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p53 as a therapeutic target.
scientific article published on August 2008
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instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PubMed publication ID
18697367
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18697367%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 January 2020
review article
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stated in
Europe PubMed Central
title
p53 as a therapeutic target
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
18697367
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18697367%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 January 2020
author name string
O D Staples
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
18697367
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18697367%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 January 2020
R J C Steele
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
18697367
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18697367%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 January 2020
S Lain
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed publication ID
18697367
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18697367%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 January 2020
publication date
1 August 2008
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stated in
Europe PubMed Central
PubMed publication ID
18697367
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18697367%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 January 2020
published in
Journal of the Royal College of Surgeons of Edinburgh
1 reference
stated in
Europe PubMed Central
PubMed publication ID
18697367
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18697367%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 January 2020
volume
6
1 reference
stated in
Europe PubMed Central
PubMed publication ID
18697367
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18697367%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 January 2020
issue
4
1 reference
stated in
Europe PubMed Central
PubMed publication ID
18697367
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18697367%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 January 2020
page(s)
240-243
1 reference
stated in
Europe PubMed Central
PubMed publication ID
18697367
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18697367%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 January 2020
cites work
T antigen is bound to a host protein in SY40-transformed cells
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reference URL
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7 January 2021
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inferred from DOI database lookup
Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells
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7 January 2021
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inferred from DOI database lookup
Mutations in the p53 gene occur in diverse human tumour types
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1479-666X%2808%2980034-0
retrieved
7 January 2021
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inferred from DOI database lookup
Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1479-666X%2808%2980034-0
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7 January 2021
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inferred from DOI database lookup
The p53 proto-oncogene can act as a suppressor of transformation
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1479-666X%2808%2980034-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Wild-type p53 can inhibit oncogene-mediated focus formation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1479-666X%2808%2980034-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
P53 in cancer: a paradigm for modern management of cancer
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1479-666X%2808%2980034-0
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7 January 2021
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inferred from DOI database lookup
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1479-666X%2808%2980034-0
retrieved
7 January 2021
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inferred from DOI database lookup
Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1479-666X%2808%2980034-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Improving cancer therapy by non-genotoxic activation of p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1479-666X%2808%2980034-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Live or let die: the cell's response to p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1479-666X%2808%2980034-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1479-666X%2808%2980034-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mdm2 promotes the rapid degradation of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1479-666X%2808%2980034-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of p53 stability by Mdm2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1479-666X%2808%2980034-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mapping of the p53 and mdm-2 interaction domains
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1479-666X%2808%2980034-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1479-666X%2808%2980034-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1479-666X%2808%2980034-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Therapeutic exploitation of the p53 pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1479-666X%2808%2980034-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Wild-type p53: tumors can't stand it.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1479-666X%2808%2980034-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
P53 abnormalities and outcomes in colorectal cancer: a systematic review.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1479-666X%2808%2980034-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1479-666X%2808%2980034-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Reactivation of mutant p53: molecular mechanisms and therapeutic potential
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1479-666X%2808%2980034-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1479-666X%2808%2980034-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Small molecules that reactivate mutant p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1479-666X%2808%2980034-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proteomic identification of heat shock protein 90 as a candidate target for p53 mutation reactivation by PRIMA-1 in breast cancer cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1479-666X%2808%2980034-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Strategies for therapeutic targeting of the p53 pathway in cancer.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1479-666X%2808%2980034-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1479-666X%2808%2980034-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53 in health and disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1479-666X%2808%2980034-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The ARF/p53 pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1479-666X%2808%2980034-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of mutated TP53 on response of advanced breast cancers to high-dose chemotherapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1479-666X%2808%2980034-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1479-666X%2808%2980034-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1479-666X%2808%2980034-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pilot screening programme for small molecule activators of p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1479-666X%2808%2980034-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1479-666X%2808%2980034-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1479-666X%2808%2980034-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effects on normal fibroblasts and neuroblastoma cells of the activation of the p53 response by the nuclear export inhibitor leptomycin B.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1479-666X%2808%2980034-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An inhibitor of nuclear export activates the p53 response and induces the localization of HDM2 and p53 to U1A-positive nuclear bodies associated with the PODs
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1479-666X%2808%2980034-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Synergistic activation of p53-dependent transcription by two cooperating damage recognition pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1479-666X%2808%2980034-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1479-666X%2808%2980034-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of p53 by MDM2 antagonists can protect proliferating cells from mitotic inhibitors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1479-666X%2808%2980034-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S1479-666X(08)80034-0
1 reference
stated in
Europe PubMed Central
PubMed publication ID
18697367
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18697367%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 January 2020
PubMed publication ID
18697367
1 reference
stated in
Europe PubMed Central
PubMed publication ID
18697367
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18697367%20AND%20SRC:MED&resulttype=core&format=json
retrieved
12 January 2020
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