(Q36999089)

17 August 2017

1 reference

title

HIF gene expression in cancer therapy (English)

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17 August 2017

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4

Amato J Giaccia

1 reference

17 August 2017

Denise A Chan

1

1 reference

17 August 2017

Adam J Krieg

series ordinal

2

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17 August 2017

Sandra Turcotte

series ordinal

3

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17 August 2017

language of work or name

English

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publication date

1 January 2007

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17 August 2017

published in

Methods in Enzymology

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17 August 2017

volume

435

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17 August 2017

page(s)

323-345

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Hypoxia-inducible factor-1 and oncogenic signalling

17 August 2017

cites work

1 reference

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7 January 2021

Hypoxia inducible factor-1: a novel target for cancer therapy

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7 January 2021

MAP kinases and hypoxia in the control of VEGF expression

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7 January 2021

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

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7 January 2021

Genetic instability and the tumor microenvironment: towards the concept of microenvironment-induced mutagenesis

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7 January 2021

Co-repression of mismatch repair gene expression by hypoxia in cancer cells: role of the Myc/Max network

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7 January 2021

Suppression of the hypoxia-inducible factor-1 response in cervical carcinoma xenografts by proteasome inhibitors

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7 January 2021

Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment

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7 January 2021

TSC2 regulates VEGF through mTOR-dependent and -independent pathways

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7 January 2021

A conserved family of prolyl-4-hydroxylases that modify HIF

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7 January 2021

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

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7 January 2021

Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1

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7 January 2021

Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha

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7 January 2021

Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1 alpha

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7 January 2021

Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing

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7 January 2021

Identification of novel small molecule inhibitors of hypoxia-inducible factor-1 that differentially block hypoxia-inducible factor-1 activity and hypoxia-inducible factor-1alpha induction in response to hypoxic stress and growth factors

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7 January 2021

Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Inhibitory effect of YC-1 on the hypoxic induction of erythropoietin and vascular endothelial growth factor in Hep3B cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Cell type-specific, topoisomerase II-dependent inhibition of hypoxia-inducible factor-1alpha protein accumulation by NSC 644221.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Hypoxia-inducible factor-1alpha promotes nonhypoxia-mediated proliferation in colon cancer cells and xenografts

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Soluble nickel inhibits HIF-prolyl-hydroxylases creating persistent hypoxic signaling in A549 cells

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Investigating hypoxic tumor physiology through gene expression patterns

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

RETRACTED: Lysyl oxidase is essential for hypoxia-induced metastasis

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Histone deacetylase inhibitors repress the transactivation potential of hypoxia-inducible factors independently of direct acetylation of HIF-alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Arsenite induces HIF-1a and VEGF through PI3K, Akt and reactive oxygen species in DU145 human prostate carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Vanadate-induced expression of hypoxia-inducible factor 1alpha and vascular endothelial growth factor through phosphatidylinositol 3-kinase/Akt pathway and reactive oxygen species

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

p38 signaling-mediated hypoxia-inducible factor 1 alpha and vascular endothelial growth factor induction by Cr(VI) in DU145 human prostate carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

HIF-1 as a target for drug development

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Oligomycin inhibits HIF-1alpha expression in hypoxic tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Hypoxia-inducible factor 1alpha and antiangiogenic activity of farnesyltransferase inhibitor SCH66336 in human aerodigestive tract cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Hypoxia-induced genetic instability--a calculated mechanism underlying tumor progression

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

1 reference

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7 January 2021

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Heat induction of the unphosphorylated form of hypoxia-inducible factor-1alpha is dependent on heat shock protein-90 activity

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Histone deacetylase inhibitors induce VHL and ubiquitin-independent proteasomal degradation of hypoxia-inducible factor 1alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Interplay between Estrogen Response Element Sequence and Ligands Controls in Vivo Binding of Estrogen Receptor to Regulated Genes

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Suppression of tumor growth through disruption of hypoxia-inducible transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Transcriptional response to hypoxia in human tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Nickel compounds act through phosphatidylinositol-3-kinase/Akt-dependent, p70(S6k)-independent pathway to induce hypoxia inducible factor transactivation and Cap43 expression in mouse epidermal Cl41 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Imatinib inhibits c-Kit-induced hypoxia-inducible factor-1alpha activity and vascular endothelial growth factor expression in small cell lung cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Inhibition of angiogenesis and HIF-1alpha activity by antimycin A1.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Inhibiting hypoxia-inducible factor 1 for cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Transduction pathways involved in Hypoxia-Inducible Factor-1 phosphorylation and activation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Regulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Nelfinavir down-regulates hypoxia-inducible factor 1alpha and VEGF expression and increases tumor oxygenation: implications for radiotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Accumulation of HIF-1alpha under the influence of nitric oxide.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Targeting HIF-1 for cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Arsenite induces p70S6K1 activation and HIF-1alpha expression in prostate cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

MAPK and Akt act cooperatively but independently on hypoxia inducible factor-1alpha in rasV12 upregulation of VEGF.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Characterization of an oxygen/redox-dependent degradation domain of hypoxia-inducible factor alpha (HIF-alpha) proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Purification and characterization of hypoxia-inducible factor 1

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Differential gene up-regulation by hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha in HEK293T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Differentiating the functional role of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Regulation of the multidrug resistance transporter P-glycoprotein in multicellular tumor spheroids by hypoxia-inducible factor (HIF-1) and reactive oxygen species

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

HIF1alpha delays premature senescence through the activation of MIF.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

S-nitrosation of Cys-800 of HIF-1alpha protein activates its interaction with p300 and stimulates its transcriptional activity

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

NS398 reduces hypoxia-inducible factor (HIF)-1alpha and HIF-1 activity: multiple-level effects involving cyclooxygenase-2 dependent and independent mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935016-7

7 January 2021

10.1016/S0076-6879(07)35016-7

Identifiers

DOI

1 reference

17 August 2017

1 reference