(Q37448942)

20 August 2017

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title

Oncolytic adenoviral gene therapy in ovarian cancer: why we are not wasting our time (English)

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20 August 2017

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Iain A McNeish

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author name string

Am Young

series ordinal

1

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20 August 2017

language of work or name

English

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publication date

1 April 2009

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20 August 2017

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20 August 2017

volume

5

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20 August 2017

issue

3

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20 August 2017

page(s)

339-357

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Regression of Burkitt's lymphoma in association with measles infection.

20 August 2017

cites work

1 reference

Progress and problems with the use of viral vectors for gene therapy

21 January 2018

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A phase III clinical evaluation of herpes simplex virus type 1 thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme.

21 January 2018

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Oncolytic biotherapy: a novel therapeutic plafform

21 January 2018

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Replication-selective oncolytic viruses in the treatment of cancer.

21 January 2018

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Recent lessons in gene expression, cell cycle control, and cell biology from adenovirus

21 January 2018

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Retinoblastoma family proteins as key targets of the small DNA virus oncoproteins.

21 January 2018

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Regulation of the cell cycle and apoptosis by the oncogenes of adenovirus

21 January 2018

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The RB and p53 pathways in cancer

21 January 2018

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Adenovirus E1A oncogene expression in tumor cells enhances killing by TNF-related apoptosis-inducing ligand (TRAIL).

21 January 2018

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Functions and mechanisms of action of the adenovirus E3 proteins

21 January 2018

1 reference

Three adenovirus E3 proteins cooperate to evade apoptosis by tumor necrosis factor-related apoptosis-inducing ligand receptor-1 and -2.

21 January 2018

1 reference

Interaction of an adenovirus E3 14.7-kilodalton protein with a novel tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains

21 January 2018

1 reference

To replicate or not to replicate: achieving selective oncolytic virus replication in cancer cells through translational control

21 January 2018

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Functions of the adenovirus E4 proteins and their impact on viral vectors

21 January 2018

1 reference

Inactivating intracellular antiviral responses during adenovirus infection

21 January 2018

1 reference

Control of adenovirus packaging.

21 January 2018

1 reference

Activation of the early-late switch in adenovirus type 5 major late transcription unit expression by L4 gene products.

21 January 2018

1 reference

Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity

21 January 2018

1 reference

Adenovirus inhibition of cellular protein synthesis involves inactivation of cap-binding protein

21 January 2018

1 reference

Adenovirus tripartite leader sequence enhances translation of mRNAs late after infection

21 January 2018

1 reference

A phase I/II trial of rAd/p53 (SCH 58500) gene replacement in recurrent ovarian cancer

21 January 2018

1 reference

Assessment of p53 gene transfer and biological activities in a clinical study of adenovirus-p53 gene therapy for recurrent ovarian cancer

21 January 2018

1 reference

Why did p53 gene therapy fail in ovarian cancer?

21 January 2018

1 reference

An adenovirus mutant that replicates selectively in p53-deficient human tumor cells

21 January 2018

1 reference

Dissection of functional domains in the adenovirus 2 early 1B 55K polypeptide by suppressor-linker insertional mutagenesis

21 January 2018

1 reference

Domains required for in vitro association between the cellular p53 and the adenovirus 2 E1B 55K proteins.

21 January 2018

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p53-dependent cell death/apoptosis is required for a productive adenovirus infection

21 January 2018

1 reference

Efficacy of a replication-selective adenovirus against ovarian carcinomatosis is dependent on tumor burden, viral replication and p53 status

21 January 2018

1 reference

Nuclear export of the E1B 55-kDa and E4 34-kDa adenoviral oncoproteins mediated by a rev-like signal sequence

21 January 2018

1 reference

Mechanisms by which DNA tumor virus oncoproteins target the Rb family of pocket proteins

21 January 2018

1 reference

Activity of the adenoviral E1A deletion mutant dl922-947 in ovarian cancer: comparison with E1A wild-type viruses, bioluminescence monitoring, and intraperitoneal delivery in icodextrin.

21 January 2018

1 reference

Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment

21 January 2018

1 reference

Modified adenoviral vectors ablated for coxsackievirus-adenovirus receptor, alphav integrin, and heparan sulfate binding reduce in vivo tissue transduction and toxicity.

21 January 2018

1 reference

Adenovirus Binding to Blood Factors Results in Liver Cell Infection and Hepatotoxicity

21 January 2018

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Adenovirus-platelet interaction in blood causes virus sequestration to the reticuloendothelial system of the liver

21 January 2018

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Determination of molecules regulating gene delivery using adenoviral vectors in ovarian carcinomas

21 January 2018

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Oncolytic adenoviruses - selective retargeting to tumor cells

21 January 2018

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Retargeting polymer-coated adenovirus to the FGF receptor allows productive infection and mediates efficacy in a peritoneal model of human ovarian cancer

21 January 2018

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Virotherapy of ovarian cancer with polymer-cloaked adenovirus retargeted to the epidermal growth factor receptor.

21 January 2018

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Gene transfer to ovarian cancer versus normal tissues with fiber-modified adenoviruses

21 January 2018

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A mosaic fiber adenovirus serotype 5 vector containing reovirus sigma 1 and adenovirus serotype 3 knob fibers increases transduction in an ovarian cancer ex vivo system via a coxsackie and adenovirus receptor-independent pathway

21 January 2018

1 reference

Preclinical Characterization of the Antiglioma Activity of a Tropism-Enhanced Adenovirus Targeted to the Retinoblastoma Pathway

21 January 2018

1 reference

Treatment of ovarian cancer with a novel dual targeted conditionally replicative adenovirus (CRAd).

21 January 2018

1 reference

Development of transcriptionally regulated oncolytic adenoviruses

21 January 2018

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Transcriptional targeting of adenoviral vector through the CXCR4 tumor-specific promoter

21 January 2018

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Triple-targeted oncolytic adenoviruses featuring the cox2 promoter, E1A transcomplementation, and serotype chimerism for enhanced selectivity for ovarian cancer cells

21 January 2018

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A cyclooxygenase-2 promoter-based conditionally replicating adenovirus with enhanced infectivity for treatment of ovarian adenocarcinoma

21 January 2018

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Antitumor efficacy and tumor-selective replication with a single intravenous injection of OAS403, an oncolytic adenovirus dependent on two prevalent alterations in human cancer

21 January 2018

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Good manufacturing practice production of adenoviral vectors for clinical trials

21 January 2018

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Meeting product development challenges in manufacturing clinical grade oncolytic adenoviruses

21 January 2018

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Intraperitoneal cisplatin and paclitaxel in ovarian cancer.

21 January 2018

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Intraperitoneal carboplatin-based chemotherapy for epithelial ovarian cancer

21 January 2018

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Intraperitoneal cisplatin plus intravenous cyclophosphamide versus intravenous cisplatin plus intravenous cyclophosphamide for stage III ovarian cancer.

21 January 2018

1 reference

Fluid dynamics in man of an intraperitoneal drug delivery solution: 4% icodextrin

21 January 2018

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A pilot study of adjuvant intraperitoneal 5-fluorouracil using 4% icodextrin as a novel carrier solution

21 January 2018

1 reference

Pharmacokinetic study of 5-fluorouracil in a novel dialysate solution: a long-term intraperitoneal treatment approach for advanced colorectal carcinoma

21 January 2018

1 reference

A phase I study of Adp53 (INGN 201; ADVEXIN) for patients with platinum- and paclitaxel-resistant epithelial ovarian cancer

21 January 2018

1 reference

Impact of carrier solutions on pharmacokinetics of intraperitoneal chemotherapy

21 January 2018

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Development of a formulation that enhances gene expression and efficacy following intraperitoneal administration in rabbits and mice

21 January 2018

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Icodextrin enhances survival in an intraperitoneal ovarian cancer murine model utilizing gene therapy

21 January 2018

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Advancing animal models of neoplasia through in vivo bioluminescence imaging

21 January 2018

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Visualizing gene expression in living mammals using a bioluminescent reporter.

21 January 2018

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Bioluminescent indicators in living mammals

21 January 2018

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Quantifying the activity of adenoviral E1A CR2 deletion mutants using renilla luciferase bioluminescence and 3'-deoxy-3'-[18F]fluorothymidine positron emission tomography imaging.

21 January 2018

1 reference

A pilot study of in vivo liver-directed gene transfer with an adenoviral vector in partial ornithine transcarbamylase deficiency

21 January 2018

1 reference

A phase I trial of intravenous CG7870, a replication-selective, prostate-specific antigen-targeted oncolytic adenovirus, for the treatment of hormone-refractory, metastatic prostate cancer.

21 January 2018

1 reference

Intratumoral spread of wild-type adenovirus is limited after local injection of human xenograft tumors: virus persists and spreads systemically at late time points

21 January 2018

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Selectively replicating adenoviruses targeting deregulated E2F activity are potent, systemic antitumor agents

21 January 2018

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Blood clearance rates of adenovirus type 5 in mice

21 January 2018

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The innate immune response to adenovirus vectors

21 January 2018

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Rapid Kupffer cell death after intravenous injection of adenovirus vectors

21 January 2018

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Sequestration of adenoviral vector by Kupffer cells leads to a nonlinear dose response of transduction in liver

21 January 2018

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CAR-binding ablation does not change biodistribution and toxicity of adenoviral vectors

21 January 2018

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Adenovirus serotype 5 fiber shaft influences in vivo gene transfer in mice

21 January 2018

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Influence of coagulation factor zymogens on the infectivity of adenoviruses pseudotyped with fibers from subgroup D.

21 January 2018

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Targeting of adenovirus serotype 5 (Ad5) and 5/47 pseudotyped vectors in vivo: fundamental involvement of coagulation factors and redundancy of CAR binding by Ad5.

21 January 2018

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Adenovirus serotype 5 hexon mediates liver gene transfer

21 January 2018

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Systemic interleukin-6 responses following administration of adenovirus gene transfer vectors to humans by different routes

21 January 2018

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Induction by E1A oncogene expression of cellular susceptibility to lysis by TNF.

21 January 2018

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Acute hepatotoxicity of oncolytic adenoviruses in mouse models is associated with expression of wild-type E1a and induction of TNF-alpha

21 January 2018

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Macrophage depletion combined with anticoagulant therapy increases therapeutic window of systemic treatment with oncolytic adenovirus

21 January 2018

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ADP-overexpressing adenovirus elicits enhanced cytopathic effect by induction of apoptosis

21 January 2018

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Oncolytic adenoviral mutants induce a novel mode of programmed cell death in ovarian cancer

21 January 2018

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Conditionally replicating adenoviruses kill tumor cells via a basic apoptotic machinery-independent mechanism that resembles necrosis-like programmed cell death

21 January 2018

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Autophagic cell death of malignant glioma cells induced by a conditionally replicating adenovirus

21 January 2018

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Oncolytic adenovirus Ad5/3-delta24 and chemotherapy for treatment of orthotopic ovarian cancer

21 January 2018

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Nonapoptotic functions of FADD-binding death receptors and their signaling molecules

21 January 2018

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Inhibition of TNF receptor 1 internalization by adenovirus 14.7K as a novel immune escape mechanism

21 January 2018

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Adenovirus E3-6.7K protein is required in conjunction with the E3-RID protein complex for the internalization and degradation of TRAIL receptor 2

21 January 2018

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An E1B-19 kDa gene deletion mutant adenovirus demonstrates tumor necrosis factor-enhanced cancer selectivity and enhanced oncolytic potency

21 January 2018

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Functional interactions of antiapoptotic proteins and tumor necrosis factor in the context of a replication-competent adenovirus.

21 January 2018

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Restricted replication of human adenovirus type 5 in mouse cell lines

21 January 2018

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Productive replication of human adenoviruses in mouse epidermal cells

21 January 2018

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Novel immunocompetent murine tumor models for the assessment of replication-competent oncolytic adenovirus efficacy.

21 January 2018

1 reference

E3 gene manipulations affect oncolytic adenovirus activity in immunocompetent tumor models

21 January 2018

1 reference

Replication properties of human adenovirus in vivo and in cultures of primary cells from different animal species

21 January 2018

1 reference

A canine conditionally replicating adenovirus for evaluating oncolytic virotherapy in a syngeneic animal model

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.2217/FON.09.11

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20 August 2017

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