(Q35778961)

10 August 2017

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title

Clinical pharmacology: special safety considerations in drug development and pharmacovigilance (English)

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10 August 2017

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Dyfrig Hughes

2

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Munir Pirmohamed

object named as

Munir Pirmohamed

series ordinal

3

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author name string

Kwame N Atuah

series ordinal

1

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10 August 2017

1 January 2004

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10 August 2017

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10 August 2017

27

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10 August 2017

535-554

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10 August 2017

8

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https://scigraph.springernature.com/pub.10.2165/00002018-200427080-00006

10 August 2017

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cites work

The use of cimetidine as a selective inhibitor of dapsone N-hydroxylation in man.

1 reference

Crossref

https://api.crossref.org/works/10.2165%2F00002018-200427080-00006

Drug-drug interaction mediated by inhibition and induction of P-glycoprotein.

21 January 2018

1 reference

12 December 2020

Faster clearance of sustained release verapamil in men versus women: continuing observations on sex-specific differences after oral administration of verapamil

1 reference

12 December 2020

Coadministration of oral cyclosporin A enables oral therapy with paclitaxel

1 reference

12 December 2020

Metabolism of dapsone to a hydroxylamine by human neutrophils and mononuclear cells

1 reference

12 December 2020

Prescription-event monitoring--recent progress and future horizons

1 reference

12 December 2020

Determination of an optimal dosage regimen using a Bayesian decision analysis of efficacy and adverse effect data

1 reference

12 December 2020

Reasons for disagreement in the standardized assessment of suspected adverse drug reactions

1 reference

12 December 2020

Understanding the dose-effect relationship: clinical application of pharmacokinetic-pharmacodynamic models

1 reference

12 December 2020

Challenges in conducting pediatric drug trials

1 reference

12 December 2020

Changes in prescribed drug doses after market introduction

1 reference

12 December 2020

A new extrapolation method from animals to man: application to a metabolized compound, mofarotene

1 reference

12 December 2020

Clinical pharmacokinetics of dapsone

1 reference

12 December 2020

Pharmacokinetics of imipenem-cilastatin in neonates

1 reference

12 December 2020

Danger: the view from the bottom of the cliff

1 reference

12 December 2020

Unlicensed and off-label uses of drugs in paediatrics: a review of the literature.

1 reference

12 December 2020

Adverse renal effects of anti-inflammatory agents: evaluation of selective and nonselective cyclooxygenase inhibitors

1 reference

12 December 2020

How important are gender differences in pharmacokinetics?

1 reference

12 December 2020

Immunoquantification of epoxide hydrolase and cytochrome P-450 isozymes in fetal and adult human liver microsomes

1 reference

12 December 2020

Bioactivation of dapsone to a cytotoxic metabolite: in vitro use of a novel two compartment system which contains human tissues

1 reference

12 December 2020

Postmarketing drug dosage changes of 499 FDA-approved new molecular entities, 1980-1999.

1 reference

12 December 2020

Maximizing the value of medicines by including pharmacogenetic research in drug development and surveillance

1 reference

12 December 2020

Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase

1 reference

12 December 2020

Metabolic activation in drug allergies.

1 reference

12 December 2020

Pathway-selective sex differences in the metabolic clearance of propranolol in human subjects

1 reference

12 December 2020

Drug development process for a product with a primary pediatric indication.

1 reference

12 December 2020

Bone marrow toxicity caused by azathioprine in inflammatory bowel disease: 27 years of experience

1 reference

12 December 2020

Effect of food and gastric acidity on absorption of orally administered ketoconazole

1 reference

12 December 2020

Incidence of adverse drug reactions in paediatric in/out-patients: a systematic review and meta-analysis of prospective studies

1 reference

12 December 2020

Advances in molecular toxicology-towards understanding idiosyncratic drug toxicity

1 reference

12 December 2020

Expression of CYP3A in the human liver--evidence that the shift between CYP3A7 and CYP3A4 occurs immediately after birth

1 reference

12 December 2020

Pharmacogenetics and future drug development and delivery

1 reference

12 December 2020

Pharmacogenetics and personalised medicine

1 reference

12 December 2020

Low-dose captopril for the treatment of mild to moderate hypertension. I. Results of a 14-week trial. Veterans Administration Cooperative Study Group on Antihypertensive Agents

1 reference

12 December 2020

Drug metabolism and disposition in children

1 reference

12 December 2020

The impact of genomics-based technologies on drug safety evaluation

1 reference

12 December 2020

Reporting of adverse drug reactions by nurses

1 reference

12 December 2020

Drug interactions at the renal level. Implications for drug development

1 reference

12 December 2020

Adverse drug reactions to unlicensed and off-label drugs on paediatric wards: a prospective study

1 reference

12 December 2020

Clinical pharmacology: future prospects for the discipline

1 reference

12 December 2020

Women experience greater toxicity with fluorouracil-based chemotherapy for colorectal cancer

1 reference

12 December 2020

UK's yellow card scheme to be extended

1 reference

12 December 2020

Implementing the FDA Modernization Act

1 reference

12 December 2020

Bosentan, a new endothelin receptor antagonist: prediction of the systemic plasma clearance in man from combined in vivo and in vitro data

1 reference

12 December 2020

Rheumatoid arthritis: the effects of treatment with dapsone on hemoglobin

1 reference

12 December 2020

Molecular genetics of CYP2D6: clinical relevance with focus on psychotropic drugs

1 reference

12 December 2020

Sex differences in absorption kinetics of sodium salicylate

1 reference

12 December 2020

Causality assessment of adverse drug reactions: comparison of the results obtained from published decisional algorithms and from the evaluations of an expert panel, according to different levels of imputability.

1 reference

12 December 2020

Hemolysis by diphenylsulfones: comparative effects of DDS and hydroxylamine-DDS

1 reference

12 December 2020

Direct, MHC-dependent presentation of the drug sulfamethoxazole to human alphabeta T cell clones

1 reference

12 December 2020

Biochemistry of multidrug resistance mediated by the multidrug transporter

1 reference

12 December 2020

Impact of St John's wort treatment on the pharmacokinetics of tacrolimus and mycophenolic acid in renal transplant patients

1 reference

12 December 2020

Joining the DoTS: new approach to classifying adverse drug reactions

1 reference

12 December 2020

Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences

1 reference

12 December 2020

An investigation of the role of metabolism in dapsone-induced methaemoglobinaemia using a two compartment in vitro test system

1 reference

12 December 2020

The effect of preincubation with cimetidine on the N-hydroxylation of dapsone by human liver microsomes

1 reference

12 December 2020

Renal clearance of imipenem in children

1 reference

12 December 2020

Adverse drug reactions

1 reference

12 December 2020

Diazepam Kinetics in Relation to Age and Sex

1 reference

12 December 2020

Cytochrome P450 enzyme polymorphisms and adverse drug reactions

1 reference

12 December 2020

Azathioprine-induced severe pancytopenia due to a homozygous two-point mutation of the thiopurine methyltransferase gene in a patient with juvenile HLA-B27-associated spondylarthritis

1 reference

12 December 2020

Pharmacogenetics of antidepressants: clinical aspects

1 reference

12 December 2020

Cimetidine improves the therapeutic/toxic ratio of dapsone in patients on chronic dapsone therapy

1 reference

12 December 2020

Captopril: a preliminary review of its pharmacological properties and therapeutic efficacy

1 reference

12 December 2020

Cardiovascular drug therapy in the elderly: theoretical and practical considerations

1 reference

12 December 2020

High-throughput screening approaches for investigating drug metabolism and pharmacokinetics

1 reference

12 December 2020

P-glycoprotein system as a determinant of drug interactions: the case of digoxin-verapamil

1 reference

12 December 2020

Captopril: clinical pharmacology and benefit-to-risk ratio in hypertension and congestive heart failure

1 reference

12 December 2020

Under-reporting of adverse drug reactions. Estimate based on a spontaneous reporting scheme and a sentinel system

1 reference

12 December 2020

Clinical trials in the elderly. Pivotal points.

1 reference

12 December 2020

Including elderly people in clinical trials

1 reference

12 December 2020

Adverse drug reactions and off-label drug use in paediatric outpatients

1 reference

12 December 2020

Update: the clinical importance of acetaminophen hepatotoxicity in non-alcoholic and alcoholic subjects

1 reference

12 December 2020

Immunological principles of adverse drug reactions: the initiation and propagation of immune responses elicited by drug treatment

1 reference

12 December 2020

Pharmacokinetic interaction of digoxin with an herbal extract from St John's wort (Hypericum perforatum)

1 reference

12 December 2020

Genetic and molecular basis of cardiac arrhythmias: impact on clinical management parts I and II

1 reference

12 December 2020

From pharmacovigilance to pharmacoperformance

1 reference

12 December 2020

Drug absorption limited by P-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers

1 reference

12 December 2020

Pharmacokinetic/pharmacodynamic studies in drug product development

1 reference

12 December 2020

Comparison of two cyclosporine formulations in healthy volunteers: bioequivalence of the new Sang-35 formulation and Neoral

1 reference

12 December 2020

Thiopurine methyltransferase genotype predicts therapy-limiting severe toxicity from azathioprine

1 reference

12 December 2020

Review of the Overall Experience of Captopril in Hypertension

1 reference

12 December 2020

Mechanism of action of adverse drug reactions: an overview

1 reference

12 December 2020

Relationship between phenytoin and tolbutamide hydroxylations in human liver microsomes

1 reference

12 December 2020

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

1 reference

12 December 2020

Safety and efficacy of chronic therapy with captopril in hypertensive patients: an update

1 reference

12 December 2020

The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

1 reference

12 December 2020

Simulation of clinical trials

1 reference

12 December 2020

First-time-in-human dose selection: allometric thoughts and perspectives

1 reference

12 December 2020

Involvement of T cells in drug-induced allergies

1 reference

12 December 2020

Immunopharmacology of hypersensitivity reactions to drugs

1 reference

12 December 2020

Pharmacogenetics of cytochrome p4502D6: genetic background and clinical implication

1 reference

12 December 2020

Quantitative characterization of therapeutic index: application of mixed-effects modeling to evaluate oxybutynin dose-efficacy and dose-side effect relationships

1 reference

12 December 2020

Expression profiling using cDNA microarrays

1 reference

12 December 2020

Toward the operational identification of adverse drug reactions

1 reference

12 December 2020

The use of population pharmacokinetics in drug development

1 reference

12 December 2020

Genetic polymorphisms in drug-metabolizing enzymes and drug targets

1 reference

12 December 2020

Paediatric medicines research in the UK: how to move forward?

1 reference

12 December 2020

Antiretroviral pharmacokinetics in the paediatric population: a review

1 reference

12 December 2020

A method for estimating the probability of adverse drug reactions

1 reference

12 December 2020

Captopril in hypertension; seven years later

1 reference

12 December 2020

A drug is not a drug is not a drug: a commentary

1 reference

12 December 2020

Potential role of pharmacogenomics in reducing adverse drug reactions: a systematic review

1 reference

12 December 2020

Self-reported side effects from antihypertensive drugs. A clinical trial. Quality of Life Research Group

1 reference

12 December 2020

Pharmacokinetic consequences of drug displacement from blood and tissue proteins

1 reference

12 December 2020

Adverse drug reactions in the community health setting: approaches to recognizing, counseling, and reporting

1 reference

12 December 2020

Genetic susceptibility to adverse drug reactions

1 reference

12 December 2020

beta(2)-adrenergic receptor pharmacogenetics

1 reference

12 December 2020

Cytochrome P450 2C9 polymorphisms: a comprehensive review of the in-vitro and human data.

1 reference

12 December 2020

Incentive to study drugs in children and other governmental initiatives: will patients with asthma benefit?

1 reference

12 December 2020

Pediatric drug labeling: improving the safety and efficacy of pediatric therapies

1 reference

12 December 2020

Pharmacogenetics of asthma

1 reference

12 December 2020

Pharmacogenetics: an opportunity for a safer and more efficient pharmacotherapy

1 reference

12 December 2020

Use of prescription medications in an elderly rural population: the MoVIES Project

1 reference

12 December 2020

Pediatric clinical pharmacology. A practical review

1 reference

12 December 2020

Genetic polymorphism of the CYP2C subfamily and excessive serum phenytoin concentration with central nervous system intoxication

1 reference

12 December 2020

What is the true clinical significance of plasma protein binding displacement interactions?

1 reference

12 December 2020

The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data.

1 reference

12 December 2020

Adverse drug reactions: back to the future

1 reference

12 December 2020

Cisapride disposition in neonates and infants: in vivo reflection of cytochrome P450 3A4 ontogeny

1 reference

12 December 2020

Self-management of over-the-counter medications by older adults

1 reference

12 December 2020

What will be the role of pharmacogenetics in evaluating drug safety and minimising adverse effects?

1 reference

12 December 2020

Aspects of standardization as applied to the assessment of drug-event associations.

1 reference

12 December 2020

Interactions of warfarin with drugs and food

1 reference

12 December 2020

Clinical pharmacology. Adverse reactions to drugs.

1 reference

12 December 2020

Possible role of the intestinal P-450 enzyme system in a cyclosporine-clarithromycin interaction

1 reference

12 December 2020

Pharmacokinetic drug interactions with cyclosporin (Part I).

1 reference

12 December 2020

Women in clinical trials--a portfolio for success

1 reference

12 December 2020

The influence of sex on pharmacokinetics

1 reference

12 December 2020

Population Pharmacokinetics/Dynamics*

1 reference

12 December 2020

Gender-specific effects on verapamil pharmacokinetics and pharmacodynamics in humans

1 reference

12 December 2020

Evidence of impaired cisapride metabolism in neonates

1 reference

12 December 2020

Digoxin pharmacokinetics and MDR1 genetic polymorphisms

1 reference

12 December 2020

Drug interaction between St John's wort and nevirapine

1 reference

12 December 2020

Coadministration of cyclosporine strongly enhances the oral bioavailability of docetaxel

1 reference

12 December 2020

Clinically relevant drug-drug interactions in oncology

1 reference

12 December 2020

Clinical pharmacology and therapeutic applications of the new oral angiotensin converting enzyme inhibitor, captopril

1 reference

12 December 2020

Screening lead compounds for QT interval prolongation

1 reference

12 December 2020

Survey of unlicensed and off label drug use in paediatric wards in European countries. European Network for Drug Investigation in Children

1 reference

12 December 2020

Assessing methods for causality assessment of suspected adverse drug reactions

1 reference

12 December 2020

The danger hypothesis--potential role in idiosyncratic drug reactions

1 reference

12 December 2020

Do non-steroidal anti-inflammatory drugs and COX-2 selective inhibitors have different renal effects?

1 reference

12 December 2020

Attitudinal survey of voluntary reporting of adverse drug reactions

1 reference

12 December 2020

The effect of nonsteroidal anti-inflammatory drugs on blood pressure in patients treated with different antihypertensive drugs

1 reference

12 December 2020

Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism

1 reference

12 December 2020

Exploring clinical study design by computer simulation based on pharmacokinetic/pharmacodynamic modelling

1 reference

12 December 2020

Adverse drug reactions: definitions, diagnosis, and management

1 reference

12 December 2020

Debrisoquine/sparteine hydroxylation genotype and phenotype: analysis of common mutations and alleles of CYP2D6 in a European population

1 reference

12 December 2020

Dapsone, trimethoprim, and sulfamethoxazole plasma levels during treatment of Pneumocystis pneumonia in patients with the acquired immunodeficiency syndrome (AIDS). Evidence of drug interactions

1 reference

12 December 2020

Lead optimization strategies as part of a drug metabolism environment

1 reference

12 December 2020

Comparative kinetics and response to the benzodiazepine agonists triazolam and zolpidem: evaluation of sex-dependent differences.

1 reference

12 December 2020

Clinical trial simulation in drug development

1 reference

12 December 2020

Severe pancytopenia in a patient taking low dose methotrexate and probenecid

1 reference

12 December 2020

Allergic and autoimmune reactions to xenobiotics: how do they arise?

1 reference

12 December 2020

Indinavir concentrations and St John's wort.

1 reference

12 December 2020

The safety of newly approved medicines: do recent market removals mean there is a problem?

1 reference

12 December 2020

10.2165/00002018-200427080-00006

Identifiers

DOI

1 reference

PubMed ID

15154826

Dimensions Publication ID

10 August 2017

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1 reference

PubMed ID

15154826