases types 1 (PP1) and 2A (PP2A), is highly selective for PP2A.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Fostriecin: a review of the preclinical data

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Crystal structure of the protein serine/threonine phosphatase 2C at 2.0 A resolution

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

The tetratricopeptide repeat domain of protein phosphatase 5 mediates binding to glucocorticoid receptor heterocomplexes and acts as a dominant negative mutant

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Ceramide activates heterotrimeric protein phosphatase 2A.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

A mutant of protein phosphatase-1 that exhibits altered toxin sensitivity.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

NF-AT-AP-1 and Rel-bZIP: hybrid vigor and binding under the influence

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Mutagenesis of the catalytic subunit of rabbit muscle protein phosphatase-1.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Crystal structure of the catalytic subunit of human protein phosphatase 1 and its complex with tungstate

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Inhibition of protein phosphatases by microcystins and nodularin associated with hepatotoxicity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Characterization of microcystin-LR, a potent inhibitor of type 1 and type 2A protein phosphatases.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

A novel protein phosphatase inhibitor, tautomycin. Effect on smooth muscle.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Signal integration at the level of protein kinases, protein phosphatases and their substrates

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Biological effects of cyclosporin A: A new antilymphocytic agent

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling

28 July 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12481

Phosphatases: providing safe passage through mitotic exit

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12481

Structure and mechanism of RNA polymerase II CTD phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12481

Protein tyrosine phosphatases in the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12481

Chemical inhibition of Wip1 phosphatase contributes to suppression of tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12481

Small molecule tools for functional interrogation of protein tyrosine phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12481

An essential component of a C-terminal domain phosphatase that interacts with transcription factor IIF in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12481

Different strategies for carboxyl-terminal domain (CTD) recognition by serine 5-specific CTD phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12481

Small CTD phosphatases function in silencing neuronal gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12481

Characterization of the CTD phosphatase Fcp1 from fission yeast. Preferential dephosphorylation of serine 2 versus serine 5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12481

Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12481

Suppression of survival signalling pathways by the phosphatase PHLPP

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12481

The cyanobacterial toxin microcystin binds covalently to cysteine-273 on protein phosphatase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12481

A structural basis for the reduced toxicity of dinophysistoxin-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12481

PP1 and PP2A phosphatases--cooperating partners in modulating retinoblastoma protein activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12481

Activation of protein phosphatase 1 by a small molecule designed to bind to the enzyme's regulatory site

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12481

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12481

Disruption of protein phosphatase 2A subunit interaction in human cancers with mutations in the A alpha subunit gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12481

The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12481

Coordinate involvement of cell cycle arrest and apoptosis strengthen the effect of FTY720.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12481

Fundamental role of the fostriecin unsaturated lactone and implications for selective protein phosphatase inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12481

Phase I and pharmacokinetic study of fostriecin given as an intravenous bolus daily for five consecutive days

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12481

Preliminary evidence for in vivo tumour initiation by oral administration of extracts of the blue-green alga cylindrospermopsis raciborskii containing the toxin cylindrospermopsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12481

The toxic responses induced by okadaic acid involve processing of multiple caspase isoforms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12481

Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12481

The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12481

Protein phosphatase 5 is required for ATR-mediated checkpoint activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12481

The cross-sectional and longitudinal association of the BODE index with quality of life in patients with chronic obstructive pulmonary disease.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Small-molecule inhibitors of ser/thr protein phosphatases: specificity, use and common forms of abuse

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

PPM1D is a potential target for 17q gain in neuroblastoma

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Hyperphosphorylation of cytokeratins by okadaic acid class tumor promoters in primary human keratinocytes.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

The complex of FK506-binding protein 12 and FK506 inhibits calcineurin phosphatase activity and IgE activation-induced cytokine transcripts, but not exocytosis, in mouse mast cells.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4349438

Okadaic acid, a cytotoxic polyether from two marine sponges of the genus Halichondria

27 September 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12481

Wip1 Phosphatase Modulates ATM-Dependent Signaling Pathways

21 January 2018

1 reference

12 December 2020

Cyclosporin A inhibits Ca2+/calmodulin-dependent protein phosphatase and secretion in pancreatic acinar cells

1 reference

12 December 2020

Calyculin A and okadaic acid: inhibitors of protein phosphatase activity

1 reference

12 December 2020

Development of a substrate-based cyclic phosphopeptide inhibitor of protein phosphatase 2Cdelta, Wip1

1 reference

12 December 2020

Molecular mechanisms underlying he interaction of motuporin and microcystins with type-1 and type-2A protein phosphatases

1 reference

12 December 2020

Role of protein phosphatases in malignant transformation

1 reference

12 December 2020

Tyrosine-272 is involved in the inhibition of protein phosphatase-1 by multiple toxins

1 reference

12 December 2020

Protein phosphatase 2A--a 'ménage à trois'

1 reference

12 December 2020

Identifiers

DOI

10.1111/FEBS.12481

1 reference

6 August 2017

1 reference

6 August 2017

1 reference