(Q35830448)

10 August 2017

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title

New concepts in the regulation of an ancient reaction: transposition by RAG1/RAG2. (English)

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10 August 2017

Monalisa Chatterji

1

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10 August 2017

Chia-Lun Tsai

series ordinal

2

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10 August 2017

David G Schatz

series ordinal

3

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10 August 2017

language of work or name

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1 August 2004

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10 August 2017

published in

Immunological Reviews

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10 August 2017

volume

200

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10 August 2017

page(s)

261-271

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Somatic generation of antibody diversity

10 August 2017

cites work

1 reference

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The V(D)J recombination activating gene, RAG-1.

21 January 2018

1 reference

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Stimulation of V(D)J cleavage by high mobility group proteins

21 January 2018

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V(D)J recombination: modulation of RAG1 and RAG2 cleavage activity on 12/23 substrates by whole cell extract and DNA-bending proteins

21 January 2018

1 reference

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Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps.

21 January 2018

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RAG1 and RAG2 in V(D)J recombination and transposition

21 January 2018

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A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavage

21 January 2018

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Distinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequences

21 January 2018

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RAG1 and RAG2 cooperate in specific binding to the recombination signal sequence in vitro

21 January 2018

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The RAG-HMG1 complex enforces the 12/23 rule of V(D)J recombination specifically at the double-hairpin formation step

21 January 2018

1 reference

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Nicking is asynchronous and stimulated by synapsis in 12/23 rule-regulated V(D)J cleavage

21 January 2018

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Functional analysis of coordinated cleavage in V(D)J recombination

21 January 2018

1 reference

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Assembly of a 12/23 paired signal complex: a critical control point in V(D)J recombination

21 January 2018

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Evidence of a critical architectural function for the RAG proteins in end processing, protection, and joining in V(D)J recombination

21 January 2018

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RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination

21 January 2018

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The RAG proteins and V(D)J recombination: complexes, ends, and transposition

21 January 2018

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V(D)J recombination: RAG proteins, repair factors, and regulation

21 January 2018

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The mechanism and regulation of chromosomal V(D)J recombination

21 January 2018

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Intermediates in V(D)J recombination: a stable RAG1/2 complex sequesters cleaved RSS ends.

21 January 2018

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The "dispensable" portion of RAG2 is necessary for efficient V-to-DJ rearrangement during B and T cell development

21 January 2018

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Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice

21 January 2018

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Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice.

21 January 2018

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Roles of the "dispensable" portions of RAG-1 and RAG-2 in V(D)J recombination

21 January 2018

1 reference

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Autoubiquitylation of the V(D)J recombinase protein RAG1

21 January 2018

1 reference

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The RAG1 N-terminal domain is an E3 ubiquitin ligase

21 January 2018

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Chromosomal translocations in lymphoid malignancies reveal novel proto-oncogenes

21 January 2018

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Genetic instabilities in human cancers

21 January 2018

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The role of DNA breaks in genomic instability and tumorigenesis

21 January 2018

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Restraining the V(D)J recombinase

21 January 2018

1 reference

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A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex

21 January 2018

1 reference

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DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations

21 January 2018

1 reference

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Identification of two catalytic residues in RAG1 that define a single active site within the RAG1/RAG2 protein complex.

21 January 2018

1 reference

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Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system

21 January 2018

1 reference

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The outs and ins of transposition: from mu to kangaroo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00167.X

Integrating DNA: transposases and retroviral integrases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00167.X

Resident aliens: the Tc1/mariner superfamily of transposable elements

21 January 2018

1 reference

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In vivo transposition mediated by V(D)J recombinase in human T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00167.X

V(D)J recombination and RAG-mediated transposition in yeast.

21 January 2018

1 reference

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T-cell receptor alpha locus V(D)J recombination by-products are abundant in thymocytes and mature T cells

21 January 2018

1 reference

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Cell cycle-dependent accumulation in vivo of transposition-competent complexes between recombination signal ends and full-length RAG proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00167.X

Rejoining of DNA by the RAG1 and RAG2 proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00167.X

Increased accumulation of hybrid V(D)J joins in cells expressing truncated versus full-length RAGs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00167.X

Ku86 is not required for protection of signal ends or for formation of nonstandard V(D)J recombination products

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00167.X

Regulation of RAG1/RAG2-mediated transposition by GTP and the C-terminal region of RAG2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00167.X

The C-terminal portion of RAG2 protects against transposition in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00167.X

Full-length RAG-2, and Not Full-length RAG-1, Specifically Suppresses RAG-mediated Transposition but Not Hybrid Joint Formation or Disintegration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00167.X

Ordered DNA release and target capture in RAG transposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00167.X

RAG transposase can capture and commit to target DNA before or after donor cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00167.X

V(D)J recombination defects in lymphocytes due to RAG mutations: severe immunodeficiency with a spectrum of clinical presentations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00167.X

10.1111/J.0105-2896.2004.00167.X

21 January 2018

Identifiers

DOI

1 reference

10 August 2017

1 reference