(Q36729104)

15 August 2017

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title

Tumor hypoxia and targeted gene therapy (English)

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15 August 2017

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1

Olga Greco

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15 August 2017

Simon Scott

2

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15 August 2017

publication date

1 January 2007

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International Review of Cytology

15 August 2017

published in

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15 August 2017

volume

257

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15 August 2017

page(s)

181-212

1 reference

Validating survivin as a cancer therapeutic target

15 August 2017

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7 January 2021

Hypoxia targeted gene therapy to increase the efficacy of tirapazamine as an adjuvant to radiotherapy: reversing tumor radioresistance and effecting cure

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7 January 2021

A phase I/II evaluation of tirapazamine administered intravenously concurrent with cisplatin and radiotherapy in women with locally advanced cervical cancer

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7 January 2021

Inhibition of hypoxia inducible factor 1alpha causes oxygen-independent cytotoxicity and induces p53 independent apoptosis in glioblastoma cells

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Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance

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7 January 2021

Analysis of ARD1 function in hypoxia response using retroviral RNA interference

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7 January 2021

Bifidobacterium longum as an oral delivery system of endostatin for gene therapy on solid liver cancer

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7 January 2021

Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer.

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7 January 2021

Effect of cancer chemotherapy on the hypoxic fraction of a solid tumor measured using a local tumor control assay

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7 January 2021

Gene directed enzyme/prodrug therapy of cancer: historical appraisal and future prospectives

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7 January 2021

Novel chimeric gene promoters responsive to hypoxia and ionizing radiation.

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7 January 2021

How to overcome (and exploit) tumor hypoxia for targeted gene therapy.

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7 January 2021

Can gene therapy overcome the problem of hypoxia in radiotherapy?

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7 January 2021

Hypoxia- and radiation-activated Cre/loxP 'molecular switch' vectors for gene therapy of cancer.

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7 January 2021

Are cancer cells acidic?

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7 January 2021

The macrophage - a novel system to deliver gene therapy to pathological hypoxia

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7 January 2021

Endothelin-2 is a macrophage chemoattractant: implications for macrophage distribution in tumors

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7 January 2021

Hypoxia inducible factor activates the transforming growth factor-alpha/epidermal growth factor receptor growth stimulatory pathway in VHL(-/-) renal cell carcinoma cells

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7 January 2021

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7 January 2021

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7 January 2021

Expression of hypoxia-inducible factor-1alpha in cervical carcinomas: correlation with tumor oxygenation

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Transcriptional targeting of acute hypoxia in the tumour stroma is a novel and viable strategy for cancer gene therapy

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7 January 2021

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

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7 January 2021

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7 January 2021

Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation

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7 January 2021

Macrophages in human breast disease: a quantitative immunohistochemical study

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7 January 2021

Hypoxia-inducible factor (HIF1A and HIF2A), angiogenesis, and chemoradiotherapy outcome of squamous cell head-and-neck cancer

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7 January 2021

Suppression of tumor growth through disruption of hypoxia-inducible transcription

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7 January 2021

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

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7 January 2021

HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

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7 January 2021

Hypoxic gene expression and metastasis

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7 January 2021

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7 January 2021

Anaerobic bacteria as a gene delivery system that is controlled by the tumor microenvironment

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7 January 2021

Expression of vascular endothelial growth factor by macrophages is up-regulated in poorly vascularized areas of breast carcinomas

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7 January 2021

Evaluating hypoxia-inducible factor-1alpha as a cancer therapeutic target via inducible RNA interference in vivo

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7 January 2021

Bifidobacterium adolescentis as a delivery system of endostatin for cancer gene therapy: selective inhibitor of angiogenesis and hypoxic tumor growth

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7 January 2021

A hypoxia-independent hypoxia-inducible factor-1 activation pathway induced by phosphatidylinositol-3 kinase/Akt in HER2 overexpressing cells

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Expression of hypoxia-inducible factor-1alpha protein predicts survival in patients with transitional cell carcinoma of the upper urinary tract.

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7 January 2021

Hypoxia down-regulates MCP-1 expression: implications for macrophage distribution in tumors.

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7 January 2021

Pilot trial of genetically modified, attenuated Salmonella expressing the E. coli cytosine deaminase gene in refractory cancer patients

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7 January 2021

Radio-responsive recA promoter significantly increases TNFalpha production in recombinant clostridia after 2 Gy irradiation

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7 January 2021

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7 January 2021

Anti-tumor angiogenesis therapy using soluble receptors: enhanced inhibition of tumor growth when soluble fibroblast growth factor receptor-1 is used with soluble vascular endothelial growth factor receptor.

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7 January 2021

A tumor-specific gene therapy strategy targeting dysregulation of the VHL/HIF pathway in renal cell carcinomas

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7 January 2021

Functionality of hypoxia-induced BAX expression in a human glioblastoma xenograft model

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7 January 2021

Hypoxia inhibition of apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).

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7 January 2021

Spleen necrosis virus-derived C-type retroviral vectors for gene transfer to quiescent cells

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7 January 2021

Generation of high-titer retroviral vector-producing macrophages as vehicles for in vivo gene transfer.

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7 January 2021

Overexpression of human NADPH:cytochrome c (P450) reductase confers enhanced sensitivity to both tirapazamine (SR 4233) and RSU 1069

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7 January 2021

Prodrugs in genetic chemoradiotherapy.

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7 January 2021

Oxygen-sensitive enzyme-prodrug gene therapy for the eradication of radiation-resistant solid tumours

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7 January 2021

Targeted macrophage cytotoxicity using a nonreplicative live vector expressing a tumor-specific single-chain variable region fragment

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7 January 2021

Herpes simplex virus amplicon delivery of a hypoxia-inducible angiogenic inhibitor blocks capillary formation in hepatocellular carcinoma

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7 January 2021

Employing tumor hypoxia to enhance oncolytic viral therapy in breast cancer

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7 January 2021

Hypoxia reduces adenoviral replication in cancer cells by downregulation of viral protein expression

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7 January 2021

Tumor size and oxygenation are independent predictors of nodal diseases in patients with cervix cancer

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7 January 2021

A novel hypoxia-inducible factor (HIF) activated oncolytic adenovirus for cancer therapy

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7 January 2021

Cancer therapy with a replicating oncolytic adenovirus targeting the hypoxic microenvironment of tumors

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7 January 2021

Replicative oncolytic herpes simplex viruses in combination cancer therapies

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7 January 2021

Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

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7 January 2021

Utilizing tumor hypoxia to enhance oncolytic viral therapy in colorectal metastases

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7 January 2021

Phase I trial of concurrent tirapazamine, cisplatin, and radiotherapy in patients with advanced head and neck cancer

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7 January 2021

Hypoxia-induced treatment failure in advanced squamous cell carcinoma of the uterine cervix is primarily due to hypoxia-induced radiation resistance rather than hypoxia-induced metastasis

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7 January 2021

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

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7 January 2021

Hypoxia-induced resistance to doxorubicin and methotrexate in human melanoma cell lines in vitro.

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7 January 2021

NADPH:cytochrome c (P450) reductase activates tirapazamine (SR4233) to restore hypoxic and oxic cytotoxicity in an aerobic resistant derivative of the A549 lung cancer cell line

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7 January 2021

Adenovirus-mediated gene transfer into monocyte-derived macrophages of patients with X-linked chronic granulomatous disease: ex vivo correction of deficient respiratory burst

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7 January 2021

Transduction of human PBMC-derived dendritic cells and macrophages by an HIV-1-based lentiviral vector system

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7 January 2021

Radiation and hypoxia inducible gene therapy systems.

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7 January 2021

Targeting HIF-1 for cancer therapy

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7 January 2021

Effect of hypoxia on Ad5 infection, transgene expression and replication.

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7 January 2021

Coinduction of glucose-regulated proteins and doxorubicin resistance in Chinese hamster cells

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7 January 2021

Transfection of human macrophages by lipoplexes via the combined use of transferrin and pH-sensitive peptides

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7 January 2021

Attenuation of proteasome-induced proteolysis in skeletal muscle by {beta}-hydroxy-{beta}-methylbutyrate in cancer-induced muscle loss

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7 January 2021

Gene transfer of antisense hypoxia inducible factor-1 alpha enhances the therapeutic efficacy of cancer immunotherapy

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7 January 2021

Regression of solid tumors by engineered overexpression of von Hippel–Lindau tumor suppressor protein and antisense hypoxia-inducible factor-1α

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7 January 2021

Overexpression of von Hippel-Lindau tumor suppressor protein and antisense HIF-1alpha eradicates gliomas

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7 January 2021

Tumour hypoxia and vascular density as predictors of metastasis in squamous cell carcinoma of the uterine cervix

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7 January 2021

Hypoxia-inducible factor-1 alpha in non small cell lung cancer: relation to growth factor, protease and apoptosis pathways

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7 January 2021

The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

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7 January 2021

M-CSF (monocyte colony stimulating factor) and M-CSF receptor expression by breast tumour cells: M-CSF mediated recruitment of tumour infiltrating monocytes?

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7 January 2021

Specific targeting of cytosine deaminase to solid tumors by engineered Clostridium acetobutylicum.

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7 January 2021

The histological structure of some human lung cancers and the possible implications for radiotherapy

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7 January 2021

Disrupting tumour blood vessels

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7 January 2021

The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy.

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7 January 2021

Development of a hypoxia-inducible cytosine deaminase expression vector for gene-directed prodrug cancer therapy.

1 reference

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7 January 2021

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

1 reference

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7 January 2021

Embryonic endothelial progenitor cells armed with a suicide gene target hypoxic lung metastases after intravenous delivery

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7 January 2021

In vivo expression of mRNAs encoding hypoxia-inducible factor 1

1 reference

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7 January 2021

Enhanced response to radiotherapy in tumours deficient in the function of hypoxia-inducible factor-1

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7 January 2021

Tumor-specific gene expression using the survivin promoter is further increased by hypoxia

1 reference

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7 January 2021

Bifidobacterium longum as a delivery system for cancer gene therapy: selective localization and growth in hypoxic tumors

1 reference

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7 January 2021

Bifidobacterium longum as a delivery system for gene therapy of chemically induced rat mammary tumors

1 reference

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7 January 2021

Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2957005-1

7 January 2021

Enhancement of hypoxia-induced tumor cell death in vitro and radiation therapy in vivo by use of small interfering RNA targeted to hypoxia-inducible factor-1alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0074-7696%2807%2957005-1

7 January 2021

10.1016/S0074-7696(07)57005-1

Identifiers

DOI

1 reference

15 August 2017

1 reference