(Q37146087)

18 August 2017

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title

Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival (English)

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18 August 2017

H Llewelyn Roderick

1

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18 August 2017

Simon J Cook

series ordinal

2

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18 August 2017

language of work or name

English

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publication date

1 May 2008

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18 August 2017

published in

Nature Reviews Cancer

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18 August 2017

volume

8

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18 August 2017

issue

5

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18 August 2017

page(s)

361-375

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https://scigraph.springernature.com/pub.10.1038/nrc2374

18 August 2017

exact match

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Calmodulin is required for cell-cycle progression during G1 and mitosis

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CaMK-II inhibition reduces cyclin D1 levels and enhances the association of p27kip1 with Cdk2 to cause G1 arrest in NIH 3T3 cells

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Cyclosporine inhibits growth through the activating transcription factor/cAMP-responsive element-binding protein binding site in the cyclin D1 promoter

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TRPV6 channel controls prostate cancer cell proliferation via Ca(2+)/NFAT-dependent pathways.

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A constitutively active NFATc1 mutant induces a transformed phenotype in 3T3-L1 fibroblasts

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Overexpression of c-myc in pancreatic cancer caused by ectopic activation of NFATc1 and the Ca2+/calcineurin signaling pathway

31 March 2020

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Interaction between ROCK II and nucleophosmin/B23 in the regulation of centrosome duplication

31 March 2020

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Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression

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31 March 2020

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Identification of a human centrosomal calmodulin-binding protein that shares homology with pericentrin

31 March 2020

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Calcium, calmodulin, and CaMKII requirement for initiation of centrosome duplication in Xenopus egg extracts

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CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells

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CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability

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Calcium as a regulator of the proliferation of normal, but not of transformed, chicken fibroblasts in a plasma-containing medium

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Ras signalling is required for inactivation of the tumour suppressor pRb cell-cycle control protein

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Loss of Rb overrides the requirement for ERK activity for cell proliferation

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Ca2+ pools and cell growth. Evidence for sarcoendoplasmic Ca2+-ATPases 2B involvement in human prostate cancer cell growth control

31 March 2020

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T-type calcium channels and tumor proliferation

31 March 2020

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Variation of T-type calcium channel protein expression affects cell division of cultured tumor cells

31 March 2020

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Calcium and cancer: targeting Ca2+ transport

31 March 2020

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Alterations in the ATP2A2 gene in correlation with colon and lung cancer.

31 March 2020

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Haploinsufficiency of Atp2a2, encoding the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 Ca2+ pump, predisposes mice to squamous cell tumors via a novel mode of cancer susceptibility

31 March 2020

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Normal p21N-ras couples bombesin and other growth factor receptors to inositol phosphate production

31 March 2020

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Phospholipase C epsilon: linking second messengers and small GTPases

31 March 2020

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Transformation of Rat-1 fibroblasts with the v-src oncogene increases the tyrosine phosphorylation state and activity of the alpha subunit of Gq/G11.

31 March 2020

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Myc stimulates B lymphocyte differentiation and amplifies calcium signaling

31 March 2020

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Sarcoendoplasmic reticulum Ca(2+) ATPase type 2 downregulated in human oral squamous cell carcinoma

31 March 2020

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A genome-wide survey of RAS transformation targets

31 March 2020

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Analysis of the transcriptional program induced by Raf in epithelial cells

31 March 2020

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Initiating oncogenic event determines gene-expression patterns of human breast cancer models

31 March 2020

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Coamplification in tumors of KRAS2, type 2 inositol 1,4,5 triphosphate receptor gene, and a novel human gene, KRAG.

31 March 2020

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S100 proteins and their influence on pro-survival pathways in cancer

31 March 2020

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S100A2, a Putative Tumor Suppressor Gene, Regulates In Vitro Squamous Cell Carcinoma Migration

31 March 2020

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Integration of calcium and Ras signalling.

31 March 2020

1 reference

CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway

31 March 2020

1 reference

Identification of a Ras GTPase-activating protein regulated by receptor-mediated Ca2+ oscillations

31 March 2020

1 reference

CAPRI and RASAL impose different modes of information processing on Ras due to contrasting temporal filtering of Ca2+.

31 March 2020

1 reference

NF1 tumor suppressor gene function: narrowing the GAP

31 March 2020

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Nonsense mutations in the C-terminal SH2 region of the GTPase activating protein (GAP) gene in human tumours

31 March 2020

1 reference

A genetic screen for candidate tumor suppressors identifies REST

31 March 2020

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Candidate gene isolation and comparative analysis of a commonly deleted segment of 7q22 implicated in myeloid malignancies.

31 March 2020

1 reference

A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity

31 March 2020

1 reference

Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers.

31 March 2020

1 reference

Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1.

31 March 2020

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Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

31 March 2020

1 reference

Sustained MAP kinase activation is required for the expression of cyclin D1, p21Cip1 and a subset of AP-1 proteins in CCL39 cells

31 March 2020

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Calmodulin inhibitor W13 induces sustained activation of ERK2 and expression of p21(cip1).

31 March 2020

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Modulation of the Ras/Raf/MEK/ERK pathway by Ca(2+), and calmodulin

31 March 2020

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Regulation of mitogen-activated protein kinase phosphatase-1 expression by extracellular signal-related kinase-dependent and Ca2+-dependent signal pathways in Rat-1 cells

31 March 2020

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xCT expression reduces the early cell cycle requirement for calcium signaling

31 March 2020

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Glutathione S-transferases as regulators of kinase pathways and anticancer drug targets

31 March 2020

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31 March 2020

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The Bcl2 family: regulators of the cellular life-or-death switch

31 March 2020

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Death by design: apoptosis, necrosis and autophagy

31 March 2020

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Regulation of cell death: the calcium-apoptosis link

31 March 2020

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Ca2+ dysregulation induces mitochondrial depolarization and apoptosis: role of Na+/Ca2+ exchanger and AKT.

31 March 2020

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Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis

31 March 2020

1 reference

Bcl-2 protein family members: versatile regulators of calcium signaling in cell survival and apoptosis

31 March 2020

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The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action

31 March 2020

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BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis

31 March 2020

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Genetic evidence for involvement of type 1, type 2 and type 3 inositol 1,4,5-trisphosphate receptors in signal transduction through the B-cell antigen receptor

31 March 2020

1 reference

T cells deficient in inositol 1,4,5-trisphosphate receptor are resistant to apoptosis

31 March 2020

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Inositol 1,4,5-trisphosphate receptor type 1 is a substrate for caspase-3 and is cleaved during apoptosis in a caspase-3-dependent manner

31 March 2020

1 reference

Caspase-3-induced truncation of type 1 inositol trisphosphate receptor accelerates apoptotic cell death and induces inositol trisphosphate-independent calcium release during apoptosis

31 March 2020

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Control of apoptosis by IP(3) and ryanodine receptor driven calcium signals

31 March 2020

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Structural and functional features and significance of the physical linkage between ER and mitochondria.

31 March 2020

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Microdomains with high Ca2+ close to IP3-sensitive channels that are sensed by neighboring mitochondria

31 March 2020

1 reference

Cell signalling: IP3 receptors channel calcium into cell death.

31 March 2020

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Quasi-synaptic calcium signal transmission between endoplasmic reticulum and mitochondria

31 March 2020

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Apoptosis driven by IP(3)-linked mitochondrial calcium signals

31 March 2020

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Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels.

31 March 2020

1 reference

Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival

31 March 2020

1 reference

Recombinant expression of the voltage-dependent anion channel enhances the transfer of Ca2+ microdomains to mitochondria

31 March 2020

1 reference

Mitochondria, oxidative stress and cell death

31 March 2020

1 reference

Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis

31 March 2020

1 reference

Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc

31 March 2020

1 reference

Critical role of phospholipase Cgamma1 in the generation of H2O2-evoked [Ca2+]i oscillations in cultured rat cortical astrocytes

31 March 2020

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Selective role for superoxide in InsP3 receptor-mediated mitochondrial dysfunction and endothelial apoptosis

31 March 2020

1 reference

Mitochondrial reactive oxygen species and Ca2+ signaling

31 March 2020

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A key role for TRPM7 channels in anoxic neuronal death

31 March 2020

1 reference

Ceramide and reactive oxygen species generated by H2O2 induce caspase-3-independent degradation of Akt/protein kinase B.

31 March 2020

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Redox regulation of PI 3-kinase signalling via inactivation of PTEN

31 March 2020

1 reference

Regulation of apoptosis by endoplasmic reticulum pathways.

31 March 2020

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Integrated endoplasmic reticulum stress responses in cancer

31 March 2020

1 reference

Regulation of calnexin sub-cellular localization modulates endoplasmic reticulum stress-induced apoptosis in MCF-7 cells.

31 March 2020

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Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol

31 March 2020

1 reference

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

31 March 2020

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Involvement of ASK1 in Ca2+-induced p38 MAP kinase activation

31 March 2020

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Multiple death pathways in retina-derived 661W cells following growth factor deprivation: crosstalk between caspases and calpains.

31 March 2020

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Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis

31 March 2020

1 reference

The enemy at the gates. Ca2+ entry through TRPM7 channels and anoxic neuronal death

31 March 2020

1 reference

Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members.

31 March 2020

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Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

31 March 2020

1 reference

Up-regulation of ALG-2 in hepatomas and lung cancer tissue

31 March 2020

1 reference

Cell death: critical control points

31 March 2020

1 reference

Bcl-2 decreases the free Ca2+ concentration within the endoplasmic reticulum

31 March 2020

1 reference

Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate.

31 March 2020

1 reference

Reduced loading of intracellular Ca(2+) stores and downregulation of capacitative Ca(2+) influx in Bcl-2-overexpressing cells.

31 March 2020

1 reference

Anti-apoptotic protein Bcl-2 interacts with and destabilizes the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA).

31 March 2020

1 reference

Bcl-2-dependent modulation of Ca(2+) homeostasis and store-operated channels in prostate cancer cells

31 March 2020

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Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria

31 March 2020

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Bcl-2 differentially regulates Ca2+ signals according to the strength of T cell receptor activation

31 March 2020

1 reference

The endoplasmic reticulum gateway to apoptosis by Bcl-X(L) modulation of the InsP3R

31 March 2020

1 reference

Squamous cell tumors in mice heterozygous for a null allele of Atp2a2, encoding the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 Ca2+ pump

31 March 2020

1 reference

Loss of the Atp2c1 secretory pathway Ca(2+)-ATPase (SPCA1) in mice causes Golgi stress, apoptosis, and midgestational death in homozygous embryos and squamous cell tumors in adult heterozygotes

31 March 2020

1 reference

SPCA1 pumps and Hailey-Hailey disease

31 March 2020

1 reference

Akt kinase phosphorylation of inositol 1,4,5-trisphosphate receptors

31 March 2020

1 reference

PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells

31 March 2020

1 reference

Lucifer's labyrinth--ten years of path finding in cell death

31 March 2020

1 reference

The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

31 March 2020

1 reference

Glycolysis and methylaminoisobutyrate uptake in rat-1 cells transfected with ras or myc oncogenes

31 March 2020

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Ca2+-permeable AMPA receptors regulate growth of human glioblastoma via Akt activation.

31 March 2020

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Blockage of Ca(2+)-permeable AMPA receptors suppresses migration and induces apoptosis in human glioblastoma cells

31 March 2020

1 reference

Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway

31 March 2020

1 reference

The pharmacology and regulation of T type calcium channels: new opportunities for unique therapeutics for cancer

31 March 2020

1 reference

The blocking of capacitative calcium entry by 2-aminoethyl diphenylborate (2-APB) and carboxyamidotriazole (CAI) inhibits proliferation in Hep G2 and Huh-7 human hepatoma cells

31 March 2020

1 reference

Calcium/calmodulin-dependent kinase I and calcium/calmodulin-dependent kinase kinase participate in the control of cell cycle progression in MCF-7 human breast cancer cells.

31 March 2020

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alpha-CaMKII controls the growth of human osteosarcoma by regulating cell cycle progression

31 March 2020

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Redox regulation of the calcium/calmodulin-dependent protein kinases.

31 March 2020

1 reference

Inhibition of the CaM-kinases augments cell death in response to oxygen radicals and oxygen radical inducing cancer therapies in MCF-7 human breast cancer cells.

31 March 2020

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Therapeutic advantage of combining calcium channel blockers and TRAIL in prostate cancer.

31 March 2020

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

31 March 2020

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Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases.

31 March 2020

1 reference

Cancer. Addiction to oncogenes--the Achilles heal of cancer

31 March 2020

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Altered growth of human colon cancer cell lines disrupted at activated Ki-ras

31 March 2020

1 reference

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

31 March 2020

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Restoration of p53 function leads to tumour regression in vivo

31 March 2020

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Flying under the radar: the new wave of BCR-ABL inhibitors

31 March 2020

1 reference

Calretinin and calbindin D-28k, but not parvalbumin protect against glutamate-induced delayed excitotoxicity in transfected N18-RE 105 neuroblastoma-retina hybrid cells.

31 March 2020

1 reference

Modeling the effect of exogenous calcium on keratinocyte and HaCat cell proliferation and differentiation using an agent-based computational paradigm.

31 March 2020

1 reference

S100C/A11 is a key mediator of Ca2+-induced growth inhibition of human epidermal keratinocytes

31 March 2020

1 reference

A novel regulator of telomerase. S100A8 mediates differentiation-dependent and calcium-induced inhibition of telomerase activity in the human epidermal keratinocyte line HaCaT.

31 March 2020

1 reference

Role of ERK and calcium in the hypoxia-induced activation of HIF-1.

31 March 2020

1 reference

Role of PLCgamma and Ca(2+) in VEGF- and FGF-induced choroidal endothelial cell proliferation

31 March 2020

1 reference

Transient potential receptor channel 4 controls thrombospondin-1 secretion and angiogenesis in renal cell carcinoma.

31 March 2020

1 reference

Identification of channels promoting calcium spikes and waves in HT1080 tumor cells: their apparent roles in cell motility and invasion

31 March 2020

1 reference

Identification of a novel, functional role for S100A13 in invasive lung cancer cell lines.

31 March 2020

1 reference

Ras transformation results in an elevated level of cyclin D1 and acceleration of G1 progression in NIH 3T3 cells

31 March 2020

1 reference

Multiple ras effector pathways contribute to G(1) cell cycle progression

31 March 2020

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Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions

31 March 2020

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Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

31 March 2020

1 reference

The phosphoinositide 3-kinase pathway

31 March 2020

1 reference

Structure, regulation and function of PKB/AKT--a major therapeutic target

31 March 2020

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Mechanism of activation and function of protein kinase B.

31 March 2020

1 reference

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

31 March 2020

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

31 March 2020

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Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

31 March 2020

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

31 March 2020

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

31 March 2020

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

31 March 2020

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

31 March 2020

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Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway

31 March 2020

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Targeting the PI3K-Akt pathway in human cancer: rationale and promise

31 March 2020

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The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

31 March 2020

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Involvement of the bcl-2 gene in human follicular lymphoma

31 March 2020

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Errors of homeostasis and deregulated apoptosis

31 March 2020

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Life in the balance: how BH3-only proteins induce apoptosis.

31 March 2020

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p53: new roles in metabolism

31 March 2020

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Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

31 March 2020

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Regulatory phosphorylation of Bim: sorting out the ERK from the JNK

31 March 2020

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Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

31 March 2020

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Bcl-2 functions in an antioxidant pathway to prevent apoptosis

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC2374

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Dimensions Publication ID

18 August 2017

1047522069

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