(Q36725213)

15 August 2017

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title

Cellular proteolytic systems in P450 degradation: evolutionary conservation from Saccharomyces cerevisiae to mammalian liver (English)

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15 August 2017

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Saccharomyces cerevisiae

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1

Maria Almira Correia

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15 August 2017

Mingxiang Liao

2

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15 August 2017

language of work or name

English

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publication date

1 February 2007

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Expert Opinion on Drug Metabolism & Toxicology

15 August 2017

published in

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15 August 2017

volume

3

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15 August 2017

issue

1

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15 August 2017

page(s)

33-49

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Hepatic cytochrome P450 degradation: mechanistic diversity of the cellular sanitation brigade

15 August 2017

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21 January 2018

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21 January 2018

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Proteolytic degradation of heme-modified hepatic cytochromes P450: A role for phosphorylation, ubiquitination, and the 26S proteasome?

21 January 2018

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Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression

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Inactivation of cytochrome P450 3A4 by bergamottin, a component of grapefruit juice

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6'7'-Dihydroxybergamottin contributes to the grapefruit juice effect

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Two major grapefruit juice components differ in time to onset of intestinal CYP3A4 inhibition

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Endoplasmic reticulum-associated degradation

21 January 2018

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Proteasome-dependent endoplasmic reticulum-associated protein degradation: an unconventional route to a familiar fate

21 January 2018

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ER-associated degradation in protein quality control and cellular regulation

21 January 2018

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ERAD: the long road to destruction

21 January 2018

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Autophagy in the eukaryotic cell

21 January 2018

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Autophagy as a regulated pathway of cellular degradation

21 January 2018

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Autophagy: molecular machinery for self-eating

21 January 2018

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The molecular machinery of autophagy: unanswered questions

21 January 2018

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Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing.

21 January 2018

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Endoplasmic reticulum-associated degradation of the human type 2 iodothyronine deiodinase (D2) is mediated via an association between mammalian UBC7 and the carboxyl region of D2.

21 January 2018

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Cytochrome P450 ubiquitination: branding for the proteolytic slaughter?

21 January 2018

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The unfolded protein response regulates multiple aspects of secretory and membrane protein biogenesis and endoplasmic reticulum quality control

21 January 2018

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An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

21 January 2018

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Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein

21 January 2018

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A highly conserved signal controls degradation of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase in eukaryotes

21 January 2018

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HRD gene dependence of endoplasmic reticulum-associated degradation

21 January 2018

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Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation.

21 January 2018

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Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p.

21 January 2018

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In vivo action of the HRD ubiquitin ligase complex: mechanisms of endoplasmic reticulum quality control and sterol regulation

21 January 2018

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Role of Cue1p in ubiquitination and degradation at the ER surface

21 January 2018

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The DOA pathway: studies on the functions and mechanisms of ubiquitin-dependent protein degradation in the yeast Saccharomyces cerevisiae

21 January 2018

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A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation

21 January 2018

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Distinct machinery is required in Saccharomyces cerevisiae for the endoplasmic reticulum-associated degradation of a multispanning membrane protein and a soluble luminal protein

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Membrane and soluble substrates of the Doa10 ubiquitin ligase are degraded by distinct pathways

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.3.1.33

HRD4/NPL4 is required for the proteasomal processing of ubiquitinated ER proteins

21 January 2018

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A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways

21 January 2018

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Valosin-containing protein is a multi-ubiquitin chain-targeting factor required in ubiquitin-proteasome degradation

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.3.1.33

AAA-ATPase p97/Cdc48p, a cytosolic chaperone required for endoplasmic reticulum-associated protein degradation

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane

21 January 2018

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Distinct steps in dislocation of luminal endoplasmic reticulum-associated degradation substrates: roles of endoplamic reticulum-bound p97/Cdc48p and proteasome

21 January 2018

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21 January 2018

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Polyubiquitin chains: polymeric protein signals

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Themes and variations on ubiquitylation

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.3.1.33

21 January 2018

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Tumor necrosis factor alpha-induced phosphorylation of I kappa B alpha is a signal for its degradation but not dissociation from NF-kappa B

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Roles of molecular chaperones in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Ubiquitin is conjugated by membrane ubiquitin ligase to three sites, including the N terminus, in transmembrane region of mammalian 3-hydroxy-3-methylglutaryl coenzyme A reductase: implications for sterol-regulated enzyme degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

A 'distributed degron' allows regulated entry into the ER degradation pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Function of WW domains as phosphoserine- or phosphothreonine-binding modules

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

AAA ATPase p97/valosin-containing protein interacts with gp78, a ubiquitin ligase for endoplasmic reticulum-associated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

CHIP: a link between the chaperone and proteasome systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

CHIP is a chaperone-dependent E3 ligase that ubiquitylates unfolded protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

An HRD/DER-independent ER quality control mechanism involves Rsp5p-dependent ubiquitination and ER-Golgi transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Novel interaction between Apc5p and Rsp5p in an intracellular signaling pathway in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

A proteasomal ATPase subunit recognizes the polyubiquitin degradation signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Proteasomes and their kin: proteases in the machine age

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Mobilizing the proteolytic machine: cell biological roles of proteasome activators and inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Structure and functions of the 20S and 26S proteasomes

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.3.1.33

The proteasome: paradigm of a self-compartmentalizing protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Mechanistic studies on the inactivation of the proteasome by lactacystin: a central role for clasto-lactacystin beta-lactone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits

21 January 2018

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Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Hsp70 molecular chaperone facilitates endoplasmic reticulum-associated protein degradation of cystic fibrosis transmembrane conductance regulator in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Distinct roles for the Hsp40 and Hsp90 molecular chaperones during cystic fibrosis transmembrane conductance regulator degradation in yeast

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Autophagy: in sickness and in health

21 January 2018

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Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Characterization of an ERAD gene as VPS30/ATG6 reveals two alternative and functionally distinct protein quality control pathways: one for soluble Z variant of human alpha-1 proteinase inhibitor (A1PiZ) and another for aggregates of A1PiZ.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Comparison of the degradative fate of monoamine oxidase in endogenous and transplanted mitochondrial outer membrane in rat hepatocytes. Implications for the cytomorphological basis of protein catabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Cytochrome P-450 and NADPH-cytochrome P-450 reductase are degraded in the autolysosomes in rat liver

21 January 2018

1 reference

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Ethanol withdrawal induced CYP2E1 degradation in vivo, blocked by proteasomal inhibitor PS-341.

21 January 2018

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NADPH-dependent microsomal electron transfer increases degradation of CYP2E1 by the proteasome complex: role of reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Proteasome-dependent degradation of cytochromes P450 2E1 and 2B1 expressed in tetracycline-regulated HeLa cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Role of the proteasome complex in degradation of human CYP2E1 in transfected HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Characterization of cytochrome P4502E1 turnover in transfected HepG2 cells expressing human CYP2E1.

21 January 2018

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Cytochrome P450 3A conjugation to ubiquitin in a process distinct from classical ubiquitination pathway

21 January 2018

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Selective fast degradation of cytochrome P-450 2E1 in serum-deprived hepatoma cells by a mechanism sensitive to inhibitors of vesicular transport

21 January 2018

1 reference

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Cytokine gene polymorphisms in Japanese patients with hepatitis B virus infection--association between TGF-beta1 polymorphisms and hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Regulation of cytochrome P450 2E1 by heat shock protein 90-dependent stabilization and CHIP-dependent proteasomal degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

From lysosome to proteasome: the power of yeast in the dissection of proteinase function in cellular regulation and waste disposal

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Degradation of CFTR by the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Impaired regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation in lovastatin-resistant cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Regulated degradation of HMG-CoA reductase, an integral membrane protein of the endoplasmic reticulum, in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Differential requirements of novel A1PiZ degradation deficient (ADD)genes in ER-associated protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Monitoring protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Ubiquitin-dependent 26S proteasomal pathway: a role in the degradation of native human liver CYP3A4 expressed in Saccharomyces cerevisiae?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Native CYP2C11: heterologous expression in Saccharomyces cerevisiae reveals a role for vacuolar proteases rather than the proteasome system in the degradation of this endoplasmic reticulum protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Vacuolar degradation of rat liver CYP2B1 in Saccharomyces cerevisiae: further validation of the yeast model and structural implications for the degradation of mammalian endoplasmic reticulum P450 proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Endoplasmic reticulum-associated degradation of cytochrome P450 CYP3A4 in Saccharomyces cerevisiae: further characterization of cellular participants and structural determinants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Cytochrome P-450 and the activation of promutagens in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Use of modular substrates demonstrates mechanistic diversity and reveals differences in chaperone requirement of ERAD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality control

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05-A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

A field guide to ubiquitylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

N- and C-terminal sequences control degradation of MAD3/I kappa B alpha in response to inducers of NF-kappa B activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Degradation signals recognized by the Ubc6p-Ubc7p ubiquitin-conjugating enzyme pair

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Ubiquitin-mediated proteolysis of a short-lived regulatory protein depends on its cellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin-independent substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Degradation signal masking by heterodimerization of MATalpha2 and MATa1 blocks their mutual destruction by the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Mutagenic analysis of the destruction signal of mitotic cyclins and structural characterization of ubiquitinated intermediates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

COOH-terminal truncations promote proteasome-dependent degradation of mature cystic fibrosis transmembrane conductance regulator from post-Golgi compartments

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Signals for sorting of transmembrane proteins to endosomes and lysosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Degradation of rat hepatic cytochrome P-450p

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Phosphorylation of cytochrome-P-450-dependent monooxygenase components.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Phosphorylation of cytochromes P450: first discovery of a posttranslational modification of a drug-metabolizing enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Evidence against a role for serine 129 in determining murine cytochrome P450 Cyp2e-1 protein levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Phosphorylation of native and heme-modified CYP3A4 by protein kinase C: a mass spectrometric characterization of the phosphorylated peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Proteasomal degradation of human CYP1B1: effect of the Asn453Ser polymorphism on the post-translational regulation of CYP1B1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Current trends in drug-induced autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Use of molecular simulation for mapping conformational CYP2E1 epitopes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Antigen processing by the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Characterization of the acetaminophen-induced degradation of cytochrome P450-3A4 and the proteolytic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

Inhibition of Cytochrome P450 Enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.33

21 January 2018

Identifiers

DOI

10.1517/17425255.3.1.33

1 reference

15 August 2017

1 reference