(Q36786022)

16 August 2017

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title

Structural biology of the tumor suppressor p53 and cancer-associated mutants (English)

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16 August 2017

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2

Alan R Fersht

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16 August 2017

1

Andreas C Joerger

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16 August 2017

publication date

1 January 2007

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Advances in Cancer Research

16 August 2017

published in

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16 August 2017

volume

97

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16 August 2017

page(s)

1-23

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Effects of common cancer mutations on stability and DNA binding of full-length p53 compared with isolated core domains.

16 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Four p53 DNA-binding domain peptides bind natural p53-response elements and bend the DNA.

1 reference

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7 January 2021

A global suppressor motif for p53 cancer mutants

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7 January 2021

Genetic selection of intragenic suppressor mutations that reverse the effect of common p53 cancer mutations

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7 January 2021

Some p53-binding proteins that can function as arbiters of life and death.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Thermodynamic stability of wild-type and mutant p53 core domain

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Small molecules that reactivate mutant p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Solution structure of p53 core domain: structural basis for its instability

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

How many mutant p53 molecules are needed to inactivate a tetramer?

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

High-resolution structure of the oligomerization domain of p53 by multidimensional NMR

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Refined solution structure of the oligomerization domain of the tumour suppressor p53

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

p53 protein variants: structural and functional similarities with p63 and p73 isoforms

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

The N-terminal domain of p53 is natively unfolded.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Crystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Human tumor-derived p53 proteins exhibit binding site selectivity and temperature sensitivity for transactivation in a yeast-based assay

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Definition of a consensus binding site for p53

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Pharmacological rescue of mutant p53 conformation and function

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Kinetic Instability of p53 Core Domain Mutants

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https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Structural distortion of p53 by the mutation R249S and its rescue by a designed peptide: implications for "mutant conformation".

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Modulation of binding of DNA to the C-terminal domain of p53 by acetylation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Binding of Rad51 and other peptide sequences to a promiscuous, highly electrostatic binding site in p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

p300/CBP/p53 interaction and regulation of the p53 response

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

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https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Structure of the p53 core domain dimer bound to DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Structural differences in the DNA binding domains of human p53 and its C. elegans ortholog Cep-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Structures of p53 cancer mutants and mechanism of rescue by second-site suppressor mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Structural basis for understanding oncogenic p53 mutations and designing rescue drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Structural basis of DNA recognition by p53 tetramers.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

NMR spectroscopy reveals the solution dimerization interface of p53 core domains bound to their consensus DNA

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https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

NMR indicates that the small molecule RITA does not block p53-MDM2 binding in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

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https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

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https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

The complexity of p53 stabilization and activation

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https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Local Structural Elements in the Mostly Unstructured Transcriptional Activation Domain of Human p53

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

In vitro evolution of thermostable p53 variants

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

The biological impact of the human master regulator p53 can be altered by mutations that change the spectrum and expression of its target genes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Raster3D: photorealistic molecular graphics

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https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

The p53 and Mdm2 families in cancer.

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https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

The p53-Mdm2 module and the ubiquitin system.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Crystallization and structure solution of p53 (residues 326-356) by molecular replacement using an NMR model as template

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

MDM2--master regulator of the p53 tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Identification of an additional negative regulatory region for p53 sequence-specific DNA binding

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Semirational design of active tumor suppressor p53 DNA binding domain with enhanced stability

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Mechanism of rescue of common p53 cancer mutations by second-site suppressor mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

The IARC TP53 database: new online mutation analysis and recommendations to users

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Comparison of the human and worm p53 structures suggests a way for enhancing stability

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Sequence-specific transcriptional activation is essential for growth suppression by p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Why is p53 acetylated?

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Functional mutants of the sequence-specific transcription factor p53 and implications for master genes of diversity

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https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Characterization of the p53-rescue drug CP-31398 in vitro and in living cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Recognition of DNA by p53 Core Domain and Location of Intermolecular Contacts of Cooperative Binding

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Structure of the negative regulatory domain of p53 bound to S100B(betabeta)

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Effect of phosphorylation on tetramerization of the tumor suppressor protein p53

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Nuclear accumulation of p53 protein is mediated by several nuclear localization signals and plays a role in tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Isolation of Temperature-sensitive p53 Mutations from a Comprehensive Missense Mutation Library

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

CP-31398, a putative p53-stabilizing molecule tested in mammalian cells and in yeast for its effects on p53 transcriptional activity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Effects of oncogenic mutations and DNA response elements on the binding of p53 to p53-binding protein 2 (53BP2).

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Core domain interactions in full-length p53 in solution

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Surfing the p53 network

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Live or let die: the cell's response to p53

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Identification of a novel p53 functional domain that is necessary for efficient growth suppression

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Stabilization of p53 by CP-31398 inhibits ubiquitination without altering phosphorylation at serine 15 or 20 or MDM2 binding.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Regulation of DNA binding of p53 by its C-terminal domain.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Cooperative binding of tetrameric p53 to DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Structure-based rescue of common tumor-derived p53 mutants

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Strategies for therapeutic targeting of the p53 pathway in cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Hot-spot mutants of p53 core domain evince characteristic local structural changes.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

Wild type p53 sensitizes soft tissue sarcoma cells to doxorubicin by down-regulating multidrug resistance-1 expression

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

A temperature-sensitive mutant of human p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2997001-8

7 January 2021

10.1016/S0065-230X(06)97001-8

Identifiers

DOI

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16 August 2017

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